CD38 cDNA ORF clone, Mus musculus(House mouse)

Tetrameric interaction of the ectoenzyme CD38 on the cell surface enables its catalytic and raft-association activities.
Hara-Yokoyama M, Kukimoto-Niino M, Terasawa K, Harumiya S, Podyma-Inoue KA, Hino N, Sakamoto K, Itoh S, Hashii N, Hiruta Y, Kawasaki N, Mishima-Tsumagari C, Kaitsu Y, Matsumoto T, Wakiyama M, Shirouzu M, Kasama T, Takayanagi H, Utsunomiya-Tate N, Takatsu K, Katada T, Hirabayashi Y, Yokoyama S, Yanagishita M
Structure (London, England : 1993)20(9)1585-95(2012 Sep)

CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues.
Chini EN, Chini CC, Kato I, Takasawa S, Okamoto H
The Biochemical journal362(Pt 1)125-30(2002 Feb)

Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo.
Partida-S?nchez S, Cockayne DA, Monard S, Jacobson EL, Oppenheimer N, Garvy B, Kusser K, Goodrich S, Howard M, Harmsen A, Randall TD, Lund FE
Nature medicine7(11)1209-16(2001 Nov)

Data, including data from studies on cells from knockout mice, suggest that intracellular CD38 contributes to NAADP production and cADPR production in cardiomyocytes; membrane fractions from wildtype but not CD38-/- mouse hearts support NAADP and cADPR synthesis; CD38 may be associated with sarcoplasmic reticulum of cardiomyocytes. (NAADP = nicotinate adenine dinucleotide phosphate; cADPR = cyclic ADP-ribose)
Title: Synthesis of the Ca

Study found that deletion of CD38 caused impaired astrocytic and oligodendrocytic development in the cortex, probably by increasing NAD+ levels and decreasing Cx43 expression levels.
Title: CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously.

Determined the role of CD38, an enzyme involved in cellular calcium modulation and autophagic flux, in the regulation of collagen I degradation in coronary arterial myocytes (CAMs).In primary cultured CAMs from CD38(-/-) mice, collagen I protein accumulation but not mRNA abundance was significantly increased compared with cells from CD38(+/+) mice.
Title: Implication of CD38 gene in autophagic degradation of collagen I in mouse coronary arterial myocytes.

These results suggested that CD38 may be involved in the DC function of alleviating asthma via restoration of the Th1/Th2 balance, thus providing a novel strategy for asthma therapy.
Title: CD38 gene-modified dendritic cells inhibit murine asthma development by increasing IL-12 production and promoting Th1 cell differentiation.

CD38 deficiency protects the heart from ischemia/reperfusion injury through activating SIRT1/FOXOs-mediated antioxidative stress pathway.
Title: CD38 Deficiency Protects the Heart from Ischemia/Reperfusion Injury through Activating SIRT1/FOXOs-Mediated Antioxidative Stress Pathway.