Crabp1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Crabp1
Entrez Gene ID	12903
Full Name	cellular retinoic acid binding protein I
Synonyms	AI326249,CRABP-I,Crabp-1,CrabpI,Rbp-5
General protein information	Preferred Names cellular retinoic acid binding protein I Names cellular retinoic acid-binding protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9 A5.3\|9 29.76 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001284507.1	NP_001271436.1	cellular retinoic acid-binding protein 1 isoform 2
NM_013496.3	NP_038524.1	cellular retinoic acid-binding protein 1 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CRABP1	NP_004369.1
Bos taurus (cattle)	CRABP1	NP_851371.1
Mus musculus (house mouse)	Crabp1	NP_038524.1
Pan troglodytes (chimpanzee)	CRABP1	XP_001142851.2
	CRABP1	XP_001107715.1
Rattus norvegicus (Norway rat)	Crabp1	NP_001099186.1
Gallus gallus (chicken)	CRABP1	NP_001025710.1
Xenopus tropicalis (tropical clawed frog)	crabp1	XP_002934613.1
Danio rerio (zebrafish)	crabp1b	NP_001001842.1
Danio rerio (zebrafish)	crabp1a	NP_878278.1

Gene Ontology
Bibliography

Related articles in PubMed

Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf.
Magella B, Adam M, Potter AS, Venkatasubramanian M, Chetal K, Hay SB, Salomonis N, Potter SS
Developmental biology(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The physiological role of Crabp1 in modulating stem cell proliferation and hippocampus-dependent brain activities such as learning and memory.
Title: Cellular Retinoic Acid-Binding Protein 1 Modulates Stem Cell Proliferation to Affect Learning and Memory in Male Mice.

This study reveals a physiological relevance of the non-genomic action of atRA, mediated by Crabp1, in modulating cell cycle progression and apoptosis induction
Title: All trans-retinoic acid analogs promote cancer cell apoptosis through non-genomic Crabp1 mediating ERK1/2 phosphorylation.

Only a small fraction of CRABP1 populates this functionally important but vulnerable conformation of CRABP1, enabling efficient ligand binding.
Title: Delicate balance between functionally required flexibility and aggregation risk in a ?-rich protein.

CRABPI binds to all-trans retinoic acid in the cytoplasm, resulting in rapid ERK1/2 activation that is independent of membrane signal and nuclear RA receptors.
Title: Cellular retinoic acid binding protein I mediates rapid non-canonical activation of ERK1/2 by all-trans retinoic acid.

Increases in CRABPI and II transcripts in the absence of leukemia inhibitory factor may regulate aspects of embryonic stem cell differentiation in response to retinol.
Title: LIF removal increases CRABPI and CRABPII transcripts in embryonic stem cells cultured in retinol or 4-oxoretinol.

The following Crabp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Crabp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20211	NM_013496.3 Latest version!	Mus musculus cellular retinoic acid binding protein I (Crabp1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu23051	NM_001284507.1 Latest version!	Mus musculus cellular retinoic acid binding protein I (Crabp1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Crabp1 ( NM_013496.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038524.1 Mus musculus cellular retinoic acid binding protein I (Crabp1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu20211
Clone ID Related Accession (Same CDS sequence)	NM_013496.3
Accession Version	NM_013496.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Mus musculus(house mouse)
Product	cellular retinoic acid-binding protein 1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC159892.2, AK144397.1 and CD742428.1. On Oct 18, 2013 this sequence version replaced NM_013496.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB203815.1, AK144397.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAACT TCGCCGGTAC CTGGAAGATG CGCAGCAGCG AGAATTTCGA CGAGCTCCTC 
AAGGCGTTGG GTGTGAACGC CATGCTGAGG AAGGTGGCCG TGGCGGCTGC GTCTAAGCCG 
CACGTGGAGA TCCGCCAAGA CGGGGATCAG TTCTACATCA AGACATCCAC TACTGTGCGC 
ACCACGGAGA TCAACTTCAA GGTCGGAGAG GGCTTCGAGG AGGAGACAGT GGACGGACGC 
AAATGCAGGA GTTTACCCAC GTGGGAGAAT GAGAACAAGA TTCACTGCAC ACAGACACTT 
CTTGAGGGGG ATGGCCCTAA AACTTACTGG ACCCGAGAGC TGGCCAACGA TGAGCTAATC 
CTGACATTTG GCGCCGATGA TGTGGTGTGC ACAAGAATTT ATGTCCGGGA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038524.1
CDS	155..568
Translation	MPNFAGTWKMRSSENFDELLKALGVNAMLRKVAVAAASKPHVEIRQDGDQFYIKTSTTVRTTEINFKVGEGFEEETVDGRKCRSLPTWENENKIHCTQTLLEGDGPKTYWTRELANDELILTFGADDVVCTRIYVRE

