Fkbp5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fkbp5
Entrez Gene ID	14229
Full Name	FK506 binding protein 5
Synonyms	D17Ertd592e,Dit1,FKBP-5,FKBP51
General protein information	Preferred Names FK506 binding protein 5 Names peptidyl-prolyl cis-trans isomerase FKBP5 51 kDa FK506-binding protein 51 kDa FKBP PPIase FKBP5 rotamase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 A3.3\|17 14.66 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010220.4	NP_034350.1	peptidyl-prolyl cis-trans isomerase FKBP5

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Fkbp5	NP_034350.1
Bos taurus (cattle)	FKBP5	NP_001179791.1
Pan troglodytes (chimpanzee)	FKBP5	XP_001172420.1
Rattus norvegicus (Norway rat)	Fkbp5	NP_001012174.1
Gallus gallus (chicken)	FKBP5	NP_001005431.1
Homo sapiens (human)	FKBP5	NP_004108.1
Canis lupus familiaris (dog)	FKBP5	XP_538880.2
Danio rerio (zebrafish)	fkbp5	NP_998314.1

Gene Ontology
Bibliography

Related articles in PubMed

Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function.
Balsevich G, H?usl AS, Meyer CW, Karamihalev S, Feng X, P?hlmann ML, Dournes C, Uribe-Marino A, Santarelli S, Labermaier C, Hafner K, Mao T, Breitsamer M, Theodoropoulou M, Namendorf C, Uhr M, Paez-Pereda M, Winter G, Hausch F, Chen A, Tsch?p MH, Rein T, Gassen NC, Schmidt MV
Nature communications8(1)1725(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings indicate a role of FK506 binding protein 5 (FKBP5) in hypoxia-regulated adipogenesis.
Title: Loss of FKBP5 impedes adipocyte differentiation under both normoxia and hypoxic stress.

important regulator of PPARgamma in white adipose tissue
Title: FKBP51 Null Mice Are Resistant to Diet-Induced Obesity and the PPAR? Agonist Rosiglitazone.

FKBP5 might increase muscle mass through the enhancements of muscle protein synthesis and myotube differentiation as well as an inhibition of muscle protein degradation in mice
Title: Novel roles of FKBP5 in muscle alteration induced by gravity change in mice.

These results suggest that the association between FKBP5 and alcohol consumption is conserved in both mice and humans.
Title: The FKBP5 Gene Affects Alcohol Drinking in Knockout Mice and Is Implicated in Alcohol Drinking in Humans.

findings show that miR-511 is a functional regulator of FKBP5 and can contribute to neuronal differentiation.
Title: MicroRNA-511 Binds to FKBP5 mRNA, Which Encodes a Chaperone Protein, and Regulates Neuronal Differentiation.

The following Fkbp5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fkbp5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18247	NM_010220.4 Latest version!	Mus musculus FK506 binding protein 5 (Fkbp5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fkbp5 ( NM_010220.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034350.1 Mus musculus FK506 binding protein 5 (Fkbp5), mRNA.

