Hoxa10 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hoxa10
Entrez Gene ID	15395
Full Name	homeobox A10
Synonyms	Hox-1.8,Hoxa-10
General protein information	Preferred Names homeobox A10 Names homeobox protein Hox-A10 homeo box A10 homeobox protein Hox-1.8
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 B3\|6 25.4 cM
Summary	In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of a cluster on chromosome 6 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_008263.3	NP_032289.2	homeobox protein Hox-A10 isoform a
NM_001122950.2	NP_001116422.1	homeobox protein Hox-A10 isoform b

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HOXA10	XP_003951020.1
Canis lupus familiaris (dog)	HOXA10	NP_001193361.1
Rattus norvegicus (Norway rat)	LOC100909714	XP_003749805.1
Danio rerio (zebrafish)	hoxa10b	NP_571230.1
Mus musculus (house mouse)	Hoxa10	NP_032289.2
Gallus gallus (chicken)	LOC100858051	XP_003640791.1
Gallus gallus (chicken)	LOC100858905	XP_003640755.1
Rattus norvegicus (Norway rat)	LOC100912608	XP_006236585.1
Rattus norvegicus (Norway rat)	LOC100911668	XP_006257771.1
Xenopus tropicalis (tropical clawed frog)	hoxa10	XP_002933440.2
Homo sapiens (human)	HOXA10	NP_061824.3
Gallus gallus (chicken)	HOXA10	XP_001235693.2

Gene Ontology
Bibliography

Related articles in PubMed

Nuclear Shp2 directs normal embryo implantation via facilitating the ER? tyrosine phosphorylation by the Src kinase.
Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng GS, Xia G, Lu Z, Wang C, Wang H
Proceedings of the National Academy of Sciences of the United States of America114(18)4816-4821(2017 May)

Muscle-specific expression of the RNA-binding protein Staufen1 induces progressive skeletal muscle atrophy via regulation of phosphatase tensin homolog.
Crawford Parks TE, Ravel-Chapuis A, Bondy-Chorney E, Renaud JM, C?t? J, Jasmin BJ
Human molecular genetics26(10)1821-1838(2017 05)

Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip.
Pradeepa MM, McKenna F, Taylor GC, Bengani H, Grimes GR, Wood AJ, Bhatia S, Bickmore WA
PLoS genetics13(4)e1006677(2017 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that progesterone receptor overexpression in endometrial stromal cells, likely due to high progesterone levels, triggers cyclin D3 and Hoxa-10 overexpression, which may be involved in the pathological mechanisms of the mouse uterine decidual reaction.
Title: Hoxa-10 and Cyclin D3 Overexpression in the Decidual Reaction in a Superovulation Protocol in Young Adult C57BL/6J Mice.

Our results suggest that NA10HD increases the number of gamma-globin-transduced HSCs that engraft, leading to an elevated number of fetal hemoglobin-containing red cells.
Title: Lentiviral Transfer of ?-Globin with Fusion Gene NUP98-HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates Murine ?-Thalassemia.

Hmgn5 might act downstream of Hoxa10 to regulate the expression of Cox-2, Vegf and Mmp2.
Title: Hmgn5 functions downstream of Hoxa10 to regulate uterine decidualization in mice.

Gene-environment interactions driven by early life xenoestrogen exposure likely contributes to increased risk of estrogen-related disease in adults.-
Title: Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol-A) exposure.

we suggest that proper regional decidualization and polyploidy development requires FoxM1 signaling downstream of Hoxa10 and cyclin D3.
Title: Control of regional decidualization in implantation: Role of FoxM1 downstream of Hoxa10 and cyclin D3.

The following Hoxa10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hoxa10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18267	NM_001122950.2 Latest version!	Mus musculus homeobox A10 (Hoxa10), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu18280	NM_008263.3 Latest version!	Mus musculus homeobox A10 (Hoxa10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hoxa10 ( NM_001122950.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001116422.1 Mus musculus homeobox A10 (Hoxa10), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu18267
Clone ID Related Accession (Same CDS sequence)	NM_001122950.2
Accession Version	NM_001122950.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 285bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	homeobox protein Hox-A10 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC015583.34 and BC050839.1. On May 7, 2009 this sequence version replaced NM_001122950.1. Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1, resulting in a protein (isoform b) that is shorter and has a distinct N-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BF784828.1, BU513453.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTCAAG GCAGTTCCAA AGGCGAAAAT GCAGCCAACT GGCTCACAGC AAAGAGCGGC 
CGGAAGAAAC GCTGCCCTTA CACGAAGCAC CAGACGCTGG AGCTGGAGAA GGAGTTTCTA 
TTCAACATGT ACCTTACTCG AGAGCGGCGC CTAGAGATCA GCCGTAGCGT CCACCTCACG 
GACAGACAAG TGAAAATCTG GTTTCAGAAT CGCAGGATGA AACTGAAGAA AATGAACCGA 
GAAAACCGAA TCCGGGAGCT CACAGCCAAC TTTAATTTTT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001116422.1
CDS	568..852
Translation	MSQGSSKGENAANWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISRSVHLTDRQVKIWFQNRRMKLKKMNRENRIRELTANFNFS

