Cnga1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cnga1
Entrez Gene ID	12788
Full Name	cyclic nucleotide gated channel alpha 1
Synonyms	Cncg
General protein information	Preferred Names cyclic nucleotide gated channel alpha 1 Names cGMP-gated cation channel alpha-1 CNG channel alpha-1 CNG-1 CNG1 cyclic nucleotide gated channel, cGMP gated cyclic nucleotide-gated cation channel 1 cyclic nucleotide-gated channel, photoreceptor rod photoreceptor cGMP-gated channel subunit alpha
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 C3.2\|5 38.44 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007723.2	NP_031749.2	cGMP-gated cation channel alpha-1
XM_006503709.1	XP_006503772.1	cGMP-gated cation channel alpha-1 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Cnga1	NP_031749.2
Gallus gallus (chicken)	CNGA1	NP_990551.1
Pan troglodytes (chimpanzee)	CNGA1	XP_001152062.2
Danio rerio (zebrafish)	cnga1	XP_701036.4
Bos taurus (cattle)	CNGA1	NP_776703.1
Xenopus tropicalis (tropical clawed frog)	cnga1	XP_002933507.1
Homo sapiens (human)	CNGA1	NP_001136036.1
	CNGA1	XP_002804108.1
Canis lupus familiaris (dog)	CNGA1	NP_001003222.1
Rattus norvegicus (Norway rat)	Cnga1	NP_445949.1

Gene Ontology
Bibliography

Related articles in PubMed

Ciliopathy-associated IQCB1/NPHP5 protein is required for mouse photoreceptor outer segment formation.
Ronquillo CC, Hanke-Gogokhia C, Revelo MP, Frederick JM, Jiang L, Baehr W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(10)3400-3412(2016 10)

Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia.
Ramamurthy V, Jolicoeur C, Koutroumbas D, M?hlhans J, Le YZ, Hauswirth WW, Giessl A, Cayouette M
The Journal of neuroscience : the official journal of the Society for Neuroscience34(42)13976-87(2014 Oct)

Insulin receptor regulates photoreceptor CNG channel activity.
Gupta VK, Rajala A, Rajala RV
American journal of physiology. Endocrinology and metabolism303(11)E1363-72(2012 Dec)

cGMP and cyclic nucleotide-gated channels participate in mouse sperm capacitation.
Cisneros-Mejorado A, S?nchez Herrera DP
FEBS letters586(2)149-53(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Numb protein interacts with Cnga1 in rod photoreceptor cilia to promote delivery of Cnga1.
Title: Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia.

Insulin receptor (IR), an integral membrane protein, directly phosphorylates the CNGA1 subunit of CNG channels that in turn affects the function of these channels negatively. CNGA1 is a direct substrate of IR.
Title: Insulin receptor regulates photoreceptor CNG channel activity.

that effective knockdown of GUCY2E and CNGA1 expression to counteract loss of PDE6 function may develop into a valuable approach for treating some patients with RP.
Title: shRNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosa.

Interaction with auxiliary subunit tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) is a major mechanism underlying proper expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and Ih in vivo.
Title: Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice.

Grb14 is a normal physiological modulator of CNG channel function in vivo.
Title: Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel.

The following Cnga1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cnga1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00684	NM_007723.2 Latest version!	Mus musculus cyclic nucleotide gated channel alpha 1 (Cnga1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
OMu34922	XM_006503709.1 Latest version!	Mus musculus cyclic nucleotide gated channel alpha 1 (Cnga1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cnga1 ( NM_007723.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031749.2 Mus musculus cyclic nucleotide gated channel alpha 1 (Cnga1), mRNA.

Price & Availability↑

CloneID	OMu00684
Clone ID Related Accession (Same CDS sequence)	NM_007723.2
Accession Version	NM_007723.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2055bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Mus musculus(house mouse)
Product	cGMP-gated cation channel alpha-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI738168.1, CX564336.1, CO423854.1, AC122733.11 and BI871897.1. On Aug 12, 2006 this sequence version replaced NM_007723.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: M84742.1, BC141261.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMN00849383, SAMN00849388 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGACAA ATATTATCAA TACGTGGCAT TCCTTCGTAA ATATTCCCAA TGTGATCGTA 
CCAGCCATTG AAAAGGAAAT CCGGCGGATG GAAAATGGAG CGTGCAGCTC CTTTTCTGAC 
GATGACAATG GCTCTCTGTC TGAAGAATCA GAGAATGAGG ACTCTTTCTT TAGAAGCAAC 
TCGTACAAAA GGCGAGGACC ATCACAGAGG GAGCAGCACT TGCCAGGTAC TATGGCTCTT 
TTCAATGTCA ACAACAGCAG CAACAAAGAC CAAGAGCCAA AGGAGAAAAA GAAAAAAAAG 
AAGGAAAAGA AGAGCAAGGC CGATGATAAA AATGAAAATA AAAAGGACCC AGAGAAGAAA 
AAGAAGAAGG AAAAGGAAAA AGAGAAGAAA AAGAAGGAGG AGAAAACCAA AGAGAAGAAA 
GAAGAGGAGA AGAAAGAAGT CGTGGTTATT GATCCTTCAG GAAACACATA CTACAACTGG 
CTGTTTTGTA TCACTTTGCC TGTGATGTAC AACTGGACGA TGATTATTGC AAGAGCATGT 
TTTGATGAAC TCCAGTCTGA TTACCTAGAA TACTGGCTCA TTTTTGATTA CGTATCAGAT 
GTAGTCTATC TTGCCGATAT GTTTGTACGA ACAAGGACAG GTTACCTGGA ACAAGGGCTG 
CTAGTGAAAG ACAGAATGAA ACTCATAGAG AAATACAAAG CAAACCTGCA GTTTAAACTT 
GATGTTCTGT CAGTGATACC GACCGATCTG CTGTACATCA AGTTTGGGTG GAACTATCCA 
GAAATCAGGT TAAACCGGCT GTTAAGGATC TCTCGAATGT TTGAGTTCTT CCAGAGGACG 
GAAACAAGGA CCAACTACCC AAACATCTTT AGGATTTCGA ACCTTGTGAT GTACATCGTC 
ATCATCATCC ACTGGAACGC TTGTGTGTAT TATTCCATCT CAAAAGCTAT TGGATTTGGG 
AATGACACAT GGGTCTACCC TGATGTTAAT GATCCTGAAT TCGGCCGTTT AGCTAGAAAA 
TATGTCTACA GCCTTTATTG GTCTACTTTG ACTTTGACAA CCATTGGTGA AACTCCACCT 
CCCGTGCTGG ATTCTGAGTA CATCTTTGTG GTGGTAGACT TCTTAATTGG AGTTTTAATT 
TTCGCCACCA TTGTCGGTAA CATAGGTTCC ATGATTTCCA ATATGAATGC AGCCCGGGCA 
GAATTTCAAT CAAGAGTTGA TGCTATCAAA CAGTACATGA ATTTTCGAAA TGTAAGCAAA 
GATATGGAAA AGAGGGTTAT TAAATGGTTT GACTACCTGT GGACCAACAA AAAAACAGTG 
GATGAGAGAG AAGTCCTGAG ATACCTCCCT GACAAACTAA GGGCAGAAAT TGCCATCAAC 
GTTCATCTAG ACACGTTAAA AAAGGTTCGC ATCTTTGCTG ACTGTGAAGC TGGTCTGTTG 
GTGGAGTTGG TGTTGAAACT ACAACCCCAG GTGTATAGTC CCGGAGATTA CATATGCAAG 
AAAGGGGACA TCGGGCGGGA GATGTACATC ATCAAGGAAG GCAAACTTGC TGTGGTGGCA 
GATGACGGAA TTACACAGTT TGTGGTGTTG AGTGACGGCA GTTACTTTGG TGAGATCAGC 
ATTCTTAATA TCAAAGGCAG CAAGGCTGGC AACCGAAGAA CAGCCAACAT TAAGAGCATC 
GGCTACTCGG ACCTGTTCTG CCTCTCCAAA GATGACCTCA TGGAAGCTCT TACAGAGTAC 
CCAGATGCCA AAACTATGCT GGAAGAGAAA GGGAGGCAGA TCTTAATGAA AGATGGTCTG 
CTGGATATAA ACATTGCAAA TATGGGCAGT GACCCTAAAG ACCTGGAAGA GAAGGTCACT 
CGAATGGAGG GGTCAGTGGA CCTCCTGCAA ACGCGATTTG CCCGTATCTT GGCTGAATAT 
GAGTCGATGC AGCAGAAACT CAAGCAAAGA TTAACCAAGG TCGAGAAATT TCTGAAACCG 
CTTATTGAAA CAGAATTTTC AGCTCTGGAG GAACCCGGAG GGGAAAGTGA GCTCACGGAG 
TCTCTACAGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031749.2
CDS	266..2320
Translation	MKTNIINTWHSFVNIPNVIVPAIEKEIRRMENGACSSFSDDDNGSLSEESENEDSFFRSNSYKRRGPSQREQHLPGTMALFNVNNSSNKDQEPKEKKKKKKEKKSKADDKNENKKDPEKKKKKEKEKEKKKKEEKTKEKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMIIARACFDELQSDYLEYWLIFDYVSDVVYLADMFVRTRTGYLEQGLLVKDRMKLIEKYKANLQFKLDVLSVIPTDLLYIKFGWNYPEIRLNRLLRISRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVYYSISKAIGFGNDTWVYPDVNDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVLDSEYIFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQSRVDAIKQYMNFRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLRYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGRQILMKDGLLDINIANMGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIETEFSALEEPGGESELTESLQD

Target ORF information:

RefSeq Version	NM_007723.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus cyclic nucleotide gated channel alpha 1 (Cnga1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007723.2

ORF Insert Sequence:

ATGAAGACAA ATATTATCAA TACGTGGCAT TCCTTCGTAA ATATTCCCAA TGTGATCGTA 
CCAGCCATTG AAAAGGAAAT CCGGCGGATG GAAAATGGAG CGTGCAGCTC CTTTTCTGAC 
GATGACAATG GCTCTCTGTC TGAAGAATCA GAGAATGAGG ACTCTTTCTT TAGAAGCAAC 
TCGTACAAAA GGCGAGGACC ATCACAGAGG GAGCAGCACT TGCCAGGTAC TATGGCTCTT 
TTCAATGTCA ACAACAGCAG CAACAAAGAC CAAGAGCCAA AGGAGAAAAA GAAAAAAAAG 
AAGGAAAAGA AGAGCAAGGC CGATGATAAA AATGAAAATA AAAAGGACCC AGAGAAGAAA 
AAGAAGAAGG AAAAGGAAAA AGAGAAGAAA AAGAAGGAGG AGAAAACCAA AGAGAAGAAA 
GAAGAGGAGA AGAAAGAAGT CGTGGTTATT GATCCTTCAG GAAACACATA CTACAACTGG 
CTGTTTTGTA TCACTTTGCC TGTGATGTAC AACTGGACGA TGATTATTGC AAGAGCATGT 
TTTGATGAAC TCCAGTCTGA TTACCTAGAA TACTGGCTCA TTTTTGATTA CGTATCAGAT 
GTAGTCTATC TTGCCGATAT GTTTGTACGA ACAAGGACAG GTTACCTGGA ACAAGGGCTG 
CTAGTGAAAG ACAGAATGAA ACTCATAGAG AAATACAAAG CAAACCTGCA GTTTAAACTT 
GATGTTCTGT CAGTGATACC GACCGATCTG CTGTACATCA AGTTTGGGTG GAACTATCCA 
GAAATCAGGT TAAACCGGCT GTTAAGGATC TCTCGAATGT TTGAGTTCTT CCAGAGGACG 
GAAACAAGGA CCAACTACCC AAACATCTTT AGGATTTCGA ACCTTGTGAT GTACATCGTC 
ATCATCATCC ACTGGAACGC TTGTGTGTAT TATTCCATCT CAAAAGCTAT TGGATTTGGG 
AATGACACAT GGGTCTACCC TGATGTTAAT GATCCTGAAT TCGGCCGTTT AGCTAGAAAA 
TATGTCTACA GCCTTTATTG GTCTACTTTG ACTTTGACAA CCATTGGTGA AACTCCACCT 
CCCGTGCTGG ATTCTGAGTA CATCTTTGTG GTGGTAGACT TCTTAATTGG AGTTTTAATT 
TTCGCCACCA TTGTCGGTAA CATAGGTTCC ATGATTTCCA ATATGAATGC AGCCCGGGCA 
GAATTTCAAT CAAGAGTTGA TGCTATCAAA CAGTACATGA ATTTTCGAAA TGTAAGCAAA 
GATATGGAAA AGAGGGTTAT TAAATGGTTT GACTACCTGT GGACCAACAA AAAAACAGTG 
GATGAGAGAG AAGTCCTGAG ATACCTCCCT GACAAACTAA GGGCAGAAAT TGCCATCAAC 
GTTCATCTAG ACACGTTAAA AAAGGTTCGC ATCTTTGCTG ACTGTGAAGC TGGTCTGTTG 
GTGGAGTTGG TGTTGAAACT ACAACCCCAG GTGTATAGTC CCGGAGATTA CATATGCAAG 
AAAGGGGACA TCGGGCGGGA GATGTACATC ATCAAGGAAG GCAAACTTGC TGTGGTGGCA 
GATGACGGAA TTACACAGTT TGTGGTGTTG AGTGACGGCA GTTACTTTGG TGAGATCAGC 
