Fosl1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fosl1
Entrez Gene ID	14283
Full Name	fos-like antigen 1
Synonyms	AW538199,Fra1,fra-1
General protein information	Preferred Names fos-like antigen 1 Names fos-related antigen 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19 A\|19 4.33 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010235.2	NP_034365.1	fos-related antigen 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Fosl1	NP_037085.1
Homo sapiens (human)	FOSL1	NP_005429.1
Pan troglodytes (chimpanzee)	FOSL1	XP_001170402.1
Bos taurus (cattle)	FOSL1	NP_001192914.1
Mus musculus (house mouse)	Fosl1	NP_034365.1
Canis lupus familiaris (dog)	FOSL1	XP_005631502.1
Danio rerio (zebrafish)	fosl1a	NP_001155024.1
Xenopus tropicalis (tropical clawed frog)	fosl1	XP_002939377.2

Gene Ontology
Bibliography

Related articles in PubMed

FOSL1 Promotes Kras-Induced Lung Cancer Through Amphiregulin and Cell Survival Gene Regulation.
Elangovan IM, Vaz M, Tamatam CR, Potteti HR, Reddy NM, Reddy SP
American journal of respiratory cell and molecular biology(2017 Nov)

The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport.
Paikari A, D Belair C, Saw D, Blelloch R
Development (Cambridge, England)144(20)3731-3743(2017 10)

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer.
Vallejo A, Perurena N, Guruceaga E, Mazur PK, Martinez-Canarias S, Zandueta C, Valencia K, Arricibita A, Gwinn D, Sayles LC, Chuang CH, Guembe L, Bailey P, Chang DK, Biankin A, Ponz-Sarvise M, Andersen JB, Khatri P, Bozec A, Sweet-Cordero EA, Sage J, Lecanda F, Vicent S
Nature communications814294(2017 Feb)

FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions.
Cai B, Wu J, Yu X, Su XZ, Wang RF
mBio8(1)(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3), TIR domain-containing adapter inducing IFN-beta (TRIF), and Tank-binding kinase 1 (TBK1) via impairing K63-linked polyubiquitination of TRAF3 and TRIF.
Title: FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions.

NF-kappaB and c-Jun coregulate lipopolysaccharide-induced Fra-1 transcription.
Title: c-Jun Is Required for Nuclear Factor-?B-Dependent, LPS-Stimulated Fos-Related Antigen-1 Transcription in Alveolar Macrophages.

Adipose-derived stromal cells overexpressing Fra-1 effectively protect against osteoarthritis.
Title: Inhibition of Osteoarthritis by Adipose-Derived Stromal Cells Overexpressing Fra-1 in Mice.

Overexpression of Fosl1, which encodes a component of the AP-1 transcription factor complex, in osteoblasts significantly blocked malleal capillary narrowing.
Title: Osteogenic capillaries orchestrate growth plate-independent ossification of the malleus.

Fra-1 gene expression is activated in response lipopolysaccharide induced lung-injury in mice.
Title: Visualization of Fra-1/AP-1 activation during LPS-induced inflammatory lung injury using fluorescence optical imaging.

The following Fosl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fosl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13492	NM_010235.2 Latest version!	Mus musculus fos-like antigen 1 (Fosl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fosl1 ( NM_010235.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034365.1 Mus musculus fos-like antigen 1 (Fosl1), mRNA.

Price & Availability↑

CloneID	OMu13492
Clone ID Related Accession (Same CDS sequence)	NM_010235.2
Accession Version	NM_010235.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	fos-related antigen 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC122861.4. On Nov 17, 2006 this sequence version replaced NM_010235.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK144785.1, AK144839.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END##

