Egfbp2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Egfbp2
Entrez Gene ID	13647
Full Name	epidermal growth factor binding protein type B
Synonyms	Egfbp-2,Klk1b26,PRECE-1,mGk-13
General protein information	Preferred Names epidermal growth factor binding protein type B Names epidermal growth factor-binding protein type B EGF-BP B glandular kallikrein K13 kallikrein 1b26 prorenin-converting enzyme 1 tissue kallikrein 13
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 B3\|7
Summary	The protein encoded by this gene belongs to the kallikrein family, which is a highly homologous group of serine proteases encoded by a cluster of related genes on chromosome 7. This gene has been shown to function as both a prorenin converting enzyme and as epidermal growth factor (EGF)-binding protein involved in the maturation of EGF (PMIDs: 1918045, 3322387, 9685728). This gene is thought to be distinct from Klk1b26 gene (GeneID:16618), with which it shares 98% identity (PMID:1959648, 9685728), however, it is not clear if both genes are present in all strains of mice. Blast analyses suggest that this gene is missing from the current reference (GRCm38, based on C57BL/6J genome) and alternate Celera (based on mixed strain genomes) assemblies. Therefore, the RefSeq for this locus was based on sequence from the ICR strain, which has been reported in literature (PMID:1959648) to contain both genes. [provided by RefSeq, Aug 2012].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010115.6	NP_034245.3	epidermal growth factor-binding protein type B preproprotein

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Autoimmunity against a tissue kallikrein in IQI/Jic Mice: a model for Sjogren's syndrome.
Takada K, Takiguchi M, Konno A, Inaba M
The Journal of biological chemistry280(5)3982-8(2005 Feb)

Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.
Angata T, Margulies EH, Green ED, Varki A
Proceedings of the National Academy of Sciences of the United States of America101(36)13251-6(2004 Sep)

Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen.
Olsson AY, Lilja H, Lundwall A
Genomics84(1)147-56(2004 Jul)

Human tissue kallikreins: physiologic roles and applications in cancer.
Borgo?o CA, Michael IP, Diamandis EP
Molecular cancer research : MCR2(5)257-80(2004 May)

Organization and evolution of the glandular kallikrein locus in Mus musculus.
Olsson AY, Lundwall A
Biochemical and biophysical research communications299(2)305-11(2002 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Klk-13 acts as an autoantigen and may increase T cells responsive to organs commonly expressing Klk-13, playing a pivotal role in the etiology of progression of disease in IQI/Jic mice
Title: Autoimmunity against a tissue kallikrein in IQI/Jic Mice: a model for Sjogren's syndrome.

The following Egfbp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Egfbp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu25151	NM_010115.6 Latest version!	Mus musculus epidermal growth factor binding protein type B (Egfbp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Egfbp2 ( NM_010115.6 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034245.3 Mus musculus epidermal growth factor binding protein type B (Egfbp2), mRNA.

Price & Availability↑

CloneID	OMu25151
Clone ID Related Accession (Same CDS sequence)	NM_010115.6
Accession Version	NM_010115.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-30
Organism	Mus musculus(house mouse)
Product	epidermal growth factor-binding protein type B preproprotein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X58628.1. On Aug 25, 2012 this sequence version replaced NM_010115.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X58628.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGGTTCC TGATCCTGTT CCTAGCCCTG TCCCTAGGAG GGATTGATGC TGCACCTCCT 
CTCCAGTCTC GGGTGGTTGG AGGATTTAAC TGTAAGAAGA ATTCCCAACC CTGGCAGGTG 
GCTGTGTACT ACCAAAAGGA ACACATTTGT GGGGGTGTCC TGTTGGACCG CAACTGGGTT 
CTCACAGCTG CCCACTGCTA TGTCGACCAG TATGAGGTTT GGCTGGGCAA AAACAAGTTA 
TTCCAAGAGG AACCCTCTGC TCAGCACCGA TTGGTCAGCA AAAGCTTCCC TCACCCTGGC 
TTCAACATGA GCCTCCTGAT GCTTCAAACA ATACCTCCTG GGGCTGACTT CAGCAATGAC 
CTGATGCTGC TCCGCCTCAG CAAGCCTGCT GACATCACAG ATGTTGTGAA GCCCATCGCC 
CTGCCCACAA AGGAGCCCAA GCCGGGGAGC AAATGCCTAG CCTCAGGCTG GGGCAGCATT 
ACACCCACAA GATGGCAAAA GCCAGATGAT CTTCAGTGTG TGTTCATCAC GCTCCTGCCC 
AATGAGAACT GTGCCAAAGT CTACCTACAG AAAGTCACAG ATGTCATGCT GTGTGCAGGA 
GAGATGGGTG GAGGCAAAGA CACTTGTAGG GATGACTCCG GAGGCCCACT GATTTGTGAT 
GGTATTCTCC AAGGAACCAC ATCATATGGC CCTGTACCAT GCGGTAAACC TGGTGTACCA 
GCCATCTACA CCAACCTTAT TAAGTTCAAC TCCTGGATAA AAGATACTAT GATGAAAAAT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034245.3
CDS	25..810
Translation	MWFLILFLALSLGGIDAAPPLQSRVVGGFNCKKNSQPWQVAVYYQKEHICGGVLLDRNWVLTAAHCYVDQYEVWLGKNKLFQEEPSAQHRLVSKSFPHPGFNMSLLMLQTIPPGADFSNDLMLLRLSKPADITDVVKPIALPTKEPKPGSKCLASGWGSITPTRWQKPDDLQCVFITLLPNENCAKVYLQKVTDVMLCAGEMGGGKDTCRDDSGGPLICDGILQGTTSYGPVPCGKPGVPAIYTNLIKFNSWIKDTMMKNA

