Hsd11b2 cDNA ORF clone, Mus musculus(house mouse)

Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling.
Resch JM, Fenselau H, Madara JC, Wu C, Campbell JN, Lyubetskaya A, Dawes BA, Tsai LT, Li MM, Livneh Y, Ke Q, Kang PM, Fejes-T?th G, N?ray-Fejes-T?th A, Geerling JC, Lowell BB
Neuron96(1)190-206.e7(2017 Sep)

Kidney-specific deficiency of 11beta-HSD2 leads to Salt-dependent Hypertension, which is attributed to mineralocorticoid receptor-epithelial sodium channel-Na(+)-Cl(-) cotransporter activation in the kidney.
Title: Renal Dysfunction Induced by Kidney-Specific Gene Deletion of

Rac1 GTPase regulates 11beta-HSD2 expression, mineralocorticoid receptor activation, and mineralocorticoid receptor-mediated pro-fibrotic signaling.
Title: Rac1 GTPase regulates 11? hydroxysteroid dehydrogenase type 2 and fibrotic remodeling.

Reduced brain 11betaHSD2 promotes a hunger for salt and salt sensitivity. 11betaHSD2-positive neurons integrate salt appetite and the blood pressure response to dietary sodium through a mineralocorticoid receptor-dependent pathway.
Title: Conditional Deletion of Hsd11b2 in the Brain Causes Salt Appetite and Hypertension.

Nr3c2 has a role in mouse skin development in a process that involves HSD11B1/HSD11B2
Title: The mineralocorticoid receptor plays a transient role in mouse skin development.

11betaHSD2 inhibition suppressed lung tumor growth and invasion in association with increased tissue active glucocorticoid levels, decreased COX-2 expression, inhibition of ERK and mTOR signaling pathways.
Title: Inhibition of 11?-Hydroxysteroid Dehydrogenase Type II Suppresses Lung Carcinogenesis by Blocking Tumor COX-2 Expression as Well as the ERK and mTOR Signaling Pathways.