ATGTACCGAG ACTACGGGGA ACCGGGACCG AGCTCCGGGG CTGGCAGCCC GTACGGTCGC 
CCCGCGCAGC CCCCGCAAGC TCAGGCACAG ACCGCCCAGC AGCAGAAGTT CCACCTTGTG 
CCAAGCATCG ACAGCAGCAG CCAGGAACTG CACTGGATGG TGCAGCCTCA TTTCCTGGGA 
CCCACTGGCT ATCCCCGACC TCTGGCCTAT CCCCAGTACA GTCCCCCTCA GCCCCGGCCA 
GGAGTCATAC GAGCCCTAGG GCCACCTCCG GGGGTGCGTC GCAGGCCCTG CGAGCAGATC 
AGCCCAGAGG AGGAAGAGCG CCGCAGGGTG AGACGCGAGC GGAACAAGCT AGCAGCTGCT 
AAGTGCAGAA ACCGAAGAAA GGAGCTGACA GACTTCCTGC AGGCGGAGAC CGACAAATTG 
GAGGATGAGA AATCGGGGCT GCAGCGAGAG ATTGAAGAGC TGCAGAAGCA GAAGGAACGC 
CTTGAGCTGG TGCTGGAAGC CCATCGCCCC ATCTGCAAAA TCCCAGAAGG AGACAAGAAG 
GACCCAGGTG GTTCTGGCAG CACCAGCGGT GCTAGCAGCC CACCAGCCCC CGGCCGCCCA 
GTGCCTTGCA TCTCCCTTTC TCCAGGACCC GTACTTGAAC CGGAAGCACT GCATACCCCC 
ACGCTCATGA CCACACCCTC TCTGACTCCT TTTACTCCGA GTCTGGTTTT CACCTATCCT 
AGCACACCAG AACCTTGCTC CTCCGCTCAC CGAAAGAGTA GCAGCAGCAG TGGCGACCCC 
TCCTCCGACC CCCTGGGCTC TCCTACACTC CTGGCTTTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034365.1
CDS	254..1075
Translation	MYRDYGEPGPSSGAGSPYGRPAQPPQAQAQTAQQQKFHLVPSIDSSSQELHWMVQPHFLGPTGYPRPLAYPQYSPPQPRPGVIRALGPPPGVRRRPCEQISPEEEERRRVRRERNKLAAAKCRNRRKELTDFLQAETDKLEDEKSGLQREIEELQKQKERLELVLEAHRPICKIPEGDKKDPGGSGSTSGASSPPAPGRPVPCISLSPGPVLEPEALHTPTLMTTPSLTPFTPSLVFTYPSTPEPCSSAHRKSSSSSGDPSSDPLGSPTLLAL

Target ORF information:

RefSeq Version	NM_010235.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus fos-like antigen 1 (Fosl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010235.2

ORF Insert Sequence:

ATGTACCGAG ACTACGGGGA ACCGGGACCG AGCTCCGGGG CTGGCAGCCC GTACGGTCGC 
CCCGCGCAGC CCCCGCAAGC TCAGGCACAG ACCGCCCAGC AGCAGAAGTT CCACCTTGTG 
CCAAGCATCG ACAGCAGCAG CCAGGAACTG CACTGGATGG TGCAGCCTCA TTTCCTGGGA 
CCCACTGGCT ATCCCCGACC TCTGGCCTAT CCCCAGTACA GTCCCCCTCA GCCCCGGCCA 
GGAGTCATAC GAGCCCTAGG GCCACCTCCG GGGGTGCGTC GCAGGCCCTG CGAGCAGATC 
AGCCCAGAGG AGGAAGAGCG CCGCAGGGTG AGACGCGAGC GGAACAAGCT AGCAGCTGCT 
AAGTGCAGAA ACCGAAGAAA GGAGCTGACA GACTTCCTGC AGGCGGAGAC CGACAAATTG 
GAGGATGAGA AATCGGGGCT GCAGCGAGAG ATTGAAGAGC TGCAGAAGCA GAAGGAACGC 
CTTGAGCTGG TGCTGGAAGC CCATCGCCCC ATCTGCAAAA TCCCAGAAGG AGACAAGAAG 
GACCCAGGTG GTTCTGGCAG CACCAGCGGT GCTAGCAGCC CACCAGCCCC CGGCCGCCCA 
GTGCCTTGCA TCTCCCTTTC TCCAGGACCC GTACTTGAAC CGGAAGCACT GCATACCCCC 
ACGCTCATGA CCACACCCTC TCTGACTCCT TTTACTCCGA GTCTGGTTTT CACCTATCCT 
AGCACACCAG AACCTTGCTC CTCCGCTCAC CGAAAGAGTA GCAGCAGCAG TGGCGACCCC 
TCCTCCGACC CCCTGGGCTC TCCTACACTC CTGGCTTTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FOSL1 Promotes Kras-Induced Lung Cancer Through Amphiregulin and Cell Survival Gene Regulation.
American journal of respiratory cell and molecular biology(2017 Nov)
Elangovan IM,Vaz M,Tamatam CR,Potteti HR,Reddy NM,Reddy SP

The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport.
Development (Cambridge, England)144(20)3731-3743(2017 10)
Paikari A,D Belair C,Saw D,Blelloch R

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer.
Nature communications814294(2017 Feb)
Vallejo A,Perurena N,Guruceaga E,Mazur PK,Martinez-Canarias S,Zandueta C,Valencia K,Arricibita A,Gwinn D,Sayles LC,Chuang CH,Guembe L,Bailey P,Chang DK,Biankin A,Ponz-Sarvise M,Andersen JB,Khatri P,Bozec A,Sweet-Cordero EA,Sage J,Lecanda F,Vicent S

FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions.
mBio8(1)(2017 Jan)
Cai B,Wu J,Yu X,Su XZ,Wang RF