Hexb cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hexb
Entrez Gene ID	15212
Full Name	hexosaminidase B
General protein information	Preferred Names hexosaminidase B Names beta-hexosaminidase subunit beta N-acetyl-beta-glucosaminidase subunit beta beta-N-acetylhexosaminidase subunit beta hexosaminidase subunit B
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13 D1\|13 50.66 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010422.2	NP_034552.1	beta-hexosaminidase subunit beta precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	HEXB	XP_005617969.1
Gallus gallus (chicken)	HEXB	XP_424791.3
Danio rerio (zebrafish)	hexa	NP_001108317.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010056	XP_319210.4
Xenopus tropicalis (tropical clawed frog)	hexb	NP_001120459.1
Pan troglodytes (chimpanzee)	HEXB	XP_001150632.1
Rattus norvegicus (Norway rat)	Hexb	NP_001011946.1
Oryza sativa (rice)	Os05g0115900	NP_001054468.1
Mus musculus (house mouse)	Hexb	NP_034552.1
	HEXB	XP_001103139.1
Arabidopsis thaliana (thale cress)	HEXO1	NP_567017.2
Homo sapiens (human)	HEXB	NP_000512.1
Bos taurus (cattle)	HEXB	NP_001069978.2
Bos taurus (cattle)	LOC786974	XP_002696308.3
Caenorhabditis elegans (roundworm)	hex-1	NP_508409.1

Gene Ontology
Bibliography

Related articles in PubMed

Intravenous administration of scAAV9-Hexb normalizes lifespan and prevents pathology in Sandhoff disease mice.
Niemir N, Rouvi?re L, Besse A, Vanier MT, Dmytrus J, Marais T, Astord S, Puech JP, Panasyuk G, Cooper JD, Barkats M, Caillaud C
Human molecular genetics(2018 Jan)

Abnormal differentiation of Sandhoff disease model mouse-derived multipotent stem cells toward a neural lineage.
Ogawa Y, Kaizu K, Yanagi Y, Takada S, Sakuraba H, Oishi K
PloS one12(6)e0178978(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

mast cell granule beta-hexosaminidase is crucial for defense against bacterial invasion, but is not involved in the allergic response. the bactericidal mechanism of beta-hexosaminidase involves degradation of bacterial cell wall peptidoglycan.
Title: Does ?-hexosaminidase function only as a degranulation indicator in mast cells? The primary role of ?-hexosaminidase in mast cell granules.

transgenic inducible strains of Sandhoff disease mice provide a dynamic platform with which to explore the pathophysiological sequelae immediately after loss of neuronal lysosomal beta-hexosaminidase activity.
Title: Characterization of inducible models of Tay-Sachs and related disease.

Thymic involution and corticosterone level in Sandhoff disease model mice.
Title: Thymic involution and corticosterone level in Sandhoff disease model mice: new aspects the pathogenesis of GM2 gangliosidosis.

These data suggest that the restricted ketogenic diet and N-butyldeoxynojirimycin may be a potential combinatorial therapy for Sandhoff disease.
Title: Restricted ketogenic diet enhances the therapeutic action of N-butyldeoxynojirimycin towards brain GM2 accumulation in adult Sandhoff disease mice.

Mannose receptor (-/-) liver sinusoidal endothelial cells had markedly and significantly reduced enzyme activities for four out of five lysosomal enzymes tested, i.e., cathepsin-D, alpha-mannosidase, beta-hexosaminidase and arylsulfatase.
Title: Liver sinusoidal endothelial cells depend on mannose receptor-mediated recruitment of lysosomal enzymes for normal degradation capacity.

The following Hexb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hexb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21830	NM_010422.2 Latest version!	Mus musculus hexosaminidase B (Hexb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$314.30 $449.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hexb ( NM_010422.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034552.1 Mus musculus hexosaminidase B (Hexb), mRNA.

