Fes cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fes
Entrez Gene ID	14159
Full Name	feline sarcoma oncogene
Synonyms	AI586313,BB137047,FPS,c-fes
General protein information	Preferred Names feline sarcoma oncogene Names tyrosine-protein kinase Fes/Fps proto-oncogene c-Fes proto-oncogene tyrosine-protein kinase Fes/Fps tyrosine kinase Fps/Fes
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 D2\|7 45.65 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006540604.4	XP_006540667.1	tyrosine-protein kinase Fes/Fps isoform X1
NM_010194.2	NP_034324.2	tyrosine-protein kinase Fes/Fps
XM_006540605.2	XP_006540668.1	tyrosine-protein kinase Fes/Fps isoform X2
XM_006540604.3	XP_006540667.1	tyrosine-protein kinase Fes/Fps isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Fes	NP_034324.2
Danio rerio (zebrafish)	fes	NP_001186798.1
Caenorhabditis elegans (roundworm)	ZK622.1	NP_494994.1
Xenopus tropicalis (tropical clawed frog)	LOC100489191	XP_002932286.2
	FES	XP_001093848.1
Bos taurus (cattle)	FES	NP_001027471.1
Gallus gallus (chicken)	FES	XP_003641916.2
Pan troglodytes (chimpanzee)	FES	XP_001169472.1
Canis lupus familiaris (dog)	FES	XP_851836.1
Rattus norvegicus (Norway rat)	Fes	NP_001101958.1
Homo sapiens (human)	FES	NP_001996.1

Gene Ontology
Bibliography

Related articles in PubMed

Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma.
Olvedy M, Tisserand JC, Luciani F, Boeckx B, Wouters J, Lopez S, Rambow F, Aibar S, Thienpont B, Barra J, K?hler C, Radaelli E, Tartare-Deckert S, Aerts S, Dubreuil P, van den Oord JJ, Lambrechts D, De Sepulveda P, Marine JC
The Journal of clinical investigation127(6)2310-2325(2017 Jun)

Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.
Zhang C, Ibrahim PN, Zhang J, Burton EA, Habets G, Zhang Y, Powell B, West BL, Matusow B, Tsang G, Shellooe R, Carias H, Nguyen H, Marimuthu A, Zhang KY, Oh A, Bremer R, Hurt CR, Artis DR, Wu G, Nespi M, Spevak W, Lin P, Nolop K, Hirth P, Tesch GH, Bollag G
Proceedings of the National Academy of Sciences of the United States of America110(14)5689-94(2013 Apr)

Fer kinase limits neutrophil chemotaxis toward end target chemoattractants.
Khajah M, Andonegui G, Chan R, Craig AW, Greer PA, McCafferty DM
Journal of immunology (Baltimore, Md. : 1950)190(5)2208-16(2013 Mar)

FES kinase promotes mast cell recruitment to mammary tumors via the stem cell factor/KIT receptor signaling axis.
Kwok E, Everingham S, Zhang S, Greer PA, Allingham JS, Craig AW
Molecular cancer research : MCR10(7)881-91(2012 Jul)

Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway.
Xu S, Liu X, Bao Y, Zhu X, Han C, Zhang P, Zhang X, Li W, Cao X
Nature immunology13(6)551-9(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

FES is a driver of melanoma progression in a mouse model.
Title: Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma.

Fes inhibition might provide therapeutic benefits in breast cancer, in part by attenuating tumor-associated angiogenesis and the metastasis-promoting functions of tumor-associated macrophages.
Title: Fes tyrosine kinase expression in the tumor niche correlates with enhanced tumor growth, angiogenesis, circulating tumor cells, metastasis, and infiltrating macrophages.

Fes protein is activated downstream of activated Kit receptor, and this is facilitated by the Fes SH2 domain binding to Kit, and by trans-phosphorylation by Fyn kinase.
Title: Fps/Fes protein-tyrosine kinase regulates mast cell adhesion and migration downstream of Kit and beta1 integrin receptors.

Fps/Fes is not essential for the maintenance of mammary epithelial cell adherens junctions in lactating mammae.
Title: fps/fes knockout mice display a lactation defect and the fps/fes tyrosine kinase is a component of E-cadherin-based adherens junctions in breast epithelial cells during lactation.

These findings suggest that activation of Fes by fibroblast growth factor-2 (FGF-2) enhances FAK-dependent activation of Src within focal adhesions, promoting FGF-2-induced disassembly of focal adhesions.
Title: Fibroblast growth factor-2 induces the activation of Src through Fes, which regulates focal adhesion disassembly.

