S1pr4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	S1pr4
Entrez Gene ID	13611
Full Name	sphingosine-1-phosphate receptor 4
Synonyms	Edg6,Lpc1,S1p4
General protein information	Preferred Names sphingosine-1-phosphate receptor 4 Names sphingosine 1-phosphate receptor 4 S1P receptor Edg-6 S1p receptor 4 endothelial differentiation G-protein-coupled receptor 6 lysophospholipid receptor C1 sphingosine 1-phosphate receptor Edg-6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 C1
Summary	This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The encoded protein is one of the predominant sphingosine 1-phosphate G-protein coupled receptors expressed in T cells, and it plays a role in suppression of T cell proliferation, generation of cytokines, and potentially other aspects of immune activation. [provided by RefSeq, Feb 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010102.2	NP_034232.1	sphingosine 1-phosphate receptor 4

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	S1PR4	XP_512266.2
Bos taurus (cattle)	S1PR4	XP_005209070.1
Xenopus tropicalis (tropical clawed frog)	s1pr4	XP_002936376.1
Canis lupus familiaris (dog)	S1PR4	XP_854902.1
	S1PR4	XP_001100113.1
Mus musculus (house mouse)	S1pr4	NP_034232.1
Homo sapiens (human)	S1PR4	NP_003766.1
Rattus norvegicus (Norway rat)	S1pr4	NP_001101545.1
Gallus gallus (chicken)	S1PR4	XP_004948783.1
Danio rerio (zebrafish)	s1pr4	NP_001112363.1

Gene Ontology
Bibliography

Related articles in PubMed

Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis.
Jung M, ?ren B, Mora J, Mertens C, Dziumbla S, Popp R, Weigert A, Grossmann N, Fleming I, Br?ne B
Science signaling9(434)ra64(2016 Jun)

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.
Ray JP, Staron MM, Shyer JA, Ho PC, Marshall HD, Gray SM, Laidlaw BJ, Araki K, Ahmed R, Kaech SM, Craft J
Immunity43(4)690-702(2015 Oct)

S1PR4 is required for plasmacytoid dendritic cell differentiation.
Dillmann C, Mora J, Olesch C, Br?ne B, Weigert A
Biological chemistry396(6-7)775-82(2015 Jun)

Lysophospholipid receptor nomenclature review: IUPHAR Review 8.
Kihara Y, Maceyka M, Spiegel S, Chun J
British journal of pharmacology171(15)3575-94(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data shows a reduced abundance of pDC, particularly CD4- pDC, in all organs of S1PR4-deficient vs. wildtype mice.
Title: S1PR4 is required for plasmacytoid dendritic cell differentiation.

analysis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P-R) agonists
Title: Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P?-R) agonists.

S1P4 signaling is involved in the regulation of dendritic cell function and TH17 T-cell differentiation. S1P4-mediated S1P signaling also modifies the course of various immune diseases in a murine model
Title: Sphingosine-1-phospate receptor 4 (S1P?) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model.

Megakaryocytes generated from S1P(4)-deficient murine bone marrow showed atypical and reduced formation of proplatelets in vitro.
Title: Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine-1-phosphate receptor S1P4.

S1P4 mediates immunosuppressive effects of S1P by inhibiting proliferation and secretion of effector cytokines, while enhancing secretion of the suppressive cytokine IL-10
Title: Type 4 sphingosine 1-phosphate G protein-coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration.

The following S1pr4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the S1pr4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58531	NM_010102.2 Latest version!	Mus musculus sphingosine-1-phosphate receptor 4 (S1pr4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

S1pr4 ( NM_010102.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034232.1 Mus musculus sphingosine-1-phosphate receptor 4 (S1pr4), mRNA.

