Gng3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gng3
Entrez Gene ID	14704
Full Name	guanine nucleotide binding protein (G protein), gamma 3
General protein information	Preferred Names guanine nucleotide binding protein (G protein), gamma 3 Names guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 guanine nucleotide binding protein (G protein), gamma 3 subunit
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19 A\|19 5.76 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010316.3	NP_034446.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Gng3	NP_034446.1
Xenopus tropicalis (tropical clawed frog)	gng3	NP_001165080.1
Homo sapiens (human)	GNG3	NP_036334.1
Canis lupus familiaris (dog)	GNG3	XP_540904.2
Bos taurus (cattle)	GNG3	NP_776498.1
Rattus norvegicus (Norway rat)	Gng3	NP_446110.1
Pan troglodytes (chimpanzee)	GNG3	XP_001156854.1
Danio rerio (zebrafish)	gng3	NP_571916.1

Gene Ontology
Bibliography

Related articles in PubMed

Disruption of G-protein ?5 subtype causes embryonic lethality in mice.
Moon AM, Stauffer AM, Schwindinger WF, Sheridan K, Firment A, Robishaw JD
PloS one9(3)e90970(2014)

Synergistic roles for G-protein ?3 and ?7 subtypes in seizure susceptibility as revealed in double knock-out mice.
Schwindinger WF, Mirshahi UL, Baylor KA, Sheridan KM, Stauffer AM, Usefof S, Stecker MM, Mirshahi T, Robishaw JD
The Journal of biological chemistry287(10)7121-33(2012 Mar)

Mice lacking the G protein gamma3-subunit show resistance to opioids and diet induced obesity.
Schwindinger WF, Borrell BM, Waldman LC, Robishaw JD
American journal of physiology. Regulatory, integrative and comparative physiology297(5)R1494-502(2009 Nov)

Mouse G-protein gamma3 expression in the developing CNS and neural crest cell derivatives.
Kelly GM, Saijoh Y, Finkielsztein A, Mangos S
The International journal of developmental biology52(8)1143-50(2008)

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM
Molecular & cellular proteomics : MCP6(2)283-93(2007 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Synergistic roles for G-protein gamma3 and gamma7 subtypes in seizure susceptibility as revealed in double knock-out mice.
Title: Synergistic roles for G-protein ?3 and ?7 subtypes in seizure susceptibility as revealed in double knock-out mice.

The decreased weight gain of Gng3(-/-) mice may be related to a reduced rewarding effect of the high-fat diet resulting from a defect in Oprm1 signaling and loss of the G protein gamma(3)-subunit.
Title: Mice lacking the G protein gamma3-subunit show resistance to opioids and diet induced obesity.

G protein coupled signaling involving gamma3 participates in a number of physiological roles, not only in the CNS, but also in numerous cells derived from the neural crest.
Title: Mouse G-protein gamma3 expression in the developing CNS and neural crest cell derivatives.

Data provide genetic evidence for the tight regulation and involvement of the G protein gamma3-subtype in mounting an effective immune response.
Title: Runx-dependent regulation of G-protein gamma3 expression in T-cells.

Gng3-/- mice display increased susceptibility to seizures, reduced body weights, and decreased adiposity compared to their wild-type littermates
Title: Mice with deficiency of G protein gamma3 are lean and have seizures.

The following Gng3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gng3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05948	NM_010316.3 Latest version!	Mus musculus guanine nucleotide binding protein (G protein), gamma 3 (Gng3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gng3 ( NM_010316.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034446.1 Mus musculus guanine nucleotide binding protein (G protein), gamma 3 (Gng3), mRNA.

Price & Availability↑

CloneID	OMu05948
Clone ID Related Accession (Same CDS sequence)	NM_010316.3
Accession Version	NM_010316.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 228bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY290040.1, AK032646.1 and BE949484.1. On Jan 7, 2006 this sequence version replaced NM_010316.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK032646.1, SRR1660815.461329.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAAAGGGG AGACCCCCGT TAACAGCACT ATGAGTATTG GTCAAGCACG CAAGATGGTG 
GAACAGCTTA AGATTGAGGC CAGCTTGTGC CGGATAAAGG TGTCCAAGGC AGCAGCAGAC 
CTGATGACAT ACTGTGATGC CCACGCTTGT GAGGACCCCC TCATCACTCC TGTGCCCACT 
TCCGAGAACC CCTTCCGGGA GAAGAAGTTC TTCTGTGCGC TCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034446.1
CDS	258..485
Translation	MKGETPVNSTMSIGQARKMVEQLKIEASLCRIKVSKAAADLMTYCDAHACEDPLITPVPTSENPFREKKFFCALL

Target ORF information:

RefSeq Version	NM_010316.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus guanine nucleotide binding protein (G protein), gamma 3 (Gng3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010316.3

ORF Insert Sequence:

ATGAAAGGGG AGACCCCCGT TAACAGCACT ATGAGTATTG GTCAAGCACG CAAGATGGTG 
GAACAGCTTA AGATTGAGGC CAGCTTGTGC CGGATAAAGG TGTCCAAGGC AGCAGCAGAC 
CTGATGACAT ACTGTGATGC CCACGCTTGT GAGGACCCCC TCATCACTCC TGTGCCCACT 
TCCGAGAACC CCTTCCGGGA GAAGAAGTTC TTCTGTGCGC TCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Disruption of G-protein ?5 subtype causes embryonic lethality in mice.
PloS one9(3)e90970(2014)
Moon AM,Stauffer AM,Schwindinger WF,Sheridan K,Firment A,Robishaw JD

Synergistic roles for G-protein ?3 and ?7 subtypes in seizure susceptibility as revealed in double knock-out mice.
The Journal of biological chemistry287(10)7121-33(2012 Mar)
Schwindinger WF,Mirshahi UL,Baylor KA,Sheridan KM,Stauffer AM,Usefof S,Stecker MM,Mirshahi T,Robishaw JD

Mice lacking the G protein gamma3-subunit show resistance to opioids and diet induced obesity.
American journal of physiology. Regulatory, integrative and comparative physiology297(5)R1494-502(2009 Nov)
Schwindinger WF,Borrell BM,Waldman LC,Robishaw JD

Mouse G-protein gamma3 expression in the developing CNS and neural crest cell derivatives.
The International journal of developmental biology52(8)1143-50(2008)
Kelly GM,Saijoh Y,Finkielsztein A,Mangos S

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Molecular & cellular proteomics : MCP6(2)283-93(2007 Feb)
Munton RP,Tweedie-Cullen R,Livingstone-Zatchej M,Weinandy F,Waidelich M,Longo D,Gehrig P,Potthast F,Rutishauser D,Gerrits B,Panse C,Schlapbach R,Mansuy IM

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Gng3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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