Gal cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gal
Entrez Gene ID	14419
Full Name	galanin
Synonyms	Galn
General protein information	Preferred Names galanin Names galanin peptides
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19 A\|19 3.16 cM
Summary	This gene encodes a neuroendocrine peptide that is principally produced by a subpopulation of lactotrophs in the pituitary gland. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP). Mice lacking the encoded protein fail to lactate sufficiently due to abnormalities in the expression of prolactin and lactotroph proliferation, exhibit attenuated chronic neuropathic pain and developmental deficits in the dorsal root ganglion neurons. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature proteins. [provided by RefSeq, Jul 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001329667.1	NP_001316596.1	galanin peptides isoform 2 precursor
NM_010253.3	NP_034383.1	galanin peptides precursor
NM_010253.4	NP_034383.1	galanin peptides isoform 1 preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GAL	XP_001173776.1
Mus musculus (house mouse)	Gal	NP_034383.1
Bos taurus (cattle)	GAL	NP_776339.1
Canis lupus familiaris (dog)	GAL	XP_854576.3
Homo sapiens (human)	GAL	NP_057057.2
Rattus norvegicus (Norway rat)	Gal	NP_150240.1

Gene Ontology
Bibliography

Related articles in PubMed

Galanin-Expressing GABA Neurons in the Lateral Hypothalamus Modulate Food Reward and Noncompulsive Locomotion.
Qualls-Creekmore E, Yu S, Francois M, Hoang J, Huesing C, Bruce-Keller A, Burk D, Berthoud HR, Morrison CD, M?nzberg H
The Journal of neuroscience : the official journal of the Society for Neuroscience37(25)6053-6065(2017 Jun)

Genetic mapping of the galanin-GMAP (Galn) gene to mouse chromosome 19.
Guida LC, Charlton P, Gilbert DJ, Jenkins NA, Copeland NG, Nicholls RD
Mammalian genome : official journal of the International Mammalian Genome Society9(3)240-2(1998 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Galanin, acting via the GAL1 receptor and Gi -coupled signalling in L and K cells, is a potent inhibitor of GLP-1 and GIP secretion
Title: Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells.

Study shows that LIF-treated postmitotic oligodendrocytes secrete a number of neuropeptides, in particular galanin, at the mRNA and peptide level, and galanin itself was shown to be a survival factor for oligodendrocytes
Title: Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor.

Galanin released by cancer induces neuritogenesis, facilitating perineural invasion.
Title: Galanin modulates the neural niche to favour perineural invasion in head and neck cancer.

Results suggest that GAL is a regulator of myelination, as demonstrated by MBP synthesis, and may be one of the myelination promoters
Title: An elevated level of circulating galanin promotes developmental expression of myelin basic protein in the mouse brain.

Oleuropein protects mice from gh-fat diet induced adiposity by upregulation of genes involved in WNT10b-mediated signaling and downregulation of genes involved in galanin-mediated signaling cascades.
Title: Oleuropein attenuates visceral adiposity in high-fat diet-induced obese mice through the modulation of WNT10b- and galanin-mediated signalings.

The following Gal gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gal cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu18192	NM_010253.4 Latest version!	Mus musculus galanin and GMAP prepropeptide (Gal), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu83521	NM_001329667.1 Latest version!	Mus musculus galanin and GMAP prepropeptide (Gal), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu18192	NM_010253.3	Mus musculus galanin (Gal), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gal ( NM_010253.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034383.1 Mus musculus galanin (Gal), mRNA.

Price & Availability↑

CloneID	OMu18192
Clone ID Related Accession (Same CDS sequence)	NM_010253.3 , NM_010253.4
Accession Version	NM_010253.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	galanin peptides precursor
Comment

