Cnn2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cnn2
Entrez Gene ID	12798
Full Name	calponin 2
Synonyms	AA408047,AI324678,Calpo2
General protein information	Preferred Names calponin 2 Names calponin-2 calponin H2, smooth muscle h2-calponin neutral calponin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 C1

mRNA and Protein(s)

mRNA	Protein	Name
NM_007725.2	NP_031751.1	calponin-2

Pathways from BioSystems

Homologies

	CNN2	XP_001110773.1
Rattus norvegicus (Norway rat)	Cnn2	XP_006241100.1
Gallus gallus (chicken)	CNN2	NP_001135728.1
Danio rerio (zebrafish)	cnn2	NP_998514.1
Xenopus tropicalis (tropical clawed frog)	cnn1	NP_998841.1
Mus musculus (house mouse)	Cnn2	NP_031751.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012304	XP_320237.3
Homo sapiens (human)	CNN2	NP_004359.1
Drosophila melanogaster (fruit fly)	Mp20	NP_476643.1
Canis lupus familiaris (dog)	CNN2	XP_854646.1
Bos taurus (cattle)	CNN2	NP_001030497.1

Gene Ontology
Bibliography

Related articles in PubMed

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A
Developmental cell41(4)349-365.e3(2017 05)

Deletion of Calponin 2 in Mouse Fibroblasts Increases Myosin II-Dependent Cell Traction Force.
Hossain MM, Zhao G, Woo MS, Wang JH, Jin JP
Biochemistry55(43)6046-6055(2016 Nov)

Deletion of calponin 2 in macrophages alters cytoskeleton-based functions and attenuates the development of atherosclerosis.
Liu R, Jin JP
Journal of molecular and cellular cardiology9987-99(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The novel finding that calponin 2 regulates myosin-dependent CTF in non-muscle cells demonstrates a mechanism for controlling cell motility-based functions
Title: Deletion of Calponin 2 in Mouse Fibroblasts Increases Myosin II-Dependent Cell Traction Force.

Calponin 2-null macrophages and foam cells have significantly weakened cell adhesion, indicating a role of cytoskeleton regulation in macrophage functions and inflammatory responses, and a novel therapeutic target for the treatment of arterial atherosclerosis.
Title: Deletion of calponin 2 in macrophages alters cytoskeleton-based functions and attenuates the development of atherosclerosis.

h2-Calponin gene expression is further affected by the treatment of cells with Notch inhibitor and activator, suggesting an upstream signaling mechanism.
Title: Mechanoregulation of h2-calponin gene expression and the role of Notch signaling.

H2-calponin has a role in regulating macrophage motility and phagocytosis
Title: Role of H2-calponin in regulating macrophage motility and phagocytosis.

Expressed h2-calponin is associated with actin-tropomyosin microfilaments and may regulate cytokinesis by inhibiting the activity of the actin cytoskeleton.
Title: Developmentally regulated expression of calponin isoforms and the effect of h2-calponin on cell proliferation.

The following Cnn2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cnn2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14967	NM_007725.2 Latest version!	Mus musculus calponin 2 (Cnn2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cnn2 ( NM_007725.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031751.1 Mus musculus calponin 2 (Cnn2), mRNA.