Price & Availability↑

CloneID	OMu58531
Clone ID Related Accession (Same CDS sequence)	NM_010102.2
Accession Version	NM_010102.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1161bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	sphingosine 1-phosphate receptor 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC159474.9. On Feb 24, 2010 this sequence version replaced NM_010102.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGAACATCA GTACCTGGTC CACGCTGGTG ACCCCAGAGT CCTGCCACCG GCTGGCAGCC 
AGCGGCCACA GCCTCCTCAT TGTCCTGCAC TACAATCACA GCGGCAGGCT GGCCAGCCGC 
GGGGGCTCTG AGGACGGTGG AGGGCTAGGG ATGCTGAGGG GGCCGTCGGT GGCCGCAGGT 
TGCCTGGTGG TGCTGGAGAA CGCCATGGTG CTGGCCGCCA TCGCCATCTA CATGCGGTCC 
CGCCGCTGGG TGTACTACTG CCTGCTGAAC ATCACACTGA GTGACCTGCT CACAGGCCTG 
GCCTACGTGG TCAACGTGCT GCTGTCAGGG ACTCGTACCT TCCAGCTGTC ACCGGTGCAC 
TGGTTCCTGC GGGAGGGCCT GCTCTTCATG GCCTTGGCCG CATCCACCTT CAGTCTGCTC 
TTCACGGCCG GCGAGCGCTT CGCCACCATG GTGCGGGTGG CTGAGAGTGG GGCCACCAAG 
ACCAGCCGTG TGTATGGCTG CATCGGTCTG TGCTGGCTAC TGGCAGCTAT CCTGGGCCTG 
CTGCCCCTGC TGGGCTGGAA CTGTGTGTGC GCCTTCCCAC GCTGCTCCAG CCTGCTGCCC 
CTCTACTCCA AGGGCTATGT GCTCTTTTGT GTGGTGGTCT TCGCCCTCAT CCTAGTGGCT 
ATCCTGAGCC TCTACGGGGC CATCTTTAGA GTGGTCCGAG CCAATGGGCA GAAGTCTCCA 
CGTCCTCCTG CCCGCCGCAA GTCCCGCAGG CTACTCAACA CCGTGCTGAT GATCTTGGTG 
GCCTTTGTGG TGTGCTGGGG TCCCCTGTTT GGCCTGCTCC TGGCTGACAT CTTTGGTTCT 
AATGTCTGGG CCCAGGAGTA CCTGCGTGGC ATGGACTGGA TCCTGGCCCT GGCCGTGTTC 
AACTCAGCCA TTAATCCTCT CATCTACTCC TTCCGCAGCC GTGAGGTGCA GCGCGCTGTG 
CTGGCCTTCC TGTGCTGCGG CTGTCTCTGG CTAGGTCTGC GAGGTCCAGG AGACTGCCTG 
ACCCGGATCA CCGAGGCCCA CTCCGGTGCA TCCACCACTG ACAGCTCCCT GAGGCCCAGG 
GACAGTTTTC GGACTTCTCG GTCACTCAGC TTCAGGATGA GAGAGCCGCT GTCCAGCATT 
TCCAGCGTCC GCAGCACCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034232.1
CDS	500..1660
Translation	MNISTWSTLVTPESCHRLAASGHSLLIVLHYNHSGRLASRGGSEDGGGLGMLRGPSVAAGCLVVLENAMVLAAIAIYMRSRRWVYYCLLNITLSDLLTGLAYVVNVLLSGTRTFQLSPVHWFLREGLLFMALAASTFSLLFTAGERFATMVRVAESGATKTSRVYGCIGLCWLLAAILGLLPLLGWNCVCAFPRCSSLLPLYSKGYVLFCVVVFALILVAILSLYGAIFRVVRANGQKSPRPPARRKSRRLLNTVLMILVAFVVCWGPLFGLLLADIFGSNVWAQEYLRGMDWILALAVFNSAINPLIYSFRSREVQRAVLAFLCCGCLWLGLRGPGDCLTRITEAHSGASTTDSSLRPRDSFRTSRSLSFRMREPLSSISSVRST

Target ORF information:

RefSeq Version	NM_010102.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus sphingosine-1-phosphate receptor 4 (S1pr4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010102.2

ORF Insert Sequence:

ATGAACATCA GTACCTGGTC CACGCTGGTG ACCCCAGAGT CCTGCCACCG GCTGGCAGCC 
AGCGGCCACA GCCTCCTCAT TGTCCTGCAC TACAATCACA GCGGCAGGCT GGCCAGCCGC 
GGGGGCTCTG AGGACGGTGG AGGGCTAGGG ATGCTGAGGG GGCCGTCGGT GGCCGCAGGT 
TGCCTGGTGG TGCTGGAGAA CGCCATGGTG CTGGCCGCCA TCGCCATCTA CATGCGGTCC 
CGCCGCTGGG TGTACTACTG CCTGCTGAAC ATCACACTGA GTGACCTGCT CACAGGCCTG 
GCCTACGTGG TCAACGTGCT GCTGTCAGGG ACTCGTACCT TCCAGCTGTC ACCGGTGCAC 
TGGTTCCTGC GGGAGGGCCT GCTCTTCATG GCCTTGGCCG CATCCACCTT CAGTCTGCTC 
TTCACGGCCG GCGAGCGCTT CGCCACCATG GTGCGGGTGG CTGAGAGTGG GGCCACCAAG 
ACCAGCCGTG TGTATGGCTG CATCGGTCTG TGCTGGCTAC TGGCAGCTAT CCTGGGCCTG 
CTGCCCCTGC TGGGCTGGAA CTGTGTGTGC GCCTTCCCAC GCTGCTCCAG CCTGCTGCCC 
CTCTACTCCA AGGGCTATGT GCTCTTTTGT GTGGTGGTCT TCGCCCTCAT CCTAGTGGCT 
ATCCTGAGCC TCTACGGGGC CATCTTTAGA GTGGTCCGAG CCAATGGGCA GAAGTCTCCA 
CGTCCTCCTG CCCGCCGCAA GTCCCGCAGG CTACTCAACA CCGTGCTGAT GATCTTGGTG 
GCCTTTGTGG TGTGCTGGGG TCCCCTGTTT GGCCTGCTCC TGGCTGACAT CTTTGGTTCT 
AATGTCTGGG CCCAGGAGTA CCTGCGTGGC ATGGACTGGA TCCTGGCCCT GGCCGTGTTC 
AACTCAGCCA TTAATCCTCT CATCTACTCC TTCCGCAGCC GTGAGGTGCA GCGCGCTGTG 
CTGGCCTTCC TGTGCTGCGG CTGTCTCTGG CTAGGTCTGC GAGGTCCAGG AGACTGCCTG 
ACCCGGATCA CCGAGGCCCA CTCCGGTGCA TCCACCACTG ACAGCTCCCT GAGGCCCAGG 
GACAGTTTTC GGACTTCTCG GTCACTCAGC TTCAGGATGA GAGAGCCGCT GTCCAGCATT 
TCCAGCGTCC GCAGCACCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis.
Science signaling9(434)ra64(2016 Jun)
Jung M,?ren B,Mora J,Mertens C,Dziumbla S,Popp R,Weigert A,Grossmann N,Fleming I,Br?ne B

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.
Immunity43(4)690-702(2015 Oct)
Ray JP,Staron MM,Shyer JA,Ho PC,Marshall HD,Gray SM,Laidlaw BJ,Araki K,Ahmed R,Kaech SM,Craft J

S1PR4 is required for plasmacytoid dendritic cell differentiation.
Biological chemistry396(6-7)775-82(2015 Jun)
Dillmann C,Mora J,Olesch C,Br?ne B,Weigert A

Lysophospholipid receptor nomenclature review: IUPHAR Review 8.
British journal of pharmacology171(15)3575-94(2014 Aug)
Kihara Y,Maceyka M,Spiegel S,Chun J

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S1pr4 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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