ATTCTTAATA TCAAAGGCAG CAAGGCTGGC AACCGAAGAA CAGCCAACAT TAAGAGCATC 
GGCTACTCGG ACCTGTTCTG CCTCTCCAAA GATGACCTCA TGGAAGCTCT TACAGAGTAC 
CCAGATGCCA AAACTATGCT GGAAGAGAAA GGGAGGCAGA TCTTAATGAA AGATGGTCTG 
CTGGATATAA ACATTGCAAA TATGGGCAGT GACCCTAAAG ACCTGGAAGA GAAGGTCACT 
CGAATGGAGG GGTCAGTGGA CCTCCTGCAA ACGCGATTTG CCCGTATCTT GGCTGAATAT 
GAGTCGATGC AGCAGAAACT CAAGCAAAGA TTAACCAAGG TCGAGAAATT TCTGAAACCG 
CTTATTGAAA CAGAATTTTC AGCTCTGGAG GAACCCGGAG GGGAAAGTGA GCTCACGGAG 
TCTCTACAGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cnga1 ( XM_006503709.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006503772.1 Mus musculus cyclic nucleotide gated channel alpha 1 (Cnga1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu34922
Clone ID Related Accession (Same CDS sequence)	XM_006503709.1
Accession Version	XM_006503709.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2100bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	cGMP-gated cation channel alpha-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAGCTA GAAGTGGAGT CTGGGATGAA GATATTAAAC TAACCATGAA GACAAATATT 
ATCAATACGT GGCATTCCTT CGTAAATATT CCCAATGTGA TCGTACCAGC CATTGAAAAG 
GAAATCCGGC GGATGGAAAA TGGAGCGTGC AGCTCCTTTT CTGACGATGA CAATGGCTCT 
CTGTCTGAAG AATCAGAGAA TGAGGACTCT TTCTTTAGAA GCAACTCGTA CAAAAGGCGA 
GGACCATCAC AGAGGGAGCA GCACTTGCCA GGTACTATGG CTCTTTTCAA TGTCAACAAC 
AGCAGCAACA AAGACCAAGA GCCAAAGGAG AAAAAGAAAA AAAAGAAGGA AAAGAAGAGC 
AAGGCCGATG ATAAAAATGA AAATAAAAAG GACCCAGAGA AGAAAAAGAA GAAGGAAAAG 
GAAAAAGAGA AGAAAAAGAA GGAGGAGAAA ACCAAAGAGA AGAAAGAAGA GGAGAAGAAA 
GAAGTCGTGG TTATTGATCC TTCAGGAAAC ACATACTACA ACTGGCTGTT TTGTATCACT 
TTGCCTGTGA TGTACAACTG GACGATGATT ATTGCAAGAG CATGTTTTGA TGAACTCCAG 
TCTGATTACC TAGAATACTG GCTCATTTTT GATTACGTAT CAGATGTAGT CTATCTTGCC 
GATATGTTTG TACGAACAAG GACAGGTTAC CTGGAACAAG GGCTGCTAGT GAAAGACAGA 
ATGAAACTCA TAGAGAAATA CAAAGCAAAC CTGCAGTTTA AACTTGATGT TCTGTCAGTG 
ATACCGACCG ATCTGCTGTA CATCAAGTTT GGGTGGAACT ATCCAGAAAT CAGGTTAAAC 
CGGCTGTTAA GGATCTCTCG AATGTTTGAG TTCTTCCAGA GGACGGAAAC AAGGACCAAC 
TACCCAAACA TCTTTAGGAT TTCGAACCTT GTGATGTACA TCGTCATCAT CATCCACTGG 
