Btg3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Btg3
Entrez Gene ID	12228
Full Name	B cell translocation gene 3
Synonyms	ANA,tob5
General protein information	Preferred Names B cell translocation gene 3 Names protein BTG3 BTG family member 3 abundant in neuroepithelium area protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16\|16 C3.1
Summary	This gene encodes B cell translocation gene 3, a member of the BTG gene family. This family is defined by a conserved N-terminal domain, known to bind transcription factors, and a less conserved C-terminal domain. This protein is thought to have anti-proliferative properties, and may be involved in regulating the G1-S transition to suppress cell cycle progression. Mice deficient for this gene display an increased incidence of lung cancers, and many human lung cancer cells exhibit decreased levels of B cell translocation gene 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17. [provided by RefSeq, Jul 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001297747.1	NP_001284676.1	protein BTG3
NM_009770.3	NP_033900.1	protein BTG3

Pathways from BioSystems

Homologies

Homo sapiens (human)	BTG3	NP_001124386.1
Rattus norvegicus (Norway rat)	Btg3	NP_062163.1
Danio rerio (zebrafish)	btg3	NP_001007352.1
Xenopus tropicalis (tropical clawed frog)	btg3	NP_001090840.1
Bos taurus (cattle)	BTG3	NP_001029894.1
Pan troglodytes (chimpanzee)	BTG3	XP_001170879.2
Mus musculus (house mouse)	Btg3	NP_033900.1
	BTG3	XP_001106829.1
Canis lupus familiaris (dog)	LOC487695	XP_005638828.1

Gene Ontology
Bibliography

Related articles in PubMed

Integration of H-2Z1, a somatosensory cortex-expressed transgene, interferes with the expression of the Satb1 and Tbc1d5 flanking genes and affects the differentiation of a subset of cortical interneurons.
Narboux-N?me N, Go?ame R, Matt?i MG, Cohen-Tannoudji M, Wassef M
The Journal of neuroscience : the official journal of the Society for Neuroscience32(21)7287-300(2012 May)

Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala.
Boyle MP, Bernard A, Thompson CL, Ng L, Boe A, Mortrud M, Hawrylycz MJ, Jones AR, Hevner RF, Lein ES
The Journal of comparative neurology519(11)2061-89(2011 Aug)

The mammalian anti-proliferative BTG/Tob protein family.
Winkler GS
Journal of cellular physiology222(1)66-72(2010 Jan)

ANA deficiency enhances bone morphogenetic protein-induced ectopic bone formation via transcriptional events.
Miyai K, Yoneda M, Hasegawa U, Toita S, Izu Y, Hemmi H, Hayata T, Ezura Y, Mizutani S, Miyazono K, Akiyoshi K, Yamamoto T, Noda M
The Journal of biological chemistry284(16)10593-600(2009 Apr)

Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma.
Yoneda M, Suzuki T, Nakamura T, Ajima R, Yoshida Y, Kakuta S, Katsuko S, Iwakura Y, Shibutani M, Mitsumori K, Yokota J, Yamamoto T
Cancer science100(2)225-32(2009 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results suggest that ANA is a suppressor of ectopic bone formation induced by bone morphogenetic proteins, and this inhibitory ANA activity is a part of the negative feedback regulation of BMP function.
Title: ANA deficiency enhances bone morphogenetic protein-induced ectopic bone formation via transcriptional events.

Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma.
Title: Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma.