The following Fes gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fes cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu38665	XM_006540605.2 Latest version!	Mus musculus feline sarcoma oncogene (Fes), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu13363	NM_010194.2 Latest version!	Mus musculus feline sarcoma oncogene (Fes), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OMu13363	XM_006540604.4 Latest version!	Mus musculus feline sarcoma oncogene (Fes), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
View Old Accession Versions >>
OMu13363	XM_006540604.3	Mus musculus feline sarcoma oncogene (Fes), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fes ( XM_006540605.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006540668.1 Mus musculus feline sarcoma oncogene (Fes), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu38665
Clone ID Related Accession (Same CDS sequence)	XM_006540605.2
Accession Version	XM_006540605.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	tyrosine-protein kinase Fes/Fps isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006540605.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCTTCT CTTCAGAGCT GTGCAGCCCC CAGGGCCACG GGGCAGTGCA GCAGATGCAG 
GAAGCTGAGC TGCGCTTATT GGAGGGCATG AGGAAGTGGA TGGCCCAGAG GGTCAAGAGT 
GACCGGGAAT ATGCAGGATT GCTTCACCAC ATGTCCTTGC AGGACAGCGG AGGCCAGAGC 
TGGAGCAGCG GCCCCGACAG CCCTGTCAGC CAGTCCTGGG CAGAGATAAC AAGCCAGACC 
GAGAACTTGA GCCGGGTGCT GCGGCAGCAT GCAGAAGATC TGAACTCGGG GCCCTTGAGC 
AAACTGAGCG TGCTGATCCG GGAGCGGCAG CACCTGAGAA AGACGTACAA CGAGCAGTGG 
CAGCAGCTGC AGCAGGAGCT CACCAAGACC CACAGCCAGG ACATTGAGAA GCTGAAGACT 
CAGTACCGGA CCCTGGTACG AGATAGCACC CAGGCCAGGC GCAAGTACCA GGAAGCCAGC 
AAAGACAAGG ATCGAGACAA GGCCAAAGAC AAGTATGTCC GGAGCCTGTG GAAGCTCTTT 
GCCCACCACA ACCGCTACGT CCTGGGTGTG AGGGCCGCAC AGCTGCACCA CCACCACCAC 
CACCGGTTCA TGCTGCCTGG CCTGCTGCAG TCACTGCAGG ATTTGCACGA GGAGATGGCG 
GGCATTCTGA AGGACATCCT GCAGGAATAC CTGGAGATTA GCAGTCTGGT GCAGGACGAT 
GTGGCATCCA TTCACCGTGA GCTGGCTGCA GCTGCTGCTC GGATCCAGCC TGAGTTTGAG 
TACCTAGGCT TCCTGCGACA ATATGGATCC ACCCCTGATG TGCCACCTTG TGTCACTTTT 
GATGAGTCGC TTCTTGAAGA CGGGGAACAG CTGGAGCCAG GGGAGCTGCA GCTGAACGAG 
TTGACCTTGG AGAGCGTGCA ACACACGCTG ACTTCTGTGA CAGATGAACT GGCTGTGGCC 
ACCAAAGAGG TGCTGAGCCG GCAGGAGATG GTCAGTCAGC TGCAGCGTGA GCTCCAAAGT 
GAGGAACAGA ACACCCACCC CCGGGAACGG GTGCAGCTTC TGAGCAAGAG GCAGATGCTG 
CAAGAGGCAA TACAAGGGTT GCAGATAGCA CTGTGCAGCC AGGACAAGCT TCAGGCCCAG 
CAGGAACTTC TGCAGAGCAA GATGGAGCAG CTCGGCACGG GCGAGCCCCC AGCCGTGCCG 
CTCCTTCAGG ATGACCGCCA TTCCACCTCC TCCACGCCTG GCCACTCGCT GACGTCTGTC 
CCTGGCCTCA GGAGCAGGAG CGAGAGGGGG GAAGGACACC CACACTGGAG ATCCTTAAAA 
GCCACTTCTC CGGAATCTTC CGCCCCAAGT TCTCTATCCC TCCACCACTG CAGCTCGTGC 
CGGAGGTGCA GAAGCCTCTC TATGAGCAGC TGTGGTACCA CGGGGCTATC CCTCGGGCAG 
AGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006540668.1
CDS	128..1573
Translation	MGFSSELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSWSSGPDSPVSQSWAEITSQTENLSRVLRQHAEDLNSGPLSKLSVLIRERQHLRKTYNEQWQQLQQELTKTHSQDIEKLKTQYRTLVRDSTQARRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHHHHHRFMLPGLLQSLQDLHEEMAGILKDILQEYLEISSLVQDDVASIHRELAAAAARIQPEFEYLGFLRQYGSTPDVPPCVTFDESLLEDGEQLEPGELQLNELTLESVQHTLTSVTDELAVATKEVLSRQEMVSQLQRELQSEEQNTHPRERVQLLSKRQMLQEAIQGLQIALCSQDKLQAQQELLQSKMEQLGTGEPPAVPLLQDDRHSTSSTPGHSLTSVPGLRSRSERGEGHPHWRSLKATSPESSAPSSLSLHHCSSCRRCRSLSMSSCGTTGLSLGQR

Target ORF information:

RefSeq Version	XM_006540605.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus feline sarcoma oncogene (Fes), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006540605.2

ORF Insert Sequence:

ATGGGCTTCT CTTCAGAGCT GTGCAGCCCC CAGGGCCACG GGGCAGTGCA GCAGATGCAG 
GAAGCTGAGC TGCGCTTATT GGAGGGCATG AGGAAGTGGA TGGCCCAGAG GGTCAAGAGT 
GACCGGGAAT ATGCAGGATT GCTTCACCAC ATGTCCTTGC AGGACAGCGG AGGCCAGAGC 
TGGAGCAGCG GCCCCGACAG CCCTGTCAGC CAGTCCTGGG CAGAGATAAC AAGCCAGACC 
GAGAACTTGA GCCGGGTGCT GCGGCAGCAT GCAGAAGATC TGAACTCGGG GCCCTTGAGC 
AAACTGAGCG TGCTGATCCG GGAGCGGCAG CACCTGAGAA AGACGTACAA CGAGCAGTGG 
CAGCAGCTGC AGCAGGAGCT CACCAAGACC CACAGCCAGG ACATTGAGAA GCTGAAGACT 
CAGTACCGGA CCCTGGTACG AGATAGCACC CAGGCCAGGC GCAAGTACCA GGAAGCCAGC 
AAAGACAAGG ATCGAGACAA GGCCAAAGAC AAGTATGTCC GGAGCCTGTG GAAGCTCTTT 
GCCCACCACA ACCGCTACGT CCTGGGTGTG AGGGCCGCAC AGCTGCACCA CCACCACCAC 
CACCGGTTCA TGCTGCCTGG CCTGCTGCAG TCACTGCAGG ATTTGCACGA GGAGATGGCG 
GGCATTCTGA AGGACATCCT GCAGGAATAC CTGGAGATTA GCAGTCTGGT GCAGGACGAT 
GTGGCATCCA TTCACCGTGA GCTGGCTGCA GCTGCTGCTC GGATCCAGCC TGAGTTTGAG 
TACCTAGGCT TCCTGCGACA ATATGGATCC ACCCCTGATG TGCCACCTTG TGTCACTTTT 
GATGAGTCGC TTCTTGAAGA CGGGGAACAG CTGGAGCCAG GGGAGCTGCA GCTGAACGAG 
TTGACCTTGG AGAGCGTGCA ACACACGCTG ACTTCTGTGA CAGATGAACT GGCTGTGGCC 
ACCAAAGAGG TGCTGAGCCG GCAGGAGATG GTCAGTCAGC TGCAGCGTGA GCTCCAAAGT 
GAGGAACAGA ACACCCACCC CCGGGAACGG GTGCAGCTTC TGAGCAAGAG GCAGATGCTG 
CAAGAGGCAA TACAAGGGTT GCAGATAGCA CTGTGCAGCC AGGACAAGCT TCAGGCCCAG 
CAGGAACTTC TGCAGAGCAA GATGGAGCAG CTCGGCACGG GCGAGCCCCC AGCCGTGCCG 
CTCCTTCAGG ATGACCGCCA TTCCACCTCC TCCACGCCTG GCCACTCGCT GACGTCTGTC 
CCTGGCCTCA GGAGCAGGAG CGAGAGGGGG GAAGGACACC CACACTGGAG ATCCTTAAAA 
GCCACTTCTC CGGAATCTTC CGCCCCAAGT TCTCTATCCC TCCACCACTG CAGCTCGTGC 
CGGAGGTGCA GAAGCCTCTC TATGAGCAGC TGTGGTACCA CGGGGCTATC CCTCGGGCAG 
AGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fes ( NM_010194.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034324.2 Mus musculus feline sarcoma oncogene (Fes), mRNA.

