Bche cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bche
Entrez Gene ID	12038
Full Name	butyrylcholinesterase
Synonyms	C730038G20Rik
General protein information	Preferred Names butyrylcholinesterase Names cholinesterase acylcholine acylhydrolase butyrylcholine esterase choline esterase II pseudocholinesterase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 E3

mRNA and Protein(s)

mRNA	Protein	Name
XM_011240000.2	XP_011238302.1	cholinesterase isoform X1
NM_009738.3	NP_033868.3	cholinesterase precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	BCHE	XP_516857.2
	BCHE	XP_002808379.1
Bos taurus (cattle)	BCHE	NP_001070374.1
Neurospora crassa	NCU06573	XP_961743.2
Xenopus tropicalis (tropical clawed frog)	LOC100495889	XP_002931610.1
Rattus norvegicus (Norway rat)	Bche	NP_075231.1
Canis lupus familiaris (dog)	BCHE	XP_545267.2
Mus musculus (house mouse)	Bche	NP_033868.3
Homo sapiens (human)	BCHE	NP_000046.1
Gallus gallus (chicken)	BCHE	NP_989977.1
Magnaporthe oryzae (rice blast fungus)	MGG_15094	XP_003715640.1

Gene Ontology
Bibliography

Related articles in PubMed

Endochondral Ossification Is Accelerated in Cholinesterase-Deficient Mice and in Avian Mesenchymal Micromass Cultures.
Spieker J, Mudersbach T, Vogel-H?pker A, Layer PG
PloS one12(1)e0170252(2017)

Reduced fibrillar ?-amyloid in subcortical structures in a butyrylcholinesterase-knockout Alzheimer disease mouse model.
Darvesh S, Reid GA
Chemico-biological interactions259(Pt B)307-312(2016 Nov)

Butyrylcholinesterase Deficiency Promotes Adipose Tissue Growth and Hepatic Lipid Accumulation in Male Mice on High-Fat Diet.
Chen VP, Gao Y, Geng L, Stout MB, Jensen MD, Brimijoin S
Endocrinology157(8)3086-95(2016 Aug)

Learning performances and vulnerability to amyloid toxicity in the butyrylcholinesterase knockout mouse.
Maurice T, Strehaiano M, Sim?on N, Bertrand C, Chatonnet A
Behavioural brain research296351-360(2016 Jan)

Bone status of adult female butyrylcholinesterase gene-deficient mice.
Haupt M, Kauschke V, Sender J, Kampschulte M, Kovtun A, D?rselen L, Heiss C, Lips KS
International immunopharmacology29(1)208-14(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the absence of BChE leads to diminished fibrillar Abeta deposition in amygdala, hippocampal formation, thalamus and basal ganglia.
Title: Reduced fibrillar ?-amyloid in subcortical structures in a butyrylcholinesterase-knockout Alzheimer disease mouse model.

BChE strongly affects fat metabolism, has an important impact on fat accumulation and may be a promising tool for combating obesity.
Title: Butyrylcholinesterase Deficiency Promotes Adipose Tissue Growth and Hepatic Lipid Accumulation in Male Mice on High-Fat Diet.

It was concluded that in adult murine bone the role of BChE is limited to bone specific changes in microarchitecture and to an increase in relative number of bone resorbing osteoclasts.
Title: Bone status of adult female butyrylcholinesterase gene-deficient mice.

Mice that had undergone gene transfer with mouse CocH (mCocH) showed no place preference or aversion after repeated treatments with a near-lethal 80 mg/kg cocaine dose.
Title: Reward and Toxicity of Cocaine Metabolites Generated by Cocaine Hydrolase.

we conclude that toxoplasmosis reduces BChE activity in mice, and this alteration is probably related to the liver damage caused by the parasitism
Title: Relationship between butyrylcholinesterase activity and liver injury in mice acute infected with Toxoplasma gondii.

The following Bche gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bche cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04749	NM_009738.3 Latest version!	Mus musculus butyrylcholinesterase (Bche), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$349.30 $499.00
OMu67197	XM_011240000.2 Latest version!	Mus musculus butyrylcholinesterase (Bche), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bche ( NM_009738.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033868.3 Mus musculus butyrylcholinesterase (Bche), mRNA.

