Ctsg cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ctsg
Entrez Gene ID	13035
Full Name	cathepsin G
Synonyms	CatG,VSP
General protein information	Preferred Names cathepsin G Names cathepsin G vimentin-specific protease
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14 C3\|14 28.19 cM
Summary	This gene encodes a member of the peptidase S1 (chymotrypsin) family of serine endopeptidases. The encoded preproprotein is proteolytically processed to generate a mature protein product. This product appears to play a role in host defense, including inflammation and antigen processing. Homozygous knockout mice for this gene exhibit enhanced susceptibility to bacterial and fungal infection. [provided by RefSeq, Aug 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_007800.2	NP_031826.1	cathepsin G preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CTSG	XP_522810.1
Bos taurus (cattle)	LOC509956	XP_002696689.1
Mus musculus (house mouse)	Ctsg	NP_031826.1
Rattus norvegicus (Norway rat)	Ctsg	NP_001099511.1
Homo sapiens (human)	CTSG	NP_001902.1
	CTSG	XP_001114339.1
Bos taurus (cattle)	CTSG	XP_002696688.1

Gene Ontology
Bibliography

Related articles in PubMed

HDAC3 activity is required for initiation of leukemogenesis in acute promyelocytic leukemia.
Mehdipour P, Santoro F, Botrugno OA, Romanenghi M, Pagliuca C, Matthews GM, Johnstone RW, Minucci S
Leukemia31(4)995-997(2017 Apr)

Neutrophils and neutrophil serine proteases are increased in the spleens of estrogen-treated C57BL/6 mice and several strains of spontaneous lupus-prone mice.
Dai R, Cowan C, Heid B, Khan D, Liang Z, Pham CT, Ahmed SA
PloS one12(2)e0172105(2017)

The CCL2/CCR2 Axis Affects Transmigration and Proliferation but Not Resistance to Chemotherapy of Acute Myeloid Leukemia Cells.
Macanas-Pirard P, Quezada T, Navarrete L, Broekhuizen R, Leisewitz A, Nervi B, Ram?rez PA
PloS one12(1)e0168888(2017)

Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment.
Ortega-Gomez A, Salvermoser M, Rossaint J, Pick R, Brauner J, Lemnitzer P, Tilgner J, de Jong RJ, Megens RT, Jamasbi J, D?ring Y, Pham CT, Scheiermann C, Siess W, Drechsler M, Weber C, Grommes J, Zarbock A, Walzog B, Soehnlein O
Circulation134(16)1176-1188(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these findings present evidence of an arterial-specific recruitment pattern centered on CatG-instructed adhesion strengthening. The inhibition of this process could provide a novel strategy for treatment of arterial inflammation with limited side effects.
Title: Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment.

Cathepsin G activity may impair efferocytosis, which could lead to an accumulation of lesion-associated apoptotic cells and the accelerated progression of early atherosclerotic lesions to more complex lesions in Apoe(-/-) mice.
Title: Cathepsin G deficiency decreases complexity of atherosclerotic lesions in apolipoprotein E-deficient mice.

SerpinB1 is critical for maintaining polymorphonuclear neutrophils survival by antagonizing intracellular cathepsin G activity.
Title: SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G.

Cathepsin G-regulated release of formyl peptide receptor agonists modulate neutrophil effector functions.
Title: Cathepsin G-regulated release of formyl peptide receptor agonists modulate neutrophil effector functions.

Cathepsin G and neutrophil elastase contribute to lung-protective immunity against mycobacterial infections in mice.
Title: Cathepsin G and neutrophil elastase contribute to lung-protective immunity against mycobacterial infections in mice.

The following Ctsg gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ctsg cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22059	NM_007800.2 Latest version!	Mus musculus cathepsin G (Ctsg), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ctsg ( NM_007800.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031826.1 Mus musculus cathepsin G (Ctsg), mRNA.

