Car6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Car6
Entrez Gene ID	12353
Full Name	carbonic anhydrase 6
Synonyms	Ca6,DOC1
General protein information	Preferred Names carbonic anhydrase 6 Names carbonic anhydrase 6 CA-VI carbonate dehydratase VI carbonic anhydrase VI salivary carbonic anhydrase secreted carbonic anhydrase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 E2

mRNA and Protein(s)

mRNA	Protein	Name
NM_009802.2	NP_033932.2	carbonic anhydrase 6 precursor

Pathways from BioSystems

Homologies

	LOC709540	XP_001099188.2
Bos taurus (cattle)	CA6	NP_776323.1
Gallus gallus (chicken)	CA6	XP_425745.4
Mus musculus (house mouse)	Car6	NP_033932.2
Homo sapiens (human)	CA6	NP_001206.2
Pan troglodytes (chimpanzee)	CA6	XP_003307839.2
Canis lupus familiaris (dog)	CA6	NP_001002999.1
Rattus norvegicus (Norway rat)	Car6	NP_001128313.1
Danio rerio (zebrafish)	LOC100006448	XP_002666525.1

Gene Ontology
Bibliography

Related articles in PubMed

Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response.
Xu J, Xu X, Wang B, Ma Y, Zhang L, Xu H, Hu Y, Wu J, Cao X
Proceedings of the National Academy of Sciences of the United States of America114(32)8620-8625(2017 Aug)

Altered gene expression in the lower respiratory tract of Car6 (-/-) mice.
Patrikainen MS, Pan P, Barker HR, Parkkila S
Transgenic research25(5)649-64(2016 10)

The role of carbonic anhydrase VI in bitter taste perception: evidence from the Car6?/? mouse model.
Patrikainen M, Pan P, Kulesskaya N, Voikar V, Parkkila S
Journal of biomedical science2182(2014 Aug)

Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation.
Reibring CG, El Shahawy M, Hallberg K, Kannius-Janson M, Nilsson J, Parkkila S, Sly WS, Waheed A, Linde A, Gritli-Linde A
PloS one9(5)e96007(2014)

A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development.
Wu L, Sagong B, Choi JY, Kim UK, Bok J
Developmental dynamics : an official publication of the American Association of Anatomists242(3)269-80(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

he altered biological processes included antigen transport by M-cells, potassium transport, muscle contraction, and thyroid hormone synthesis. Immunohistochemical staining confirmed the absence of CA VI in the submandibular gland of Car6 (-/-) mice
Title: Altered gene expression in the lower respiratory tract of Car6 (-/-) mice.

knockout mouse model confirms that CA VI is involved in bitter taste perception. CA VI may be one of the factors which contribute to avoidance of bitter, potentially harmful, substances.
Title: The role of carbonic anhydrase VI in bitter taste perception: evidence from the Car6?/? mouse model.

The generation of Car6 (-/-) mice and examination of the effects of CAVI deficiency on gene transcription have revealed several affected clusters of biological processes, which implicate CAVI in catabolic processes and the immune system response.
Title: Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice.

expression of Car6 significantly decreased in enamel organs from Mmp20(-/-) mice. A feedback mechanism regulates ion-responsive gene expression during enamel development.
Title: Altered ion-responsive gene expression in Mmp20 null mice.

Car4, Car6, and Car12 showed moderate expression levels in the mouse harderian gland.
Title: Carbonic anhydrases in the mouse harderian gland.

The following Car6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Car6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04879	NM_009802.2 Latest version!	Mus musculus carbonic anhydrase 6 (Car6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Car6 ( NM_009802.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033932.2 Mus musculus carbonic anhydrase 6 (Car6), mRNA.

