Cyp1a2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cyp1a2
Entrez Gene ID	13077
Full Name	cytochrome P450, family 1, subfamily a, polypeptide 2
Synonyms	CP12,CYPIA2,P450-3
General protein information	Preferred Names cytochrome P450, family 1, subfamily a, polypeptide 2 Names cytochrome P450 1A2 cholesterol 25-hydroxylase cytochrome P450 family 1 subfamily a polypeptide 1 cytochrome P450, 1a2, aromatic compound inducible cytochrome P450-P2 cytochrome P450-P3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9 B\|9 31.3 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009993.3	NP_034123.1	cytochrome P450 1A2

Pathways from BioSystems

Homologies

Homo sapiens (human)	CYP1A2	NP_000752.2
Canis lupus familiaris (dog)	CYP1A2	NP_001008720.1
Bos taurus (cattle)	CYP1A2	NP_001092834.1
Mus musculus (house mouse)	Cyp1a2	NP_034123.1
Arabidopsis thaliana (thale cress)	CYP703A2	NP_171635.1
Pan troglodytes (chimpanzee)	LOC735881	XP_001135509.2
Rattus norvegicus (Norway rat)	Cyp1a2	NP_036673.3
Oryza sativa (rice)	Os08g0131100	NP_001060927.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders.
Klinefelter K, Hooven MK, Bates C, Colter BT, Dailey A, Infante SK, Kania-Korwel I, Lehmler HJ, L?pez-Ju?rez A, Ludwig CP, Curran CP
Mammalian genome : official journal of the International Mammalian Genome Society(2017 Dec)

2,3,4',5-tetrahydroxystilbene-2-O-?-D-glucoside exacerbates acetaminophen-induced hepatotoxicity by inducing hepatic expression of CYP2E1, CYP3A4 and CYP1A2.
Xu S, Liu J, Shi J, Wang Z, Ji L
Scientific reports7(1)16511(2017 Nov)

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.
Planas-Paz L, Orsini V, Boulter L, Calabrese D, Pikiolek M, Nigsch F, Xie Y, Roma G, Donovan A, Marti P, Beckmann N, Dill MT, Carbone W, Bergling S, Isken A, Mueller M, Kinzel B, Yang Y, Mao X, Nicholson TB, Zamponi R, Capodieci P, Valdez R, Rivera D, Loew A, Ukomadu C, Terracciano LM, Bouwmeester T, Cong F, Heim MH, Forbes SJ, Ruffner H, Tchorz JS
Nature cell biology18(5)467-79(2016 05)

Liver maturation deficiency in p57(Kip2)-/- mice occurs in a hepatocytic p57(Kip2) expression-independent manner.
Yanagida A, Chikada H, Ito K, Umino A, Kato-Itoh M, Yamazaki Y, Sato H, Kobayashi T, Yamaguchi T, Nakayama KI, Nakauchi H, Kamiya A
Developmental biology407(2)331-43(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our results suggest a more important contribution of CYP1A2 to the in vivo plasma clearance and thus detoxification of 4-Aminobiphenyl
Title: Relative Contributions of CYP1A2 and CYP2E1 to the Bioactivation and Clearance of 4-Aminobiphenyl in Adult Mice.

Suggest an important role for CYP1A enzymes in the gender-specific modulation of hyperoxic lung injury.
Title: Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A.

hepatic CYP1A2 plays a critical role in the attenuation of hyperoxic lung injury by decreasing lipid peroxidation and oxidative stress in vivo.
Title: Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury.

Aryl hydrocarbon receptor mediated induction of hepatic CYP1A1/1A2 is dependent on the presence of ctnnb1.
Title: Cooperation of structurally different aryl hydrocarbon receptor agonists and ?-catenin in the regulation of CYP1A expression.

Results indicate Cyp1a2 genotype is important in susceptibility to PCB-induced deficits in learning and memory.
Title: Ahrd Cyp1a2(-/-) mice show increased susceptibility to PCB-induced developmental neurotoxicity.

The following Cyp1a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cyp1a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17930	NM_009993.3 Latest version!	Mus musculus cytochrome P450, family 1, subfamily a, polypeptide 2 (Cyp1a2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$300.30 $429.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cyp1a2 ( NM_009993.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034123.1 Mus musculus cytochrome P450, family 1, subfamily a, polypeptide 2 (Cyp1a2), mRNA.

