Gp1bb cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gp1bb
Entrez Gene ID	14724
Full Name	glycoprotein Ib, beta polypeptide
General protein information	Preferred Names glycoprotein Ib, beta polypeptide Names platelet glycoprotein Ib beta chain GP-Ib beta GPIb-beta GPIbB
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16 A3\|16 11.53 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010327.2	NP_034457.1	platelet glycoprotein Ib beta chain isoform 2 precursor
NM_001001999.1	NP_001001999.1	platelet glycoprotein Ib beta chain isoform 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GP1BB	NP_000398.1
Canis lupus familiaris (dog)	GP1BB	XP_005636645.1
Xenopus tropicalis (tropical clawed frog)	gp1bb	XP_002931927.1
	LOC712129	XP_001105321.1
Danio rerio (zebrafish)	gp1bb	NP_001138284.1
Mus musculus (house mouse)	Gp1bb	NP_034457.1
Rattus norvegicus (Norway rat)	Gp1bb	NP_446382.1

Gene Ontology
Bibliography

Related articles in PubMed

Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions.
Gowert NS, Kr?ger I, Klier M, Donner L, Kipkeew F, Gliem M, Bradshaw NJ, Lutz D, K?ber S, Langer H, Jander S, Jurk K, Frotscher M, Korth C, Bock HH, Elvers M
Cellular signalling40210-221(2017 Dec)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Lentiviral gene rescue of a Bernard-Soulier mouse model to study platelet glycoprotein Ib? function.
Strassel C, Bull A, Moog S, Receveur N, Mallo L, Mangin P, Eckly A, Freund M, Dubart-Kupperschmitt A, Gachet C, Lanza F
Journal of thrombosis and haemostasis : JTH14(7)1470-9(2016 Jul)

Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity.
Frame JM, Fegan KH, Conway SJ, McGrath KE, Palis J
Stem cells (Dayton, Ohio)34(2)431-44(2016 Feb)

Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis.
Dai X, Jiang W, Zhang Q, Xu L, Geng P, Zhuang S, Petrich BG, Jiang C, Peng L, Bhattacharya S, Evans SM, Sun Y, Chen J, Liang X
BMC biology11107(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GPIbbeta has a repressor function in thrombus formation
Title: Lentiviral gene rescue of a Bernard-Soulier mouse model to study platelet glycoprotein Ib? function.

These data indicate an important role for the platelet adhesion receptor GPIb-IX in endotoxin-induced thrombosis and thrombocytopenia.
Title: Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality.

Data show that the surface-bound VWF appears as a large, linear structure on the surface of 50% of the PT-VWD platelets.
Title: Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation.

Role of GPIbbeta in modulating vWF mediated platelet adhesion.
Title: A novel monoclonal antibody against the extracellular domain of GPIbbeta modulates vWF mediated platelet adhesion.

The following Gp1bb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gp1bb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05969	NM_010327.2 Latest version!	Mus musculus glycoprotein Ib, beta polypeptide (Gp1bb), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00
OMu58140	NM_001001999.1 Latest version!	Mus musculus glycoprotein Ib, beta polypeptide (Gp1bb), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gp1bb ( NM_010327.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034457.1 Mus musculus glycoprotein Ib, beta polypeptide (Gp1bb), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu05969
Clone ID Related Accession (Same CDS sequence)	NM_010327.2
Accession Version	NM_010327.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	platelet glycoprotein Ib beta chain isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC053108.1, AA024279.1, AA222119.1 and BX631606.1. On Jul 16, 2004 this sequence version replaced NM_010327.1. Transcript Variant: This variant (2) lacks an internal segment, as compared to variant 1. It encodes isoform 2 which has an alternate N-terminus, as compared to isoform 1. Sequence Note: This RefSeq record was created using sequences from two different strains, C57BL/6J and C57BL/6, because no single transcript from the same strain was available for the full length of the gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CJ043921.1, AI324189.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGGCTCCC GGCCCCGTGG GGCGCTGAGC CTGCTGCTTC TGTTGCTAGC GCTGCTCAGC 
CGCCCAGCCT CTGGCTGCCC CGCGCCATGC AGCTGCGCAG GGACGCTCGT GGACTGTGGG 
CGCCGCGGGC TGACCTGGGC GTCGCTGCCG GCTGCCTTCC CTCCCGACAC CACCGAATTG 
GTGCTGACCG GCAACAACCT GACGGCGCTG CCGCCCGGGC TTCTGGACGC GTTGCCTGCT 
CTGCGCGCAG CACACCTGGG CGCCAACCCC TGGCGCTGCG ACTGCCGCCT ATTGCCGCTG 
CGCGCCTGGC TGGCCGGCCG CCCGGAGCGC GCGCCCTACC GCGACCTGCG CTGTGTCGCG 
CCCCCAGCGC TGCGCGGCCG CTTGCTGCCC TACGTGGCGG AGGATGAGCT GCGGGCCGCG 
TGCGCACCCG GTCTACTCTG CTGGGGAGCA CTGGTGGCCC AGCTAGCACT GCTGGTCCTC 
GGGCTGCTAC ACGCGCTGCT ATTGGCACTT CTACTAGGTC GCCTGCGGAG GCTGCGCGCG 
CGTGCGCGCG CACGCTCCAT CCAAGAGTTC TCTCTCACAG CCCCGCTGGT GGCCGAGTCG 
GCCAGAGGTG GTGCATCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034457.1
CDS	824..1444
Translation	MGSRPRGALSLLLLLLALLSRPASGCPAPCSCAGTLVDCGRRGLTWASLPAAFPPDTTELVLTGNNLTALPPGLLDALPALRAAHLGANPWRCDCRLLPLRAWLAGRPERAPYRDLRCVAPPALRGRLLPYVAEDELRAACAPGLLCWGALVAQLALLVLGLLHALLLALLLGRLRRLRARARARSIQEFSLTAPLVAESARGGAS

Target ORF information:

RefSeq Version	NM_010327.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus glycoprotein Ib, beta polypeptide (Gp1bb), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010327.2

ORF Insert Sequence:

ATGGGCTCCC GGCCCCGTGG GGCGCTGAGC CTGCTGCTTC TGTTGCTAGC GCTGCTCAGC 
CGCCCAGCCT CTGGCTGCCC CGCGCCATGC AGCTGCGCAG GGACGCTCGT GGACTGTGGG 
CGCCGCGGGC TGACCTGGGC GTCGCTGCCG GCTGCCTTCC CTCCCGACAC CACCGAATTG 
GTGCTGACCG GCAACAACCT GACGGCGCTG CCGCCCGGGC TTCTGGACGC GTTGCCTGCT 
CTGCGCGCAG CACACCTGGG CGCCAACCCC TGGCGCTGCG ACTGCCGCCT ATTGCCGCTG 
CGCGCCTGGC TGGCCGGCCG CCCGGAGCGC GCGCCCTACC GCGACCTGCG CTGTGTCGCG 
CCCCCAGCGC TGCGCGGCCG CTTGCTGCCC TACGTGGCGG AGGATGAGCT GCGGGCCGCG 
TGCGCACCCG GTCTACTCTG CTGGGGAGCA CTGGTGGCCC AGCTAGCACT GCTGGTCCTC 
GGGCTGCTAC ACGCGCTGCT ATTGGCACTT CTACTAGGTC GCCTGCGGAG GCTGCGCGCG 
CGTGCGCGCG CACGCTCCAT CCAAGAGTTC TCTCTCACAG CCCCGCTGGT GGCCGAGTCG 
GCCAGAGGTG GTGCATCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gp1bb ( NM_001001999.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001001999.1 Mus musculus glycoprotein Ib, beta polypeptide (Gp1bb), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu58140
Clone ID Related Accession (Same CDS sequence)	NM_001001999.1
Accession Version	NM_001001999.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 645bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	platelet glycoprotein Ib beta chain isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC053108.1, AA222119.1 and BX631606.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created using sequences from two different strains, C57BL/6J and C57BL/6, because no single transcript from the same strain was available for the full length of the gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGCTCCCGC CTCATCCTAG TGCTTCTCTT TCAGGGCCCC GTGGGGCGCT GAGCCTGCTG 
CTTCTGTTGC TAGCGCTGCT CAGCCGCCCA GCCTCTGGCT GCCCCGCGCC ATGCAGCTGC 
GCAGGGACGC TCGTGGACTG TGGGCGCCGC GGGCTGACCT GGGCGTCGCT GCCGGCTGCC 
TTCCCTCCCG ACACCACCGA ATTGGTGCTG ACCGGCAACA ACCTGACGGC GCTGCCGCCC 
GGGCTTCTGG ACGCGTTGCC TGCTCTGCGC GCAGCACACC TGGGCGCCAA CCCCTGGCGC 
TGCGACTGCC GCCTATTGCC GCTGCGCGCC TGGCTGGCCG GCCGCCCGGA GCGCGCGCCC 
TACCGCGACC TGCGCTGTGT CGCGCCCCCA GCGCTGCGCG GCCGCTTGCT GCCCTACGTG 
GCGGAGGATG AGCTGCGGGC CGCGTGCGCA CCCGGTCTAC TCTGCTGGGG AGCACTGGTG 
GCCCAGCTAG CACTGCTGGT CCTCGGGCTG CTACACGCGC TGCTATTGGC ACTTCTACTA 
GGTCGCCTGC GGAGGCTGCG CGCGCGTGCG CGCGCACGCT CCATCCAAGA GTTCTCTCTC 
ACAGCCCCGC TGGTGGCCGA GTCGGCCAGA GGTGGTGCAT CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001999.1
CDS	1038..1682
Translation	MLPPHPSASLSGPRGALSLLLLLLALLSRPASGCPAPCSCAGTLVDCGRRGLTWASLPAAFPPDTTELVLTGNNLTALPPGLLDALPALRAAHLGANPWRCDCRLLPLRAWLAGRPERAPYRDLRCVAPPALRGRLLPYVAEDELRAACAPGLLCWGALVAQLALLVLGLLHALLLALLLGRLRRLRARARARSIQEFSLTAPLVAESARGGAS