Target ORF information:

RefSeq Version	NM_001122950.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus homeobox A10 (Hoxa10), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001122950.2

ORF Insert Sequence:

ATGAGTCAAG GCAGTTCCAA AGGCGAAAAT GCAGCCAACT GGCTCACAGC AAAGAGCGGC 
CGGAAGAAAC GCTGCCCTTA CACGAAGCAC CAGACGCTGG AGCTGGAGAA GGAGTTTCTA 
TTCAACATGT ACCTTACTCG AGAGCGGCGC CTAGAGATCA GCCGTAGCGT CCACCTCACG 
GACAGACAAG TGAAAATCTG GTTTCAGAAT CGCAGGATGA AACTGAAGAA AATGAACCGA 
GAAAACCGAA TCCGGGAGCT CACAGCCAAC TTTAATTTTT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hoxa10 ( NM_008263.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032289.2 Mus musculus homeobox A10 (Hoxa10), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu18280
Clone ID Related Accession (Same CDS sequence)	NM_008263.3
Accession Version	NM_008263.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1251bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	homeobox protein Hox-A10 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC015583.34 and BC050839.1. On May 7, 2009 this sequence version replaced NM_008263.2. Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050839.1, AA636231.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCAGCCA GAAAGGGCTA TCTGCTCCCT TCGCCAAATT ATCCCACAAC AATGTCATGC 
TCGGAGAGCC CTGCCGCGAA CTCCTTTTTG GTCGACTCGC TCATCAGCTC AGGCAGAGGC 
GAGGCTGGTG TTGGTGGCGG TAGCGCGGGG GGCGGTGGAG GTGGCTACTA CGCCCACGGT 
GGGGTCTACC TGCCGCCTGC CAGCGACCTG CCCTACGGGC TGCAAAGCTG CGGGCTCTTC 
CCCGCGCTGG GCAGCAAGCG TAATGAAGCG CCGTCGCCCG GAGGCGGTGG CGGTGGTGGC 
AGCGGGGGCC TGGGTCCTGG GACGCATGGC TACGCGCCCG CGCCCCTAGA CCTGTGGCTG 
GACGCGCCCC GCTCCTGCCG GATGGAGCCG CCCGACGGGC CGCCGCCACC GCAGCCACAA 
CCCCAGCAGC AGCAGCAGCA GCCGCCGCCG CCCCCGCCGC AGCCACCTCA ACCCCAGCCA 
CAGGCCACTT CGTGTTCTTT TGCGCAGAAC ATCAAAGAAG AGAGCTCCTA CTGCCTCTAC 
GATGCTGCGG ACAAATGCCC CAAGGGCTCG GCCGCCGCTG ATCTGGCCCC TTTCCCGCGG 
GGCCCGCCGC CCGACGGCTG CGCCCTGGGC GCCTCCAGCG GAGTGCCAGT ACCCGGCTAC 
TTCCGCCTGT CGCAGGCCTA CGGCACGGCC AAGGGCTTCG GCAGTGGCGG CGGCGGCACG 
CAGCAGCTCG CTAGTCCCTT TCCTGCGCAG CCCCCGGGGC GCGGTTTCGA CCCGCCGCCC 
GCACTGGCCT CTGGCTCGAC CGAGGCAGCC GGGAAGGAGC GAGTCCTAGA CTCCACGCCA 
CCACCCACTC TGGTTTGCAC CGGTGGCGGC GGCTCGCAGG GCGACGAGGA GGCACACGCG 
TCATCCTCGG CGGCTGAGGA GCTGTCTCCA GCCCCTTCAG AAAACAGTAA AGCTTCGCCG 
GAGAAGGACT CCCTGGGCAG TTCCAAAGGC GAAAATGCAG CCAACTGGCT CACAGCAAAG 
AGCGGCCGGA AGAAACGCTG CCCTTACACG AAGCACCAGA CGCTGGAGCT GGAGAAGGAG 
TTTCTATTCA ACATGTACCT TACTCGAGAG CGGCGCCTAG AGATCAGCCG TAGCGTCCAC 
CTCACGGACA GACAAGTGAA AATCTGGTTT CAGAATCGCA GGATGAAACT GAAGAAAATG 
AACCGAGAAA ACCGAATCCG GGAGCTCACA GCCAACTTTA ATTTTTCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032289.2
CDS	6..1256
Translation	MSARKGYLLPSPNYPTTMSCSESPAANSFLVDSLISSGRGEAGVGGGSAGGGGGGYYAHGGVYLPPASDLPYGLQSCGLFPALGSKRNEAPSPGGGGGGGSGGLGPGTHGYAPAPLDLWLDAPRSCRMEPPDGPPPPQPQPQQQQQQPPPPPPQPPQPQPQATSCSFAQNIKEESSYCLYDAADKCPKGSAAADLAPFPRGPPPDGCALGASSGVPVPGYFRLSQAYGTAKGFGSGGGGTQQLASPFPAQPPGRGFDPPPALASGSTEAAGKERVLDSTPPPTLVCTGGGGSQGDEEAHASSSAAEELSPAPSENSKASPEKDSLGSSKGENAANWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISRSVHLTDRQVKIWFQNRRMKLKKMNRENRIRELTANFNFS