Target ORF information:

RefSeq Version	NM_013496.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus cellular retinoic acid binding protein I (Crabp1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013496.3

ORF Insert Sequence:

ATGCCCAACT TCGCCGGTAC CTGGAAGATG CGCAGCAGCG AGAATTTCGA CGAGCTCCTC 
AAGGCGTTGG GTGTGAACGC CATGCTGAGG AAGGTGGCCG TGGCGGCTGC GTCTAAGCCG 
CACGTGGAGA TCCGCCAAGA CGGGGATCAG TTCTACATCA AGACATCCAC TACTGTGCGC 
ACCACGGAGA TCAACTTCAA GGTCGGAGAG GGCTTCGAGG AGGAGACAGT GGACGGACGC 
AAATGCAGGA GTTTACCCAC GTGGGAGAAT GAGAACAAGA TTCACTGCAC ACAGACACTT 
CTTGAGGGGG ATGGCCCTAA AACTTACTGG ACCCGAGAGC TGGCCAACGA TGAGCTAATC 
CTGACATTTG GCGCCGATGA TGTGGTGTGC ACAAGAATTT ATGTCCGGGA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Crabp1 ( NM_001284507.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001271436.1 Mus musculus cellular retinoic acid binding protein I (Crabp1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu23051
Clone ID Related Accession (Same CDS sequence)	NM_001284507.1
Accession Version	NM_001284507.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 300bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Mus musculus(house mouse)
Product	cellular retinoic acid-binding protein 1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC159892.2. Transcript Variant: This variant (2) lacks an in-frame exon in the coding region compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB193870.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAACT TCGCCGGTAC CTGGAAGATG CGCAGCAGCG AGAATTTCGA CGAGCTCCTC 
AAGGCGTTGG GTGTGAACGC CATGCTGAGG AAGGTGGCCG TGGCGGCTGC GTCTAAGCCG 
CACGTGGAGA TCCGCCAAGA CGGGGATCAG TTCTACATCA AGACATCCAC TACTGTGCGC 
ACCACGGAGA TCAACTTCAA GGTCGGAGAG GGCTTCGAGG AGGAGACAGT GGACGGACGC 
AAATGCAGGA CATTTGGCGC CGATGATGTG GTGTGCACAA GAATTTATGT CCGGGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001271436.1
CDS	155..454
Translation	MPNFAGTWKMRSSENFDELLKALGVNAMLRKVAVAAASKPHVEIRQDGDQFYIKTSTTVRTTEINFKVGEGFEEETVDGRKCRTFGADDVVCTRIYVRE

Target ORF information:

RefSeq Version	NM_001284507.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus cellular retinoic acid binding protein I (Crabp1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001284507.1

ORF Insert Sequence:

ATGCCCAACT TCGCCGGTAC CTGGAAGATG CGCAGCAGCG AGAATTTCGA CGAGCTCCTC 
AAGGCGTTGG GTGTGAACGC CATGCTGAGG AAGGTGGCCG TGGCGGCTGC GTCTAAGCCG 
CACGTGGAGA TCCGCCAAGA CGGGGATCAG TTCTACATCA AGACATCCAC TACTGTGCGC 
ACCACGGAGA TCAACTTCAA GGTCGGAGAG GGCTTCGAGG AGGAGACAGT GGACGGACGC 
AAATGCAGGA CATTTGGCGC CGATGATGTG GTGTGCACAA GAATTTATGT CCGGGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf.
Developmental biology(2017 Nov)
Magella B,Adam M,Potter AS,Venkatasubramanian M,Chetal K,Hay SB,Salomonis N,Potter SS

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Crabp1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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