Defb2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Defb2
Entrez Gene ID	13215
Full Name	defensin beta 2
Synonyms	BD-2
General protein information	Preferred Names defensin beta 2 Names beta-defensin 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8 A2\|8 10.45 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010030.1	NP_034160.1	beta-defensin 2 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease.
Manko A, Motta JP, Cotton JA, Feener T, Oyeyemi A, Vallance BA, Wallace JL, Buret AG
PloS one12(6)e0178647(2017)

Murine ?-defensin-2 may regulate the effect of bacillus Calmette-Gu?rin (BCG) in normal mouse bladder.
Kwon JK, Chi BH, Choi SY, Kim SJ, Lee TJ, Kim K, Chang IH
Urologic oncology33(3)111.e9-16(2015 Mar)

NOD2/RICK-dependent ?-defensin 2 regulation is protective for nontypeable Haemophilus influenzae-induced middle ear infection.
Woo JI, Oh S, Webster P, Lee YJ, Lim DJ, Moon SK
PloS one9(3)e90933(2014)

Visfatin enhances the production of cathelicidin antimicrobial peptide, human ?-defensin-2, human ?-defensin-3, and S100A7 in human keratinocytes and their orthologs in murine imiquimod-induced psoriatic skin.
Hau CS, Kanda N, Noda S, Tatsuta A, Kamata M, Shibata S, Asano Y, Sato S, Watanabe S, Tada Y
The American journal of pathology182(5)1705-17(2013 May)

Expression of TLR9 and BD-2 protein genes in corneal cells of mice of different strains with herpetic keratitis.
Chereshnev VA, Gankovskaya LV, Koval'chuk LV, Chereshneva MV, Gankovskaya OA, Gavrilova TV
Bulletin of experimental biology and medicine153(2)236-9(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease.
Title: Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease.

mouse urothelium produces mBD2 in response to intravesicular BCG as a defense mechanism against BCG
Title: Murine ?-defensin-2 may regulate the effect of bacillus Calmette-Gu?rin (BCG) in normal mouse bladder.

NOD2-mediated beta-defensin 2 regulation contributes to the protection against NTHi-induced otitis media
Title: NOD2/RICK-dependent ?-defensin 2 regulation is protective for nontypeable Haemophilus influenzae-induced middle ear infection.

visfatin enhances CAMP, hBD-2, hBD-3, and S100A7 production in human keratinocytes and their orthologs in murine imiquimod-treated psoriatic skin.
Title: Visfatin enhances the production of cathelicidin antimicrobial peptide, human ?-defensin-2, human ?-defensin-3, and S100A7 in human keratinocytes and their orthologs in murine imiquimod-induced psoriatic skin.

studied the time course of TLR9 and BD-2gene expression by the corneal epithelial cells in herpetic keratitis in C57Bl/6 and BALB/c mice
Title: Expression of TLR9 and BD-2 protein genes in corneal cells of mice of different strains with herpetic keratitis.

The following Defb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Defb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15812	NM_010030.1 Latest version!	Mus musculus defensin beta 2 (Defb2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Defb2 ( NM_010030.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034160.1 Mus musculus defensin beta 2 (Defb2), mRNA.

Price & Availability↑

CloneID	OMu15812
Clone ID Related Accession (Same CDS sequence)	NM_010030.1
Accession Version	NM_010030.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 216bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	beta-defensin 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ011800.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ011800.1, BC109129.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849384 [ECO:0000348] ##Evidence-Data-END##

ATGAGGACTC TCTGCTCTCT GCTGCTGATA TGCTGCCTCC TTTTCTCATA TACCACTCCA 
GCTGTTGGAA GTTTAAAAAG TATTGGATAC GAAGCAGAAC TTGACCACTG CCACACCAAT 
GGAGGGTACT GTGTCAGAGC CATTTGTCCT CCTTCTGCCA GGCGTCCTGG GAGCTGTTTC 
CCAGAGAAGA ACCCCTGTTG CAAGTACATG AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034160.1
CDS	34..249
Translation	MRTLCSLLLICCLLFSYTTPAVGSLKSIGYEAELDHCHTNGGYCVRAICPPSARRPGSCFPEKNPCCKYMK

Target ORF information:

RefSeq Version	NM_010030.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus defensin beta 2 (Defb2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010030.1

ORF Insert Sequence:

ATGAGGACTC TCTGCTCTCT GCTGCTGATA TGCTGCCTCC TTTTCTCATA TACCACTCCA 
GCTGTTGGAA GTTTAAAAAG TATTGGATAC GAAGCAGAAC TTGACCACTG CCACACCAAT 
GGAGGGTACT GTGTCAGAGC CATTTGTCCT CCTTCTGCCA GGCGTCCTGG GAGCTGTTTC 
CCAGAGAAGA ACCCCTGTTG CAAGTACATG AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease.
PloS one12(6)e0178647(2017)
Manko A,Motta JP,Cotton JA,Feener T,Oyeyemi A,Vallance BA,Wallace JL,Buret AG

Murine ?-defensin-2 may regulate the effect of bacillus Calmette-Gu?rin (BCG) in normal mouse bladder.
Urologic oncology33(3)111.e9-16(2015 Mar)
Kwon JK,Chi BH,Choi SY,Kim SJ,Lee TJ,Kim K,Chang IH

NOD2/RICK-dependent ?-defensin 2 regulation is protective for nontypeable Haemophilus influenzae-induced middle ear infection.
PloS one9(3)e90933(2014)
Woo JI,Oh S,Webster P,Lee YJ,Lim DJ,Moon SK

Visfatin enhances the production of cathelicidin antimicrobial peptide, human ?-defensin-2, human ?-defensin-3, and S100A7 in human keratinocytes and their orthologs in murine imiquimod-induced psoriatic skin.
The American journal of pathology182(5)1705-17(2013 May)
Hau CS,Kanda N,Noda S,Tatsuta A,Kamata M,Shibata S,Asano Y,Sato S,Watanabe S,Tada Y

Expression of TLR9 and BD-2 protein genes in corneal cells of mice of different strains with herpetic keratitis.
Bulletin of experimental biology and medicine153(2)236-9(2012 Jun)
Chereshnev VA,Gankovskaya LV,Koval'chuk LV,Chereshneva MV,Gankovskaya OA,Gavrilova TV