Cdk5r2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdk5r2
Entrez Gene ID	12570
Full Name	cyclin-dependent kinase 5, regulatory subunit 2 (p39)
Synonyms	B230310J22Rik,p39
General protein information	Preferred Names cyclin-dependent kinase 5, regulatory subunit 2 (p39) Names cyclin-dependent kinase 5 activator 2 CDK5 activator 2 cyclin-dependent kinase 5 regulatory subunit 2 p39I
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 C4

mRNA and Protein(s)

mRNA	Protein	Name
NM_009872.3	NP_034002.2	cyclin-dependent kinase 5 activator 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CDK5R2	XP_005640725.1
Homo sapiens (human)	CDK5R2	NP_003927.1
Mus musculus (house mouse)	Cdk5r2	NP_034002.2
Bos taurus (cattle)	CDK5R2	XP_002685622.1
Rattus norvegicus (Norway rat)	Cdk5r2	NP_001102779.1
Xenopus tropicalis (tropical clawed frog)	cdk5r2	NP_001072258.1
Pan troglodytes (chimpanzee)	CDK5R2	XP_516099.2
Gallus gallus (chicken)	CDK5R2	XP_003641695.1

Gene Ontology
Bibliography

Related articles in PubMed

Cdk5 is required for the positioning and survival of GABAergic neurons in developing mouse striatum.
Sasamoto K, Nagai J, Nakabayashi T, He X, Ohshima T
Developmental neurobiology77(4)483-492(2017 04)

[EXPRESS] Peripheral and orofacial pain sensation is unaffected by the loss of p39.
Prochazkova M, Hall B, Hu M, Okine T, Reukauf J, Binukumar BK, Amin ND, Roque E, Pant HC, Kulkarni A
Molecular pain131744806917737205(2017 Jan-Dec)

p39 Is Responsible for Increasing Cdk5 Activity during Postnatal Neuron Differentiation and Governs Neuronal Network Formation and Epileptic Responses.
Li W, Allen ME, Rui Y, Ku L, Liu G, Bankston AN, Zheng JQ, Feng Y
The Journal of neuroscience : the official journal of the Society for Neuroscience36(44)11283-11294(2016 Nov)

The Activators of Cyclin-Dependent Kinase 5 p35 and p39 Are Essential for Oligodendrocyte Maturation, Process Formation, and Myelination.
Luo F, Zhang J, Burke K, Miller RH, Yang Y
The Journal of neuroscience : the official journal of the Society for Neuroscience36(10)3024-37(2016 Mar)

Cyclin-Dependent Kinase 5 Regulates Dendritic Spine Formation and Maintenance of Cortical Neuron in the Mouse Brain.
Mita N, He X, Sasamoto K, Mishiba T, Ohshima T
Cerebral cortex (New York, N.Y. : 1991)26(3)967-976(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In this study, we discovered that selective upregulation of p39 is the underlying mechanism that accommodates the increased functional requirement of Cdk5 activation during neuronal differentiation. In addition, we demonstrated that p39 selectively directs Cdk5 to phosphorylate protein substrates essential for axonal development, dendritic spine formation, and synaptogenesis. Moreover, our studies suggest opposing roles o
Title: p39 Is Responsible for Increasing Cdk5 Activity during Postnatal Neuron Differentiation and Governs Neuronal Network Formation and Epileptic Responses.

These data suggest p35 and p39 have specific and overlapping roles in oligodendrocyte development, some of which may be independent of Cdk5 activation.
Title: The Activators of Cyclin-Dependent Kinase 5 p35 and p39 Are Essential for Oligodendrocyte Maturation, Process Formation, and Myelination.

it was found that Tyr-15 phosphorylation occurred only on monomeric Cdk5, and the coexpression of activators, p35/p25, p39, or Cyclin I, inhibited the phosphorylation.
Title: Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5.

Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators.
Title: Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators.

Data indicate that p39 is selectively up-regulated in oligodendroglia (OL) during differentiation along with elevated Cdk5 activity.
Title: p39, the primary activator for cyclin-dependent kinase 5 (Cdk5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair.