Price & Availability↑

CloneID	OMu13363
Clone ID Related Accession (Same CDS sequence)	XM_006540604.4 , NM_010194.2 , XM_006540604.3
Accession Version	NM_010194.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2469bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	tyrosine-protein kinase Fes/Fps
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC136740.10, AK143639.1 and BC038130.1. On Aug 5, 2006 this sequence version replaced NM_010194.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK143639.1, AK170418.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGGCTTCT CTTCAGAGCT GTGCAGCCCC CAGGGCCACG GGGCAGTGCA GCAGATGCAG 
GAAGCTGAGC TGCGCTTATT GGAGGGCATG AGGAAGTGGA TGGCCCAGAG GGTCAAGAGT 
GACCGGGAAT ATGCAGGATT GCTTCACCAC ATGTCCTTGC AGGACAGCGG AGGCCAGAGC 
TGGAGCAGCG GCCCCGACAG CCCTGTCAGC CAGTCCTGGG CAGAGATAAC AAGCCAGACC 
GAGAACTTGA GCCGGGTGCT GCGGCAGCAT GCAGAAGATC TGAACTCGGG GCCCTTGAGC 
AAACTGAGCG TGCTGATCCG GGAGCGGCAG CACCTGAGAA AGACGTACAA CGAGCAGTGG 
CAGCAGCTGC AGCAGGAGCT CACCAAGACC CACAGCCAGG ACATTGAGAA GCTGAAGACT 
CAGTACCGGA CCCTGGTACG AGATAGCACC CAGGCCAGGC GCAAGTACCA GGAAGCCAGC 
AAAGACAAGG ATCGAGACAA GGCCAAAGAC AAGTATGTCC GGAGCCTGTG GAAGCTCTTT 
GCCCACCACA ACCGCTACGT CCTGGGTGTG AGGGCCGCAC AGCTGCACCA CCACCACCAC 
CACCGGTTCA TGCTGCCTGG CCTGCTGCAG TCACTGCAGG ATTTGCACGA GGAGATGGCG 
GGCATTCTGA AGGACATCCT GCAGGAATAC CTGGAGATTA GCAGTCTGGT GCAGGACGAT 
GTGGCATCCA TTCACCGTGA GCTGGCTGCA GCTGCTGCTC GGATCCAGCC TGAGTTTGAG 
TACCTAGGCT TCCTGCGACA ATATGGATCC ACCCCTGATG TGCCACCTTG TGTCACTTTT 
GATGAGTCGC TTCTTGAAGA CGGGGAACAG CTGGAGCCAG GGGAGCTGCA GCTGAACGAG 
TTGACCTTGG AGAGCGTGCA ACACACGCTG ACTTCTGTGA CAGATGAACT GGCTGTGGCC 
ACCAAAGAGG TGCTGAGCCG GCAGGAGATG GTCAGTCAGC TGCAGCGTGA GCTCCAAAGT 
GAGGAACAGA ACACCCACCC CCGGGAACGG GTGCAGCTTC TGAGCAAGAG GCAGATGCTG 
CAAGAGGCAA TACAAGGGTT GCAGATAGCA CTGTGCAGCC AGGACAAGCT TCAGGCCCAG 
CAGGAACTTC TGCAGAGCAA GATGGAGCAG CTCGGCACGG GCGAGCCCCC AGCCGTGCCG 
CTCCTTCAGG ATGACCGCCA TTCCACCTCC TCCACGGAGC AGGAGCGAGA GGGGGGAAGG 
ACACCCACAC TGGAGATCCT TAAAAGCCAC TTCTCCGGAA TCTTCCGCCC CAAGTTCTCT 
ATCCCTCCAC CACTGCAGCT CGTGCCGGAG GTGCAGAAGC CTCTCTATGA GCAGCTGTGG 
TACCACGGGG CTATCCCTCG GGCAGAGGTA GCTGAGCTGC TAACACACTC CGGGGACTTC 
CTGGTTCGGG AGAGCCAGGG CAAGCAGGAG TATGTACTGT CTGTGATGTG GGATGGCCAG 
CCCCGACATT TCATCATCCA GTCCTCAGAT AACCTGTACC GGCTGGAAGG GGATGGCTTC 
CCCAGCATAC CTCTGCTCAT CACTCACCTG CTGTCCTCCC AGCAACCCCT TACAAAGAAG 
AGTGGTGTTG TCCTGTTCAG GGCGGTGCCC AAGGACAAGT GGGTTCTGAA GCACGAGGAC 
CTGGTGCTGG GAGAGCAGAT CGGAAGGGGG AACTTCGGAG AGGTGTTTAG TGGCCGCCTT 
CGTGCAGACA ATACCCCGGT GGCTGTGAAG TCTTGCCGAG AGACACTCCC ACCTGACCTC 
AAGGCCAAGT TTCTGCAAGA AGCAAGGATC CTGAAACAGT ACAACCACCC CAACATTGTG 
CGTCTCATCG GGGTCTGCAC ACAGAAACAG CCGATCTACA TCGTCATGGA GCTCGTTCAA 
GGGGGCGACT TTCTCACCTT CCTGCGGACA GAGGGAGCCC GCCTGCGGGT GAAGACTCTG 
CTGCAGATGG TAGGGGACGC AGCTGCTGGC ATGGAATACT TGGAAAGCAA GTGTTGTATC 
CACAGGGACC TGGCTGCTCG GAACTGCCTG GTGACAGAGA AGAATGTCCT GAAGATCAGC 
GACTTTGGGA TGTCCCGCGA AGAAGCTGAT GGGATCTATG CCGCCTCAGC GGGCCTCAGA 
CAAGTCCCTG TTAAGTGGAC TGCCCCTGAG GCCCTTAACT ACGGACGCTA CTCCTCAGAG 
AGTGATGTGT GGAGCTTTGG CATTTTGCTG TGGGAGACCT TCAGCCTGGG GGCCTCACCC 
TATCCCAACC TCACCAATCA GCAGACACGG GAGTTTGTAG AAAAGGGGCA TCGTCTGCCT 
TGCCCAGAGC TGTGCCCTGA TGCGGTCTTC AGGCTCATGG AGCAGTGCTG GGCCTATGAG 
CCTGGGCAGA GACCTAGTTT CAGCATCATC TGCCAGGAGC TCCACAGTAT CCGCAAGCGG 
CATCGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034324.2
CDS	120..2588
Translation	MGFSSELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSWSSGPDSPVSQSWAEITSQTENLSRVLRQHAEDLNSGPLSKLSVLIRERQHLRKTYNEQWQQLQQELTKTHSQDIEKLKTQYRTLVRDSTQARRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHHHHHRFMLPGLLQSLQDLHEEMAGILKDILQEYLEISSLVQDDVASIHRELAAAAARIQPEFEYLGFLRQYGSTPDVPPCVTFDESLLEDGEQLEPGELQLNELTLESVQHTLTSVTDELAVATKEVLSRQEMVSQLQRELQSEEQNTHPRERVQLLSKRQMLQEAIQGLQIALCSQDKLQAQQELLQSKMEQLGTGEPPAVPLLQDDRHSTSSTEQEREGGRTPTLEILKSHFSGIFRPKFSIPPPLQLVPEVQKPLYEQLWYHGAIPRAEVAELLTHSGDFLVRESQGKQEYVLSVMWDGQPRHFIIQSSDNLYRLEGDGFPSIPLLITHLLSSQQPLTKKSGVVLFRAVPKDKWVLKHEDLVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAASAGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLTNQQTREFVEKGHRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSIICQELHSIRKRHR

Target ORF information:

RefSeq Version	NM_010194.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus feline sarcoma oncogene (Fes), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010194.2

ORF Insert Sequence:

ATGGGCTTCT CTTCAGAGCT GTGCAGCCCC CAGGGCCACG GGGCAGTGCA GCAGATGCAG 
GAAGCTGAGC TGCGCTTATT GGAGGGCATG AGGAAGTGGA TGGCCCAGAG GGTCAAGAGT 
GACCGGGAAT ATGCAGGATT GCTTCACCAC ATGTCCTTGC AGGACAGCGG AGGCCAGAGC 
TGGAGCAGCG GCCCCGACAG CCCTGTCAGC CAGTCCTGGG CAGAGATAAC AAGCCAGACC 
GAGAACTTGA GCCGGGTGCT GCGGCAGCAT GCAGAAGATC TGAACTCGGG GCCCTTGAGC 
AAACTGAGCG TGCTGATCCG GGAGCGGCAG CACCTGAGAA AGACGTACAA CGAGCAGTGG 
CAGCAGCTGC AGCAGGAGCT CACCAAGACC CACAGCCAGG ACATTGAGAA GCTGAAGACT 
CAGTACCGGA CCCTGGTACG AGATAGCACC CAGGCCAGGC GCAAGTACCA GGAAGCCAGC 
AAAGACAAGG ATCGAGACAA GGCCAAAGAC AAGTATGTCC GGAGCCTGTG GAAGCTCTTT 
GCCCACCACA ACCGCTACGT CCTGGGTGTG AGGGCCGCAC AGCTGCACCA CCACCACCAC 
CACCGGTTCA TGCTGCCTGG CCTGCTGCAG TCACTGCAGG ATTTGCACGA GGAGATGGCG 
GGCATTCTGA AGGACATCCT GCAGGAATAC CTGGAGATTA GCAGTCTGGT GCAGGACGAT 
GTGGCATCCA TTCACCGTGA GCTGGCTGCA GCTGCTGCTC GGATCCAGCC TGAGTTTGAG 
TACCTAGGCT TCCTGCGACA ATATGGATCC ACCCCTGATG TGCCACCTTG TGTCACTTTT 
GATGAGTCGC TTCTTGAAGA CGGGGAACAG CTGGAGCCAG GGGAGCTGCA GCTGAACGAG 
TTGACCTTGG AGAGCGTGCA ACACACGCTG ACTTCTGTGA CAGATGAACT GGCTGTGGCC 
ACCAAAGAGG TGCTGAGCCG GCAGGAGATG GTCAGTCAGC TGCAGCGTGA GCTCCAAAGT 
GAGGAACAGA ACACCCACCC CCGGGAACGG GTGCAGCTTC TGAGCAAGAG GCAGATGCTG 
CAAGAGGCAA TACAAGGGTT GCAGATAGCA CTGTGCAGCC AGGACAAGCT TCAGGCCCAG 
CAGGAACTTC TGCAGAGCAA GATGGAGCAG CTCGGCACGG GCGAGCCCCC AGCCGTGCCG 
CTCCTTCAGG ATGACCGCCA TTCCACCTCC TCCACGGAGC AGGAGCGAGA GGGGGGAAGG 
ACACCCACAC TGGAGATCCT TAAAAGCCAC TTCTCCGGAA TCTTCCGCCC CAAGTTCTCT 
ATCCCTCCAC CACTGCAGCT CGTGCCGGAG GTGCAGAAGC CTCTCTATGA GCAGCTGTGG 
TACCACGGGG CTATCCCTCG GGCAGAGGTA GCTGAGCTGC TAACACACTC CGGGGACTTC 
CTGGTTCGGG AGAGCCAGGG CAAGCAGGAG TATGTACTGT CTGTGATGTG GGATGGCCAG 
CCCCGACATT TCATCATCCA GTCCTCAGAT AACCTGTACC GGCTGGAAGG GGATGGCTTC 
CCCAGCATAC CTCTGCTCAT CACTCACCTG CTGTCCTCCC AGCAACCCCT TACAAAGAAG 
AGTGGTGTTG TCCTGTTCAG GGCGGTGCCC AAGGACAAGT GGGTTCTGAA GCACGAGGAC 
CTGGTGCTGG GAGAGCAGAT CGGAAGGGGG AACTTCGGAG AGGTGTTTAG TGGCCGCCTT 
CGTGCAGACA ATACCCCGGT GGCTGTGAAG TCTTGCCGAG AGACACTCCC ACCTGACCTC 
AAGGCCAAGT TTCTGCAAGA AGCAAGGATC CTGAAACAGT ACAACCACCC CAACATTGTG 
CGTCTCATCG GGGTCTGCAC ACAGAAACAG CCGATCTACA TCGTCATGGA GCTCGTTCAA 
GGGGGCGACT TTCTCACCTT CCTGCGGACA GAGGGAGCCC GCCTGCGGGT GAAGACTCTG 
CTGCAGATGG TAGGGGACGC AGCTGCTGGC ATGGAATACT TGGAAAGCAA GTGTTGTATC 
CACAGGGACC TGGCTGCTCG GAACTGCCTG GTGACAGAGA AGAATGTCCT GAAGATCAGC 
GACTTTGGGA TGTCCCGCGA AGAAGCTGAT GGGATCTATG CCGCCTCAGC GGGCCTCAGA 
CAAGTCCCTG TTAAGTGGAC TGCCCCTGAG GCCCTTAACT ACGGACGCTA CTCCTCAGAG 
AGTGATGTGT GGAGCTTTGG CATTTTGCTG TGGGAGACCT TCAGCCTGGG GGCCTCACCC 
TATCCCAACC TCACCAATCA GCAGACACGG GAGTTTGTAG AAAAGGGGCA TCGTCTGCCT 
TGCCCAGAGC TGTGCCCTGA TGCGGTCTTC AGGCTCATGG AGCAGTGCTG GGCCTATGAG 
CCTGGGCAGA GACCTAGTTT CAGCATCATC TGCCAGGAGC TCCACAGTAT CCGCAAGCGG 
CATCGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fes ( XM_006540604.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006540667.1 Mus musculus feline sarcoma oncogene (Fes), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu13363
Clone ID Related Accession (Same CDS sequence)	XM_006540604.4 , NM_010194.2 , XM_006540604.3
Accession Version	XM_006540604.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2469bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	tyrosine-protein kinase Fes/Fps isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006540604.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCTTCT CTTCAGAGCT GTGCAGCCCC CAGGGCCACG GGGCAGTGCA GCAGATGCAG 
