Hcls1 cDNA ORF clone, Mus musculus(house mouse)

The Arp2/3 complex binding protein HS1 is required for efficient dendritic cell random migration and force generation.
Bendell AC, Williamson EK, Chen CS, Burkhardt JK, Hammer DA
Integrative biology : quantitative biosciences from nano to macro9(8)695-708(2017 Aug)

HS1 deficiency impairs neutrophil recruitment in vivo and activation of the small GTPases Rac1 and Rap1.
Latasiewicz J, Artz A, Jing D, Blanco MP, Currie SM, Avila MV, Schnoor M, Vestweber D
Journal of leukocyte biology101(5)1133-1142(2017 05)

Identification of RNA-binding Proteins in Macrophages by Interactome Capture.
Liepelt A, Naarmann-de Vries IS, Simons N, Eichelbaum K, F?hr S, Archer SK, Castello A, Usadel B, Krijgsveld J, Preiss T, Marx G, Hentze MW, Ostareck DH, Ostareck-Lederer A
Molecular & cellular proteomics : MCP15(8)2699-714(2016 08)

Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors.
Habif G, Grasset MF, Kieffer-Jaquinod S, Kuhn L, Mouchiroud G, Gobert-Gosse S
Journal of proteomics78231-44(2013 Jan)

Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.
Skokowa J, Klimiankou M, Klimenkova O, Lan D, Gupta K, Hussein K, Carrizosa E, Kusnetsova I, Li Z, Sustmann C, Ganser A, Zeidler C, Kreipe HH, Burkhardt J, Grosschedl R, Welte K
Nature medicine18(10)1550-9(2012 Oct)

HS1 as an important regulator of proper Rac1 and Rap1 activation and neutrophil extravasation.
Title: HS1 deficiency impairs neutrophil recruitment in vivo and activation of the small GTPases Rac1 and Rap1.

Results identified two proteins P23 and HCLS1, which were not known as RNA-binding proteins, exhibiting RNA-binding activity.
Title: Identification of RNA-binding Proteins in Macrophages by Interactome Capture.

Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors.
Title: Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors.

studies show that HS1 promotes an early step in the endocytic pathway that is required for efficient Ag presentation of exogenous Ag by dendritic cells
Title: The actin regulatory protein HS1 is required for antigen uptake and presentation by dendritic cells.

Studies show that HS1 functions in concert with WASp to fine-tune DC cytoarchitecture and direct cell migration.
Title: Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells.