Ercc2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ercc2
Entrez Gene ID	13871
Full Name	excision repair cross-complementing rodent repair deficiency, complementation group 2
Synonyms	AA407812,AU020867,AW240756,CXPD,Ercc-2,Mhdarco15,RCO015,XPD
General protein information	Preferred Names excision repair cross-complementing rodent repair deficiency, complementation group 2 Names TFIIH basal transcription factor complex helicase XPD subunit DNA excision repair protein ERCC-2 DNA repair protein complementing XP-D cells TFIIH basal transcription factor complex helicase subunit xeroderma pigmentosum group D-complementing protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 A3\|7 9.62 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007949.5	NP_031975.2	general transcription and DNA repair factor IIH helicase subunit XPD isoform 1
NM_007949.4	NP_031975.2	TFIIH basal transcription factor complex helicase XPD subunit
NM_001363981.1	NP_001350910.1	general transcription and DNA repair factor IIH helicase subunit XPD isoform 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ercc2	NP_031975.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002988	XP_311900.4
Bos taurus (cattle)	ERCC2	NP_001096787.1
Magnaporthe oryzae (rice blast fungus)	MGG_03132	XP_003716866.1
Pan troglodytes (chimpanzee)	ERCC2	NP_001233519.1
Danio rerio (zebrafish)	ercc2	NP_957220.1
Drosophila melanogaster (fruit fly)	Xpd	NP_726036.2
Schizosaccharomyces pombe (fission yeast)	rad15	NP_593025.1
Oryza sativa (rice)	Os05g0144800	NP_001054627.1
Xenopus tropicalis (tropical clawed frog)	ercc2	NP_001008131.1
Homo sapiens (human)	ERCC2	NP_000391.1
Canis lupus familiaris (dog)	ERCC2	XP_541562.3
Kluyveromyces lactis	KLLA0C17776g	XP_452994.1
Neurospora crassa	NCU01625	XP_956536.2
Arabidopsis thaliana (thale cress)	UVH6	NP_171818.1
	LOC715485	XP_002808245.1
Rattus norvegicus (Norway rat)	Ercc2	NP_001166280.1
Caenorhabditis elegans (roundworm)	Y50D7A.2	NP_497182.2
Saccharomyces cerevisiae (baker's yeast)	RAD3	NP_011098.3
Eremothecium gossypii	AGOS_AGR114C	NP_986780.1

Gene Ontology
Bibliography

Related articles in PubMed

Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract risk.
Dalke C, Neff F, Bains SK, Bright S, Lord D, Reitmeir P, R??ler U, Samaga D, Unger K, Braselmann H, Wagner F, Greiter M, Gomolka M, Hornhardt S, Kunze S, Kempf SJ, Garrett L, H?lter SM, Wurst W, Rosemann M, Azimzadeh O, Tapio S, Aubele M, Theis F, Hoeschen C, Slijepcevic P, Kadhim M, Atkinson M, Zitzelsberger H, Kulka U, Graw J
Radiation and environmental biophysics(2018 Jan)

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.
Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, van der Pluijm I, Essers J, van Cappellen WA, van IJcken WF, Houtsmuller AB, Pothof J, de Bruin RWF, Madl T, Hoeijmakers JHJ, Campisi J, de Keizer PLJ
Cell169(1)132-147.e16(2017 Mar)

New mutation in the mouse Xpd/Ercc2 gene leads to recessive cataracts.
Kunze S, Dalke C, Fuchs H, Klaften M, R?ssler U, Hornhardt S, Gomolka M, Puk O, Sabrautzki S, Kulka U, Hrab? de Angelis M, Graw J
PloS one10(5)e0125304(2015)

Dynamic partnership between TFIIH, PGC-1? and SIRT1 is impaired in trichothiodystrophy.
Traboulsi H, Davoli S, Catez P, Egly JM, Compe E
PLoS genetics10(10)e1004732(2014 Oct)

XPD-dependent activation of apoptosis in response to triplex-induced DNA damage.
Kaushik Tiwari M, Rogers FA
Nucleic acids research41(19)8979-94(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results describe a recessive cataract caused by a mutation in the Xpd/Ercc2 gene and demonstrate the importance of the gene not only for lens fiber cell differentiation, but also for the sensitivity to ionizing radiation.
Title: New mutation in the mouse Xpd/Ercc2 gene leads to recessive cataracts.

Compound TTD/XPCS heterozygosity partially rescues metabolic phenotype associated with homozygous XPD alleles. TTD allele dominates over XPCS allele in measures of UV-sensitivity.
Title: Effects of compound heterozygosity at the Xpd locus on cancer and ageing in mouse models.

ERCC2 plays role in lung cancer development in a Chinese population.
Title: HapMap-based study of the DNA repair gene ERCC2 and lung cancer susceptibility in a Chinese population.

results support a general model for premature aging in Xpd DNA repair deficient mice based on cellular responses to DNA damage that impair normal tissue homeostasis
Title: Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice.

a variety of biallelic effects on organismal phenotype which attributes to combinations of recessive Xpd alleles
Title: Rescue of progeria in trichothiodystrophy by homozygous lethal Xpd alleles.

The following Ercc2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ercc2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19648	NM_007949.5 Latest version!	Mus musculus excision repair cross-complementing rodent repair deficiency, complementation group 2 (Ercc2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$447.30 $639.00
OMu84250	NM_001363981.1 Latest version!	Mus musculus excision repair cross-complementing rodent repair deficiency, complementation group 2 (Ercc2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
View Old Accession Versions >>
OMu19648	NM_007949.4	Mus musculus excision repair cross-complementing rodent repair deficiency, complementation group 2 (Ercc2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$447.30 $639.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ercc2 ( NM_007949.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031975.2 Mus musculus excision repair cross-complementing rodent repair deficiency, complementation group 2 (Ercc2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu19648
Clone ID Related Accession (Same CDS sequence)	NM_007949.5 , NM_007949.4
Accession Version	NM_007949.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2283bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Mus musculus(house mouse)
Product	general transcription and DNA repair factor IIH helicase subunit XPD isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC118017.15. On Jun 3, 2018 this sequence version replaced NM_007949.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK141692.1, AK145969.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTCA ACGTGGACGG GCTGCTGGTC TACTTCCCGT ACGACTACAT CTACCCGGAG 
CAGTTCTCCT ACATGCTGGA GCTCAAGCGC ACGCTGGACG CCAAGGGTCA TGGAGTCCTG 
GAGATGCCCT CGGGCACTGG GAAGACAGTG TCCCTATTGG CCCTGATTGT GGCCTATCAG 
CGGGCTTATC CGCTGGAGGT GACCAAACTT ATCTACTGCT CACGGACCGT GCCAGAGATT 
GAGAAGGTCA TAGAAGAGCT TCGTAAGCTA CTCAGCTTCT ACGAGCAGCA GGAGGGCGAG 
AAGCTGCCGT TCTTAGGACT GGCTCTGAGC TCAAGAAAGA ACCTGTGCAT TCATCCCGAG 
GTGACTCCAC TGCGCTTTGG GAAGGATGTT GATGGGAAGT GTCACAGCCT AACGGCGTCG 
TATGTGCGGG CACAGTACCA GCAGGATGCC AGCCTGCCTC ACTGCCGCTT CTATGAGGAA 
TTTGACATCC ATGGACGCCA GATGCCGCTC CCTGCGGGCA TCTACAACCT GGATGACCTG 
AAGGCCCTAG GGCAGCGCCA GGGCTGGTGC CCCTACTTCC TGGCTCGATA CTCGATCCTG 
CATGCCAACG TGGTGGTTTA CAGCTACCAC TACCTCCTGG ACCCCAAGAT CGCAGACCTG 
GTATCCAAAG AGCTGGCTCG CAAGGCTGTT GTGGTCTTCG ATGAAGCTCA CAACATCGAC 
AATGTCTGCA TTGACTCCAT GAGTGTCAAC CTCACCCGCA GGACTCTGGA CCGTTGCCAG 
AGCAACTTAG ACACCCTACA GAAGACCGTG CTCAGGATCA AGGAGACGGA TGAGCAGCGG 
CTGCGGGATG AGTACCGGCG CCTGGTGGAG GGCCTGCGGG AGGCCAGTGT GGCCCGGGAG 
ACAGATGCCC ACCTGGCCAA CCCTGTGCTG CCGGACGAGG TGCTGCAGGA GGCTGTGCCT 
GGCTCCATCC GTACGGCTGA GCACTTCCTG GGCTTTCTGC GGCGGCTGCT GGAGTATGTC 
AAGTGGCGTC TGCGCGTGCA GCATGTGGTG CAGGAGAGTC CACCTGCCTT TCTGAGCGGC 
CTGGCCCAGC GGGTGTGCAT CCAGCGCAAG CCCCTCAGGT TCTGTGCTGA ACGCCTGCGC 
TCCCTGCTGC ACACCCTGGA GATTGCCGAC CTGGCCGACT TCTCCCCGCT CACACTCCTT 
GCTAACTTCG CCACTCTCGT CAGCACTTAC GCCAAGGGCT TCACCATTAT CATTGAGCCC 
TTTGACGACA GGACCCCCAC CATCGCCAAC CCCGTTCTGC ACTTCAGCTG TATGGACGCC 
TCCTTGGCCA TCAAGCCTGT GTTTGAGCGC TTCCAGTCTG TCATCATCAC TTCTGGGACA 
CTGTCCCCAC TGGACATCTA CCCCAAGATC CTGGACTTCC ACCCTGTCAC AATGGCAACC 
TTCACCATGA CGCTGGCCCG AGTCTGCCTC TGCCCGATGA TCATTGGCCG TGGTAATGAC 
CAGGTAGCAA TCAGCTCCAA ATTTGAGACC AGAGAAGATA TTGCTGTGAT CCGAAACTAT 
GGCAACCTCC TGCTGGAGAT GTCCGCCGTG GTCCCAGATG GCATTGTGGC CTTCTTTACC 
AGCTACCAGT ACATGGAAAG CACCGTGGCC TCCTGGTATG AGCAGGGCAT CCTTGAGAAC 
ATCCAGAGGA ACAAACTGCT CTTCATTGAG ACCCAGGATG GGGCTGAGAC CAGTGTGGCC 
CTGGAGAAGT ACCAAGAGGC ATGCGAGAAT GGCCGTGGGG CCATTCTGCT CTCAGTGGCT 
CGGGGCAAAG TATCAGAAGG GATTGACTTT GTACACCACT ACGGACGGGC TGTGATCATG 
TTTGGAGTTC CCTATGTCTA TACCCAGAGC CGAATTCTCA AGGCCCGGCT AGAGTATCTG 
CGGGACCAGT TCCAGATCCG AGAGAACGAC TTCCTCACCT TTGATGCTAT GCGCCATGCA 
GCCCAGTGTG TGGGTCGTGC CATCAGGGGC AAGACGGACT ATGGACTCAT GGTCTTTGCT 
GACAAGCGGT TTGCTCGGGC GGACAAGCGT GGTAAGCTGC CTCGCTGGAT CCAGGAGCAC 
CTGACCGACT CCAACCTCAA CCTGACCGTG GATGAGGGTG TACAGGTCGC CAAGTACTTC 
CTGCGGCAGA TGGCGCAGCC CTTCCACCGG GAGGATCAGC TGGGCCTGTC GCTGCTCAGC 
CTGGAGCAGC TGCAGTCAGA GGAGACACTA CAGCGAATTG AGCAGATCGC ACAGCAGCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031975.2
CDS	39..2321
Translation	MKLNVDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPSGTGKTVSLLALIVAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEQQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDASLPHCRFYEEFDIHGRQMPLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASVARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPVLHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLQSEETLQRIEQIAQQL

Target ORF information:

RefSeq Version	NM_007949.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus excision repair cross-complementing rodent repair deficiency, complementation group 2 (Ercc2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007949.5

ORF Insert Sequence:

ATGAAGCTCA ACGTGGACGG GCTGCTGGTC TACTTCCCGT ACGACTACAT CTACCCGGAG 
CAGTTCTCCT ACATGCTGGA GCTCAAGCGC ACGCTGGACG CCAAGGGTCA TGGAGTCCTG 
GAGATGCCCT CGGGCACTGG GAAGACAGTG TCCCTATTGG CCCTGATTGT GGCCTATCAG 
CGGGCTTATC CGCTGGAGGT GACCAAACTT ATCTACTGCT CACGGACCGT GCCAGAGATT 
GAGAAGGTCA TAGAAGAGCT TCGTAAGCTA CTCAGCTTCT ACGAGCAGCA GGAGGGCGAG 
AAGCTGCCGT TCTTAGGACT GGCTCTGAGC TCAAGAAAGA ACCTGTGCAT TCATCCCGAG 
GTGACTCCAC TGCGCTTTGG GAAGGATGTT GATGGGAAGT GTCACAGCCT AACGGCGTCG 
TATGTGCGGG CACAGTACCA GCAGGATGCC AGCCTGCCTC ACTGCCGCTT CTATGAGGAA 
TTTGACATCC ATGGACGCCA GATGCCGCTC CCTGCGGGCA TCTACAACCT GGATGACCTG 
AAGGCCCTAG GGCAGCGCCA GGGCTGGTGC CCCTACTTCC TGGCTCGATA CTCGATCCTG 
CATGCCAACG TGGTGGTTTA CAGCTACCAC TACCTCCTGG ACCCCAAGAT CGCAGACCTG 
GTATCCAAAG AGCTGGCTCG CAAGGCTGTT GTGGTCTTCG ATGAAGCTCA CAACATCGAC 
AATGTCTGCA TTGACTCCAT GAGTGTCAAC CTCACCCGCA GGACTCTGGA CCGTTGCCAG 
AGCAACTTAG ACACCCTACA GAAGACCGTG CTCAGGATCA AGGAGACGGA TGAGCAGCGG 
CTGCGGGATG AGTACCGGCG CCTGGTGGAG GGCCTGCGGG AGGCCAGTGT GGCCCGGGAG 
ACAGATGCCC ACCTGGCCAA CCCTGTGCTG CCGGACGAGG TGCTGCAGGA GGCTGTGCCT 
GGCTCCATCC GTACGGCTGA GCACTTCCTG GGCTTTCTGC GGCGGCTGCT GGAGTATGTC 
AAGTGGCGTC TGCGCGTGCA GCATGTGGTG CAGGAGAGTC CACCTGCCTT TCTGAGCGGC 
CTGGCCCAGC GGGTGTGCAT CCAGCGCAAG CCCCTCAGGT TCTGTGCTGA ACGCCTGCGC 
TCCCTGCTGC ACACCCTGGA GATTGCCGAC CTGGCCGACT TCTCCCCGCT CACACTCCTT 
GCTAACTTCG CCACTCTCGT CAGCACTTAC GCCAAGGGCT TCACCATTAT CATTGAGCCC 
TTTGACGACA GGACCCCCAC CATCGCCAAC CCCGTTCTGC ACTTCAGCTG TATGGACGCC 
TCCTTGGCCA TCAAGCCTGT GTTTGAGCGC TTCCAGTCTG TCATCATCAC TTCTGGGACA 
CTGTCCCCAC TGGACATCTA CCCCAAGATC CTGGACTTCC ACCCTGTCAC AATGGCAACC 
TTCACCATGA CGCTGGCCCG AGTCTGCCTC TGCCCGATGA TCATTGGCCG TGGTAATGAC 
CAGGTAGCAA TCAGCTCCAA ATTTGAGACC AGAGAAGATA TTGCTGTGAT CCGAAACTAT 
GGCAACCTCC TGCTGGAGAT GTCCGCCGTG GTCCCAGATG GCATTGTGGC CTTCTTTACC 
AGCTACCAGT ACATGGAAAG CACCGTGGCC TCCTGGTATG AGCAGGGCAT CCTTGAGAAC 
ATCCAGAGGA ACAAACTGCT CTTCATTGAG ACCCAGGATG GGGCTGAGAC CAGTGTGGCC 
CTGGAGAAGT ACCAAGAGGC ATGCGAGAAT GGCCGTGGGG CCATTCTGCT CTCAGTGGCT 
CGGGGCAAAG TATCAGAAGG GATTGACTTT GTACACCACT ACGGACGGGC TGTGATCATG 
TTTGGAGTTC CCTATGTCTA TACCCAGAGC CGAATTCTCA AGGCCCGGCT AGAGTATCTG 
CGGGACCAGT TCCAGATCCG AGAGAACGAC TTCCTCACCT TTGATGCTAT GCGCCATGCA 
GCCCAGTGTG TGGGTCGTGC CATCAGGGGC AAGACGGACT ATGGACTCAT GGTCTTTGCT 
GACAAGCGGT TTGCTCGGGC GGACAAGCGT GGTAAGCTGC CTCGCTGGAT CCAGGAGCAC 
CTGACCGACT CCAACCTCAA CCTGACCGTG GATGAGGGTG TACAGGTCGC CAAGTACTTC 
CTGCGGCAGA TGGCGCAGCC CTTCCACCGG GAGGATCAGC TGGGCCTGTC GCTGCTCAGC 
CTGGAGCAGC TGCAGTCAGA GGAGACACTA CAGCGAATTG AGCAGATCGC ACAGCAGCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ercc2 ( NM_007949.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031975.2 Mus musculus excision repair cross-complementing rodent repair deficiency, complementation group 2 (Ercc2), mRNA.