GAAGCTGAGC TGCGCTTATT GGAGGGCATG AGGAAGTGGA TGGCCCAGAG GGTCAAGAGT 
GACCGGGAAT ATGCAGGATT GCTTCACCAC ATGTCCTTGC AGGACAGCGG AGGCCAGAGC 
TGGAGCAGCG GCCCCGACAG CCCTGTCAGC CAGTCCTGGG CAGAGATAAC AAGCCAGACC 
GAGAACTTGA GCCGGGTGCT GCGGCAGCAT GCAGAAGATC TGAACTCGGG GCCCTTGAGC 
AAACTGAGCG TGCTGATCCG GGAGCGGCAG CACCTGAGAA AGACGTACAA CGAGCAGTGG 
CAGCAGCTGC AGCAGGAGCT CACCAAGACC CACAGCCAGG ACATTGAGAA GCTGAAGACT 
CAGTACCGGA CCCTGGTACG AGATAGCACC CAGGCCAGGC GCAAGTACCA GGAAGCCAGC 
AAAGACAAGG ATCGAGACAA GGCCAAAGAC AAGTATGTCC GGAGCCTGTG GAAGCTCTTT 
GCCCACCACA ACCGCTACGT CCTGGGTGTG AGGGCCGCAC AGCTGCACCA CCACCACCAC 
CACCGGTTCA TGCTGCCTGG CCTGCTGCAG TCACTGCAGG ATTTGCACGA GGAGATGGCG 
GGCATTCTGA AGGACATCCT GCAGGAATAC CTGGAGATTA GCAGTCTGGT GCAGGACGAT 
GTGGCATCCA TTCACCGTGA GCTGGCTGCA GCTGCTGCTC GGATCCAGCC TGAGTTTGAG 
TACCTAGGCT TCCTGCGACA ATATGGATCC ACCCCTGATG TGCCACCTTG TGTCACTTTT 
GATGAGTCGC TTCTTGAAGA CGGGGAACAG CTGGAGCCAG GGGAGCTGCA GCTGAACGAG 
TTGACCTTGG AGAGCGTGCA ACACACGCTG ACTTCTGTGA CAGATGAACT GGCTGTGGCC 
ACCAAAGAGG TGCTGAGCCG GCAGGAGATG GTCAGTCAGC TGCAGCGTGA GCTCCAAAGT 
GAGGAACAGA ACACCCACCC CCGGGAACGG GTGCAGCTTC TGAGCAAGAG GCAGATGCTG 
CAAGAGGCAA TACAAGGGTT GCAGATAGCA CTGTGCAGCC AGGACAAGCT TCAGGCCCAG 
CAGGAACTTC TGCAGAGCAA GATGGAGCAG CTCGGCACGG GCGAGCCCCC AGCCGTGCCG 
CTCCTTCAGG ATGACCGCCA TTCCACCTCC TCCACGGAGC AGGAGCGAGA GGGGGGAAGG 
ACACCCACAC TGGAGATCCT TAAAAGCCAC TTCTCCGGAA TCTTCCGCCC CAAGTTCTCT 
ATCCCTCCAC CACTGCAGCT CGTGCCGGAG GTGCAGAAGC CTCTCTATGA GCAGCTGTGG 
TACCACGGGG CTATCCCTCG GGCAGAGGTA GCTGAGCTGC TAACACACTC CGGGGACTTC 
CTGGTTCGGG AGAGCCAGGG CAAGCAGGAG TATGTACTGT CTGTGATGTG GGATGGCCAG 
CCCCGACATT TCATCATCCA GTCCTCAGAT AACCTGTACC GGCTGGAAGG GGATGGCTTC 
CCCAGCATAC CTCTGCTCAT CACTCACCTG CTGTCCTCCC AGCAACCCCT TACAAAGAAG 
AGTGGTGTTG TCCTGTTCAG GGCGGTGCCC AAGGACAAGT GGGTTCTGAA GCACGAGGAC 
CTGGTGCTGG GAGAGCAGAT CGGAAGGGGG AACTTCGGAG AGGTGTTTAG TGGCCGCCTT 
CGTGCAGACA ATACCCCGGT GGCTGTGAAG TCTTGCCGAG AGACACTCCC ACCTGACCTC 
AAGGCCAAGT TTCTGCAAGA AGCAAGGATC CTGAAACAGT ACAACCACCC CAACATTGTG 
CGTCTCATCG GGGTCTGCAC ACAGAAACAG CCGATCTACA TCGTCATGGA GCTCGTTCAA 
GGGGGCGACT TTCTCACCTT CCTGCGGACA GAGGGAGCCC GCCTGCGGGT GAAGACTCTG 
CTGCAGATGG TAGGGGACGC AGCTGCTGGC ATGGAATACT TGGAAAGCAA GTGTTGTATC 
CACAGGGACC TGGCTGCTCG GAACTGCCTG GTGACAGAGA AGAATGTCCT GAAGATCAGC 
GACTTTGGGA TGTCCCGCGA AGAAGCTGAT GGGATCTATG CCGCCTCAGC GGGCCTCAGA 
CAAGTCCCTG TTAAGTGGAC TGCCCCTGAG GCCCTTAACT ACGGACGCTA CTCCTCAGAG 
AGTGATGTGT GGAGCTTTGG CATTTTGCTG TGGGAGACCT TCAGCCTGGG GGCCTCACCC 
TATCCCAACC TCACCAATCA GCAGACACGG GAGTTTGTAG AAAAGGGGCA TCGTCTGCCT 
TGCCCAGAGC TGTGCCCTGA TGCGGTCTTC AGGCTCATGG AGCAGTGCTG GGCCTATGAG 
CCTGGGCAGA GACCTAGTTT CAGCATCATC TGCCAGGAGC TCCACAGTAT CCGCAAGCGG 
CATCGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006540667.1
CDS	204..2672
Translation	MGFSSELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSWSSGPDSPVSQSWAEITSQTENLSRVLRQHAEDLNSGPLSKLSVLIRERQHLRKTYNEQWQQLQQELTKTHSQDIEKLKTQYRTLVRDSTQARRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHHHHHRFMLPGLLQSLQDLHEEMAGILKDILQEYLEISSLVQDDVASIHRELAAAAARIQPEFEYLGFLRQYGSTPDVPPCVTFDESLLEDGEQLEPGELQLNELTLESVQHTLTSVTDELAVATKEVLSRQEMVSQLQRELQSEEQNTHPRERVQLLSKRQMLQEAIQGLQIALCSQDKLQAQQELLQSKMEQLGTGEPPAVPLLQDDRHSTSSTEQEREGGRTPTLEILKSHFSGIFRPKFSIPPPLQLVPEVQKPLYEQLWYHGAIPRAEVAELLTHSGDFLVRESQGKQEYVLSVMWDGQPRHFIIQSSDNLYRLEGDGFPSIPLLITHLLSSQQPLTKKSGVVLFRAVPKDKWVLKHEDLVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAASAGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLTNQQTREFVEKGHRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSIICQELHSIRKRHR

Target ORF information:

RefSeq Version	XM_006540604.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus feline sarcoma oncogene (Fes), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006540604.3

ORF Insert Sequence:

ATGGGCTTCT CTTCAGAGCT GTGCAGCCCC CAGGGCCACG GGGCAGTGCA GCAGATGCAG 
GAAGCTGAGC TGCGCTTATT GGAGGGCATG AGGAAGTGGA TGGCCCAGAG GGTCAAGAGT 
GACCGGGAAT ATGCAGGATT GCTTCACCAC ATGTCCTTGC AGGACAGCGG AGGCCAGAGC 
TGGAGCAGCG GCCCCGACAG CCCTGTCAGC CAGTCCTGGG CAGAGATAAC AAGCCAGACC 
GAGAACTTGA GCCGGGTGCT GCGGCAGCAT GCAGAAGATC TGAACTCGGG GCCCTTGAGC 
AAACTGAGCG TGCTGATCCG GGAGCGGCAG CACCTGAGAA AGACGTACAA CGAGCAGTGG 
CAGCAGCTGC AGCAGGAGCT CACCAAGACC CACAGCCAGG ACATTGAGAA GCTGAAGACT 
CAGTACCGGA CCCTGGTACG AGATAGCACC CAGGCCAGGC GCAAGTACCA GGAAGCCAGC 
AAAGACAAGG ATCGAGACAA GGCCAAAGAC AAGTATGTCC GGAGCCTGTG GAAGCTCTTT 
GCCCACCACA ACCGCTACGT CCTGGGTGTG AGGGCCGCAC AGCTGCACCA CCACCACCAC 
CACCGGTTCA TGCTGCCTGG CCTGCTGCAG TCACTGCAGG ATTTGCACGA GGAGATGGCG 
GGCATTCTGA AGGACATCCT GCAGGAATAC CTGGAGATTA GCAGTCTGGT GCAGGACGAT 
GTGGCATCCA TTCACCGTGA GCTGGCTGCA GCTGCTGCTC GGATCCAGCC TGAGTTTGAG 
TACCTAGGCT TCCTGCGACA ATATGGATCC ACCCCTGATG TGCCACCTTG TGTCACTTTT 
GATGAGTCGC TTCTTGAAGA CGGGGAACAG CTGGAGCCAG GGGAGCTGCA GCTGAACGAG 
TTGACCTTGG AGAGCGTGCA ACACACGCTG ACTTCTGTGA CAGATGAACT GGCTGTGGCC 
ACCAAAGAGG TGCTGAGCCG GCAGGAGATG GTCAGTCAGC TGCAGCGTGA GCTCCAAAGT 
GAGGAACAGA ACACCCACCC CCGGGAACGG GTGCAGCTTC TGAGCAAGAG GCAGATGCTG 
CAAGAGGCAA TACAAGGGTT GCAGATAGCA CTGTGCAGCC AGGACAAGCT TCAGGCCCAG 
CAGGAACTTC TGCAGAGCAA GATGGAGCAG CTCGGCACGG GCGAGCCCCC AGCCGTGCCG 
CTCCTTCAGG ATGACCGCCA TTCCACCTCC TCCACGGAGC AGGAGCGAGA GGGGGGAAGG 
ACACCCACAC TGGAGATCCT TAAAAGCCAC TTCTCCGGAA TCTTCCGCCC CAAGTTCTCT 
ATCCCTCCAC CACTGCAGCT CGTGCCGGAG GTGCAGAAGC CTCTCTATGA GCAGCTGTGG 
TACCACGGGG CTATCCCTCG GGCAGAGGTA GCTGAGCTGC TAACACACTC CGGGGACTTC 
CTGGTTCGGG AGAGCCAGGG CAAGCAGGAG TATGTACTGT CTGTGATGTG GGATGGCCAG 
CCCCGACATT TCATCATCCA GTCCTCAGAT AACCTGTACC GGCTGGAAGG GGATGGCTTC 
CCCAGCATAC CTCTGCTCAT CACTCACCTG CTGTCCTCCC AGCAACCCCT TACAAAGAAG 
AGTGGTGTTG TCCTGTTCAG GGCGGTGCCC AAGGACAAGT GGGTTCTGAA GCACGAGGAC 
CTGGTGCTGG GAGAGCAGAT CGGAAGGGGG AACTTCGGAG AGGTGTTTAG TGGCCGCCTT 
CGTGCAGACA ATACCCCGGT GGCTGTGAAG TCTTGCCGAG AGACACTCCC ACCTGACCTC 
AAGGCCAAGT TTCTGCAAGA AGCAAGGATC CTGAAACAGT ACAACCACCC CAACATTGTG 
CGTCTCATCG GGGTCTGCAC ACAGAAACAG CCGATCTACA TCGTCATGGA GCTCGTTCAA 
GGGGGCGACT TTCTCACCTT CCTGCGGACA GAGGGAGCCC GCCTGCGGGT GAAGACTCTG 
CTGCAGATGG TAGGGGACGC AGCTGCTGGC ATGGAATACT TGGAAAGCAA GTGTTGTATC 
CACAGGGACC TGGCTGCTCG GAACTGCCTG GTGACAGAGA AGAATGTCCT GAAGATCAGC 
GACTTTGGGA TGTCCCGCGA AGAAGCTGAT GGGATCTATG CCGCCTCAGC GGGCCTCAGA 
CAAGTCCCTG TTAAGTGGAC TGCCCCTGAG GCCCTTAACT ACGGACGCTA CTCCTCAGAG 
AGTGATGTGT GGAGCTTTGG CATTTTGCTG TGGGAGACCT TCAGCCTGGG GGCCTCACCC 
TATCCCAACC TCACCAATCA GCAGACACGG GAGTTTGTAG AAAAGGGGCA TCGTCTGCCT 
TGCCCAGAGC TGTGCCCTGA TGCGGTCTTC AGGCTCATGG AGCAGTGCTG GGCCTATGAG 
CCTGGGCAGA GACCTAGTTT CAGCATCATC TGCCAGGAGC TCCACAGTAT CCGCAAGCGG 
CATCGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fes ( XM_006540604.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006540667.1 Mus musculus feline sarcoma oncogene (Fes), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu13363
Clone ID Related Accession (Same CDS sequence)	XM_006540604.4 , NM_010194.2 , XM_006540604.3
Accession Version	XM_006540604.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2469bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	tyrosine-protein kinase Fes/Fps isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006540604.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCTTCT CTTCAGAGCT GTGCAGCCCC CAGGGCCACG GGGCAGTGCA GCAGATGCAG 
