Cdkn2d cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdkn2d
Entrez Gene ID	12581
Full Name	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
Synonyms	INK4d,p19,p19INK4d
General protein information	Preferred Names cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) Names cyclin-dependent kinase 4 inhibitor D p19-INK4d
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 A3

mRNA and Protein(s)

mRNA	Protein	Name
XM_006509968.2	XP_006510031.1	cyclin-dependent kinase 4 inhibitor D isoform X1
XM_006509968.1	XP_006510031.1	cyclin-dependent kinase 4 inhibitor D isoform X1
NM_009878.3	NP_034008.2	cyclin-dependent kinase 4 inhibitor D

Pathways from BioSystems

Homologies

Homo sapiens (human)	CDKN2D	NP_001791.1
Mus musculus (house mouse)	Cdkn2d	NP_034008.2
Danio rerio (zebrafish)	LOC100333252	XP_002662282.2
Xenopus tropicalis (tropical clawed frog)	cdkn2d	NP_001072839.1
	CDKN2D	XP_001102138.1
Pan troglodytes (chimpanzee)	CDKN2D	XP_003953404.1
Canis lupus familiaris (dog)	CDKN2D	XP_853946.1
Bos taurus (cattle)	CDKN2D	NP_001039515.1

Gene Ontology
Bibliography

Related articles in PubMed

Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer.
Gamell C, Gulati T, Levav-Cohen Y, Young RJ, Do H, Pilling P, Takano E, Watkins N, Fox SB, Russell P, Ginsberg D, Monahan BJ, Wright G, Dobrovic A, Haupt S, Solomon B, Haupt Y
Science signaling10(461)(2017 Jan)

p53 and p16
Azzopardi S, Pang S, Klimstra DS, Du YN
Neoplasia (New York, N.Y.)18(10)610-617(2016 Oct)

Transcriptional repression of p27 is essential for murine embryonic development.
Teratake Y, Kuga C, Hasegawa Y, Sato Y, Kitahashi M, Fujimura L, Watanabe-Takano H, Sakamoto A, Arima M, Tokuhisa T, Hatano M
Scientific reports626244(2016 May)

Rescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase inhibitor p19Ink4d.
Ma Q, Grati M, Bai F, Pei J, Pei XH, Liu X
Cell death & disease7e2131(2016 Mar)

Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium.
Mardaryev AN, Liu B, Rapisarda V, Poterlowicz K, Malashchuk I, Rudolf J, Sharov AA, Jahoda CA, Fessing MY, Benitah SA, Xu GL, Botchkarev VA
The Journal of cell biology212(1)77-89(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The expression of three tumor suppressor genes encoded in the INK4/ARF locus (p15(INK4b), p16(INK4a), and p19(ARF)) was decreased in E6AP(-/-) embryo fibroblasts.
Title: Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer.

TWIST1-E protein heterodimeric complexes may thus constitute the main active forms of TWIST1 with regard to senescence inhibition over the time course of breast tumorigenesis.
Title: p53 and p16

Rescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase inhibitor p19Ink4d.
Title: Rescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase inhibitor p19Ink4d.

p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging
Title: p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging.

Cdk4 and Cdk6 cooperate in hematopoietic tumor development and suggest a role for Cdk6 in sequestering INK4 proteins away from Cdk4.
Title: Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis.

The following Cdkn2d gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdkn2d cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu21001	NM_009878.3 Latest version!	Mus musculus cyclin dependent kinase inhibitor 2D (Cdkn2d), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu21001	XM_006509968.2 Latest version!	Mus musculus cyclin dependent kinase inhibitor 2D (Cdkn2d), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu21001	XM_006509968.1	Mus musculus cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) (Cdkn2d), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdkn2d ( NM_009878.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034008.2 Mus musculus cyclin dependent kinase inhibitor 2D (Cdkn2d), mRNA.

Price & Availability↑

CloneID	OMu21001
Clone ID Related Accession (Same CDS sequence)	XM_006509968.2 , XM_006509968.1 , NM_009878.3
Accession Version	NM_009878.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Mus musculus(house mouse)
Product	cyclin-dependent kinase 4 inhibitor D
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC122525.4 and AK140808.1. On Aug 1, 2007 this sequence version replaced NM_009878.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013898.1, SRR1660813.137042.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCTTCTGG AAGAAGTCTG CGTCGGCGAC CGGTTGAGTG GCGCAGCGGC CCGTGGCGAC 
GTGCAAGAGG TCCGCCGCCT TCTTCACCGG GAGCTGGTGC ATCCTGACGC CCTGAACCGC 
TTTGGCAAGA CGGCCTTGCA GGTCATGATG TTTGGAAGTC CAGCAGTTGC TTTGGAGCTC 
CTGAAGCAAG GTGCCAGCCC CAATGTCCAA GATGCCTCCG GTACTAGTCC TGTGCATGAT 
GCGGCTCGCA CCGGGTTCCT GGACACCCTG AAGGTTCTGG TGGAGCATGG TGCTGATGTC 
AATGCCCTGG ACAGCACTGG GTCGCTCCCC ATCCATCTGG CGATAAGAGA GGGCCATAGC 
TCCGTGGTCA GCTTCCTAGC TCCTGAATCT GATCTCCACC ACAGGGACGC TTCCGGTCTC 
ACTCCCCTGG AGTTGGCTCG GCAGAGAGGG GCTCAGAACC TCATGGACAT TCTGCAGGGG 
CACATGATGA TCCCAATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034008.2
CDS	261..761
Translation	MLLEEVCVGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSPAVALELLKQGASPNVQDASGTSPVHDAARTGFLDTLKVLVEHGADVNALDSTGSLPIHLAIREGHSSVVSFLAPESDLHHRDASGLTPLELARQRGAQNLMDILQGHMMIPM