The following Btg3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Btg3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04805	NM_001297747.1 Latest version!	Mus musculus BTG anti-proliferation factor 3 (Btg3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu04805	NM_009770.3 Latest version!	Mus musculus BTG anti-proliferation factor 3 (Btg3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Btg3 ( NM_001297747.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001284676.1 Mus musculus BTG anti-proliferation factor 3 (Btg3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu04805
Clone ID Related Accession (Same CDS sequence)	NM_001297747.1 , NM_009770.3
Accession Version	NM_001297747.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 759bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Mus musculus(house mouse)
Product	protein BTG3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC130844.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAACG AAATTGCGGC TGTTGTCTTC TTTTTCACAA GGCTAGTTCG AAAGCATGAC 
AAGTTGAAAA AAGAAGCAGT TGAGAGGTTT GCTGAGAAAT TAACTCAAAT ACTTCAAGAG 
AAATATAAAA ATCACTGGTA TCCAGAAAAA CCATCCAAAG GTCAGGCCTA CAGATGCATT 
CGTGTCAATA AGTTTCAGAG AGTTGATCCC GATGTCCTGA AAGCCTGTGA GAACAGCTGC 
ATCTTGTACA GCGACCTGGG CTTGCCTAAG GAGCTTACAC TCTGGGTGGA TCCGTGTGAG 
GTGTGCTGCC GGTATGGAGA GAAAAACAAT GCGTTCATTG TTGCCAGCTT TGAAAATGAG 
GACGAGAACA AGGATGAAAT CTCCAAGAAA GTTAGCAGGG CTCTGGATAA GGTGACCTCT 
GATTATCACT CAGGGTCCTC TTCCTCAGAT GAAGACACAA GCAAGGAAGT GGACGTGAAA 
CCCAGCTCAG TGGCGGCAAC ACCAAGCCCC GTGTACCAGA TTTCAGAACT GATATTCCCA 
CCTCTTCCAA TGTGGCACCC TTTGCCCAGA AAAAAGCCAG GAATGTATCG AGGGAGCGGC 
CATCAGACTC ACTACCCTCC TCCTGTTCCA TTTGCTTATC CAAATCCAGG AAGGAAGAAT 
AAACCATTCC GCCCAATTCC AGTGACATGG GTACCTCCTC CTGGAATGCA TTGTGACCGA 
AATCACTGGA TTAATCCTCA CATGTTAGCA CCTCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001284676.1
CDS	21..779
Translation	MKNEIAAVVFFFTRLVRKHDKLKKEAVERFAEKLTQILQEKYKNHWYPEKPSKGQAYRCIRVNKFQRVDPDVLKACENSCILYSDLGLPKELTLWVDPCEVCCRYGEKNNAFIVASFENEDENKDEISKKVSRALDKVTSDYHSGSSSSDEDTSKEVDVKPSSVAATPSPVYQISELIFPPLPMWHPLPRKKPGMYRGSGHQTHYPPPVPFAYPNPGRKNKPFRPIPVTWVPPPGMHCDRNHWINPHMLAPH

Target ORF information:

RefSeq Version	NM_001297747.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus BTG anti-proliferation factor 3 (Btg3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001297747.1

ORF Insert Sequence:

ATGAAGAACG AAATTGCGGC TGTTGTCTTC TTTTTCACAA GGCTAGTTCG AAAGCATGAC 
AAGTTGAAAA AAGAAGCAGT TGAGAGGTTT GCTGAGAAAT TAACTCAAAT ACTTCAAGAG 
AAATATAAAA ATCACTGGTA TCCAGAAAAA CCATCCAAAG GTCAGGCCTA CAGATGCATT 
CGTGTCAATA AGTTTCAGAG AGTTGATCCC GATGTCCTGA AAGCCTGTGA GAACAGCTGC 
ATCTTGTACA GCGACCTGGG CTTGCCTAAG GAGCTTACAC TCTGGGTGGA TCCGTGTGAG 
GTGTGCTGCC GGTATGGAGA GAAAAACAAT GCGTTCATTG TTGCCAGCTT TGAAAATGAG 
GACGAGAACA AGGATGAAAT CTCCAAGAAA GTTAGCAGGG CTCTGGATAA GGTGACCTCT 
GATTATCACT CAGGGTCCTC TTCCTCAGAT GAAGACACAA GCAAGGAAGT GGACGTGAAA 
CCCAGCTCAG TGGCGGCAAC ACCAAGCCCC GTGTACCAGA TTTCAGAACT GATATTCCCA 
CCTCTTCCAA TGTGGCACCC TTTGCCCAGA AAAAAGCCAG GAATGTATCG AGGGAGCGGC 
CATCAGACTC ACTACCCTCC TCCTGTTCCA TTTGCTTATC CAAATCCAGG AAGGAAGAAT 
AAACCATTCC GCCCAATTCC AGTGACATGG GTACCTCCTC CTGGAATGCA TTGTGACCGA 
AATCACTGGA TTAATCCTCA CATGTTAGCA CCTCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Btg3 ( NM_009770.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033900.1 Mus musculus BTG anti-proliferation factor 3 (Btg3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu04805
Clone ID Related Accession (Same CDS sequence)	NM_001297747.1 , NM_009770.3
Accession Version	NM_009770.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 759bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	protein BTG3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CK623612.1, AK144415.1 and AC130844.3. On Jul 10, 2014 this sequence version replaced NM_009770.2. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAACG AAATTGCGGC TGTTGTCTTC TTTTTCACAA GGCTAGTTCG AAAGCATGAC 
AAGTTGAAAA AAGAAGCAGT TGAGAGGTTT GCTGAGAAAT TAACTCAAAT ACTTCAAGAG 
AAATATAAAA ATCACTGGTA TCCAGAAAAA CCATCCAAAG GTCAGGCCTA CAGATGCATT 
CGTGTCAATA AGTTTCAGAG AGTTGATCCC GATGTCCTGA AAGCCTGTGA GAACAGCTGC 
ATCTTGTACA GCGACCTGGG CTTGCCTAAG GAGCTTACAC TCTGGGTGGA TCCGTGTGAG 
GTGTGCTGCC GGTATGGAGA GAAAAACAAT GCGTTCATTG TTGCCAGCTT TGAAAATGAG 
GACGAGAACA AGGATGAAAT CTCCAAGAAA GTTAGCAGGG CTCTGGATAA GGTGACCTCT 
GATTATCACT CAGGGTCCTC TTCCTCAGAT GAAGACACAA GCAAGGAAGT GGACGTGAAA 
CCCAGCTCAG TGGCGGCAAC ACCAAGCCCC GTGTACCAGA TTTCAGAACT GATATTCCCA 
CCTCTTCCAA TGTGGCACCC TTTGCCCAGA AAAAAGCCAG GAATGTATCG AGGGAGCGGC 
CATCAGACTC ACTACCCTCC TCCTGTTCCA TTTGCTTATC CAAATCCAGG AAGGAAGAAT 
AAACCATTCC GCCCAATTCC AGTGACATGG GTACCTCCTC CTGGAATGCA TTGTGACCGA 
AATCACTGGA TTAATCCTCA CATGTTAGCA CCTCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033900.1
CDS	217..975
Translation	MKNEIAAVVFFFTRLVRKHDKLKKEAVERFAEKLTQILQEKYKNHWYPEKPSKGQAYRCIRVNKFQRVDPDVLKACENSCILYSDLGLPKELTLWVDPCEVCCRYGEKNNAFIVASFENEDENKDEISKKVSRALDKVTSDYHSGSSSSDEDTSKEVDVKPSSVAATPSPVYQISELIFPPLPMWHPLPRKKPGMYRGSGHQTHYPPPVPFAYPNPGRKNKPFRPIPVTWVPPPGMHCDRNHWINPHMLAPH