Target ORF information:

RefSeq Version	NM_001001999.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus glycoprotein Ib, beta polypeptide (Gp1bb), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001999.1

ORF Insert Sequence:

ATGCTCCCGC CTCATCCTAG TGCTTCTCTT TCAGGGCCCC GTGGGGCGCT GAGCCTGCTG 
CTTCTGTTGC TAGCGCTGCT CAGCCGCCCA GCCTCTGGCT GCCCCGCGCC ATGCAGCTGC 
GCAGGGACGC TCGTGGACTG TGGGCGCCGC GGGCTGACCT GGGCGTCGCT GCCGGCTGCC 
TTCCCTCCCG ACACCACCGA ATTGGTGCTG ACCGGCAACA ACCTGACGGC GCTGCCGCCC 
GGGCTTCTGG ACGCGTTGCC TGCTCTGCGC GCAGCACACC TGGGCGCCAA CCCCTGGCGC 
TGCGACTGCC GCCTATTGCC GCTGCGCGCC TGGCTGGCCG GCCGCCCGGA GCGCGCGCCC 
TACCGCGACC TGCGCTGTGT CGCGCCCCCA GCGCTGCGCG GCCGCTTGCT GCCCTACGTG 
GCGGAGGATG AGCTGCGGGC CGCGTGCGCA CCCGGTCTAC TCTGCTGGGG AGCACTGGTG 
GCCCAGCTAG CACTGCTGGT CCTCGGGCTG CTACACGCGC TGCTATTGGC ACTTCTACTA 
GGTCGCCTGC GGAGGCTGCG CGCGCGTGCG CGCGCACGCT CCATCCAAGA GTTCTCTCTC 
ACAGCCCCGC TGGTGGCCGA GTCGGCCAGA GGTGGTGCAT CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions.
Cellular signalling40210-221(2017 Dec)
Gowert NS,Kr?ger I,Klier M,Donner L,Kipkeew F,Gliem M,Bradshaw NJ,Lutz D,K?ber S,Langer H,Jander S,Jurk K,Frotscher M,Korth C,Bock HH,Elvers M

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Lentiviral gene rescue of a Bernard-Soulier mouse model to study platelet glycoprotein Ib? function.
Journal of thrombosis and haemostasis : JTH14(7)1470-9(2016 Jul)
Strassel C,Bull A,Moog S,Receveur N,Mallo L,Mangin P,Eckly A,Freund M,Dubart-Kupperschmitt A,Gachet C,Lanza F

Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity.
Stem cells (Dayton, Ohio)34(2)431-44(2016 Feb)
Frame JM,Fegan KH,Conway SJ,McGrath KE,Palis J

Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis.
BMC biology11107(2013 Oct)
Dai X,Jiang W,Zhang Q,Xu L,Geng P,Zhuang S,Petrich BG,Jiang C,Peng L,Bhattacharya S,Evans SM,Sun Y,Chen J,Liang X

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Gp1bb cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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