Chil3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Chil3
Entrez Gene ID	12655
Full Name	chitinase-like 3
Synonyms	AI505981,Chi3l3,ECF-L,Ym1
General protein information	Preferred Names chitinase-like 3 Names chitinase-like protein 3 beta-N-acetylhexosaminidase Ym1 eosinophil chemotactic cytokine eosinophil chemotactic factor-L secreted protein Ym1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3 F2.2\|3 46.49 cM
Summary	The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is thought to function as a lectin and may be involved in inflammation and allergy. [provided by RefSeq, Sep 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_009892.3	NP_034022.2	chitinase-like protein 3 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Chil3	NP_034022.2
Rattus norvegicus (Norway rat)	Chi3l3	NP_001178641.1
Mus musculus (house mouse)	Chil4	NP_660108.2

Gene Ontology
Bibliography

Related articles in PubMed

First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment.
Saluzzo S, Gorki AD, Rana BMJ, Martins R, Scanlon S, Starkl P, Lakovits K, Hladik A, Korosec A, Sharif O, Warszawska JM, Jolin H, Mesteri I, McKenzie ANJ, Knapp S
Cell reports18(8)1893-1905(2017 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The soluble antigen from A. cantonensis could promote the Chil3 expression in macrophage and microglial cell lines induced by interleukin-13.
Title: Soluble antigen derived from IV larva of Angiostrongylus cantonensis promotes chitinase-like protein 3 (Chil3) expression induced by interleukin-13.

A significant increase of CHI3L3 mRNA expression was observed in the spinal cord of experimental autoimmune encephalitis mice compared to controls during the inflammatory phase.
Title: Breast regression protein-39 is not required for experimental autoimmune encephalomyelitis induction.

neutrophil-derived Ym1 protein uptake distinguishes wound macrophages in the absence of interleukin-4 signaling in murine wound healing
Title: Uptake of neutrophil-derived Ym1 protein distinguishes wound macrophages in the absence of interleukin-4 signaling in murine wound healing.

These results indicate that catalytically inactive BRP-39 and Ym1 are constitutive genes in normal mouse lung.
Title: Establishment of a quantitative PCR system for discriminating chitinase-like proteins: catalytically inactive breast regression protein-39 and Ym1 are constitutive genes in mouse lung.

These data indicate that helminth-induced immunomodulation occurs independently of changes in the microbiota but is dependent on Ym1.
Title: Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation.

The following Chil3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Chil3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14724	NM_009892.3 Latest version!	Mus musculus chitinase-like 3 (Chil3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Chil3 ( NM_009892.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034022.2 Mus musculus chitinase-like 3 (Chil3), mRNA.

Price & Availability↑

CloneID	OMu14724
Clone ID Related Accession (Same CDS sequence)	NM_009892.3
Accession Version	NM_009892.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-30
Organism	Mus musculus(house mouse)
Product	chitinase-like protein 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC125461.4 and AK137503.1. On Sep 15, 2015 this sequence version replaced NM_009892.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061154.1, AK137503.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849387 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAAGC TCATTCTTGT CACAGGTCTG GCAATTCTTC TGAACGTACA GCTGGGATCT 
TCCTACCAGC TGATGTGCTA CTATACCAGT TGGGCTAAGG ACAGGCCAAT AGAAGGGAGT 
TTCAAACCTG GTAATATTGA CCCCTGCCTG TGTACTCACC TGATCTATGC CTTTGCTGGA 
ATGCAGAATA ATGAGATCAC TTACACACAT GAGCAAGACT TGCGTGACTA TGAAGCATTG 
AATGGTCTGA AAGACAAGAA CACTGAGCTA AAAACTCTCC TGGCCATTGG AGGATGGAAG 
TTTGGACCTG CCCCGTTCAG TGCCATGGTC TCTACTCCTC AGAACCGTCA GATATTCATT 
CAGTCAGTTA TCAGATTCCT TCGTCAATAT AACTTTGATG GCCTCAACCT GGACTGGCAG 
TACCCTGGGT CTCGAGGAAG CCCTCCTAAG GACAAACATC TCTTCAGTGT TCTGGTGAAG 
GAAATGCGTA AAGCTTTTGA GGAAGAATCT GTGGAGAAAG ACATTCCAAG GCTGCTACTC 
ACTTCCACAG GAGCAGGAAT CATTGACGTA ATCAAGTCTG GGTACAAGAT CCCTGAACTG 
TCTCAGTCTC TTGACTATAT TCAGGTCATG ACATATGATC TCCATGATCC TAAGGATGGC 
TACACTGGAG AAAATAGTCC CCTCTATAAA TCTCCATATG ACATTGGAAA GAGTGCTGAT 
CTCAATGTGG ATTCAATCAT TTCCTACTGG AAGGACCATG GAGCAGCTTC TGAGAAGCTC 
ATTGTGGGAT TTCCAGCATA TGGGCATACC TTTATCCTGA GTGACCCTTC TAAGACTGGA 
ATTGGTGCCC CTACAATTAG TACTGGCCCA CCAGGAAAGT ACACAGATGA ATCAGGACTC 
CTGGCTTACT ATGAGGTTTG TACATTTCTG AATGAAGGAG CCACTGAGGT CTGGGATGCC 
CCCCAGGAAG TACCCTATGC CTATCAGGGT AATGAGTGGG TTGGTTATGA CAATGTCAGG 
AGCTTCAAGT TGAAGGCTCA GTGGCTCAAG GACAACAATT TAGGAGGTGC CGTGGTCTGG 
CCCCTGGACA TGGATGACTT CAGTGGTTCT TTCTGTCACC AGAGACATTT CCCTCTGACA 
TCTACTTTAA AGGGAGATCT CAATATACAC AGTGCAAGTT GCAAGGGCCC TTATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034022.2
CDS	44..1240
Translation	MAKLILVTGLAILLNVQLGSSYQLMCYYTSWAKDRPIEGSFKPGNIDPCLCTHLIYAFAGMQNNEITYTHEQDLRDYEALNGLKDKNTELKTLLAIGGWKFGPAPFSAMVSTPQNRQIFIQSVIRFLRQYNFDGLNLDWQYPGSRGSPPKDKHLFSVLVKEMRKAFEEESVEKDIPRLLLTSTGAGIIDVIKSGYKIPELSQSLDYIQVMTYDLHDPKDGYTGENSPLYKSPYDIGKSADLNVDSIISYWKDHGAASEKLIVGFPAYGHTFILSDPSKTGIGAPTISTGPPGKYTDESGLLAYYEVCTFLNEGATEVWDAPQEVPYAYQGNEWVGYDNVRSFKLKAQWLKDNNLGGAVVWPLDMDDFSGSFCHQRHFPLTSTLKGDLNIHSASCKGPY