Price & Availability↑

CloneID	OMu04879
Clone ID Related Accession (Same CDS sequence)	NM_009802.2
Accession Version	NM_009802.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	carbonic anhydrase 6 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK132599.1, AK161216.1 and AI323978.1. On Oct 6, 2007 this sequence version replaced NM_009802.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF079835.1, AK132599.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGGCCC TGGTGAGCGT GGTGTCCCTG TTCTTCCTGG GCATCCAGGC CCACAGTGAT 
TGGAGCTATT CAGGGGATGA TGGCGTGGGA GAAAGTCAGT GGTCTGAGCA GTATCCTTCC 
TGCGGCGGGG AAAGGCAGTC GCCCATCGAC GTGAAGACGG AGGAGGTGAT GTTCAATCCC 
TCCTTGAAGC CCCTGAGCTT GGTGAACTAT GAGAAGGAGA ACCTGGAGTT CACTATGACT 
AACAACGGAC ACACAGTATC GATCGATCTG CCGCCCTCCA TGTACCTTGA AACCTCTGAC 
GGCACTGAGT TCATCTCAAA GGCCTTTCAC TTTCACTGGG GGGGTCGGGA CTGGGAACTC 
AGCGGCTCTG AACACACCAT TGATGGGATC AGGAGTATAA TGGAGGCTCA CTTTGTTCAC 
TTCAATAAGG AATACGGGAC CTATGAGAAT GCCAAGGATC AAAAAAACGG CCTAGCTGTG 
TTAGCCGTCT TGTTTAAGAT TGACGAGTAT GCCGAAAACA CTTACTACAG CGACATCATT 
TCTGCCTTGA AGAACATCGA GAAGCCAGGA GAAACTACAA CTCTGAAAGA CACGACCATT 
AGGAACTTGT TGCCTAAGGA CGTCCACCAC TATTACACCT ACCCAGGCTC GCTCACCACA 
CCCCCCTGCA CAGAGAATGT CCAGTGGTTT GTGCTTAGAG ACAAAGTCAC TTTGTCCAAG 
GCCCAGGTGG TGACCATAGA AAACTCTGTT ATGGATCACA ACAACAACAC CATTCAAAAT 
GGTTACCGCA GCACACAGCC CAACAACCAC AGGGTGGTGG AAGCCAATTT CCTGAACGTC 
CAGGATATGT ACTCTTCGTA CCACCTTTAC CTAAAAAACA TGCAGAAGGA GATTCTACAA 
CCTAAGAAAC AGAAGAAAAC AAAGAAGAAC CGGCACTTTT GGAGCCGGAA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033932.2
CDS	27..980
Translation	MRALVSVVSLFFLGIQAHSDWSYSGDDGVGESQWSEQYPSCGGERQSPIDVKTEEVMFNPSLKPLSLVNYEKENLEFTMTNNGHTVSIDLPPSMYLETSDGTEFISKAFHFHWGGRDWELSGSEHTIDGIRSIMEAHFVHFNKEYGTYENAKDQKNGLAVLAVLFKIDEYAENTYYSDIISALKNIEKPGETTTLKDTTIRNLLPKDVHHYYTYPGSLTTPPCTENVQWFVLRDKVTLSKAQVVTIENSVMDHNNNTIQNGYRSTQPNNHRVVEANFLNVQDMYSSYHLYLKNMQKEILQPKKQKKTKKNRHFWSRK

Target ORF information:

RefSeq Version	NM_009802.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus carbonic anhydrase 6 (Car6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009802.2

ORF Insert Sequence:

ATGAGGGCCC TGGTGAGCGT GGTGTCCCTG TTCTTCCTGG GCATCCAGGC CCACAGTGAT 
TGGAGCTATT CAGGGGATGA TGGCGTGGGA GAAAGTCAGT GGTCTGAGCA GTATCCTTCC 
TGCGGCGGGG AAAGGCAGTC GCCCATCGAC GTGAAGACGG AGGAGGTGAT GTTCAATCCC 
TCCTTGAAGC CCCTGAGCTT GGTGAACTAT GAGAAGGAGA ACCTGGAGTT CACTATGACT 
AACAACGGAC ACACAGTATC GATCGATCTG CCGCCCTCCA TGTACCTTGA AACCTCTGAC 
GGCACTGAGT TCATCTCAAA GGCCTTTCAC TTTCACTGGG GGGGTCGGGA CTGGGAACTC 
AGCGGCTCTG AACACACCAT TGATGGGATC AGGAGTATAA TGGAGGCTCA CTTTGTTCAC 
TTCAATAAGG AATACGGGAC CTATGAGAAT GCCAAGGATC AAAAAAACGG CCTAGCTGTG 
TTAGCCGTCT TGTTTAAGAT TGACGAGTAT GCCGAAAACA CTTACTACAG CGACATCATT 
TCTGCCTTGA AGAACATCGA GAAGCCAGGA GAAACTACAA CTCTGAAAGA CACGACCATT 
AGGAACTTGT TGCCTAAGGA CGTCCACCAC TATTACACCT ACCCAGGCTC GCTCACCACA 
CCCCCCTGCA CAGAGAATGT CCAGTGGTTT GTGCTTAGAG ACAAAGTCAC TTTGTCCAAG 
GCCCAGGTGG TGACCATAGA AAACTCTGTT ATGGATCACA ACAACAACAC CATTCAAAAT 
GGTTACCGCA GCACACAGCC CAACAACCAC AGGGTGGTGG AAGCCAATTT CCTGAACGTC 
CAGGATATGT ACTCTTCGTA CCACCTTTAC CTAAAAAACA TGCAGAAGGA GATTCTACAA 
CCTAAGAAAC AGAAGAAAAC AAAGAAGAAC CGGCACTTTT GGAGCCGGAA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response.
Proceedings of the National Academy of Sciences of the United States of America114(32)8620-8625(2017 Aug)
Xu J,Xu X,Wang B,Ma Y,Zhang L,Xu H,Hu Y,Wu J,Cao X

Altered gene expression in the lower respiratory tract of Car6 (-/-) mice.
Transgenic research25(5)649-64(2016 10)
Patrikainen MS,Pan P,Barker HR,Parkkila S

The role of carbonic anhydrase VI in bitter taste perception: evidence from the Car6?/? mouse model.
Journal of biomedical science2182(2014 Aug)
Patrikainen M,Pan P,Kulesskaya N,Voikar V,Parkkila S

Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation.
PloS one9(5)e96007(2014)
Reibring CG,El Shahawy M,Hallberg K,Kannius-Janson M,Nilsson J,Parkkila S,Sly WS,Waheed A,Linde A,Gritli-Linde A

A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development.
Developmental dynamics : an official publication of the American Association of Anatomists242(3)269-80(2013 Mar)
Wu L,Sagong B,Choi JY,Kim UK,Bok J

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Car6 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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