Price & Availability↑

CloneID	OMu19648
Clone ID Related Accession (Same CDS sequence)	NM_007949.5 , NM_007949.4
Accession Version	NM_007949.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2283bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Mus musculus(house mouse)
Product	TFIIH basal transcription factor complex helicase XPD subunit
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC118017.15. On Apr 27, 2007 this sequence version replaced NM_007949.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK082761.1, AK145969.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAAGCTCA ACGTGGACGG GCTGCTGGTC TACTTCCCGT ACGACTACAT CTACCCGGAG 
CAGTTCTCCT ACATGCTGGA GCTCAAGCGC ACGCTGGACG CCAAGGGTCA TGGAGTCCTG 
GAGATGCCCT CGGGCACTGG GAAGACAGTG TCCCTATTGG CCCTGATTGT GGCCTATCAG 
CGGGCTTATC CGCTGGAGGT GACCAAACTT ATCTACTGCT CACGGACCGT GCCAGAGATT 
GAGAAGGTCA TAGAAGAGCT TCGTAAGCTA CTCAGCTTCT ACGAGCAGCA GGAGGGCGAG 
AAGCTGCCGT TCTTAGGACT GGCTCTGAGC TCAAGAAAGA ACCTGTGCAT TCATCCCGAG 
GTGACTCCAC TGCGCTTTGG GAAGGATGTT GATGGGAAGT GTCACAGCCT AACGGCGTCG 
TATGTGCGGG CACAGTACCA GCAGGATGCC AGCCTGCCTC ACTGCCGCTT CTATGAGGAA 
TTTGACATCC ATGGACGCCA GATGCCGCTC CCTGCGGGCA TCTACAACCT GGATGACCTG 
AAGGCCCTAG GGCAGCGCCA GGGCTGGTGC CCCTACTTCC TGGCTCGATA CTCGATCCTG 
CATGCCAACG TGGTGGTTTA CAGCTACCAC TACCTCCTGG ACCCCAAGAT CGCAGACCTG 
GTATCCAAAG AGCTGGCTCG CAAGGCTGTT GTGGTCTTCG ATGAAGCTCA CAACATCGAC 
AATGTCTGCA TTGACTCCAT GAGTGTCAAC CTCACCCGCA GGACTCTGGA CCGTTGCCAG 
AGCAACTTAG ACACCCTACA GAAGACCGTG CTCAGGATCA AGGAGACGGA TGAGCAGCGG 
CTGCGGGATG AGTACCGGCG CCTGGTGGAG GGCCTGCGGG AGGCCAGTGT GGCCCGGGAG 
ACAGATGCCC ACCTGGCCAA CCCTGTGCTG CCGGACGAGG TGCTGCAGGA GGCTGTGCCT 
GGCTCCATCC GTACGGCTGA GCACTTCCTG GGCTTTCTGC GGCGGCTGCT GGAGTATGTC 
AAGTGGCGTC TGCGCGTGCA GCATGTGGTG CAGGAGAGTC CACCTGCCTT TCTGAGCGGC 
CTGGCCCAGC GGGTGTGCAT CCAGCGCAAG CCCCTCAGGT TCTGTGCTGA ACGCCTGCGC 
TCCCTGCTGC ACACCCTGGA GATTGCCGAC CTGGCCGACT TCTCCCCGCT CACACTCCTT 
GCTAACTTCG CCACTCTCGT CAGCACTTAC GCCAAGGGCT TCACCATTAT CATTGAGCCC 
TTTGACGACA GGACCCCCAC CATCGCCAAC CCCGTTCTGC ACTTCAGCTG TATGGACGCC 
TCCTTGGCCA TCAAGCCTGT GTTTGAGCGC TTCCAGTCTG TCATCATCAC TTCTGGGACA 
CTGTCCCCAC TGGACATCTA CCCCAAGATC CTGGACTTCC ACCCTGTCAC AATGGCAACC 
TTCACCATGA CGCTGGCCCG AGTCTGCCTC TGCCCGATGA TCATTGGCCG TGGTAATGAC 
CAGGTAGCAA TCAGCTCCAA ATTTGAGACC AGAGAAGATA TTGCTGTGAT CCGAAACTAT 
GGCAACCTCC TGCTGGAGAT GTCCGCCGTG GTCCCAGATG GCATTGTGGC CTTCTTTACC 
AGCTACCAGT ACATGGAAAG CACCGTGGCC TCCTGGTATG AGCAGGGCAT CCTTGAGAAC 
ATCCAGAGGA ACAAACTGCT CTTCATTGAG ACCCAGGATG GGGCTGAGAC CAGTGTGGCC 
CTGGAGAAGT ACCAAGAGGC ATGCGAGAAT GGCCGTGGGG CCATTCTGCT CTCAGTGGCT 
CGGGGCAAAG TATCAGAAGG GATTGACTTT GTACACCACT ACGGACGGGC TGTGATCATG 
TTTGGAGTTC CCTATGTCTA TACCCAGAGC CGAATTCTCA AGGCCCGGCT AGAGTATCTG 
CGGGACCAGT TCCAGATCCG AGAGAACGAC TTCCTCACCT TTGATGCTAT GCGCCATGCA 
GCCCAGTGTG TGGGTCGTGC CATCAGGGGC AAGACGGACT ATGGACTCAT GGTCTTTGCT 
GACAAGCGGT TTGCTCGGGC GGACAAGCGT GGTAAGCTGC CTCGCTGGAT CCAGGAGCAC 
CTGACCGACT CCAACCTCAA CCTGACCGTG GATGAGGGTG TACAGGTCGC CAAGTACTTC 
CTGCGGCAGA TGGCGCAGCC CTTCCACCGG GAGGATCAGC TGGGCCTGTC GCTGCTCAGC 
CTGGAGCAGC TGCAGTCAGA GGAGACACTA CAGCGAATTG AGCAGATCGC ACAGCAGCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031975.2
CDS	17..2299
Translation	MKLNVDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPSGTGKTVSLLALIVAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEQQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDASLPHCRFYEEFDIHGRQMPLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASVARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPVLHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLQSEETLQRIEQIAQQL

Target ORF information:

RefSeq Version	NM_007949.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus excision repair cross-complementing rodent repair deficiency, complementation group 2 (Ercc2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007949.4

ORF Insert Sequence:

ATGAAGCTCA ACGTGGACGG GCTGCTGGTC TACTTCCCGT ACGACTACAT CTACCCGGAG 
CAGTTCTCCT ACATGCTGGA GCTCAAGCGC ACGCTGGACG CCAAGGGTCA TGGAGTCCTG 
GAGATGCCCT CGGGCACTGG GAAGACAGTG TCCCTATTGG CCCTGATTGT GGCCTATCAG 
CGGGCTTATC CGCTGGAGGT GACCAAACTT ATCTACTGCT CACGGACCGT GCCAGAGATT 
GAGAAGGTCA TAGAAGAGCT TCGTAAGCTA CTCAGCTTCT ACGAGCAGCA GGAGGGCGAG 
AAGCTGCCGT TCTTAGGACT GGCTCTGAGC TCAAGAAAGA ACCTGTGCAT TCATCCCGAG 
GTGACTCCAC TGCGCTTTGG GAAGGATGTT GATGGGAAGT GTCACAGCCT AACGGCGTCG 
TATGTGCGGG CACAGTACCA GCAGGATGCC AGCCTGCCTC ACTGCCGCTT CTATGAGGAA 
TTTGACATCC ATGGACGCCA GATGCCGCTC CCTGCGGGCA TCTACAACCT GGATGACCTG 
AAGGCCCTAG GGCAGCGCCA GGGCTGGTGC CCCTACTTCC TGGCTCGATA CTCGATCCTG 
CATGCCAACG TGGTGGTTTA CAGCTACCAC TACCTCCTGG ACCCCAAGAT CGCAGACCTG 
GTATCCAAAG AGCTGGCTCG CAAGGCTGTT GTGGTCTTCG ATGAAGCTCA CAACATCGAC 
AATGTCTGCA TTGACTCCAT GAGTGTCAAC CTCACCCGCA GGACTCTGGA CCGTTGCCAG 
AGCAACTTAG ACACCCTACA GAAGACCGTG CTCAGGATCA AGGAGACGGA TGAGCAGCGG 
CTGCGGGATG AGTACCGGCG CCTGGTGGAG GGCCTGCGGG AGGCCAGTGT GGCCCGGGAG 
ACAGATGCCC ACCTGGCCAA CCCTGTGCTG CCGGACGAGG TGCTGCAGGA GGCTGTGCCT 
GGCTCCATCC GTACGGCTGA GCACTTCCTG GGCTTTCTGC GGCGGCTGCT GGAGTATGTC 
AAGTGGCGTC TGCGCGTGCA GCATGTGGTG CAGGAGAGTC CACCTGCCTT TCTGAGCGGC 
CTGGCCCAGC GGGTGTGCAT CCAGCGCAAG CCCCTCAGGT TCTGTGCTGA ACGCCTGCGC 
TCCCTGCTGC ACACCCTGGA GATTGCCGAC CTGGCCGACT TCTCCCCGCT CACACTCCTT 
GCTAACTTCG CCACTCTCGT CAGCACTTAC GCCAAGGGCT TCACCATTAT CATTGAGCCC 
TTTGACGACA GGACCCCCAC CATCGCCAAC CCCGTTCTGC ACTTCAGCTG TATGGACGCC 
TCCTTGGCCA TCAAGCCTGT GTTTGAGCGC TTCCAGTCTG TCATCATCAC TTCTGGGACA 
CTGTCCCCAC TGGACATCTA CCCCAAGATC CTGGACTTCC ACCCTGTCAC AATGGCAACC 
TTCACCATGA CGCTGGCCCG AGTCTGCCTC TGCCCGATGA TCATTGGCCG TGGTAATGAC 
CAGGTAGCAA TCAGCTCCAA ATTTGAGACC AGAGAAGATA TTGCTGTGAT CCGAAACTAT 
GGCAACCTCC TGCTGGAGAT GTCCGCCGTG GTCCCAGATG GCATTGTGGC CTTCTTTACC 
AGCTACCAGT ACATGGAAAG CACCGTGGCC TCCTGGTATG AGCAGGGCAT CCTTGAGAAC 
ATCCAGAGGA ACAAACTGCT CTTCATTGAG ACCCAGGATG GGGCTGAGAC CAGTGTGGCC 
CTGGAGAAGT ACCAAGAGGC ATGCGAGAAT GGCCGTGGGG CCATTCTGCT CTCAGTGGCT 
CGGGGCAAAG TATCAGAAGG GATTGACTTT GTACACCACT ACGGACGGGC TGTGATCATG 
TTTGGAGTTC CCTATGTCTA TACCCAGAGC CGAATTCTCA AGGCCCGGCT AGAGTATCTG 
CGGGACCAGT TCCAGATCCG AGAGAACGAC TTCCTCACCT TTGATGCTAT GCGCCATGCA 
GCCCAGTGTG TGGGTCGTGC CATCAGGGGC AAGACGGACT ATGGACTCAT GGTCTTTGCT 
GACAAGCGGT TTGCTCGGGC GGACAAGCGT GGTAAGCTGC CTCGCTGGAT CCAGGAGCAC 
CTGACCGACT CCAACCTCAA CCTGACCGTG GATGAGGGTG TACAGGTCGC CAAGTACTTC 
CTGCGGCAGA TGGCGCAGCC CTTCCACCGG GAGGATCAGC TGGGCCTGTC GCTGCTCAGC 
CTGGAGCAGC TGCAGTCAGA GGAGACACTA CAGCGAATTG AGCAGATCGC ACAGCAGCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ercc2 ( NM_001363981.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001350910.1 Mus musculus excision repair cross-complementing rodent repair deficiency, complementation group 2 (Ercc2), transcript variant 2, mRNA.