Target ORF information:

RefSeq Version	NM_008263.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus homeobox A10 (Hoxa10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008263.3

ORF Insert Sequence:

ATGTCAGCCA GAAAGGGCTA TCTGCTCCCT TCGCCAAATT ATCCCACAAC AATGTCATGC 
TCGGAGAGCC CTGCCGCGAA CTCCTTTTTG GTCGACTCGC TCATCAGCTC AGGCAGAGGC 
GAGGCTGGTG TTGGTGGCGG TAGCGCGGGG GGCGGTGGAG GTGGCTACTA CGCCCACGGT 
GGGGTCTACC TGCCGCCTGC CAGCGACCTG CCCTACGGGC TGCAAAGCTG CGGGCTCTTC 
CCCGCGCTGG GCAGCAAGCG TAATGAAGCG CCGTCGCCCG GAGGCGGTGG CGGTGGTGGC 
AGCGGGGGCC TGGGTCCTGG GACGCATGGC TACGCGCCCG CGCCCCTAGA CCTGTGGCTG 
GACGCGCCCC GCTCCTGCCG GATGGAGCCG CCCGACGGGC CGCCGCCACC GCAGCCACAA 
CCCCAGCAGC AGCAGCAGCA GCCGCCGCCG CCCCCGCCGC AGCCACCTCA ACCCCAGCCA 
CAGGCCACTT CGTGTTCTTT TGCGCAGAAC ATCAAAGAAG AGAGCTCCTA CTGCCTCTAC 
GATGCTGCGG ACAAATGCCC CAAGGGCTCG GCCGCCGCTG ATCTGGCCCC TTTCCCGCGG 
GGCCCGCCGC CCGACGGCTG CGCCCTGGGC GCCTCCAGCG GAGTGCCAGT ACCCGGCTAC 
TTCCGCCTGT CGCAGGCCTA CGGCACGGCC AAGGGCTTCG GCAGTGGCGG CGGCGGCACG 
CAGCAGCTCG CTAGTCCCTT TCCTGCGCAG CCCCCGGGGC GCGGTTTCGA CCCGCCGCCC 
GCACTGGCCT CTGGCTCGAC CGAGGCAGCC GGGAAGGAGC GAGTCCTAGA CTCCACGCCA 
CCACCCACTC TGGTTTGCAC CGGTGGCGGC GGCTCGCAGG GCGACGAGGA GGCACACGCG 
TCATCCTCGG CGGCTGAGGA GCTGTCTCCA GCCCCTTCAG AAAACAGTAA AGCTTCGCCG 
GAGAAGGACT CCCTGGGCAG TTCCAAAGGC GAAAATGCAG CCAACTGGCT CACAGCAAAG 
AGCGGCCGGA AGAAACGCTG CCCTTACACG AAGCACCAGA CGCTGGAGCT GGAGAAGGAG 
TTTCTATTCA ACATGTACCT TACTCGAGAG CGGCGCCTAG AGATCAGCCG TAGCGTCCAC 
CTCACGGACA GACAAGTGAA AATCTGGTTT CAGAATCGCA GGATGAAACT GAAGAAAATG 
AACCGAGAAA ACCGAATCCG GGAGCTCACA GCCAACTTTA ATTTTTCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nuclear Shp2 directs normal embryo implantation via facilitating the ER? tyrosine phosphorylation by the Src kinase.
Proceedings of the National Academy of Sciences of the United States of America114(18)4816-4821(2017 May)
Ran H,Kong S,Zhang S,Cheng J,Zhou C,He B,Xin Q,Lydon JP,DeMayo FJ,Feng GS,Xia G,Lu Z,Wang C,Wang H

Muscle-specific expression of the RNA-binding protein Staufen1 induces progressive skeletal muscle atrophy via regulation of phosphatase tensin homolog.
Human molecular genetics26(10)1821-1838(2017 05)
Crawford Parks TE,Ravel-Chapuis A,Bondy-Chorney E,Renaud JM,C?t? J,Jasmin BJ

Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip.
PLoS genetics13(4)e1006677(2017 04)
Pradeepa MM,McKenna F,Taylor GC,Bengani H,Grimes GR,Wood AJ,Bhatia S,Bickmore WA

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Hoxa10 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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