Target ORF information:

RefSeq Version	NM_009892.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus chitinase-like 3 (Chil3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009892.3

ORF Insert Sequence:

ATGGCCAAGC TCATTCTTGT CACAGGTCTG GCAATTCTTC TGAACGTACA GCTGGGATCT 
TCCTACCAGC TGATGTGCTA CTATACCAGT TGGGCTAAGG ACAGGCCAAT AGAAGGGAGT 
TTCAAACCTG GTAATATTGA CCCCTGCCTG TGTACTCACC TGATCTATGC CTTTGCTGGA 
ATGCAGAATA ATGAGATCAC TTACACACAT GAGCAAGACT TGCGTGACTA TGAAGCATTG 
AATGGTCTGA AAGACAAGAA CACTGAGCTA AAAACTCTCC TGGCCATTGG AGGATGGAAG 
TTTGGACCTG CCCCGTTCAG TGCCATGGTC TCTACTCCTC AGAACCGTCA GATATTCATT 
CAGTCAGTTA TCAGATTCCT TCGTCAATAT AACTTTGATG GCCTCAACCT GGACTGGCAG 
TACCCTGGGT CTCGAGGAAG CCCTCCTAAG GACAAACATC TCTTCAGTGT TCTGGTGAAG 
GAAATGCGTA AAGCTTTTGA GGAAGAATCT GTGGAGAAAG ACATTCCAAG GCTGCTACTC 
ACTTCCACAG GAGCAGGAAT CATTGACGTA ATCAAGTCTG GGTACAAGAT CCCTGAACTG 
TCTCAGTCTC TTGACTATAT TCAGGTCATG ACATATGATC TCCATGATCC TAAGGATGGC 
TACACTGGAG AAAATAGTCC CCTCTATAAA TCTCCATATG ACATTGGAAA GAGTGCTGAT 
CTCAATGTGG ATTCAATCAT TTCCTACTGG AAGGACCATG GAGCAGCTTC TGAGAAGCTC 
ATTGTGGGAT TTCCAGCATA TGGGCATACC TTTATCCTGA GTGACCCTTC TAAGACTGGA 
ATTGGTGCCC CTACAATTAG TACTGGCCCA CCAGGAAAGT ACACAGATGA ATCAGGACTC 
CTGGCTTACT ATGAGGTTTG TACATTTCTG AATGAAGGAG CCACTGAGGT CTGGGATGCC 
CCCCAGGAAG TACCCTATGC CTATCAGGGT AATGAGTGGG TTGGTTATGA CAATGTCAGG 
AGCTTCAAGT TGAAGGCTCA GTGGCTCAAG GACAACAATT TAGGAGGTGC CGTGGTCTGG 
CCCCTGGACA TGGATGACTT CAGTGGTTCT TTCTGTCACC AGAGACATTT CCCTCTGACA 
TCTACTTTAA AGGGAGATCT CAATATACAC AGTGCAAGTT GCAAGGGCCC TTATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment.
Cell reports18(8)1893-1905(2017 Feb)
Saluzzo S,Gorki AD,Rana BMJ,Martins R,Scanlon S,Starkl P,Lakovits K,Hladik A,Korosec A,Sharif O,Warszawska JM,Jolin H,Mesteri I,McKenzie ANJ,Knapp S

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Chil3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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