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CloneID	OMu84250
Clone ID Related Accession (Same CDS sequence)	NM_001363981.1
Accession Version	NM_001363981.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2220bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Mus musculus(house mouse)
Product	general transcription and DNA repair factor IIH helicase subunit XPD isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC118017.15. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034517.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTCA ACGTGGACGG GCTGCTGGTC TACTTCCCGT ACGACTACAT CTACCCGGAG 
CAGTTCTCCT ACATGCTGGA GCTCAAGCGC ACGCTGGACG CCAAGGGTCA TGGAGTCCTG 
GAGATGCCCT CGGGCACTGG GAAGACAGTG TCCCTATTGG CCCTGATTGT GGCCTATCAG 
CGGGTCATAG AAGAGCTTCG TAAGCTACTC AGCTTCTACG AGCAGCAGGA GGGCGAGAAG 
CTGCCGTTCT TAGGACTGGC TCTGAGCTCA AGAAAGAACC TGTGCATTCA TCCCGAGGTG 
ACTCCACTGC GCTTTGGGAA GGATGTTGAT GGGAAGTGTC ACAGCCTAAC GGCGTCGTAT 
GTGCGGGCAC AGTACCAGCA GGATGCCAGC CTGCCTCACT GCCGCTTCTA TGAGGAATTT 
GACATCCATG GACGCCAGAT GCCGCTCCCT GCGGGCATCT ACAACCTGGA TGACCTGAAG 
GCCCTAGGGC AGCGCCAGGG CTGGTGCCCC TACTTCCTGG CTCGATACTC GATCCTGCAT 
GCCAACGTGG TGGTTTACAG CTACCACTAC CTCCTGGACC CCAAGATCGC AGACCTGGTA 
TCCAAAGAGC TGGCTCGCAA GGCTGTTGTG GTCTTCGATG AAGCTCACAA CATCGACAAT 
GTCTGCATTG ACTCCATGAG TGTCAACCTC ACCCGCAGGA CTCTGGACCG TTGCCAGAGC 
AACTTAGACA CCCTACAGAA GACCGTGCTC AGGATCAAGG AGACGGATGA GCAGCGGCTG 
CGGGATGAGT ACCGGCGCCT GGTGGAGGGC CTGCGGGAGG CCAGTGTGGC CCGGGAGACA 
GATGCCCACC TGGCCAACCC TGTGCTGCCG GACGAGGTGC TGCAGGAGGC TGTGCCTGGC 
TCCATCCGTA CGGCTGAGCA CTTCCTGGGC TTTCTGCGGC GGCTGCTGGA GTATGTCAAG 
TGGCGTCTGC GCGTGCAGCA TGTGGTGCAG GAGAGTCCAC CTGCCTTTCT GAGCGGCCTG 
GCCCAGCGGG TGTGCATCCA GCGCAAGCCC CTCAGGTTCT GTGCTGAACG CCTGCGCTCC 
CTGCTGCACA CCCTGGAGAT TGCCGACCTG GCCGACTTCT CCCCGCTCAC ACTCCTTGCT 
AACTTCGCCA CTCTCGTCAG CACTTACGCC AAGGGCTTCA CCATTATCAT TGAGCCCTTT 
GACGACAGGA CCCCCACCAT CGCCAACCCC GTTCTGCACT TCAGCTGTAT GGACGCCTCC 
TTGGCCATCA AGCCTGTGTT TGAGCGCTTC CAGTCTGTCA TCATCACTTC TGGGACACTG 
TCCCCACTGG ACATCTACCC CAAGATCCTG GACTTCCACC CTGTCACAAT GGCAACCTTC 
ACCATGACGC TGGCCCGAGT CTGCCTCTGC CCGATGATCA TTGGCCGTGG TAATGACCAG 
GTAGCAATCA GCTCCAAATT TGAGACCAGA GAAGATATTG CTGTGATCCG AAACTATGGC 
AACCTCCTGC TGGAGATGTC CGCCGTGGTC CCAGATGGCA TTGTGGCCTT CTTTACCAGC 
TACCAGTACA TGGAAAGCAC CGTGGCCTCC TGGTATGAGC AGGGCATCCT TGAGAACATC 
CAGAGGAACA AACTGCTCTT CATTGAGACC CAGGATGGGG CTGAGACCAG TGTGGCCCTG 
GAGAAGTACC AAGAGGCATG CGAGAATGGC CGTGGGGCCA TTCTGCTCTC AGTGGCTCGG 
GGCAAAGTAT CAGAAGGGAT TGACTTTGTA CACCACTACG GACGGGCTGT GATCATGTTT 
GGAGTTCCCT ATGTCTATAC CCAGAGCCGA ATTCTCAAGG CCCGGCTAGA GTATCTGCGG 
GACCAGTTCC AGATCCGAGA GAACGACTTC CTCACCTTTG ATGCTATGCG CCATGCAGCC 
CAGTGTGTGG GTCGTGCCAT CAGGGGCAAG ACGGACTATG GACTCATGGT CTTTGCTGAC 
AAGCGGTTTG CTCGGGCGGA CAAGCGTGGT AAGCTGCCTC GCTGGATCCA GGAGCACCTG 
ACCGACTCCA ACCTCAACCT GACCGTGGAT GAGGGTGTAC AGGTCGCCAA GTACTTCCTG 
CGGCAGATGG CGCAGCCCTT CCACCGGGAG GATCAGCTGG GCCTGTCGCT GCTCAGCCTG 
GAGCAGCTGC AGTCAGAGGA GACACTACAG CGAATTGAGC AGATCGCACA GCAGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350910.1
CDS	39..2258
Translation	MKLNVDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPSGTGKTVSLLALIVAYQRVIEELRKLLSFYEQQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDASLPHCRFYEEFDIHGRQMPLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASVARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPVLHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLQSEETLQRIEQIAQQL

Target ORF information:

RefSeq Version	NM_001363981.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus excision repair cross-complementing rodent repair deficiency, complementation group 2 (Ercc2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363981.1

ORF Insert Sequence:

ATGAAGCTCA ACGTGGACGG GCTGCTGGTC TACTTCCCGT ACGACTACAT CTACCCGGAG 
CAGTTCTCCT ACATGCTGGA GCTCAAGCGC ACGCTGGACG CCAAGGGTCA TGGAGTCCTG 
GAGATGCCCT CGGGCACTGG GAAGACAGTG TCCCTATTGG CCCTGATTGT GGCCTATCAG 
CGGGTCATAG AAGAGCTTCG TAAGCTACTC AGCTTCTACG AGCAGCAGGA GGGCGAGAAG 
CTGCCGTTCT TAGGACTGGC TCTGAGCTCA AGAAAGAACC TGTGCATTCA TCCCGAGGTG 
ACTCCACTGC GCTTTGGGAA GGATGTTGAT GGGAAGTGTC ACAGCCTAAC GGCGTCGTAT 
GTGCGGGCAC AGTACCAGCA GGATGCCAGC CTGCCTCACT GCCGCTTCTA TGAGGAATTT 
GACATCCATG GACGCCAGAT GCCGCTCCCT GCGGGCATCT ACAACCTGGA TGACCTGAAG 
GCCCTAGGGC AGCGCCAGGG CTGGTGCCCC TACTTCCTGG CTCGATACTC GATCCTGCAT 
GCCAACGTGG TGGTTTACAG CTACCACTAC CTCCTGGACC CCAAGATCGC AGACCTGGTA 
TCCAAAGAGC TGGCTCGCAA GGCTGTTGTG GTCTTCGATG AAGCTCACAA CATCGACAAT 
GTCTGCATTG ACTCCATGAG TGTCAACCTC ACCCGCAGGA CTCTGGACCG TTGCCAGAGC 
AACTTAGACA CCCTACAGAA GACCGTGCTC AGGATCAAGG AGACGGATGA GCAGCGGCTG 
CGGGATGAGT ACCGGCGCCT GGTGGAGGGC CTGCGGGAGG CCAGTGTGGC CCGGGAGACA 
GATGCCCACC TGGCCAACCC TGTGCTGCCG GACGAGGTGC TGCAGGAGGC TGTGCCTGGC 
TCCATCCGTA CGGCTGAGCA CTTCCTGGGC TTTCTGCGGC GGCTGCTGGA GTATGTCAAG 
TGGCGTCTGC GCGTGCAGCA TGTGGTGCAG GAGAGTCCAC CTGCCTTTCT GAGCGGCCTG 
GCCCAGCGGG TGTGCATCCA GCGCAAGCCC CTCAGGTTCT GTGCTGAACG CCTGCGCTCC 
CTGCTGCACA CCCTGGAGAT TGCCGACCTG GCCGACTTCT CCCCGCTCAC ACTCCTTGCT 
AACTTCGCCA CTCTCGTCAG CACTTACGCC AAGGGCTTCA CCATTATCAT TGAGCCCTTT 
GACGACAGGA CCCCCACCAT CGCCAACCCC GTTCTGCACT TCAGCTGTAT GGACGCCTCC 
TTGGCCATCA AGCCTGTGTT TGAGCGCTTC CAGTCTGTCA TCATCACTTC TGGGACACTG 
TCCCCACTGG ACATCTACCC CAAGATCCTG GACTTCCACC CTGTCACAAT GGCAACCTTC 
ACCATGACGC TGGCCCGAGT CTGCCTCTGC CCGATGATCA TTGGCCGTGG TAATGACCAG 
GTAGCAATCA GCTCCAAATT TGAGACCAGA GAAGATATTG CTGTGATCCG AAACTATGGC 
AACCTCCTGC TGGAGATGTC CGCCGTGGTC CCAGATGGCA TTGTGGCCTT CTTTACCAGC 
TACCAGTACA TGGAAAGCAC CGTGGCCTCC TGGTATGAGC AGGGCATCCT TGAGAACATC 
CAGAGGAACA AACTGCTCTT CATTGAGACC CAGGATGGGG CTGAGACCAG TGTGGCCCTG 