Price & Availability↑

CloneID	OMu22059
Clone ID Related Accession (Same CDS sequence)	NM_007800.2
Accession Version	NM_007800.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	cathepsin G preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC091783.9, CJ056088.1 and BU755975.1. On Aug 12, 2015 this sequence version replaced NM_007800.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X78544.1, BC125511.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164140 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGCCTC TCCTGCTCCT GTTGACCTTT ATTCTACTCC AAGGAGATGA GGCAGGGAAG 
ATCATTGGAG GCCGAGAAGC CAGGCCCCAT TCCTACCCCT ACATGGCATT TCTTCTGATC 
CAGAGTCCAG AAGGGCTGAG TGCTTGTGGA GGGTTTCTGG TGCGAGAAGA CTTCGTCCTA 
ACAGCAGCTC ATTGCTTGGG AAGCTCCATA AATGTTACTC TAGGGGCCCA CAACATCCAA 
ATGCGAGAAA GGACCCAGCA ACTCATCACA GTGCTCAGAG CCATCCGCCA TCCTGATTAC 
AATCCGCAGA ACATCCGGAA TGACATCATG CTTCTGCAGC TGAGGCGCAG AGCCCGGAGG 
AGTGGATCGG TGAAGCCTGT GGCTCTGCCT CAGGCCAGCA AAAAACTGCA GCCAGGGGAT 
TTGTGCACAG TGGCTGGCTG GGGCCGGGTA AGCCAGAGCA GGGGAACAAA TGTACTCCAG 
GAGGTGCAGC TAAGAGTGCA GATGGACCAA ATGTGCGCCA ATCGCTTCCA GTTCTACAAC 
AGCCAGACTC AGATCTGTGT GGGAAACCCG AGAGAAAGGA AGTCTGCCTT CAGGGGTGAT 
TCTGGTGGCC CCCTGGTATG TAGCAATGTG GCCCAGGGCA TCGTCTCCTA TGGAAGCAAC 
AATGGTAACC CTCCAGCTGT ATTCACCAAA ATCCAGAGCT TCATGCCCTG GATCAAAAGA 
ACAATGAGAC GCTTTGCACC AAGATATCAG AGACCTGCTA ACTCCCTGTC TCAGGCACAG 
ACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031826.1
CDS	139..924
Translation	MQPLLLLLTFILLQGDEAGKIIGGREARPHSYPYMAFLLIQSPEGLSACGGFLVREDFVLTAAHCLGSSINVTLGAHNIQMRERTQQLITVLRAIRHPDYNPQNIRNDIMLLQLRRRARRSGSVKPVALPQASKKLQPGDLCTVAGWGRVSQSRGTNVLQEVQLRVQMDQMCANRFQFYNSQTQICVGNPRERKSAFRGDSGGPLVCSNVAQGIVSYGSNNGNPPAVFTKIQSFMPWIKRTMRRFAPRYQRPANSLSQAQT

Target ORF information:

RefSeq Version	NM_007800.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus cathepsin G (Ctsg), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007800.2

ORF Insert Sequence:

ATGCAGCCTC TCCTGCTCCT GTTGACCTTT ATTCTACTCC AAGGAGATGA GGCAGGGAAG 
ATCATTGGAG GCCGAGAAGC CAGGCCCCAT TCCTACCCCT ACATGGCATT TCTTCTGATC 
CAGAGTCCAG AAGGGCTGAG TGCTTGTGGA GGGTTTCTGG TGCGAGAAGA CTTCGTCCTA 
ACAGCAGCTC ATTGCTTGGG AAGCTCCATA AATGTTACTC TAGGGGCCCA CAACATCCAA 
ATGCGAGAAA GGACCCAGCA ACTCATCACA GTGCTCAGAG CCATCCGCCA TCCTGATTAC 
AATCCGCAGA ACATCCGGAA TGACATCATG CTTCTGCAGC TGAGGCGCAG AGCCCGGAGG 
AGTGGATCGG TGAAGCCTGT GGCTCTGCCT CAGGCCAGCA AAAAACTGCA GCCAGGGGAT 
TTGTGCACAG TGGCTGGCTG GGGCCGGGTA AGCCAGAGCA GGGGAACAAA TGTACTCCAG 
GAGGTGCAGC TAAGAGTGCA GATGGACCAA ATGTGCGCCA ATCGCTTCCA GTTCTACAAC 
AGCCAGACTC AGATCTGTGT GGGAAACCCG AGAGAAAGGA AGTCTGCCTT CAGGGGTGAT 
TCTGGTGGCC CCCTGGTATG TAGCAATGTG GCCCAGGGCA TCGTCTCCTA TGGAAGCAAC 
AATGGTAACC CTCCAGCTGT ATTCACCAAA ATCCAGAGCT TCATGCCCTG GATCAAAAGA 
ACAATGAGAC GCTTTGCACC AAGATATCAG AGACCTGCTA ACTCCCTGTC TCAGGCACAG 
ACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HDAC3 activity is required for initiation of leukemogenesis in acute promyelocytic leukemia.
Leukemia31(4)995-997(2017 Apr)
Mehdipour P,Santoro F,Botrugno OA,Romanenghi M,Pagliuca C,Matthews GM,Johnstone RW,Minucci S

Neutrophils and neutrophil serine proteases are increased in the spleens of estrogen-treated C57BL/6 mice and several strains of spontaneous lupus-prone mice.
PloS one12(2)e0172105(2017)
Dai R,Cowan C,Heid B,Khan D,Liang Z,Pham CT,Ahmed SA

The CCL2/CCR2 Axis Affects Transmigration and Proliferation but Not Resistance to Chemotherapy of Acute Myeloid Leukemia Cells.
PloS one12(1)e0168888(2017)
Macanas-Pirard P,Quezada T,Navarrete L,Broekhuizen R,Leisewitz A,Nervi B,Ram?rez PA

Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment.
Circulation134(16)1176-1188(2016 Oct)
Ortega-Gomez A,Salvermoser M,Rossaint J,Pick R,Brauner J,Lemnitzer P,Tilgner J,de Jong RJ,Megens RT,Jamasbi J,D?ring Y,Pham CT,Scheiermann C,Siess W,Drechsler M,Weber C,Grommes J,Zarbock A,Walzog B,Soehnlein O

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Ctsg cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Services & Products

見積依頼

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電話

FAX

オンラインフォーム