GAAGCTGAGC TGCGCTTATT GGAGGGCATG AGGAAGTGGA TGGCCCAGAG GGTCAAGAGT 
GACCGGGAAT ATGCAGGATT GCTTCACCAC ATGTCCTTGC AGGACAGCGG AGGCCAGAGC 
TGGAGCAGCG GCCCCGACAG CCCTGTCAGC CAGTCCTGGG CAGAGATAAC AAGCCAGACC 
GAGAACTTGA GCCGGGTGCT GCGGCAGCAT GCAGAAGATC TGAACTCGGG GCCCTTGAGC 
AAACTGAGCG TGCTGATCCG GGAGCGGCAG CACCTGAGAA AGACGTACAA CGAGCAGTGG 
CAGCAGCTGC AGCAGGAGCT CACCAAGACC CACAGCCAGG ACATTGAGAA GCTGAAGACT 
CAGTACCGGA CCCTGGTACG AGATAGCACC CAGGCCAGGC GCAAGTACCA GGAAGCCAGC 
AAAGACAAGG ATCGAGACAA GGCCAAAGAC AAGTATGTCC GGAGCCTGTG GAAGCTCTTT 
GCCCACCACA ACCGCTACGT CCTGGGTGTG AGGGCCGCAC AGCTGCACCA CCACCACCAC 
CACCGGTTCA TGCTGCCTGG CCTGCTGCAG TCACTGCAGG ATTTGCACGA GGAGATGGCG 
GGCATTCTGA AGGACATCCT GCAGGAATAC CTGGAGATTA GCAGTCTGGT GCAGGACGAT 
GTGGCATCCA TTCACCGTGA GCTGGCTGCA GCTGCTGCTC GGATCCAGCC TGAGTTTGAG 
TACCTAGGCT TCCTGCGACA ATATGGATCC ACCCCTGATG TGCCACCTTG TGTCACTTTT 
GATGAGTCGC TTCTTGAAGA CGGGGAACAG CTGGAGCCAG GGGAGCTGCA GCTGAACGAG 
TTGACCTTGG AGAGCGTGCA ACACACGCTG ACTTCTGTGA CAGATGAACT GGCTGTGGCC 
ACCAAAGAGG TGCTGAGCCG GCAGGAGATG GTCAGTCAGC TGCAGCGTGA GCTCCAAAGT 
GAGGAACAGA ACACCCACCC CCGGGAACGG GTGCAGCTTC TGAGCAAGAG GCAGATGCTG 
CAAGAGGCAA TACAAGGGTT GCAGATAGCA CTGTGCAGCC AGGACAAGCT TCAGGCCCAG 
CAGGAACTTC TGCAGAGCAA GATGGAGCAG CTCGGCACGG GCGAGCCCCC AGCCGTGCCG 
CTCCTTCAGG ATGACCGCCA TTCCACCTCC TCCACGGAGC AGGAGCGAGA GGGGGGAAGG 
ACACCCACAC TGGAGATCCT TAAAAGCCAC TTCTCCGGAA TCTTCCGCCC CAAGTTCTCT 
ATCCCTCCAC CACTGCAGCT CGTGCCGGAG GTGCAGAAGC CTCTCTATGA GCAGCTGTGG 
TACCACGGGG CTATCCCTCG GGCAGAGGTA GCTGAGCTGC TAACACACTC CGGGGACTTC 
CTGGTTCGGG AGAGCCAGGG CAAGCAGGAG TATGTACTGT CTGTGATGTG GGATGGCCAG 
CCCCGACATT TCATCATCCA GTCCTCAGAT AACCTGTACC GGCTGGAAGG GGATGGCTTC 
CCCAGCATAC CTCTGCTCAT CACTCACCTG CTGTCCTCCC AGCAACCCCT TACAAAGAAG 
AGTGGTGTTG TCCTGTTCAG GGCGGTGCCC AAGGACAAGT GGGTTCTGAA GCACGAGGAC 
CTGGTGCTGG GAGAGCAGAT CGGAAGGGGG AACTTCGGAG AGGTGTTTAG TGGCCGCCTT 
CGTGCAGACA ATACCCCGGT GGCTGTGAAG TCTTGCCGAG AGACACTCCC ACCTGACCTC 
AAGGCCAAGT TTCTGCAAGA AGCAAGGATC CTGAAACAGT ACAACCACCC CAACATTGTG 
CGTCTCATCG GGGTCTGCAC ACAGAAACAG CCGATCTACA TCGTCATGGA GCTCGTTCAA 
GGGGGCGACT TTCTCACCTT CCTGCGGACA GAGGGAGCCC GCCTGCGGGT GAAGACTCTG 
CTGCAGATGG TAGGGGACGC AGCTGCTGGC ATGGAATACT TGGAAAGCAA GTGTTGTATC 
CACAGGGACC TGGCTGCTCG GAACTGCCTG GTGACAGAGA AGAATGTCCT GAAGATCAGC 
GACTTTGGGA TGTCCCGCGA AGAAGCTGAT GGGATCTATG CCGCCTCAGC GGGCCTCAGA 
CAAGTCCCTG TTAAGTGGAC TGCCCCTGAG GCCCTTAACT ACGGACGCTA CTCCTCAGAG 
AGTGATGTGT GGAGCTTTGG CATTTTGCTG TGGGAGACCT TCAGCCTGGG GGCCTCACCC 
TATCCCAACC TCACCAATCA GCAGACACGG GAGTTTGTAG AAAAGGGGCA TCGTCTGCCT 
TGCCCAGAGC TGTGCCCTGA TGCGGTCTTC AGGCTCATGG AGCAGTGCTG GGCCTATGAG 
CCTGGGCAGA GACCTAGTTT CAGCATCATC TGCCAGGAGC TCCACAGTAT CCGCAAGCGG 
CATCGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006540667.1
CDS	214..2682
Translation	MGFSSELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSWSSGPDSPVSQSWAEITSQTENLSRVLRQHAEDLNSGPLSKLSVLIRERQHLRKTYNEQWQQLQQELTKTHSQDIEKLKTQYRTLVRDSTQARRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHHHHHRFMLPGLLQSLQDLHEEMAGILKDILQEYLEISSLVQDDVASIHRELAAAAARIQPEFEYLGFLRQYGSTPDVPPCVTFDESLLEDGEQLEPGELQLNELTLESVQHTLTSVTDELAVATKEVLSRQEMVSQLQRELQSEEQNTHPRERVQLLSKRQMLQEAIQGLQIALCSQDKLQAQQELLQSKMEQLGTGEPPAVPLLQDDRHSTSSTEQEREGGRTPTLEILKSHFSGIFRPKFSIPPPLQLVPEVQKPLYEQLWYHGAIPRAEVAELLTHSGDFLVRESQGKQEYVLSVMWDGQPRHFIIQSSDNLYRLEGDGFPSIPLLITHLLSSQQPLTKKSGVVLFRAVPKDKWVLKHEDLVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAASAGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLTNQQTREFVEKGHRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSIICQELHSIRKRHR

Target ORF information:

RefSeq Version	XM_006540604.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus feline sarcoma oncogene (Fes), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006540604.4

ORF Insert Sequence:

ATGGGCTTCT CTTCAGAGCT GTGCAGCCCC CAGGGCCACG GGGCAGTGCA GCAGATGCAG 
GAAGCTGAGC TGCGCTTATT GGAGGGCATG AGGAAGTGGA TGGCCCAGAG GGTCAAGAGT 
GACCGGGAAT ATGCAGGATT GCTTCACCAC ATGTCCTTGC AGGACAGCGG AGGCCAGAGC 
TGGAGCAGCG GCCCCGACAG CCCTGTCAGC CAGTCCTGGG CAGAGATAAC AAGCCAGACC 
GAGAACTTGA GCCGGGTGCT GCGGCAGCAT GCAGAAGATC TGAACTCGGG GCCCTTGAGC 
AAACTGAGCG TGCTGATCCG GGAGCGGCAG CACCTGAGAA AGACGTACAA CGAGCAGTGG 
CAGCAGCTGC AGCAGGAGCT CACCAAGACC CACAGCCAGG ACATTGAGAA GCTGAAGACT 
CAGTACCGGA CCCTGGTACG AGATAGCACC CAGGCCAGGC GCAAGTACCA GGAAGCCAGC 
AAAGACAAGG ATCGAGACAA GGCCAAAGAC AAGTATGTCC GGAGCCTGTG GAAGCTCTTT 
GCCCACCACA ACCGCTACGT CCTGGGTGTG AGGGCCGCAC AGCTGCACCA CCACCACCAC 
CACCGGTTCA TGCTGCCTGG CCTGCTGCAG TCACTGCAGG ATTTGCACGA GGAGATGGCG 
GGCATTCTGA AGGACATCCT GCAGGAATAC CTGGAGATTA GCAGTCTGGT GCAGGACGAT 
GTGGCATCCA TTCACCGTGA GCTGGCTGCA GCTGCTGCTC GGATCCAGCC TGAGTTTGAG 
TACCTAGGCT TCCTGCGACA ATATGGATCC ACCCCTGATG TGCCACCTTG TGTCACTTTT 
GATGAGTCGC TTCTTGAAGA CGGGGAACAG CTGGAGCCAG GGGAGCTGCA GCTGAACGAG 
TTGACCTTGG AGAGCGTGCA ACACACGCTG ACTTCTGTGA CAGATGAACT GGCTGTGGCC 
ACCAAAGAGG TGCTGAGCCG GCAGGAGATG GTCAGTCAGC TGCAGCGTGA GCTCCAAAGT 
GAGGAACAGA ACACCCACCC CCGGGAACGG GTGCAGCTTC TGAGCAAGAG GCAGATGCTG 
CAAGAGGCAA TACAAGGGTT GCAGATAGCA CTGTGCAGCC AGGACAAGCT TCAGGCCCAG 
CAGGAACTTC TGCAGAGCAA GATGGAGCAG CTCGGCACGG GCGAGCCCCC AGCCGTGCCG 
CTCCTTCAGG ATGACCGCCA TTCCACCTCC TCCACGGAGC AGGAGCGAGA GGGGGGAAGG 
ACACCCACAC TGGAGATCCT TAAAAGCCAC TTCTCCGGAA TCTTCCGCCC CAAGTTCTCT 
ATCCCTCCAC CACTGCAGCT CGTGCCGGAG GTGCAGAAGC CTCTCTATGA GCAGCTGTGG 
TACCACGGGG CTATCCCTCG GGCAGAGGTA GCTGAGCTGC TAACACACTC CGGGGACTTC 
CTGGTTCGGG AGAGCCAGGG CAAGCAGGAG TATGTACTGT CTGTGATGTG GGATGGCCAG 
CCCCGACATT TCATCATCCA GTCCTCAGAT AACCTGTACC GGCTGGAAGG GGATGGCTTC 
CCCAGCATAC CTCTGCTCAT CACTCACCTG CTGTCCTCCC AGCAACCCCT TACAAAGAAG 
AGTGGTGTTG TCCTGTTCAG GGCGGTGCCC AAGGACAAGT GGGTTCTGAA GCACGAGGAC 
CTGGTGCTGG GAGAGCAGAT CGGAAGGGGG AACTTCGGAG AGGTGTTTAG TGGCCGCCTT 
CGTGCAGACA ATACCCCGGT GGCTGTGAAG TCTTGCCGAG AGACACTCCC ACCTGACCTC 
AAGGCCAAGT TTCTGCAAGA AGCAAGGATC CTGAAACAGT ACAACCACCC CAACATTGTG 
CGTCTCATCG GGGTCTGCAC ACAGAAACAG CCGATCTACA TCGTCATGGA GCTCGTTCAA 
GGGGGCGACT TTCTCACCTT CCTGCGGACA GAGGGAGCCC GCCTGCGGGT GAAGACTCTG 
CTGCAGATGG TAGGGGACGC AGCTGCTGGC ATGGAATACT TGGAAAGCAA GTGTTGTATC 
CACAGGGACC TGGCTGCTCG GAACTGCCTG GTGACAGAGA AGAATGTCCT GAAGATCAGC 
GACTTTGGGA TGTCCCGCGA AGAAGCTGAT GGGATCTATG CCGCCTCAGC GGGCCTCAGA 
CAAGTCCCTG TTAAGTGGAC TGCCCCTGAG GCCCTTAACT ACGGACGCTA CTCCTCAGAG 
AGTGATGTGT GGAGCTTTGG CATTTTGCTG TGGGAGACCT TCAGCCTGGG GGCCTCACCC 
TATCCCAACC TCACCAATCA GCAGACACGG GAGTTTGTAG AAAAGGGGCA TCGTCTGCCT 
TGCCCAGAGC TGTGCCCTGA TGCGGTCTTC AGGCTCATGG AGCAGTGCTG GGCCTATGAG 
CCTGGGCAGA GACCTAGTTT CAGCATCATC TGCCAGGAGC TCCACAGTAT CCGCAAGCGG 
CATCGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma.
The Journal of clinical investigation127(6)2310-2325(2017 Jun)
Olvedy M,Tisserand JC,Luciani F,Boeckx B,Wouters J,Lopez S,Rambow F,Aibar S,Thienpont B,Barra J,K?hler C,Radaelli E,Tartare-Deckert S,Aerts S,Dubreuil P,van den Oord JJ,Lambrechts D,De Sepulveda P,Marine JC

Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.
Proceedings of the National Academy of Sciences of the United States of America110(14)5689-94(2013 Apr)
Zhang C,Ibrahim PN,Zhang J,Burton EA,Habets G,Zhang Y,Powell B,West BL,Matusow B,Tsang G,Shellooe R,Carias H,Nguyen H,Marimuthu A,Zhang KY,Oh A,Bremer R,Hurt CR,Artis DR,Wu G,Nespi M,Spevak W,Lin P,Nolop K,Hirth P,Tesch GH,Bollag G

Fer kinase limits neutrophil chemotaxis toward end target chemoattractants.
Journal of immunology (Baltimore, Md. : 1950)190(5)2208-16(2013 Mar)
Khajah M,Andonegui G,Chan R,Craig AW,Greer PA,McCafferty DM

FES kinase promotes mast cell recruitment to mammary tumors via the stem cell factor/KIT receptor signaling axis.
Molecular cancer research : MCR10(7)881-91(2012 Jul)
Kwok E,Everingham S,Zhang S,Greer PA,Allingham JS,Craig AW

Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway.
Nature immunology13(6)551-9(2012 Apr)
Xu S,Liu X,Bao Y,Zhu X,Han C,Zhang P,Zhang X,Li W,Cao X

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Fes cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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