GAGAAGTACC AAGAGGCATG CGAGAATGGC CGTGGGGCCA TTCTGCTCTC AGTGGCTCGG 
GGCAAAGTAT CAGAAGGGAT TGACTTTGTA CACCACTACG GACGGGCTGT GATCATGTTT 
GGAGTTCCCT ATGTCTATAC CCAGAGCCGA ATTCTCAAGG CCCGGCTAGA GTATCTGCGG 
GACCAGTTCC AGATCCGAGA GAACGACTTC CTCACCTTTG ATGCTATGCG CCATGCAGCC 
CAGTGTGTGG GTCGTGCCAT CAGGGGCAAG ACGGACTATG GACTCATGGT CTTTGCTGAC 
AAGCGGTTTG CTCGGGCGGA CAAGCGTGGT AAGCTGCCTC GCTGGATCCA GGAGCACCTG 
ACCGACTCCA ACCTCAACCT GACCGTGGAT GAGGGTGTAC AGGTCGCCAA GTACTTCCTG 
CGGCAGATGG CGCAGCCCTT CCACCGGGAG GATCAGCTGG GCCTGTCGCT GCTCAGCCTG 
GAGCAGCTGC AGTCAGAGGA GACACTACAG CGAATTGAGC AGATCGCACA GCAGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract risk.
Radiation and environmental biophysics(2018 Jan)
Dalke C,Neff F,Bains SK,Bright S,Lord D,Reitmeir P,R??ler U,Samaga D,Unger K,Braselmann H,Wagner F,Greiter M,Gomolka M,Hornhardt S,Kunze S,Kempf SJ,Garrett L,H?lter SM,Wurst W,Rosemann M,Azimzadeh O,Tapio S,Aubele M,Theis F,Hoeschen C,Slijepcevic P,Kadhim M,Atkinson M,Zitzelsberger H,Kulka U,Graw J

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.
Cell169(1)132-147.e16(2017 Mar)
Baar MP,Brandt RMC,Putavet DA,Klein JDD,Derks KWJ,Bourgeois BRM,Stryeck S,Rijksen Y,van Willigenburg H,Feijtel DA,van der Pluijm I,Essers J,van Cappellen WA,van IJcken WF,Houtsmuller AB,Pothof J,de Bruin RWF,Madl T,Hoeijmakers JHJ,Campisi J,de Keizer PLJ

New mutation in the mouse Xpd/Ercc2 gene leads to recessive cataracts.
PloS one10(5)e0125304(2015)
Kunze S,Dalke C,Fuchs H,Klaften M,R?ssler U,Hornhardt S,Gomolka M,Puk O,Sabrautzki S,Kulka U,Hrab? de Angelis M,Graw J

Dynamic partnership between TFIIH, PGC-1? and SIRT1 is impaired in trichothiodystrophy.
PLoS genetics10(10)e1004732(2014 Oct)
Traboulsi H,Davoli S,Catez P,Egly JM,Compe E

XPD-dependent activation of apoptosis in response to triplex-induced DNA damage.
Nucleic acids research41(19)8979-94(2013 Oct)
Kaushik Tiwari M,Rogers FA