Clk1 cDNA ORF clone, Mus musculus(house mouse)

A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs.
Karlas A, Berre S, Couderc T, Varjak M, Braun P, Meyer M, Gangneux N, Karo-Astover L, Weege F, Raftery M, Sch?nrich G, Klemm U, Wurzlbauer A, Bracher F, Merits A, Meyer TF, Lecuit M
Nature communications711320(2016 May)

Extended lifespan, reduced body size and leg skeletal muscle mass, and decreased mitochondrial function in clk-1 transgenic mice.
Takahashi K, Noda Y, Ohsawa I, Shirasawa T, Takahashi M
Experimental gerontology58146-53(2014 Oct)

Clk/STY (cdc2-like kinase 1) and Akt regulate alternative splicing and adipogenesis in 3T3-L1 pre-adipocytes.
Li P, Carter G, Romero J, Gower KM, Watson J, Patel NA, Cooper DR
PloS one8(1)e53268(2013)

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.
Colwill K, Pawson T, Andrews B, Prasad J, Manley JL, Bell JC, Duncan PI
The EMBO journal15(2)265-75(1996 Jan)

Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.
Hanes J, von der Kammer H, Klaudiny J, Scheit KH
Journal of molecular biology244(5)665-72(1994 Dec)

Indicate a close relationship between lifespan extension and decreased mitochondrial function, which was induced by the transgenic expression of clk-1, in leg skeletal muscles that exhibit high metabolic activity.
Title: Extended lifespan, reduced body size and leg skeletal muscle mass, and decreased mitochondrial function in clk-1 transgenic mice.

This study demonstrates the role of Akt and Clk1 kinases in the early differentiation of 3T3-L1 cells to adipocytes.
Title: Clk/STY (cdc2-like kinase 1) and Akt regulate alternative splicing and adipogenesis in 3T3-L1 pre-adipocytes.

The results indicate that clk-1 regulates growth and heart rates through CoQ-mediated mitochondrial functions in mouse embryos.
Title: Reversal of slow growth and heartbeat through the restoration of mitochondrial function in clk-1-deficient mouse embryos by exogenous administration of coenzyme Q10.

Clk1/4 expression induced by stress-responsive splicing serves to maintain the phosphorylation state of SR proteins.
Title: Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor.

Analyses of the in vitro activity of MCLK1 with quinone substrates revealed that NADH can serve directly as a reductant for catalytic activation of dioxygen and substrate oxidation
Title: The aging-associated enzyme CLK-1 is a member of the carboxylate-bridged diiron family of proteins.