H2-D1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	H2-D1
Entrez Gene ID	14964
Full Name	histocompatibility 2, D region locus 1
Synonyms	H-2D,H2-D
General protein information	Preferred Names histocompatibility 2, D region locus 1 Names H-2 class I histocompatibility antigen, D-B alpha chain H-2D cell surface glycoprotein H2-DC1-beta transplantation antigen protein MHC H2-D-q alpha-chain MHC class I H-2Dp MHC class I H2 antigen Q5k protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 B1\|17 18.61 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010380.3	NP_034510.3	H-2 class I histocompatibility antigen, D-B alpha chain precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Gm8909	NP_001074501.2
Mus musculus (house mouse)	H2-Bl	NP_032225.2
Mus musculus (house mouse)	H2-Q2	NP_034522.2
Rattus norvegicus (Norway rat)	RT1-A1	NP_001008827.1
Rattus norvegicus (Norway rat)	RT1-CE2	NP_001008840.1
Rattus norvegicus (Norway rat)	RT1-CE5	NP_001008843.1
Rattus norvegicus (Norway rat)	RT1-A2	NP_001008829.1
Rattus norvegicus (Norway rat)	LOC100364500	XP_006255953.1
Gallus gallus (chicken)	MICA	XP_415354.4
Gallus gallus (chicken)	MR1	XP_004945738.1
Gallus gallus (chicken)	LOC100858581	XP_003643753.2
Gallus gallus (chicken)	LOC417083	XP_003642294.2
Gallus gallus (chicken)	LOC100858733	XP_003643847.2
Danio rerio (zebrafish)	LOC100536229	XP_003201722.1
Danio rerio (zebrafish)	zgc:136614	NP_001077014.1
	MAMU-A3	NP_001165309.1
Mus musculus (house mouse)	H2-D1	NP_034510.3
Mus musculus (house mouse)	Gm10499	XP_006525296.1
Mus musculus (house mouse)	H2-Q4	NP_001137161.1
Mus musculus (house mouse)	H2-Q7	NP_034524.3
Rattus norvegicus (Norway rat)	RT1-CE7	NP_001008845.1
Rattus norvegicus (Norway rat)	RT1-CE1	NP_001008832.1
Rattus norvegicus (Norway rat)	RT1-CE10	NP_001008833.1
Gallus gallus (chicken)	BF2	NP_001026509.1
Gallus gallus (chicken)	LOC100859100	XP_003642292.2
Gallus gallus (chicken)	LOC769716	XP_001233005.3
Gallus gallus (chicken)	LOC100859374	XP_003643261.1
Gallus gallus (chicken)	LOC100859408	XP_003643262.1
Gallus gallus (chicken)	LOC101752075	XP_004950216.1
Gallus gallus (chicken)	YF6	XP_003643784.1
Danio rerio (zebrafish)	LOC563036	XP_001919291.4
Mus musculus (house mouse)	H2-Q1	NP_034520.2
Rattus norvegicus (Norway rat)	RT1-CE16	NP_001008839.1
Rattus norvegicus (Norway rat)	RT1-CE3	NP_001008841.1
Gallus gallus (chicken)	BF1	XP_004945708.1
Gallus gallus (chicken)	LOC417058	XP_004950006.1
Gallus gallus (chicken)	LOC417057	XP_415345.4
Gallus gallus (chicken)	LOC100859282	XP_003642295.2
Mus musculus (house mouse)	H2-Q10	NP_034521.1
Gallus gallus (chicken)	LOC430600	XP_428156.3
Gallus gallus (chicken)	LOC100859012	XP_003643257.1
Gallus gallus (chicken)	LOC100859807	XP_003643267.1
Gallus gallus (chicken)	LOC100859881	XP_003643268.1
Danio rerio (zebrafish)	mhc1zba	NP_001103588.1
Homo sapiens (human)	HLA-A	NP_002107.3
Pan troglodytes (chimpanzee)	PATR-A	NP_001009058.2
Mus musculus (house mouse)	H2-K1	NP_001001892.2
Mus musculus (house mouse)	H2-Q6	NP_997531.1
Rattus norvegicus (Norway rat)	RT1-CE13	NP_001008836.1
Rattus norvegicus (Norway rat)	RT1-CE4	NP_001008842.1
Gallus gallus (chicken)	LOC100858943	XP_003643255.2
Gallus gallus (chicken)	LOC100857553	XP_003643732.2
Gallus gallus (chicken)	LOC768350	NP_001171648.1
Gallus gallus (chicken)	LOC417080	XP_003643749.2
Danio rerio (zebrafish)	si:ch211-287j19.6	NP_001039028.1
Danio rerio (zebrafish)	LOC556263	XP_003198042.1
Danio rerio (zebrafish)	mhc1zja	NP_001103188.1