Price & Availability↑

CloneID	OMu17930
Clone ID Related Accession (Same CDS sequence)	NM_009993.3
Accession Version	NM_009993.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1542bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Mus musculus(house mouse)
Product	cytochrome P450 1A2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X00479.1. On Apr 5, 2007 this sequence version replaced NM_009993.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X00479.1, BC054827.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386 [ECO:0000348] ##Evidence-Data-END##

ATGGCGTTCT CCCAGTACAT CTCCTTAGCC CCAGAGCTGC TACTGGCCAC TGCCATCTTC 
TGTTTAGTGT TCTGGATGGT CAGAGCCTCA AGGACCCAGG TTCCCAAAGG CCTGAAGAAT 
CCACCCGGAC CCTGGGGCTT GCCCTTCATT GGGCACATGC TGACTGTGGG GAAGAACCCA 
CACCTGTCAC TGACACGGCT GAGTCAGCAG TATGGGGACG TGCTGCAGAT CCGCATCGGC 
TCCACTCCTG TGGTGGTGCT GAGCGGCCTG AACACCATCA AGCAGGCCCT GGTGAGGCAG 
GGAGATGACT TCAAGGGCCG ACCAGACCTC TACAGCTTCA CACTTATCAC TAACGGCAAG 
AGCATGACTT TCAACCCAGA CTCTGGACCC GTGTGGGCTG CCCGCCGGCG CCTGGCCCAG 
GATGCCCTGA AGAGCTTCTC CATAGCCTCG GACCCGACGT CAGCATCCTC TTGCTATTTG 
GAGGAGCACG TGAGCAAGGA GGCTAACCAT CTCGTCAGCA AGCTTCAGAA GGCGATGGCA 
GAGGTTGGCC ACTTCGAACC AGTCAGCCAG GTGGTGGAAT CGGTGGCTAA CGTCATTGGT 
GCCATGTGCT TTGGGAAGAA CTTCCCCCGG AAGAGCGAGG AGATGCTGAA CATCGTGAAT 
AACAGCAAGG ACTTTGTGGA GAATGTCACC TCAGGGAATG CAGTGGACTT CTTCCCGGTC 
CTGCGCTACC TGCCCAACCC GGCCCTCAAG AGGTTTAAGA CCTTCAATGA TAACTTCGTG 
CTGTTTCTGC AGAAAACTGT CCAGGAGCAC TACCAAGACT TCAACAAGAA CAGTATCCAA 
GACATCACAA GTGCCCTGTT CAAGCACAGC GAGAACTACA AAGACAATGG CGGTCTCATC 
CCCGAGGAGA AGATTGTCAA CATTGTCAAT GACATCTTTG GAGCTGGCTT TGACACAGTC 
ACCACAGCCA TCACCTGGAG CATTTTGCTA CTTGTGACAT GGCCTAACGT GCAGAGGAAG 
ATCCATGAGG AGCTGGACAC GGTGGTTGGC AGGGATCGGC AACCACGGCT TTCTGACCGT 
CCCCAGCTGC CATATCTAGA GGCCTTCATC CTGGAGATCT ACCGATACAC ATCCTTTGTC 
CCCTTCACCA TCCCCCACAG CACAACGAGG GACACCTCAC TGAATGGCTT CCACATTCCC 
AAGGAGCGCT GTATCTACAT AAACCAGTGG CAGGTCAACC ATGATGAGAA GCAGTGGAAA 
GACCCCTTTG TGTTCCGCCC AGAGCGGTTT CTTACCAATA ACAACTCGGC CATCGACAAG 
ACCCAGAGCG AGAAGGTGAT GCTCTTCGGC TTGGGAAAGC GCCGGTGCAT TGGGGAGATC 
CCGGCCAAGT GGGAAGTCTT CCTCTTCTTA GCCATCCTGC TGCAGCATCT GGAGTTTAGT 
GTGCCACCGG GTGTGAAGGT GGACCTGACA CCCAACTATG GGTTGACCAT GAAGCCCGGG 
ACCTGTGAAC ACGTCCAGGC ATGGCCACGC TTTTCCAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034123.1
CDS	60..1601
Translation	MAFSQYISLAPELLLATAIFCLVFWMVRASRTQVPKGLKNPPGPWGLPFIGHMLTVGKNPHLSLTRLSQQYGDVLQIRIGSTPVVVLSGLNTIKQALVRQGDDFKGRPDLYSFTLITNGKSMTFNPDSGPVWAARRRLAQDALKSFSIASDPTSASSCYLEEHVSKEANHLVSKLQKAMAEVGHFEPVSQVVESVANVIGAMCFGKNFPRKSEEMLNIVNNSKDFVENVTSGNAVDFFPVLRYLPNPALKRFKTFNDNFVLFLQKTVQEHYQDFNKNSIQDITSALFKHSENYKDNGGLIPEEKIVNIVNDIFGAGFDTVTTAITWSILLLVTWPNVQRKIHEELDTVVGRDRQPRLSDRPQLPYLEAFILEIYRYTSFVPFTIPHSTTRDTSLNGFHIPKERCIYINQWQVNHDEKQWKDPFVFRPERFLTNNNSAIDKTQSEKVMLFGLGKRRCIGEIPAKWEVFLFLAILLQHLEFSVPPGVKVDLTPNYGLTMKPGTCEHVQAWPRFSK

Target ORF information:

RefSeq Version	NM_009993.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus cytochrome P450, family 1, subfamily a, polypeptide 2 (Cyp1a2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009993.3

ORF Insert Sequence:

ATGGCGTTCT CCCAGTACAT CTCCTTAGCC CCAGAGCTGC TACTGGCCAC TGCCATCTTC 
TGTTTAGTGT TCTGGATGGT CAGAGCCTCA AGGACCCAGG TTCCCAAAGG CCTGAAGAAT 
CCACCCGGAC CCTGGGGCTT GCCCTTCATT GGGCACATGC TGACTGTGGG GAAGAACCCA 
CACCTGTCAC TGACACGGCT GAGTCAGCAG TATGGGGACG TGCTGCAGAT CCGCATCGGC 
TCCACTCCTG TGGTGGTGCT GAGCGGCCTG AACACCATCA AGCAGGCCCT GGTGAGGCAG 
GGAGATGACT TCAAGGGCCG ACCAGACCTC TACAGCTTCA CACTTATCAC TAACGGCAAG 
AGCATGACTT TCAACCCAGA CTCTGGACCC GTGTGGGCTG CCCGCCGGCG CCTGGCCCAG 
GATGCCCTGA AGAGCTTCTC CATAGCCTCG GACCCGACGT CAGCATCCTC TTGCTATTTG 
GAGGAGCACG TGAGCAAGGA GGCTAACCAT CTCGTCAGCA AGCTTCAGAA GGCGATGGCA 
GAGGTTGGCC ACTTCGAACC AGTCAGCCAG GTGGTGGAAT CGGTGGCTAA CGTCATTGGT 
GCCATGTGCT TTGGGAAGAA CTTCCCCCGG AAGAGCGAGG AGATGCTGAA CATCGTGAAT 
AACAGCAAGG ACTTTGTGGA GAATGTCACC TCAGGGAATG CAGTGGACTT CTTCCCGGTC 
CTGCGCTACC TGCCCAACCC GGCCCTCAAG AGGTTTAAGA CCTTCAATGA TAACTTCGTG 
CTGTTTCTGC AGAAAACTGT CCAGGAGCAC TACCAAGACT TCAACAAGAA CAGTATCCAA 
GACATCACAA GTGCCCTGTT CAAGCACAGC GAGAACTACA AAGACAATGG CGGTCTCATC 
CCCGAGGAGA AGATTGTCAA CATTGTCAAT GACATCTTTG GAGCTGGCTT TGACACAGTC 
ACCACAGCCA TCACCTGGAG CATTTTGCTA CTTGTGACAT GGCCTAACGT GCAGAGGAAG 
ATCCATGAGG AGCTGGACAC GGTGGTTGGC AGGGATCGGC AACCACGGCT TTCTGACCGT 
CCCCAGCTGC CATATCTAGA GGCCTTCATC CTGGAGATCT ACCGATACAC ATCCTTTGTC 
CCCTTCACCA TCCCCCACAG CACAACGAGG GACACCTCAC TGAATGGCTT CCACATTCCC 
AAGGAGCGCT GTATCTACAT AAACCAGTGG CAGGTCAACC ATGATGAGAA GCAGTGGAAA 
GACCCCTTTG TGTTCCGCCC AGAGCGGTTT CTTACCAATA ACAACTCGGC CATCGACAAG 
ACCCAGAGCG AGAAGGTGAT GCTCTTCGGC TTGGGAAAGC GCCGGTGCAT TGGGGAGATC 
CCGGCCAAGT GGGAAGTCTT CCTCTTCTTA GCCATCCTGC TGCAGCATCT GGAGTTTAGT 
GTGCCACCGG GTGTGAAGGT GGACCTGACA CCCAACTATG GGTTGACCAT GAAGCCCGGG 
ACCTGTGAAC ACGTCCAGGC ATGGCCACGC TTTTCCAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders.
Mammalian genome : official journal of the International Mammalian Genome Society(2017 Dec)
Klinefelter K,Hooven MK,Bates C,Colter BT,Dailey A,Infante SK,Kania-Korwel I,Lehmler HJ,L?pez-Ju?rez A,Ludwig CP,Curran CP

2,3,4',5-tetrahydroxystilbene-2-O-?-D-glucoside exacerbates acetaminophen-induced hepatotoxicity by inducing hepatic expression of CYP2E1, CYP3A4 and CYP1A2.
Scientific reports7(1)16511(2017 Nov)
Xu S,Liu J,Shi J,Wang Z,Ji L

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.
Nature cell biology18(5)467-79(2016 05)
Planas-Paz L,Orsini V,Boulter L,Calabrese D,Pikiolek M,Nigsch F,Xie Y,Roma G,Donovan A,Marti P,Beckmann N,Dill MT,Carbone W,Bergling S,Isken A,Mueller M,Kinzel B,Yang Y,Mao X,Nicholson TB,Zamponi R,Capodieci P,Valdez R,Rivera D,Loew A,Ukomadu C,Terracciano LM,Bouwmeester T,Cong F,Heim MH,Forbes SJ,Ruffner H,Tchorz JS

Liver maturation deficiency in p57(Kip2)-/- mice occurs in a hepatocytic p57(Kip2) expression-independent manner.
Developmental biology407(2)331-43(2015 Nov)
Yanagida A,Chikada H,Ito K,Umino A,Kato-Itoh M,Yamazaki Y,Sato H,Kobayashi T,Yamaguchi T,Nakayama KI,Nakauchi H,Kamiya A

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Cyp1a2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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