Price & Availability↑

CloneID	OMu21830
Clone ID Related Accession (Same CDS sequence)	NM_010422.2
Accession Version	NM_010422.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1611bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	beta-hexosaminidase subunit beta precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY145642.1, AK168825.1 and CD775639.1. On Mar 26, 2009 this sequence version replaced NM_010422.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK151149.1, AK159178.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGCCGCAGT CCCCGCGTAG CGCCCCCGGG CTGCTGCTGC TGCAGGCGCT GGTGTCGCTA 
GTGTCGCTGG CCCTAGTGGC CCCGGCCCGA CTGCAACCTG CGCTATGGCC CTTCCCGCGC 
TCGGTGCAGA TGTTCCCGCG GCTGTTGTAC ATCTCCGCGG AGGACTTCAG CATCGACCAC 
AGTCCCAATT CCACAGCGGG CCCTTCCTGC TCGCTGCTAC AGGAGGCGTT TCGGCGATAT 
TACAACTATG TTTTTGGTTT CTACAAGAGA CATCATGGCC CTGCTAGATT TCGAGCTGAG 
CCACAGTTGC AGAAGCTCCT GGTCTCCATT ACCCTCGAGT CAGAGTGCGA GTCCTTCCCT 
AGTCTGTCTT CAGATGAAAC CTATTCTCTG CTTGTACAAG AACCAGTAGC CGTCCTCAAG 
GCCAACAGCG TTTGGGGAGC GTTACGAGGT TTAGAGACGT TTAGCCAGTT AGTTTACCAA 
GACTCTTTCG GGACTTTCAC CATCAATGAA TCCAGTATAG CTGATTCTCC AAGATTCCCT 
CATAGAGGAA TTTTAATTGA TACATCTAGA CACTTCCTGC CTGTGAAGAC AATTTTAAAA 
ACTCTGGATG CCATGGCTTT TAATAAGTTT AATGTTCTTC ACTGGCACAT AGTGGACGAC 
CAGTCTTTCC CTTATCAGAG TACCACTTTT CCTGAGCTAA GCAATAAGGG AAGCTACTCT 
TTGTCTCATG TCTATACACC AAACGATGTC CGGATGGTGC TGGAGTACGC CCGGCTCCGA 
GGGATTCGAG TCATACCAGA ATTTGATACC CCTGGCCATA CACAGTCTTG GGGCAAAGGA 
CAGAAAAACC TTCTAACTCC ATGTTACAAT CAAAAAACTA AAACTCAAGT GTTTGGGCCT 
GTAGACCCAA CTGTAAACAC AACGTATGCA TTCTTTAACA CATTTTTCAA AGAAATCAGC 
AGTGTGTTTC CAGATCAGTT CATCCACTTG GGAGGAGATG AAGTAGAATT TCAATGTTGG 
GCATCAAATC CAAACATCCA AGGTTTCATG AAGAGAAAGG GCTTTGGCAG CGATTTTAGA 
AGACTAGAAT CCTTTTATAT TAAAAAGATT TTGGAAATTA TTTCATCCTT AAAGAAGAAC 
TCCATTGTTT GGCAAGAAGT TTTTGATGAT AAGGTGGAGC TTCAGCCGGG CACAGTAGTC 
GAAGTGTGGA AGAGTGAGCA TTATTCATAT GAGCTAAAGC AAGTCACAGG CTCTGGCTTC 
CCTGCCATCC TTTCTGCTCC TTGGTACTTA GACCTGATCA GCTATGGGCA AGACTGGAAA 
AACTACTACA AAGTTGAGCC CCTTAATTTT GAAGGCTCTG AGAAGCAGAA ACAACTTGTT 
ATTGGTGGAG AAGCTTGCCT GTGGGGAGAA TTTGTGGATG CAACTAACCT TACTCCAAGA 
TTATGGCCTC GAGCAAGCGC TGTTGGTGAG AGACTCTGGA GCCCTAAAAC TGTCACTGAC 
CTAGAAAATG CCTACAAACG ACTGGCCGTG CACCGCTGCA GAATGGTCAG CCGTGGAATA 
GCTGCACAAC CTCTCTATAC TGGATACTGT AACTATGAGA ATAAAATATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034552.1
CDS	97..1707
Translation	MPQSPRSAPGLLLLQALVSLVSLALVAPARLQPALWPFPRSVQMFPRLLYISAEDFSIDHSPNSTAGPSCSLLQEAFRRYYNYVFGFYKRHHGPARFRAEPQLQKLLVSITLESECESFPSLSSDETYSLLVQEPVAVLKANSVWGALRGLETFSQLVYQDSFGTFTINESSIADSPRFPHRGILIDTSRHFLPVKTILKTLDAMAFNKFNVLHWHIVDDQSFPYQSTTFPELSNKGSYSLSHVYTPNDVRMVLEYARLRGIRVIPEFDTPGHTQSWGKGQKNLLTPCYNQKTKTQVFGPVDPTVNTTYAFFNTFFKEISSVFPDQFIHLGGDEVEFQCWASNPNIQGFMKRKGFGSDFRRLESFYIKKILEIISSLKKNSIVWQEVFDDKVELQPGTVVEVWKSEHYSYELKQVTGSGFPAILSAPWYLDLISYGQDWKNYYKVEPLNFEGSEKQKQLVIGGEACLWGEFVDATNLTPRLWPRASAVGERLWSPKTVTDLENAYKRLAVHRCRMVSRGIAAQPLYTGYCNYENKI