Gene Ontology
Bibliography

Related articles in PubMed

Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair.
Linehan JL, Harrison OJ, Han SJ, Byrd AL, Vujkovic-Cvijin I, Villarino AV, Sen SK, Shaik J, Smelkinson M, Tamoutounour S, Collins N, Bouladoux N, Dzutsev A, Rosshart SP, Arbuckle JH, Wang CR, Kristie TM, Rehermann B, Trinchieri G, Brenchley JM, O'Shea JJ, Belkaid Y
Cell(2018 Jan)

T cells upon activation promote endothelin 1 production in monocytes via IFN-? and TNF-?.
Shinagawa S, Okazaki T, Ikeda M, Yudoh K, Kisanuki YY, Yanagisawa M, Kawahata K, Ozaki S
Scientific reports7(1)14500(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The mRNA levels of H2-d1 in the prefrontal cortex, hippocampus, and hypothalamus and C1qb in the hippocampus of the DBA/2 J strain were significantly down-regulated as compared to those in the C57BL/6 J strain
Title: Association of brain immune genes with social behavior of inbred mouse strains.

many self-peptides in the L(d) system (or the HLA-B system) would exhibit enhanced binding to Arg(97) alleles compared with Trp(97) alleles.
Title: The same major histocompatibility complex polymorphism involved in control of HIV influences peptide binding in the mouse H-2Ld system.

The identification and characterization of two CD4+ T cell epitopes of Lpp20 helps understand the protective immunity of Lpp20 in H.pylori infection.
Title: Identification and characterization of H-2d restricted CD4+ T cell epitopes on Lpp20 of Helicobacter pylori.

Data show that At early stages, tumors demonstrated reduced MHC class I expression and increased expression of natural killer group 2D ligands (NKG2D-L).
Title: Requirements for control of B-cell lymphoma by NK cells.

results show that neuronal MHC class Ia (H2-K(b)/D(b)) molecules are present in motor axons, are important for organization of neuromuscular junctions and motor recovery after nerve lesion, and that Schwann cells may mediate their actions
Title: Classical major histocompatibility complex class I molecules in motoneurons: new actors at the neuromuscular junction.

The following H2-D1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H2-D1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18039	NM_010380.3 Latest version!	Mus musculus histocompatibility 2, D region locus 1 (H2-D1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H2-D1 ( NM_010380.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034510.3 Mus musculus histocompatibility 2, D region locus 1 (H2-D1), mRNA.

Price & Availability↑

CloneID	OMu18039
Clone ID Related Accession (Same CDS sequence)	NM_010380.3
Accession Version	NM_010380.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1089bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	H-2 class I histocompatibility antigen, D-B alpha chain precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK159572.1, BY225620.1 and BY579672.1. On or before Mar 20, 2007 this sequence version replaced NM_001034908.1, NM_010380.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGCGA TGGCTCCGCG CACGCTGCTC CTGCTGCTGG CGGCCGCCCT GGCCCCGACT 
CAGACCCGCG CGGGCCCACA CTCGATGCGG TATTTCGAGA CCGCCGTGTC CCGGCCCGGC 
CTCGAGGAGC CCCGGTACAT CTCTGTCGGC TATGTGGACA ACAAGGAGTT CGTGCGCTTC 
GACAGCGACG CGGAGAATCC GAGATATGAG CCGCGGGCGC CGTGGATGGA GCAGGAGGGG 
CCGGAGTATT GGGAGCGGGA AACACAGAAA GCCAAGGGCC AAGAGCAGTG GTTCCGAGTG 
AGCCTGAGGA ACCTGCTCGG CTACTACAAC CAGAGCGCGG GCGGCTCTCA CACACTCCAG 
CAGATGTCTG GCTGTGACTT GGGGTCGGAC TGGCGCCTCC TCCGCGGGTA CCTGCAGTTC 
GCCTATGAAG GCCGCGATTA CATCGCCCTG AACGAAGACC TGAAAACGTG GACGGCGGCG 
GACATGGCGG CGCAGATCAC CCGACGCAAG TGGGAGCAGA GTGGTGCTGC AGAGCATTAC 
AAGGCCTACC TGGAGGGCGA GTGCGTGGAG TGGCTCCACA GATACCTGAA GAACGGGAAC 
GCGACGCTGC TGCGCACAGA TTCCCCAAAG GCACATGTGA CCCATCACCC CAGATCTAAA 
GGTGAAGTCA CCCTGAGGTG CTGGGCCCTG GGCTTCTACC CTGCTGACAT CACCCTGACC 
TGGCAGTTGA ATGGGGAGGA GCTGACCCAG GACATGGAGC TTGTGGAGAC CAGGCCTGCA 
GGGGATGGAA CCTTCCAGAA GTGGGCATCT GTGGTGGTGC CTCTTGGGAA GGAGCAGAAT 
TACACATGCC GTGTGTACCA TGAGGGGCTG CCTGAGCCCC TCACCCTGAG ATGGGAGCCT 
CCTCCGTCCA CTGACTCTTA CATGGTGATC GTTGCTGTTC TGGGTGTCCT TGGAGCTATG 
GCCATCATTG GAGCTGTGGT GGCTTTTGTG ATGAAGAGAA GGAGAAACAC AGGTGGAAAA 
GGAGGGGACT ATGCTCTGGC TCCAGGCTCC CAGAGCTCTG AAATGTCTCT CCGAGATTGT 
AAAGCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034510.3
CDS	21..1109
Translation	MGAMAPRTLLLLLAAALAPTQTRAGPHSMRYFETAVSRPGLEEPRYISVGYVDNKEFVRFDSDAENPRYEPRAPWMEQEGPEYWERETQKAKGQEQWFRVSLRNLLGYYNQSAGGSHTLQQMSGCDLGSDWRLLRGYLQFAYEGRDYIALNEDLKTWTAADMAAQITRRKWEQSGAAEHYKAYLEGECVEWLHRYLKNGNATLLRTDSPKAHVTHHPRSKGEVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCRVYHEGLPEPLTLRWEPPPSTDSYMVIVAVLGVLGAMAIIGAVVAFVMKRRRNTGGKGGDYALAPGSQSSEMSLRDCKA