Price & Availability↑

CloneID	OMu14967
Clone ID Related Accession (Same CDS sequence)	NM_007725.2
Accession Version	NM_007725.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Mus musculus(house mouse)
Product	calponin-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK051845.1, BE656517.1 and CB590846.1. On Oct 19, 2006 this sequence version replaced NM_007725.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC009144.1, AK051845.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCTCCA CGCAGTTCAA CAAGGGCCCG TCCTACGGGC TCTCGGCCGA GGTCAAGAAC 
CGGCTCCTGT CCAAATATGA CCCCCAAAAG GAAGCAGAAC TCCGAAGCTG GATAGAGGGA 
CTCACGGGCC TCTCCATTGG CCCTGACTTC CAGAAGGGTC TGAAAGATGG GGTTATCCTA 
TGCACACTCA TGAACAAGCT GCAGCCAGGC TCCGTCCCTA AAATCAACCG CTCTATGCAG 
AACTGGCACC AGCTAGAAAA TCTCTCCAAC TTCATCAAGG CCATGGTCAG CTACGGCATG 
AACCCTGTGG ACCTGTTTGA GGCCAATGAC CTGTTCGAGA GCGGGAACAT GACACAGGTG 
CAAGTGTCTC TGCTTGCACT GGCTGGAAAG GCCAAGACCA AGGGGCTGCA GAGTGGTGTG 
GACATTGGAG TTAAGTATTC GGAGAAACAG GAGAGGAACT TTGACGACGC CACCATGAAG 
GCCGGCCAGT GCGTCATCGG GCTGCAGATG GGCACCAACA AGTGTGCCAG CCAGTCTGGC 
ATGACAGCCT ATGGTACCAG GAGACATCTC TATGACCCCA AGAACCATAT CCTGCCTCCC 
ATGGACCACT GCACCATCAG CCTCCAGATG GGCACCAACA AGTGTGCCAG CCAGGTGGGC 
ATGACAGCTC CAGGGACCCG GAGGCACATC TATGACACCA AGCTGGGCAC CGACAAGTGC 
GACAACTCTT CCATGTCCCT GCAGATGGGC TACACGCAGG GCGCCAACCA GAGCGGTCAG 
GTCTTCGGAC TGGGGCGGCA GATCTACGAT CCCAAGTATT GCCCACAGGG CTCTGCAGCT 
GACGGGGCTC CTGCGGGTGA CGGCCAAGGC GAGGCCCCAG AGTACCTGGC CTACTGCCAG 
GAGGAAGCTG GCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031751.1
CDS	79..996
Translation	MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRSWIEGLTGLSIGPDFQKGLKDGVILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKAKTKGLQSGVDIGVKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQSGMTAYGTRRHLYDPKNHILPPMDHCTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKCDNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGSAADGAPAGDGQGEAPEYLAYCQEEAGY

Target ORF information:

RefSeq Version	NM_007725.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus calponin 2 (Cnn2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007725.2

ORF Insert Sequence:

ATGAGCTCCA CGCAGTTCAA CAAGGGCCCG TCCTACGGGC TCTCGGCCGA GGTCAAGAAC 
CGGCTCCTGT CCAAATATGA CCCCCAAAAG GAAGCAGAAC TCCGAAGCTG GATAGAGGGA 
CTCACGGGCC TCTCCATTGG CCCTGACTTC CAGAAGGGTC TGAAAGATGG GGTTATCCTA 
TGCACACTCA TGAACAAGCT GCAGCCAGGC TCCGTCCCTA AAATCAACCG CTCTATGCAG 
AACTGGCACC AGCTAGAAAA TCTCTCCAAC TTCATCAAGG CCATGGTCAG CTACGGCATG 
AACCCTGTGG ACCTGTTTGA GGCCAATGAC CTGTTCGAGA GCGGGAACAT GACACAGGTG 
CAAGTGTCTC TGCTTGCACT GGCTGGAAAG GCCAAGACCA AGGGGCTGCA GAGTGGTGTG 
GACATTGGAG TTAAGTATTC GGAGAAACAG GAGAGGAACT TTGACGACGC CACCATGAAG 
GCCGGCCAGT GCGTCATCGG GCTGCAGATG GGCACCAACA AGTGTGCCAG CCAGTCTGGC 
ATGACAGCCT ATGGTACCAG GAGACATCTC TATGACCCCA AGAACCATAT CCTGCCTCCC 
ATGGACCACT GCACCATCAG CCTCCAGATG GGCACCAACA AGTGTGCCAG CCAGGTGGGC 
ATGACAGCTC CAGGGACCCG GAGGCACATC TATGACACCA AGCTGGGCAC CGACAAGTGC 
GACAACTCTT CCATGTCCCT GCAGATGGGC TACACGCAGG GCGCCAACCA GAGCGGTCAG 
GTCTTCGGAC TGGGGCGGCA GATCTACGAT CCCAAGTATT GCCCACAGGG CTCTGCAGCT 
GACGGGGCTC CTGCGGGTGA CGGCCAAGGC GAGGCCCCAG AGTACCTGGC CTACTGCCAG 
GAGGAAGCTG GCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Developmental cell41(4)349-365.e3(2017 05)
Naiman N,Fujioka K,Fujino M,Valerius MT,Potter SS,McMahon AP,Kobayashi A

Deletion of Calponin 2 in Mouse Fibroblasts Increases Myosin II-Dependent Cell Traction Force.
Biochemistry55(43)6046-6055(2016 Nov)
Hossain MM,Zhao G,Woo MS,Wang JH,Jin JP

Deletion of calponin 2 in macrophages alters cytoskeleton-based functions and attenuates the development of atherosclerosis.
Journal of molecular and cellular cardiology9987-99(2016 Oct)
Liu R,Jin JP

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Cnn2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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