Target ORF information:

RefSeq Version	NM_009878.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus cyclin dependent kinase inhibitor 2D (Cdkn2d), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009878.3

ORF Insert Sequence:

ATGCTTCTGG AAGAAGTCTG CGTCGGCGAC CGGTTGAGTG GCGCAGCGGC CCGTGGCGAC 
GTGCAAGAGG TCCGCCGCCT TCTTCACCGG GAGCTGGTGC ATCCTGACGC CCTGAACCGC 
TTTGGCAAGA CGGCCTTGCA GGTCATGATG TTTGGAAGTC CAGCAGTTGC TTTGGAGCTC 
CTGAAGCAAG GTGCCAGCCC CAATGTCCAA GATGCCTCCG GTACTAGTCC TGTGCATGAT 
GCGGCTCGCA CCGGGTTCCT GGACACCCTG AAGGTTCTGG TGGAGCATGG TGCTGATGTC 
AATGCCCTGG ACAGCACTGG GTCGCTCCCC ATCCATCTGG CGATAAGAGA GGGCCATAGC 
TCCGTGGTCA GCTTCCTAGC TCCTGAATCT GATCTCCACC ACAGGGACGC TTCCGGTCTC 
ACTCCCCTGG AGTTGGCTCG GCAGAGAGGG GCTCAGAACC TCATGGACAT TCTGCAGGGG 
CACATGATGA TCCCAATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cdkn2d ( XM_006509968.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006510031.1 Mus musculus cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) (Cdkn2d), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu21001
Clone ID Related Accession (Same CDS sequence)	XM_006509968.2 , XM_006509968.1 , NM_009878.3
Accession Version	XM_006509968.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	cyclin-dependent kinase 4 inhibitor D isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTTCTGG AAGAAGTCTG CGTCGGCGAC CGGTTGAGTG GCGCAGCGGC CCGTGGCGAC 
GTGCAAGAGG TCCGCCGCCT TCTTCACCGG GAGCTGGTGC ATCCTGACGC CCTGAACCGC 
TTTGGCAAGA CGGCCTTGCA GGTCATGATG TTTGGAAGTC CAGCAGTTGC TTTGGAGCTC 
CTGAAGCAAG GTGCCAGCCC CAATGTCCAA GATGCCTCCG GTACTAGTCC TGTGCATGAT 
GCGGCTCGCA CCGGGTTCCT GGACACCCTG AAGGTTCTGG TGGAGCATGG TGCTGATGTC 
AATGCCCTGG ACAGCACTGG GTCGCTCCCC ATCCATCTGG CGATAAGAGA GGGCCATAGC 
TCCGTGGTCA GCTTCCTAGC TCCTGAATCT GATCTCCACC ACAGGGACGC TTCCGGTCTC 
ACTCCCCTGG AGTTGGCTCG GCAGAGAGGG GCTCAGAACC TCATGGACAT TCTGCAGGGG 
CACATGATGA TCCCAATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006510031.1
CDS	198..698
Translation	MLLEEVCVGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSPAVALELLKQGASPNVQDASGTSPVHDAARTGFLDTLKVLVEHGADVNALDSTGSLPIHLAIREGHSSVVSFLAPESDLHHRDASGLTPLELARQRGAQNLMDILQGHMMIPM

Target ORF information:

RefSeq Version	XM_006509968.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) (Cdkn2d), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006509968.1

ORF Insert Sequence:

ATGCTTCTGG AAGAAGTCTG CGTCGGCGAC CGGTTGAGTG GCGCAGCGGC CCGTGGCGAC 
GTGCAAGAGG TCCGCCGCCT TCTTCACCGG GAGCTGGTGC ATCCTGACGC CCTGAACCGC 
TTTGGCAAGA CGGCCTTGCA GGTCATGATG TTTGGAAGTC CAGCAGTTGC TTTGGAGCTC 
CTGAAGCAAG GTGCCAGCCC CAATGTCCAA GATGCCTCCG GTACTAGTCC TGTGCATGAT 
GCGGCTCGCA CCGGGTTCCT GGACACCCTG AAGGTTCTGG TGGAGCATGG TGCTGATGTC 
AATGCCCTGG ACAGCACTGG GTCGCTCCCC ATCCATCTGG CGATAAGAGA GGGCCATAGC 
TCCGTGGTCA GCTTCCTAGC TCCTGAATCT GATCTCCACC ACAGGGACGC TTCCGGTCTC 
ACTCCCCTGG AGTTGGCTCG GCAGAGAGGG GCTCAGAACC TCATGGACAT TCTGCAGGGG 
CACATGATGA TCCCAATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cdkn2d ( XM_006509968.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006510031.1 Mus musculus cyclin dependent kinase inhibitor 2D (Cdkn2d), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu21001
Clone ID Related Accession (Same CDS sequence)	XM_006509968.2 , XM_006509968.1 , NM_009878.3
Accession Version	XM_006509968.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	cyclin-dependent kinase 4 inhibitor D isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006509968.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTTCTGG AAGAAGTCTG CGTCGGCGAC CGGTTGAGTG GCGCAGCGGC CCGTGGCGAC 
GTGCAAGAGG TCCGCCGCCT TCTTCACCGG GAGCTGGTGC ATCCTGACGC CCTGAACCGC 
TTTGGCAAGA CGGCCTTGCA GGTCATGATG TTTGGAAGTC CAGCAGTTGC TTTGGAGCTC 
CTGAAGCAAG GTGCCAGCCC CAATGTCCAA GATGCCTCCG GTACTAGTCC TGTGCATGAT 
GCGGCTCGCA CCGGGTTCCT GGACACCCTG AAGGTTCTGG TGGAGCATGG TGCTGATGTC 
AATGCCCTGG ACAGCACTGG GTCGCTCCCC ATCCATCTGG CGATAAGAGA GGGCCATAGC 
TCCGTGGTCA GCTTCCTAGC TCCTGAATCT GATCTCCACC ACAGGGACGC TTCCGGTCTC 
ACTCCCCTGG AGTTGGCTCG GCAGAGAGGG GCTCAGAACC TCATGGACAT TCTGCAGGGG 
CACATGATGA TCCCAATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006510031.1
CDS	217..717
Translation	MLLEEVCVGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSPAVALELLKQGASPNVQDASGTSPVHDAARTGFLDTLKVLVEHGADVNALDSTGSLPIHLAIREGHSSVVSFLAPESDLHHRDASGLTPLELARQRGAQNLMDILQGHMMIPM

Target ORF information:

RefSeq Version	XM_006509968.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus cyclin dependent kinase inhibitor 2D (Cdkn2d), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006509968.2

ORF Insert Sequence:

ATGCTTCTGG AAGAAGTCTG CGTCGGCGAC CGGTTGAGTG GCGCAGCGGC CCGTGGCGAC 
GTGCAAGAGG TCCGCCGCCT TCTTCACCGG GAGCTGGTGC ATCCTGACGC CCTGAACCGC 
TTTGGCAAGA CGGCCTTGCA GGTCATGATG TTTGGAAGTC CAGCAGTTGC TTTGGAGCTC 
CTGAAGCAAG GTGCCAGCCC CAATGTCCAA GATGCCTCCG GTACTAGTCC TGTGCATGAT 
GCGGCTCGCA CCGGGTTCCT GGACACCCTG AAGGTTCTGG TGGAGCATGG TGCTGATGTC 
AATGCCCTGG ACAGCACTGG GTCGCTCCCC ATCCATCTGG CGATAAGAGA GGGCCATAGC 
TCCGTGGTCA GCTTCCTAGC TCCTGAATCT GATCTCCACC ACAGGGACGC TTCCGGTCTC 
ACTCCCCTGG AGTTGGCTCG GCAGAGAGGG GCTCAGAACC TCATGGACAT TCTGCAGGGG 
CACATGATGA TCCCAATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer.
Science signaling10(461)(2017 Jan)
Gamell C,Gulati T,Levav-Cohen Y,Young RJ,Do H,Pilling P,Takano E,Watkins N,Fox SB,Russell P,Ginsberg D,Monahan BJ,Wright G,Dobrovic A,Haupt S,Solomon B,Haupt Y

p53 and p16
Neoplasia (New York, N.Y.)18(10)610-617(2016 Oct)
Azzopardi S,Pang S,Klimstra DS,Du YN

Transcriptional repression of p27 is essential for murine embryonic development.
Scientific reports626244(2016 May)
Teratake Y,Kuga C,Hasegawa Y,Sato Y,Kitahashi M,Fujimura L,Watanabe-Takano H,Sakamoto A,Arima M,Tokuhisa T,Hatano M

Rescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase inhibitor p19Ink4d.
Cell death & disease7e2131(2016 Mar)
Ma Q,Grati M,Bai F,Pei J,Pei XH,Liu X

Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium.
The Journal of cell biology212(1)77-89(2016 Jan)
Mardaryev AN,Liu B,Rapisarda V,Poterlowicz K,Malashchuk I,Rudolf J,Sharov AA,Jahoda CA,Fessing MY,Benitah SA,Xu GL,Botchkarev VA

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Cdkn2d cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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