The following Cdk5r2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdk5r2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58423	NM_009872.3 Latest version!	Mus musculus cyclin-dependent kinase 5, regulatory subunit 2 (p39) (Cdk5r2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdk5r2 ( NM_009872.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034002.2 Mus musculus cyclin-dependent kinase 5, regulatory subunit 2 (p39) (Cdk5r2), mRNA.

Price & Availability↑

CloneID	OMu58423
Clone ID Related Accession (Same CDS sequence)	NM_009872.3
Accession Version	NM_009872.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1110bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	cyclin-dependent kinase 5 activator 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC139023.15. On Nov 29, 2007 this sequence version replaced NM_009872.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGGCACGG TGCTGTCGCT TTCCCCTGCT TCCTCGGCCA AGGGCCGGAG GCCGGGAGGG 
CTGCCGGAGG AGAAAAAGAA GGCGCCGCCC GCGGGGGACG AGGCGCTGGG GGGCTACGGC 
GCGCCGCCGG CCGGCAAGGG CGGCAAAGGC GAGAGCCGGC TCAAACGGCC GTCCGTGCTC 
ATCTCGGCGC TCACCTGGAA GCGCCTAGTG GCAGCCTCGG CCAAGAAGAA GAAAGGCAGC 
AAAAAGGTGA CGCCCAAGCC AGCGTCCACC GGTCCCGACC CTCTGGTCCA GCAACGCAAC 
CGCGAGAACC TTCTCCGCAA GGGCCGCGAC GGCCCCGACG GTGGCGGAAC AGCCAAGCCC 
CTGGCCGTGC CGGTGCCCAC GGTGCCCACG ACCGCTGCCA CCTGCGAGCC CCCGTCGGGG 
GGCAGCGCAG CCGCCCCTCC ACCAGGCTCA GGCGGGGGAA AGCCGCCGCC GCCGCCACCC 
CCAGCCCCGC AGGCGGCACC GCCGGCGCCC GGAGGCTCGC CGCGGCGGGT CATCGTGCAG 
GCGTCTACCG GCGAGCTGCT CCGCTGCCTC GGCGACTTCG TGTGCCGACG CTGCTACCGC 
CTCAAGGAGC TGAGCCCCGG CGAGCTGGTG GGCTGGTTCC GCGGCGTGGA CCGCTCGCTG 
CTGCTGCAGG GCTGGCAAGA CCAGGCCTTC ATTACCCCCG CCAACCTGGT GTTCGTGTAC 
CTGCTGTGCC GGGAGTCGCT TCGTGGGGAC GAGCTGGCGT CGGCCGCGGA ACTGCAGGCC 
GCCTTCCTCA CCTGCCTCTA CCTCGCCTAC TCCTACATGG GCAACGAGAT CTCCTACCCG 
CTCAAGCCGT TCCTCGTGGA GCCCGACAAG GAGCGCTTCT GGCAGCGCTG CCTGCGCCTC 
ATCCAGCGGC TCAGCCCGCA GATGCTGCGA CTCAACGCCG ACCCCCACTT CTTCACGCAA 
GTCTTTCAAG ACCTCAAGAA CGAGGGCGAG GCCGCGGCGA GCACCGGGGG TCCACCGAGC 
GGAAGCAGCG CGTCCACCAC CTCCTCCTCG AGCGCCAGGG ACAGCTGCGC GACCGGAGCC 
AAGCACTGGA CTATGAACTT GGACCGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034002.2
CDS	70..1179
Translation	MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPAGKGGKGESRLKRPSVLISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDGPDGGGTAKPLAVPVPTVPTTAATCEPPSGGSAAAPPPGSGGGKPPPPPPPAPQAAPPAPGGSPRRVIVQASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVYLLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRLIQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAASTGGPPSGSSASTTSSSSARDSCATGAKHWTMNLDR

Target ORF information:

RefSeq Version	NM_009872.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus cyclin-dependent kinase 5, regulatory subunit 2 (p39) (Cdk5r2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009872.3

ORF Insert Sequence:

ATGGGCACGG TGCTGTCGCT TTCCCCTGCT TCCTCGGCCA AGGGCCGGAG GCCGGGAGGG 
CTGCCGGAGG AGAAAAAGAA GGCGCCGCCC GCGGGGGACG AGGCGCTGGG GGGCTACGGC 
GCGCCGCCGG CCGGCAAGGG CGGCAAAGGC GAGAGCCGGC TCAAACGGCC GTCCGTGCTC 
ATCTCGGCGC TCACCTGGAA GCGCCTAGTG GCAGCCTCGG CCAAGAAGAA GAAAGGCAGC 
AAAAAGGTGA CGCCCAAGCC AGCGTCCACC GGTCCCGACC CTCTGGTCCA GCAACGCAAC 
CGCGAGAACC TTCTCCGCAA GGGCCGCGAC GGCCCCGACG GTGGCGGAAC AGCCAAGCCC 
CTGGCCGTGC CGGTGCCCAC GGTGCCCACG ACCGCTGCCA CCTGCGAGCC CCCGTCGGGG 
GGCAGCGCAG CCGCCCCTCC ACCAGGCTCA GGCGGGGGAA AGCCGCCGCC GCCGCCACCC 
CCAGCCCCGC AGGCGGCACC GCCGGCGCCC GGAGGCTCGC CGCGGCGGGT CATCGTGCAG 
GCGTCTACCG GCGAGCTGCT CCGCTGCCTC GGCGACTTCG TGTGCCGACG CTGCTACCGC 
CTCAAGGAGC TGAGCCCCGG CGAGCTGGTG GGCTGGTTCC GCGGCGTGGA CCGCTCGCTG 
CTGCTGCAGG GCTGGCAAGA CCAGGCCTTC ATTACCCCCG CCAACCTGGT GTTCGTGTAC 
CTGCTGTGCC GGGAGTCGCT TCGTGGGGAC GAGCTGGCGT CGGCCGCGGA ACTGCAGGCC 
GCCTTCCTCA CCTGCCTCTA CCTCGCCTAC TCCTACATGG GCAACGAGAT CTCCTACCCG 
CTCAAGCCGT TCCTCGTGGA GCCCGACAAG GAGCGCTTCT GGCAGCGCTG CCTGCGCCTC 
ATCCAGCGGC TCAGCCCGCA GATGCTGCGA CTCAACGCCG ACCCCCACTT CTTCACGCAA 
GTCTTTCAAG ACCTCAAGAA CGAGGGCGAG GCCGCGGCGA GCACCGGGGG TCCACCGAGC 
GGAAGCAGCG CGTCCACCAC CTCCTCCTCG AGCGCCAGGG ACAGCTGCGC GACCGGAGCC 
AAGCACTGGA CTATGAACTT GGACCGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cdk5 is required for the positioning and survival of GABAergic neurons in developing mouse striatum.
Developmental neurobiology77(4)483-492(2017 04)
Sasamoto K,Nagai J,Nakabayashi T,He X,Ohshima T

[EXPRESS] Peripheral and orofacial pain sensation is unaffected by the loss of p39.
Molecular pain131744806917737205(2017 Jan-Dec)
Prochazkova M,Hall B,Hu M,Okine T,Reukauf J,Binukumar BK,Amin ND,Roque E,Pant HC,Kulkarni A

p39 Is Responsible for Increasing Cdk5 Activity during Postnatal Neuron Differentiation and Governs Neuronal Network Formation and Epileptic Responses.
The Journal of neuroscience : the official journal of the Society for Neuroscience36(44)11283-11294(2016 Nov)
Li W,Allen ME,Rui Y,Ku L,Liu G,Bankston AN,Zheng JQ,Feng Y

The Activators of Cyclin-Dependent Kinase 5 p35 and p39 Are Essential for Oligodendrocyte Maturation, Process Formation, and Myelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience36(10)3024-37(2016 Mar)
Luo F,Zhang J,Burke K,Miller RH,Yang Y

Cyclin-Dependent Kinase 5 Regulates Dendritic Spine Formation and Maintenance of Cortical Neuron in the Mouse Brain.
Cerebral cortex (New York, N.Y. : 1991)26(3)967-976(2016 Mar)
Mita N,He X,Sasamoto K,Mishiba T,Ohshima T

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Cdk5r2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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