Target ORF information:

RefSeq Version	NM_010115.6
Organism	Mus musculus(house mouse)
Definition	Mus musculus epidermal growth factor binding protein type B (Egfbp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010115.6

ORF Insert Sequence:

ATGTGGTTCC TGATCCTGTT CCTAGCCCTG TCCCTAGGAG GGATTGATGC TGCACCTCCT 
CTCCAGTCTC GGGTGGTTGG AGGATTTAAC TGTAAGAAGA ATTCCCAACC CTGGCAGGTG 
GCTGTGTACT ACCAAAAGGA ACACATTTGT GGGGGTGTCC TGTTGGACCG CAACTGGGTT 
CTCACAGCTG CCCACTGCTA TGTCGACCAG TATGAGGTTT GGCTGGGCAA AAACAAGTTA 
TTCCAAGAGG AACCCTCTGC TCAGCACCGA TTGGTCAGCA AAAGCTTCCC TCACCCTGGC 
TTCAACATGA GCCTCCTGAT GCTTCAAACA ATACCTCCTG GGGCTGACTT CAGCAATGAC 
CTGATGCTGC TCCGCCTCAG CAAGCCTGCT GACATCACAG ATGTTGTGAA GCCCATCGCC 
CTGCCCACAA AGGAGCCCAA GCCGGGGAGC AAATGCCTAG CCTCAGGCTG GGGCAGCATT 
ACACCCACAA GATGGCAAAA GCCAGATGAT CTTCAGTGTG TGTTCATCAC GCTCCTGCCC 
AATGAGAACT GTGCCAAAGT CTACCTACAG AAAGTCACAG ATGTCATGCT GTGTGCAGGA 
GAGATGGGTG GAGGCAAAGA CACTTGTAGG GATGACTCCG GAGGCCCACT GATTTGTGAT 
GGTATTCTCC AAGGAACCAC ATCATATGGC CCTGTACCAT GCGGTAAACC TGGTGTACCA 
GCCATCTACA CCAACCTTAT TAAGTTCAAC TCCTGGATAA AAGATACTAT GATGAAAAAT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Autoimmunity against a tissue kallikrein in IQI/Jic Mice: a model for Sjogren's syndrome.
The Journal of biological chemistry280(5)3982-8(2005 Feb)
Takada K,Takiguchi M,Konno A,Inaba M

Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.
Proceedings of the National Academy of Sciences of the United States of America101(36)13251-6(2004 Sep)
Angata T,Margulies EH,Green ED,Varki A

Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen.
Genomics84(1)147-56(2004 Jul)
Olsson AY,Lilja H,Lundwall A

Human tissue kallikreins: physiologic roles and applications in cancer.
Molecular cancer research : MCR2(5)257-80(2004 May)
Borgo?o CA,Michael IP,Diamandis EP

Organization and evolution of the glandular kallikrein locus in Mus musculus.
Biochemical and biophysical research communications299(2)305-11(2002 Nov)
Olsson AY,Lundwall A

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Egfbp2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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