AACGCTTGTG TGTATTATTC CATCTCAAAA GCTATTGGAT TTGGGAATGA CACATGGGTC 
TACCCTGATG TTAATGATCC TGAATTCGGC CGTTTAGCTA GAAAATATGT CTACAGCCTT 
TATTGGTCTA CTTTGACTTT GACAACCATT GGTGAAACTC CACCTCCCGT GCTGGATTCT 
GAGTACATCT TTGTGGTGGT AGACTTCTTA ATTGGAGTTT TAATTTTCGC CACCATTGTC 
GGTAACATAG GTTCCATGAT TTCCAATATG AATGCAGCCC GGGCAGAATT TCAATCAAGA 
GTTGATGCTA TCAAACAGTA CATGAATTTT CGAAATGTAA GCAAAGATAT GGAAAAGAGG 
GTTATTAAAT GGTTTGACTA CCTGTGGACC AACAAAAAAA CAGTGGATGA GAGAGAAGTC 
CTGAGATACC TCCCTGACAA ACTAAGGGCA GAAATTGCCA TCAACGTTCA TCTAGACACG 
TTAAAAAAGG TTCGCATCTT TGCTGACTGT GAAGCTGGTC TGTTGGTGGA GTTGGTGTTG 
AAACTACAAC CCCAGGTGTA TAGTCCCGGA GATTACATAT GCAAGAAAGG GGACATCGGG 
CGGGAGATGT ACATCATCAA GGAAGGCAAA CTTGCTGTGG TGGCAGATGA CGGAATTACA 
CAGTTTGTGG TGTTGAGTGA CGGCAGTTAC TTTGGTGAGA TCAGCATTCT TAATATCAAA 
GGCAGCAAGG CTGGCAACCG AAGAACAGCC AACATTAAGA GCATCGGCTA CTCGGACCTG 
TTCTGCCTCT CCAAAGATGA CCTCATGGAA GCTCTTACAG AGTACCCAGA TGCCAAAACT 
ATGCTGGAAG AGAAAGGGAG GCAGATCTTA ATGAAAGATG GTCTGCTGGA TATAAACATT 
GCAAATATGG GCAGTGACCC TAAAGACCTG GAAGAGAAGG TCACTCGAAT GGAGGGGTCA 
GTGGACCTCC TGCAAACGCG ATTTGCCCGT ATCTTGGCTG AATATGAGTC GATGCAGCAG 
AAACTCAAGC AAAGATTAAC CAAGGTCGAG AAATTTCTGA AACCGCTTAT TGAAACAGAA 
TTTTCAGCTC TGGAGGAACC CGGAGGGGAA AGTGAGCTCA CGGAGTCTCT ACAGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006503772.1
CDS	49..2148
Translation	MEARSGVWDEDIKLTMKTNIINTWHSFVNIPNVIVPAIEKEIRRMENGACSSFSDDDNGSLSEESENEDSFFRSNSYKRRGPSQREQHLPGTMALFNVNNSSNKDQEPKEKKKKKKEKKSKADDKNENKKDPEKKKKKEKEKEKKKKEEKTKEKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMIIARACFDELQSDYLEYWLIFDYVSDVVYLADMFVRTRTGYLEQGLLVKDRMKLIEKYKANLQFKLDVLSVIPTDLLYIKFGWNYPEIRLNRLLRISRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVYYSISKAIGFGNDTWVYPDVNDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVLDSEYIFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQSRVDAIKQYMNFRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLRYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGRQILMKDGLLDINIANMGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIETEFSALEEPGGESELTESLQD

Target ORF information:

RefSeq Version	XM_006503709.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus cyclic nucleotide gated channel alpha 1 (Cnga1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006503709.1

ORF Insert Sequence:

ATGGAAGCTA GAAGTGGAGT CTGGGATGAA GATATTAAAC TAACCATGAA GACAAATATT 
ATCAATACGT GGCATTCCTT CGTAAATATT CCCAATGTGA TCGTACCAGC CATTGAAAAG 
GAAATCCGGC GGATGGAAAA TGGAGCGTGC AGCTCCTTTT CTGACGATGA CAATGGCTCT 
CTGTCTGAAG AATCAGAGAA TGAGGACTCT TTCTTTAGAA GCAACTCGTA CAAAAGGCGA 
GGACCATCAC AGAGGGAGCA GCACTTGCCA GGTACTATGG CTCTTTTCAA TGTCAACAAC 
AGCAGCAACA AAGACCAAGA GCCAAAGGAG AAAAAGAAAA AAAAGAAGGA AAAGAAGAGC 
AAGGCCGATG ATAAAAATGA AAATAAAAAG GACCCAGAGA AGAAAAAGAA GAAGGAAAAG 
GAAAAAGAGA AGAAAAAGAA GGAGGAGAAA ACCAAAGAGA AGAAAGAAGA GGAGAAGAAA 
GAAGTCGTGG TTATTGATCC TTCAGGAAAC ACATACTACA ACTGGCTGTT TTGTATCACT 
TTGCCTGTGA TGTACAACTG GACGATGATT ATTGCAAGAG CATGTTTTGA TGAACTCCAG 
TCTGATTACC TAGAATACTG GCTCATTTTT GATTACGTAT CAGATGTAGT CTATCTTGCC 
GATATGTTTG TACGAACAAG GACAGGTTAC CTGGAACAAG GGCTGCTAGT GAAAGACAGA 
ATGAAACTCA TAGAGAAATA CAAAGCAAAC CTGCAGTTTA AACTTGATGT TCTGTCAGTG 
ATACCGACCG ATCTGCTGTA CATCAAGTTT GGGTGGAACT ATCCAGAAAT CAGGTTAAAC 
CGGCTGTTAA GGATCTCTCG AATGTTTGAG TTCTTCCAGA GGACGGAAAC AAGGACCAAC 
TACCCAAACA TCTTTAGGAT TTCGAACCTT GTGATGTACA TCGTCATCAT CATCCACTGG 
AACGCTTGTG TGTATTATTC CATCTCAAAA GCTATTGGAT TTGGGAATGA CACATGGGTC 
TACCCTGATG TTAATGATCC TGAATTCGGC CGTTTAGCTA GAAAATATGT CTACAGCCTT 
TATTGGTCTA CTTTGACTTT GACAACCATT GGTGAAACTC CACCTCCCGT GCTGGATTCT 
GAGTACATCT TTGTGGTGGT AGACTTCTTA ATTGGAGTTT TAATTTTCGC CACCATTGTC 
GGTAACATAG GTTCCATGAT TTCCAATATG AATGCAGCCC GGGCAGAATT TCAATCAAGA 
GTTGATGCTA TCAAACAGTA CATGAATTTT CGAAATGTAA GCAAAGATAT GGAAAAGAGG 
GTTATTAAAT GGTTTGACTA CCTGTGGACC AACAAAAAAA CAGTGGATGA GAGAGAAGTC 