Price & Availability↑

CloneID	OMu18247
Clone ID Related Accession (Same CDS sequence)	NM_010220.4
Accession Version	NM_010220.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1371bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	peptidyl-prolyl cis-trans isomerase FKBP5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY740772.1, BU613862.1, CF949740.1 and AC154912.3. On Mar 5, 2013 this sequence version replaced NM_010220.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U16959.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTACTG ATGAGGGCAC CAGTAACAAT GGAGAGAACC CAGCAGCCAC CATGACTGAG 
CAGGGTGAAG ATATCACTAC GAAGAAAGAC AGAGGAGTAT TAAAGATTGT CAAAAGAGTG 
GGGACTAGTG ACGAGGCCCC AATGTTTGGT GACAAAGTTT ATGTCCACTA CAAAGGGATG 
TTGTCAGATG GAAAGAAGTT TGATTCCAGT CATGACAGAA AGAAGCCATT TGCCTTTAGC 
CTTGGCCAAG GCCAGGTTAT CAAAGCCTGG GACATTGGGG TGTCTACTAT GAAGAAAGGC 
GAGATCTGCC ATTTATTATG TAAACCAGAA TATGCTTATG GCTCGGCTGG CCACCTCCAA 
AAAATTCCAT CAAATGCAAC TCTCTTTTTT GAGATTGAGC TCCTTGATTT CAAAGGTGAG 
GATTTATTTG AAGATTCAGG CGTTATCCGT AGAATCAAAC GGAAAGGCGA GGGATACTCA 
AACCCAAACG AAGGAGCAAC GGTAAAAGTC CACCTGGAAG GCTGCTGTGG TGGAAGGACA 
TTTGATTGCC GAGATGTGGT GTTCGTTGTT GGGGAAGGAG AAGACCACGA CATTCCGATT 
GGGATCGACA AAGCCCTGGT GAAGATGCAG AGAGAAGAAC AGTGTATTCT ATATCTTGGA 
CCACGCTATG GTTTTGGAGA AGCCGGGAAG CCTAAGTTTG GCATTGACCC CAATGCTGAG 
CTTATGTACG AGGTCACCCT TAAGAGCTTC GAGAAGGCCA AAGAATCTTG GGAGATGGAC 
ACCAAAGAAA AGCTGACGCA GGCTGCCATC GTGAAAGAGA AGGGAACTGT GTACTTCAAG 
GGAGGCAAGT ACACGCAGGC CGTGATTCAG TACAGGAAGA TAGTGTCCTG GCTGGAGATG 
GAATACGGCC TGTCAGAGAA GGAGTCCAAA GCCTCAGAGT CGTTCCTCCT CGCAGCCTTC 
CTGAACCTGG CCATGTGCTA CCTGAAGCTC CGAGAGTACA ACAAAGCCGT GGAGTGCTGC 
GACAAGGCCC TTGGACTGGA CAGTGCCAAT GAGAAAGGCT TGTACAGAAG GGGCGAGGCC 
CAGCTGCTCA TGAATGACTT TGAGTCGGCC AAGGGCGACT TCGAGAAGGT GTTGGCAGTC 
AATCCTCAGA ACAGGGCCGC TCGCCTGCAG ATCTCCATGT GCCAGAGGAA GGCGAAGGAG 
CACAACGAGC GGGACCGCAG GGTGTACGCC AACATGTTCA AGAAGTTCGC AGAGCGGGAC 
GCAAAGGAGG AAGCCAGCAA AGCTGGGAGC AAGAAGGCTG TAGAAGGAGC CGCTGGCAAA 
CAACACGAGA GTCAGGCCAT GGAAGAAGGA AAGGCCAAAG GCCATGTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034350.1
CDS	220..1590
Translation	MTTDEGTSNNGENPAATMTEQGEDITTKKDRGVLKIVKRVGTSDEAPMFGDKVYVHYKGMLSDGKKFDSSHDRKKPFAFSLGQGQVIKAWDIGVSTMKKGEICHLLCKPEYAYGSAGHLQKIPSNATLFFEIELLDFKGEDLFEDSGVIRRIKRKGEGYSNPNEGATVKVHLEGCCGGRTFDCRDVVFVVGEGEDHDIPIGIDKALVKMQREEQCILYLGPRYGFGEAGKPKFGIDPNAELMYEVTLKSFEKAKESWEMDTKEKLTQAAIVKEKGTVYFKGGKYTQAVIQYRKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYNKAVECCDKALGLDSANEKGLYRRGEAQLLMNDFESAKGDFEKVLAVNPQNRAARLQISMCQRKAKEHNERDRRVYANMFKKFAERDAKEEASKAGSKKAVEGAAGKQHESQAMEEGKAKGHV

Target ORF information:

RefSeq Version	NM_010220.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus FK506 binding protein 5 (Fkbp5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010220.4