ATGGCCAGAG GCAGCGTTAT CCTGCTAGGC TGGCTCCTGT TGGTTGTGAC CCTGTCAGCC 
ACTCTGGGAC TTGGGATGCC TGCAAAGGAG AAGAGAGGTT GGACCCTGAA CAGCGCTGGC 
TACCTTCTGG GCCCACATGC CATTGACAAC CACAGATCAT TTAGCGACAA GCATGGCCTC 
ACAGGCAAGA GGGAGTTACA ACTGGAGGTG GAGGAAAGGA GACCAGGAAG TGTTGATGTG 
CCCCTGCCTG AGAGCAACAT TGTCCGCACT ATAATGGAGT TTCTCAGTTT CTTGCACCTT 
AAAGAGGCCG GGGCCCTCGA CAGCCTGCCT GGCATCCCCT TGGCCACCTC CTCAGAAGAC 
CTAGAGAAGT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034383.1
Translation	MARGSVILLGWLLLVVTLSATLGLGMPAKEKRGWTLNSAGYLLGPHAIDNHRSFSDKHGLTGKRELQLEVEERRPGSVDVPLPESNIVRTIMEFLSFLHLKEAGALDSLPGIPLATSSEDLEKS

Target ORF information:

RefSeq Version	NM_010253.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus galanin (Gal), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010253.3

ORF Insert Sequence:

ATGGCCAGAG GCAGCGTTAT CCTGCTAGGC TGGCTCCTGT TGGTTGTGAC CCTGTCAGCC 
ACTCTGGGAC TTGGGATGCC TGCAAAGGAG AAGAGAGGTT GGACCCTGAA CAGCGCTGGC 
TACCTTCTGG GCCCACATGC CATTGACAAC CACAGATCAT TTAGCGACAA GCATGGCCTC 
ACAGGCAAGA GGGAGTTACA ACTGGAGGTG GAGGAAAGGA GACCAGGAAG TGTTGATGTG 
CCCCTGCCTG AGAGCAACAT TGTCCGCACT ATAATGGAGT TTCTCAGTTT CTTGCACCTT 
AAAGAGGCCG GGGCCCTCGA CAGCCTGCCT GGCATCCCCT TGGCCACCTC CTCAGAAGAC 
CTAGAGAAGT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gal ( NM_010253.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034383.1 Mus musculus galanin and GMAP prepropeptide (Gal), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu18192
Clone ID Related Accession (Same CDS sequence)	NM_010253.3 , NM_010253.4
Accession Version	NM_010253.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	galanin peptides isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL626765.22, AK133522.1 and BM900055.1. On Jul 22, 2016 this sequence version replaced NM_010253.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC044055.1, BQ933399.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAGAG GCAGCGTTAT CCTGCTAGGC TGGCTCCTGT TGGTTGTGAC CCTGTCAGCC 
ACTCTGGGAC TTGGGATGCC TGCAAAGGAG AAGAGAGGTT GGACCCTGAA CAGCGCTGGC 
TACCTTCTGG GCCCACATGC CATTGACAAC CACAGATCAT TTAGCGACAA GCATGGCCTC 
ACAGGCAAGA GGGAGTTACA ACTGGAGGTG GAGGAAAGGA GACCAGGAAG TGTTGATGTG 
CCCCTGCCTG AGAGCAACAT TGTCCGCACT ATAATGGAGT TTCTCAGTTT CTTGCACCTT 
AAAGAGGCCG GGGCCCTCGA CAGCCTGCCT GGCATCCCCT TGGCCACCTC CTCAGAAGAC 
CTAGAGAAGT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034383.1
CDS	234..608
Translation	MARGSVILLGWLLLVVTLSATLGLGMPAKEKRGWTLNSAGYLLGPHAIDNHRSFSDKHGLTGKRELQLEVEERRPGSVDVPLPESNIVRTIMEFLSFLHLKEAGALDSLPGIPLATSSEDLEKS

Target ORF information:

RefSeq Version	NM_010253.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus galanin and GMAP prepropeptide (Gal), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010253.4

ORF Insert Sequence:

ATGGCCAGAG GCAGCGTTAT CCTGCTAGGC TGGCTCCTGT TGGTTGTGAC CCTGTCAGCC 
ACTCTGGGAC TTGGGATGCC TGCAAAGGAG AAGAGAGGTT GGACCCTGAA CAGCGCTGGC 
TACCTTCTGG GCCCACATGC CATTGACAAC CACAGATCAT TTAGCGACAA GCATGGCCTC 
ACAGGCAAGA GGGAGTTACA ACTGGAGGTG GAGGAAAGGA GACCAGGAAG TGTTGATGTG 
CCCCTGCCTG AGAGCAACAT TGTCCGCACT ATAATGGAGT TTCTCAGTTT CTTGCACCTT 
AAAGAGGCCG GGGCCCTCGA CAGCCTGCCT GGCATCCCCT TGGCCACCTC CTCAGAAGAC 
CTAGAGAAGT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gal ( NM_001329667.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001316596.1 Mus musculus galanin and GMAP prepropeptide (Gal), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu83521
Clone ID Related Accession (Same CDS sequence)	NM_001329667.1
Accession Version	NM_001329667.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	galanin peptides isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL626765.22, CJ048041.1, W83304.1 and BM900055.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 2 which is longer and has a distinct C-terminus, compared to isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: W83304.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAGAG GCAGCGTTAT CCTGCTAGGC TGGCTCCTGT TGGTTGTGAC CCTGTCAGCC 
ACTCTGGGAC TTGGGATGCC TGCAAAGGAG AAGAGAGGTT GGACCCTGAA CAGCGCTGGC 
TACCTTCTGG GCCCACATGC CATTGACAAC CACAGATCAT TTAGCGACAA GCATGGCCTC 
ACAGGCAAGA GGGAGTTACA ACTGGAGGTG GAGGAAAGGA GACCAGGAAG TGTTGATGTG 
CCCCTGCCTG AGAGCAACAT TGTCCGCACT ATAATGGAGT TTCTCAGTTT CTTGCACCTT 
AAAGGCCGGG GCCCTCGACA GCCTGCCTGG CATCCCCTTG GCCACCTCCT CAGAAGACCT 
AGAGAAGTCC TGAGACCATG TCCACTGTGC ACGTGTGTCC TGTGCTGTAA TTTAAAGTCA 
TTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001316596.1
CDS	234..659
Translation	MARGSVILLGWLLLVVTLSATLGLGMPAKEKRGWTLNSAGYLLGPHAIDNHRSFSDKHGLTGKRELQLEVEERRPGSVDVPLPESNIVRTIMEFLSFLHLKGRGPRQPAWHPLGHLLRRPREVLRPCPLCTCVLCCNLKSF

Target ORF information:

RefSeq Version	NM_001329667.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus galanin and GMAP prepropeptide (Gal), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001329667.1

ORF Insert Sequence:

ATGGCCAGAG GCAGCGTTAT CCTGCTAGGC TGGCTCCTGT TGGTTGTGAC CCTGTCAGCC 
ACTCTGGGAC TTGGGATGCC TGCAAAGGAG AAGAGAGGTT GGACCCTGAA CAGCGCTGGC 
TACCTTCTGG GCCCACATGC CATTGACAAC CACAGATCAT TTAGCGACAA GCATGGCCTC 
ACAGGCAAGA GGGAGTTACA ACTGGAGGTG GAGGAAAGGA GACCAGGAAG TGTTGATGTG 
CCCCTGCCTG AGAGCAACAT TGTCCGCACT ATAATGGAGT TTCTCAGTTT CTTGCACCTT 
AAAGGCCGGG GCCCTCGACA GCCTGCCTGG CATCCCCTTG GCCACCTCCT CAGAAGACCT 
AGAGAAGTCC TGAGACCATG TCCACTGTGC ACGTGTGTCC TGTGCTGTAA TTTAAAGTCA 
TTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Galanin-Expressing GABA Neurons in the Lateral Hypothalamus Modulate Food Reward and Noncompulsive Locomotion.
The Journal of neuroscience : the official journal of the Society for Neuroscience37(25)6053-6065(2017 Jun)
Qualls-Creekmore E,Yu S,Francois M,Hoang J,Huesing C,Bruce-Keller A,Burk D,Berthoud HR,Morrison CD,M?nzberg H

Genetic mapping of the galanin-GMAP (Galn) gene to mouse chromosome 19.
Mammalian genome : official journal of the International Mammalian Genome Society9(3)240-2(1998 Mar)
Guida LC,Charlton P,Gilbert DJ,Jenkins NA,Copeland NG,Nicholls RD

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Gal cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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