Target ORF information:

RefSeq Version	NM_009770.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus BTG anti-proliferation factor 3 (Btg3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009770.3

ORF Insert Sequence:

ATGAAGAACG AAATTGCGGC TGTTGTCTTC TTTTTCACAA GGCTAGTTCG AAAGCATGAC 
AAGTTGAAAA AAGAAGCAGT TGAGAGGTTT GCTGAGAAAT TAACTCAAAT ACTTCAAGAG 
AAATATAAAA ATCACTGGTA TCCAGAAAAA CCATCCAAAG GTCAGGCCTA CAGATGCATT 
CGTGTCAATA AGTTTCAGAG AGTTGATCCC GATGTCCTGA AAGCCTGTGA GAACAGCTGC 
ATCTTGTACA GCGACCTGGG CTTGCCTAAG GAGCTTACAC TCTGGGTGGA TCCGTGTGAG 
GTGTGCTGCC GGTATGGAGA GAAAAACAAT GCGTTCATTG TTGCCAGCTT TGAAAATGAG 
GACGAGAACA AGGATGAAAT CTCCAAGAAA GTTAGCAGGG CTCTGGATAA GGTGACCTCT 
GATTATCACT CAGGGTCCTC TTCCTCAGAT GAAGACACAA GCAAGGAAGT GGACGTGAAA 
CCCAGCTCAG TGGCGGCAAC ACCAAGCCCC GTGTACCAGA TTTCAGAACT GATATTCCCA 
CCTCTTCCAA TGTGGCACCC TTTGCCCAGA AAAAAGCCAG GAATGTATCG AGGGAGCGGC 
CATCAGACTC ACTACCCTCC TCCTGTTCCA TTTGCTTATC CAAATCCAGG AAGGAAGAAT 
AAACCATTCC GCCCAATTCC AGTGACATGG GTACCTCCTC CTGGAATGCA TTGTGACCGA 
AATCACTGGA TTAATCCTCA CATGTTAGCA CCTCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Integration of H-2Z1, a somatosensory cortex-expressed transgene, interferes with the expression of the Satb1 and Tbc1d5 flanking genes and affects the differentiation of a subset of cortical interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience32(21)7287-300(2012 May)
Narboux-N?me N,Go?ame R,Matt?i MG,Cohen-Tannoudji M,Wassef M

Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala.
The Journal of comparative neurology519(11)2061-89(2011 Aug)
Boyle MP,Bernard A,Thompson CL,Ng L,Boe A,Mortrud M,Hawrylycz MJ,Jones AR,Hevner RF,Lein ES

The mammalian anti-proliferative BTG/Tob protein family.
Journal of cellular physiology222(1)66-72(2010 Jan)
Winkler GS

ANA deficiency enhances bone morphogenetic protein-induced ectopic bone formation via transcriptional events.
The Journal of biological chemistry284(16)10593-600(2009 Apr)
Miyai K,Yoneda M,Hasegawa U,Toita S,Izu Y,Hemmi H,Hayata T,Ezura Y,Mizutani S,Miyazono K,Akiyoshi K,Yamamoto T,Noda M

Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma.
Cancer science100(2)225-32(2009 Feb)
Yoneda M,Suzuki T,Nakamura T,Ajima R,Yoshida Y,Kakuta S,Katsuko S,Iwakura Y,Shibutani M,Mitsumori K,Yokota J,Yamamoto T

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Btg3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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