ORF Insert Sequence:

ATGACTACTG ATGAGGGCAC CAGTAACAAT GGAGAGAACC CAGCAGCCAC CATGACTGAG 
CAGGGTGAAG ATATCACTAC GAAGAAAGAC AGAGGAGTAT TAAAGATTGT CAAAAGAGTG 
GGGACTAGTG ACGAGGCCCC AATGTTTGGT GACAAAGTTT ATGTCCACTA CAAAGGGATG 
TTGTCAGATG GAAAGAAGTT TGATTCCAGT CATGACAGAA AGAAGCCATT TGCCTTTAGC 
CTTGGCCAAG GCCAGGTTAT CAAAGCCTGG GACATTGGGG TGTCTACTAT GAAGAAAGGC 
GAGATCTGCC ATTTATTATG TAAACCAGAA TATGCTTATG GCTCGGCTGG CCACCTCCAA 
AAAATTCCAT CAAATGCAAC TCTCTTTTTT GAGATTGAGC TCCTTGATTT CAAAGGTGAG 
GATTTATTTG AAGATTCAGG CGTTATCCGT AGAATCAAAC GGAAAGGCGA GGGATACTCA 
AACCCAAACG AAGGAGCAAC GGTAAAAGTC CACCTGGAAG GCTGCTGTGG TGGAAGGACA 
TTTGATTGCC GAGATGTGGT GTTCGTTGTT GGGGAAGGAG AAGACCACGA CATTCCGATT 
GGGATCGACA AAGCCCTGGT GAAGATGCAG AGAGAAGAAC AGTGTATTCT ATATCTTGGA 
CCACGCTATG GTTTTGGAGA AGCCGGGAAG CCTAAGTTTG GCATTGACCC CAATGCTGAG 
CTTATGTACG AGGTCACCCT TAAGAGCTTC GAGAAGGCCA AAGAATCTTG GGAGATGGAC 
ACCAAAGAAA AGCTGACGCA GGCTGCCATC GTGAAAGAGA AGGGAACTGT GTACTTCAAG 
GGAGGCAAGT ACACGCAGGC CGTGATTCAG TACAGGAAGA TAGTGTCCTG GCTGGAGATG 
GAATACGGCC TGTCAGAGAA GGAGTCCAAA GCCTCAGAGT CGTTCCTCCT CGCAGCCTTC 
CTGAACCTGG CCATGTGCTA CCTGAAGCTC CGAGAGTACA ACAAAGCCGT GGAGTGCTGC 
GACAAGGCCC TTGGACTGGA CAGTGCCAAT GAGAAAGGCT TGTACAGAAG GGGCGAGGCC 
CAGCTGCTCA TGAATGACTT TGAGTCGGCC AAGGGCGACT TCGAGAAGGT GTTGGCAGTC 
AATCCTCAGA ACAGGGCCGC TCGCCTGCAG ATCTCCATGT GCCAGAGGAA GGCGAAGGAG 
CACAACGAGC GGGACCGCAG GGTGTACGCC AACATGTTCA AGAAGTTCGC AGAGCGGGAC 
GCAAAGGAGG AAGCCAGCAA AGCTGGGAGC AAGAAGGCTG TAGAAGGAGC CGCTGGCAAA 
CAACACGAGA GTCAGGCCAT GGAAGAAGGA AAGGCCAAAG GCCATGTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function.
Nature communications8(1)1725(2017 Nov)
Balsevich G,H?usl AS,Meyer CW,Karamihalev S,Feng X,P?hlmann ML,Dournes C,Uribe-Marino A,Santarelli S,Labermaier C,Hafner K,Mao T,Breitsamer M,Theodoropoulou M,Namendorf C,Uhr M,Paez-Pereda M,Winter G,Hausch F,Chen A,Tsch?p MH,Rein T,Gassen NC,Schmidt MV

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Fkbp5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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