Hoxc13 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hoxc13
Entrez Gene ID	15422
Full Name	homeobox C13
General protein information	Preferred Names homeobox C13 Names homeobox protein Hox-C13 homeo box C13
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15 F3\|15 57.99 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010464.2	NP_034594.1	homeobox protein Hox-C13

Pathways from BioSystems

Homologies

Homo sapiens (human)	HOXC13	NP_059106.2
	HOXC13	XP_001107932.1
Rattus norvegicus (Norway rat)	Hoxc13	XP_235695.3
Danio rerio (zebrafish)	hoxc13a	NP_571618.1
Pan troglodytes (chimpanzee)	HOXC13	XP_522408.2
Bos taurus (cattle)	HOXC13	NP_001076959.1
Mus musculus (house mouse)	Hoxc13	NP_034594.1
Xenopus tropicalis (tropical clawed frog)	LOC100487255	XP_002936691.1
Canis lupus familiaris (dog)	HOXC13	XP_856807.2

Gene Ontology
Bibliography

Related articles in PubMed

WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation.
Xu M, Horrell J, Snitow M, Cui J, Gochnauer H, Syrett CM, Kallish S, Seykora JT, Liu F, Gaillard D, Katz JP, Kaestner KH, Levin B, Mansfield C, Douglas JE, Cowart BJ, Tordoff M, Liu F, Zhu X, Barlow LA, Rubin AI, McGrath JA, Morrisey EE, Chu EY, Millar SE
Nature communications815397(2017 Jun)

New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.
Naruse C, Shibata S, Tamura M, Kawaguchi T, Abe K, Sugihara K, Kato T, Nishiuchi T, Wakana S, Ikawa M, Asano M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(6)2252-2266(2017 06)

Muscle-specific expression of the RNA-binding protein Staufen1 induces progressive skeletal muscle atrophy via regulation of phosphatase tensin homolog.
Crawford Parks TE, Ravel-Chapuis A, Bondy-Chorney E, Renaud JM, C?t? J, Jasmin BJ
Human molecular genetics26(10)1821-1838(2017 05)

Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip.
Pradeepa MM, McKenna F, Taylor GC, Bengani H, Grimes GR, Wood AJ, Bhatia S, Bickmore WA
PLoS genetics13(4)e1006677(2017 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Here we demonstrate that the transcription factors SPI1 (PU.1) and HOXC13 synergistically regulate Zfp521 expression, and identify the regions of the Zfp521 promoter required for this transcriptional activity. We also show that SPI1 and HOXC13 activate Zfp521 in a dose-dependent manner.
Title: Transcriptional regulation of the proto-oncogene Zfp521 by SPI1 (PU.1) and HOXC13.

data strongly suggest that Hoxc13 is a novel and crucial regulator of the hair cycle.
Title: Hoxc13 is a crucial regulator of murine hair cycle.

a potential regulatory relationship between the sterol O-acetyltransferase 1 gene and Hoxc13 gene
Title: Dysregulated expression of sterol O-acyltransferase 1 (Soat1) in the hair shaft of Hoxc13 null mice.

YAP regulates the expression of Hoxa1 and Hoxc13 in oral and dental epithelial tissues as well as in the epidermis of skin during embryonic and adult stages.
Title: YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues.

data support a regulatory model of keratinocyte differentiation in which HOXC13-dependent activation of Foxn1 is part of a regulatory cascade controlling the expression of hair and nail terminal differentiation markers
Title: The nude mutant gene Foxn1 is a HOXC13 regulatory target during hair follicle and nail differentiation.

The following Hoxc13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hoxc13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06203	NM_010464.2 Latest version!	Mus musculus homeobox C13 (Hoxc13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$216.30 $309.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hoxc13 ( NM_010464.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034594.1 Mus musculus homeobox C13 (Hoxc13), mRNA.