Target ORF information:

RefSeq Version	NM_010422.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus hexosaminidase B (Hexb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010422.2

ORF Insert Sequence:

ATGCCGCAGT CCCCGCGTAG CGCCCCCGGG CTGCTGCTGC TGCAGGCGCT GGTGTCGCTA 
GTGTCGCTGG CCCTAGTGGC CCCGGCCCGA CTGCAACCTG CGCTATGGCC CTTCCCGCGC 
TCGGTGCAGA TGTTCCCGCG GCTGTTGTAC ATCTCCGCGG AGGACTTCAG CATCGACCAC 
AGTCCCAATT CCACAGCGGG CCCTTCCTGC TCGCTGCTAC AGGAGGCGTT TCGGCGATAT 
TACAACTATG TTTTTGGTTT CTACAAGAGA CATCATGGCC CTGCTAGATT TCGAGCTGAG 
CCACAGTTGC AGAAGCTCCT GGTCTCCATT ACCCTCGAGT CAGAGTGCGA GTCCTTCCCT 
AGTCTGTCTT CAGATGAAAC CTATTCTCTG CTTGTACAAG AACCAGTAGC CGTCCTCAAG 
GCCAACAGCG TTTGGGGAGC GTTACGAGGT TTAGAGACGT TTAGCCAGTT AGTTTACCAA 
GACTCTTTCG GGACTTTCAC CATCAATGAA TCCAGTATAG CTGATTCTCC AAGATTCCCT 
CATAGAGGAA TTTTAATTGA TACATCTAGA CACTTCCTGC CTGTGAAGAC AATTTTAAAA 
ACTCTGGATG CCATGGCTTT TAATAAGTTT AATGTTCTTC ACTGGCACAT AGTGGACGAC 
CAGTCTTTCC CTTATCAGAG TACCACTTTT CCTGAGCTAA GCAATAAGGG AAGCTACTCT 
TTGTCTCATG TCTATACACC AAACGATGTC CGGATGGTGC TGGAGTACGC CCGGCTCCGA 
GGGATTCGAG TCATACCAGA ATTTGATACC CCTGGCCATA CACAGTCTTG GGGCAAAGGA 
CAGAAAAACC TTCTAACTCC ATGTTACAAT CAAAAAACTA AAACTCAAGT GTTTGGGCCT 
GTAGACCCAA CTGTAAACAC AACGTATGCA TTCTTTAACA CATTTTTCAA AGAAATCAGC 
AGTGTGTTTC CAGATCAGTT CATCCACTTG GGAGGAGATG AAGTAGAATT TCAATGTTGG 
GCATCAAATC CAAACATCCA AGGTTTCATG AAGAGAAAGG GCTTTGGCAG CGATTTTAGA 
AGACTAGAAT CCTTTTATAT TAAAAAGATT TTGGAAATTA TTTCATCCTT AAAGAAGAAC 
TCCATTGTTT GGCAAGAAGT TTTTGATGAT AAGGTGGAGC TTCAGCCGGG CACAGTAGTC 
GAAGTGTGGA AGAGTGAGCA TTATTCATAT GAGCTAAAGC AAGTCACAGG CTCTGGCTTC 
CCTGCCATCC TTTCTGCTCC TTGGTACTTA GACCTGATCA GCTATGGGCA AGACTGGAAA 
AACTACTACA AAGTTGAGCC CCTTAATTTT GAAGGCTCTG AGAAGCAGAA ACAACTTGTT 
ATTGGTGGAG AAGCTTGCCT GTGGGGAGAA TTTGTGGATG CAACTAACCT TACTCCAAGA 
TTATGGCCTC GAGCAAGCGC TGTTGGTGAG AGACTCTGGA GCCCTAAAAC TGTCACTGAC 
CTAGAAAATG CCTACAAACG ACTGGCCGTG CACCGCTGCA GAATGGTCAG CCGTGGAATA 
GCTGCACAAC CTCTCTATAC TGGATACTGT AACTATGAGA ATAAAATATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Intravenous administration of scAAV9-Hexb normalizes lifespan and prevents pathology in Sandhoff disease mice.
Human molecular genetics(2018 Jan)
Niemir N,Rouvi?re L,Besse A,Vanier MT,Dmytrus J,Marais T,Astord S,Puech JP,Panasyuk G,Cooper JD,Barkats M,Caillaud C

Abnormal differentiation of Sandhoff disease model mouse-derived multipotent stem cells toward a neural lineage.
PloS one12(6)e0178978(2017)
Ogawa Y,Kaizu K,Yanagi Y,Takada S,Sakuraba H,Oishi K

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Hexb cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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