CTGAGATACC TCCCTGACAA ACTAAGGGCA GAAATTGCCA TCAACGTTCA TCTAGACACG 
TTAAAAAAGG TTCGCATCTT TGCTGACTGT GAAGCTGGTC TGTTGGTGGA GTTGGTGTTG 
AAACTACAAC CCCAGGTGTA TAGTCCCGGA GATTACATAT GCAAGAAAGG GGACATCGGG 
CGGGAGATGT ACATCATCAA GGAAGGCAAA CTTGCTGTGG TGGCAGATGA CGGAATTACA 
CAGTTTGTGG TGTTGAGTGA CGGCAGTTAC TTTGGTGAGA TCAGCATTCT TAATATCAAA 
GGCAGCAAGG CTGGCAACCG AAGAACAGCC AACATTAAGA GCATCGGCTA CTCGGACCTG 
TTCTGCCTCT CCAAAGATGA CCTCATGGAA GCTCTTACAG AGTACCCAGA TGCCAAAACT 
ATGCTGGAAG AGAAAGGGAG GCAGATCTTA ATGAAAGATG GTCTGCTGGA TATAAACATT 
GCAAATATGG GCAGTGACCC TAAAGACCTG GAAGAGAAGG TCACTCGAAT GGAGGGGTCA 
GTGGACCTCC TGCAAACGCG ATTTGCCCGT ATCTTGGCTG AATATGAGTC GATGCAGCAG 
AAACTCAAGC AAAGATTAAC CAAGGTCGAG AAATTTCTGA AACCGCTTAT TGAAACAGAA 
TTTTCAGCTC TGGAGGAACC CGGAGGGGAA AGTGAGCTCA CGGAGTCTCT ACAGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ciliopathy-associated IQCB1/NPHP5 protein is required for mouse photoreceptor outer segment formation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(10)3400-3412(2016 10)
Ronquillo CC,Hanke-Gogokhia C,Revelo MP,Frederick JM,Jiang L,Baehr W

Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia.
The Journal of neuroscience : the official journal of the Society for Neuroscience34(42)13976-87(2014 Oct)
Ramamurthy V,Jolicoeur C,Koutroumbas D,M?hlhans J,Le YZ,Hauswirth WW,Giessl A,Cayouette M

Insulin receptor regulates photoreceptor CNG channel activity.
American journal of physiology. Endocrinology and metabolism303(11)E1363-72(2012 Dec)
Gupta VK,Rajala A,Rajala RV

cGMP and cyclic nucleotide-gated channels participate in mouse sperm capacitation.
FEBS letters586(2)149-53(2012 Jan)
Cisneros-Mejorado A,S?nchez Herrera DP

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Cnga1 cDNA ORF clone, Mus musculus(house mouse)

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