Price & Availability↑

CloneID	OMu06203
Clone ID Related Accession (Same CDS sequence)	NM_010464.2
Accession Version	NM_010464.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 987bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	homeobox protein Hox-C13
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC160979.2. On Nov 17, 2006 this sequence version replaced NM_010464.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF193796.1, AY349616.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164133, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGACTT CGCTGCTCCT GCACCCGCGC TGGCCGGAGA GCCTTATGTA CGTCTATGAG 
GACAGCGCGG CGGAGAGCGG CAGCGGCGGC GGCGGGGGAG GCGGCGGCGC GGGCGGCGCG 
GGGGGTGGCT GCAGCGGAGC GAGCCCCGGC AAAGCCCCGA GCATGGACGG GCTGGGCGGT 
AGCTGCCCGG CCAGCCACTG CCGCGACCTG CTCCCGCACC CTGTATTGGC CCGCCCGCCG 
GCTCCTCTGG GTGCCCCTCA GGGCGCCGTC TACACGGACA TCCCAGCCCC GGAGGCGGCG 
CGCCAATGCG CCCCACCGCC GGCGCCCCCC ACCTCGTCCA GCGCCACCCT GGGCTATGGT 
TACCCATTTG GGGGCAGCTA CTACGGCTGC CGCCTGTCGC ACAACGTGAA CCTGCAGCAG 
AAGCCTTGCG CCTACCATCC GGGGGACAAG TACCCAGAGC CGTCGGGCGC GCTGCCTGGT 
GACGACCTGT CCTCCAGGGC TAAGGAGTTC GCCTTCTACC CCAGCTTCGC CAGCTCCTAC 
CAGGCAATGC CCGGCTACCT GGACGTGTCG GTGGTGCCTG GGATCAGCGG GCACCCGGAG 
CCGCGTCACG ACGCGCTCAT CCCTGTTGAA GGCTACCAGC ACTGGGCTCT TTCCAATGGC 
TGGGACAGTC AGGTGTACTG CTCCAAGGAG CAGTCGCAGT CCGCCCACCT CTGGAAGTCT 
CCCTTCCCAG ACGTGGTTCC TCTACAGCCC GAAGTGAGCA GCTACCGGCG CGGGCGCAAG 
AAGCGCGTGC CCTATACCAA GGTGCAGCTG AAGGAGCTAG AGAAGGAGTA CGCAGCCAGC 
AAATTCATCA CCAAAGAGAA GCGCCGGCGC ATCTCAGCCA CCACGAACCT CTCGGAGCGT 
CAGGTCACCA TCTGGTTCCA GAATCGACGC GTGAAAGAGA AAAAGGTGGT CAGCAAATCT 
AAAGCGCCTC ATCTCCACTC CACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034594.1
CDS	58..1044
Translation	MTTSLLLHPRWPESLMYVYEDSAAESGSGGGGGGGGAGGAGGGCSGASPGKAPSMDGLGGSCPASHCRDLLPHPVLARPPAPLGAPQGAVYTDIPAPEAARQCAPPPAPPTSSSATLGYGYPFGGSYYGCRLSHNVNLQQKPCAYHPGDKYPEPSGALPGDDLSSRAKEFAFYPSFASSYQAMPGYLDVSVVPGISGHPEPRHDALIPVEGYQHWALSNGWDSQVYCSKEQSQSAHLWKSPFPDVVPLQPEVSSYRRGRKKRVPYTKVQLKELEKEYAASKFITKEKRRRISATTNLSERQVTIWFQNRRVKEKKVVSKSKAPHLHST

Target ORF information:

RefSeq Version	NM_010464.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus homeobox C13 (Hoxc13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010464.2

ORF Insert Sequence:

ATGACGACTT CGCTGCTCCT GCACCCGCGC TGGCCGGAGA GCCTTATGTA CGTCTATGAG 
GACAGCGCGG CGGAGAGCGG CAGCGGCGGC GGCGGGGGAG GCGGCGGCGC GGGCGGCGCG 
GGGGGTGGCT GCAGCGGAGC GAGCCCCGGC AAAGCCCCGA GCATGGACGG GCTGGGCGGT 
AGCTGCCCGG CCAGCCACTG CCGCGACCTG CTCCCGCACC CTGTATTGGC CCGCCCGCCG 
GCTCCTCTGG GTGCCCCTCA GGGCGCCGTC TACACGGACA TCCCAGCCCC GGAGGCGGCG 
CGCCAATGCG CCCCACCGCC GGCGCCCCCC ACCTCGTCCA GCGCCACCCT GGGCTATGGT 
TACCCATTTG GGGGCAGCTA CTACGGCTGC CGCCTGTCGC ACAACGTGAA CCTGCAGCAG 
AAGCCTTGCG CCTACCATCC GGGGGACAAG TACCCAGAGC CGTCGGGCGC GCTGCCTGGT 
GACGACCTGT CCTCCAGGGC TAAGGAGTTC GCCTTCTACC CCAGCTTCGC CAGCTCCTAC 
CAGGCAATGC CCGGCTACCT GGACGTGTCG GTGGTGCCTG GGATCAGCGG GCACCCGGAG 
CCGCGTCACG ACGCGCTCAT CCCTGTTGAA GGCTACCAGC ACTGGGCTCT TTCCAATGGC 
TGGGACAGTC AGGTGTACTG CTCCAAGGAG CAGTCGCAGT CCGCCCACCT CTGGAAGTCT 
CCCTTCCCAG ACGTGGTTCC TCTACAGCCC GAAGTGAGCA GCTACCGGCG CGGGCGCAAG 
AAGCGCGTGC CCTATACCAA GGTGCAGCTG AAGGAGCTAG AGAAGGAGTA CGCAGCCAGC 
AAATTCATCA CCAAAGAGAA GCGCCGGCGC ATCTCAGCCA CCACGAACCT CTCGGAGCGT 
CAGGTCACCA TCTGGTTCCA GAATCGACGC GTGAAAGAGA AAAAGGTGGT CAGCAAATCT 
AAAGCGCCTC ATCTCCACTC CACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation.
Nature communications815397(2017 Jun)
Xu M,Horrell J,Snitow M,Cui J,Gochnauer H,Syrett CM,Kallish S,Seykora JT,Liu F,Gaillard D,Katz JP,Kaestner KH,Levin B,Mansfield C,Douglas JE,Cowart BJ,Tordoff M,Liu F,Zhu X,Barlow LA,Rubin AI,McGrath JA,Morrisey EE,Chu EY,Millar SE

New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(6)2252-2266(2017 06)
Naruse C,Shibata S,Tamura M,Kawaguchi T,Abe K,Sugihara K,Kato T,Nishiuchi T,Wakana S,Ikawa M,Asano M

Muscle-specific expression of the RNA-binding protein Staufen1 induces progressive skeletal muscle atrophy via regulation of phosphatase tensin homolog.
Human molecular genetics26(10)1821-1838(2017 05)
Crawford Parks TE,Ravel-Chapuis A,Bondy-Chorney E,Renaud JM,C?t? J,Jasmin BJ

Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip.
PLoS genetics13(4)e1006677(2017 04)
Pradeepa MM,McKenna F,Taylor GC,Bengani H,Grimes GR,Wood AJ,Bhatia S,Bickmore WA

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Hoxc13 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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