Target ORF information:

RefSeq Version	NM_010380.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus histocompatibility 2, D region locus 1 (H2-D1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010380.3

ORF Insert Sequence:

ATGGGGGCGA TGGCTCCGCG CACGCTGCTC CTGCTGCTGG CGGCCGCCCT GGCCCCGACT 
CAGACCCGCG CGGGCCCACA CTCGATGCGG TATTTCGAGA CCGCCGTGTC CCGGCCCGGC 
CTCGAGGAGC CCCGGTACAT CTCTGTCGGC TATGTGGACA ACAAGGAGTT CGTGCGCTTC 
GACAGCGACG CGGAGAATCC GAGATATGAG CCGCGGGCGC CGTGGATGGA GCAGGAGGGG 
CCGGAGTATT GGGAGCGGGA AACACAGAAA GCCAAGGGCC AAGAGCAGTG GTTCCGAGTG 
AGCCTGAGGA ACCTGCTCGG CTACTACAAC CAGAGCGCGG GCGGCTCTCA CACACTCCAG 
CAGATGTCTG GCTGTGACTT GGGGTCGGAC TGGCGCCTCC TCCGCGGGTA CCTGCAGTTC 
GCCTATGAAG GCCGCGATTA CATCGCCCTG AACGAAGACC TGAAAACGTG GACGGCGGCG 
GACATGGCGG CGCAGATCAC CCGACGCAAG TGGGAGCAGA GTGGTGCTGC AGAGCATTAC 
AAGGCCTACC TGGAGGGCGA GTGCGTGGAG TGGCTCCACA GATACCTGAA GAACGGGAAC 
GCGACGCTGC TGCGCACAGA TTCCCCAAAG GCACATGTGA CCCATCACCC CAGATCTAAA 
GGTGAAGTCA CCCTGAGGTG CTGGGCCCTG GGCTTCTACC CTGCTGACAT CACCCTGACC 
TGGCAGTTGA ATGGGGAGGA GCTGACCCAG GACATGGAGC TTGTGGAGAC CAGGCCTGCA 
GGGGATGGAA CCTTCCAGAA GTGGGCATCT GTGGTGGTGC CTCTTGGGAA GGAGCAGAAT 
TACACATGCC GTGTGTACCA TGAGGGGCTG CCTGAGCCCC TCACCCTGAG ATGGGAGCCT 
CCTCCGTCCA CTGACTCTTA CATGGTGATC GTTGCTGTTC TGGGTGTCCT TGGAGCTATG 
GCCATCATTG GAGCTGTGGT GGCTTTTGTG ATGAAGAGAA GGAGAAACAC AGGTGGAAAA 
GGAGGGGACT ATGCTCTGGC TCCAGGCTCC CAGAGCTCTG AAATGTCTCT CCGAGATTGT 
AAAGCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair.
Cell(2018 Jan)
Linehan JL,Harrison OJ,Han SJ,Byrd AL,Vujkovic-Cvijin I,Villarino AV,Sen SK,Shaik J,Smelkinson M,Tamoutounour S,Collins N,Bouladoux N,Dzutsev A,Rosshart SP,Arbuckle JH,Wang CR,Kristie TM,Rehermann B,Trinchieri G,Brenchley JM,O'Shea JJ,Belkaid Y

T cells upon activation promote endothelin 1 production in monocytes via IFN-? and TNF-?.
Scientific reports7(1)14500(2017 Nov)
Shinagawa S,Okazaki T,Ikeda M,Yudoh K,Kisanuki YY,Yanagisawa M,Kawahata K,Ozaki S

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H2-D1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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