Price & Availability↑

CloneID	OMu04749
Clone ID Related Accession (Same CDS sequence)	NM_009738.3
Accession Version	NM_009738.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1812bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	cholinesterase precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK050337.1, CK636839.1 and AC102340.10. On Feb 6, 2007 this sequence version replaced NM_009738.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC099977.1, AK050337.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGACTC AGCATACCAA GGTAACACAG ACCCACTTCC TCCTATGGAT TCTTCTGCTC 
TGCATGCCTT TTGGGAAGTC ACACACTGAA GAAGACTTCA TAATTACAAC CAAGACCGGA 
AGGGTCCGAG GGCTGAGCAT GCCAGTTCTT GGTGGCACGG TGACTGCCTT TCTCGGTATC 
CCCTATGCAC AACCTCCTCT GGGTAGCCTA AGATTCAAAA AGCCGCAACC CTTAAACAAA 
TGGCCTGACA TCCATAATGC CACTCAATAT GCAAATTCTT GTTATCAGAA CATAGACCAA 
GCCTTCCCAG GCTTCCAGGG GTCAGAAATG TGGAATCCAA ACACAAACCT CAGTGAAGAC 
TGCTTGTATC TGAATGTTTG GATTCCAGTA CCGAAGCCTA AAAATGCCAC TGTCATGGTA 
TGGATCTATG GTGGTGGCTT TCAAACTGGG ACCTCTTCTC TACCTGTTTA CGATGGGAAG 
TTTCTAGCTC GTGTTGAAAG AGTTATTGTA GTTTCGATGA ACTATAGGGT AGGTGCTCTA 
GGATTCCTAG CTTTTCCCGG AAATCCCGAT GCTCCAGGAA ACATGGGTTT ATTTGATCAA 
CAGTTGGCAC TTCAATGGGT CCAAAGAAAT ATAGCTGCTT TTGGAGGGAA TCCTAAAAGT 
ATAACGATTT TTGGAGAAAG TGCAGGGGCA GCTTCAGTTA GCTTACATTT GCTCTGCCCC 
CAAAGTTATC CTTTGTTTAC CAGAGCCATT CTTGAAAGTG GCTCCTCTAA TGCCCCCTGG 
GCAGTAAAGC ATCCTGAGGA AGCCAGAAAC AGAACCTTGA CCTTAGCTAA ATTTACTGGT 
TGCTCAAAGG AAAATGAGAT GGAGATGATT AAATGCCTTC GAAGTAAAGA TCCTCAGGAA 
ATTCTTCGCA ATGAAAGGTT CGTTCTCCCC TCTGATTCCA TCTTATCCAT AAATTTTGGT 
CCAACAGTGG ATGGCGATTT TCTCACCGAT ATGCCCCACA CACTACTCCA ACTAGGAAAA 
GTGAAAAAAG CTCAGATCTT AGTGGGAGTT AACAAAGATG AAGGGACAGC TTTCCTAGTG 
TACGGTGCTC CGGGTTTCAG CAAAGACAAT GATAGCCTTA TCACAAGGAA GGAATTTCAA 
GAAGGTTTAA ATATGTATTT CCCTGGAGTG AGCAGATTGG GCAAGGAAGC AGTTCTTTTC 
TACTACGTGG ACTGGTTAGG TGAGCAGTCA CCAGAAGTCT ACCGTGACGC TTTGGATGAT 
GTTATTGGAG ATTACAACAT CATCTGCCCT GCACTGGAGT TTACCAAGAA ATTTGCAGAG 
CTTGAAAACA ATGCTTTTTT CTACTTTTTC GAACATCGAT CTTCCAAACT ACCTTGGCCG 
GAATGGATGG GAGTGATGCA TGGCTATGAA ATTGAATTTG TGTTTGGCTT ACCTCTGGGA 
AGAAGAGTTA ATTATACGAG AGCTGAGGAA ATCTTTAGTC GATCCATAAT GAAAACTTGG 
GCAAATTTTG CAAAATATGG ACATCCCAAT GGGACCCAGG GCAATAGCAC AATGTGGCCT 
GTCTTCACAA GTACTGAACA AAAATACCTA ACATTGAACA CAGAGAAGTC AAAAATATAC 
TCTAAACTTC GTGCTCCCCA ATGTCAGTTC TGGAGACTAT TTTTTCCAAA AGTCTTGGAA 
ATGACAGGAG ATATTGATGA AACGGAGCAA GAGTGGAAGG CAGGATTTCA TCGCTGGAGC 
AATTACATGA TGGACTGGCA AAATCAATTT AACGATTACA CTAGCAAGAA AGAGAGCTGT 
ACAGCTCTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033868.3
CDS	290..2101
Translation	MQTQHTKVTQTHFLLWILLLCMPFGKSHTEEDFIITTKTGRVRGLSMPVLGGTVTAFLGIPYAQPPLGSLRFKKPQPLNKWPDIHNATQYANSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYLNVWIPVPKPKNATVMVWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLAFPGNPDAPGNMGLFDQQLALQWVQRNIAAFGGNPKSITIFGESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNRTLTLAKFTGCSKENEMEMIKCLRSKDPQEILRNERFVLPSDSILSINFGPTVDGDFLTDMPHTLLQLGKVKKAQILVGVNKDEGTAFLVYGAPGFSKDNDSLITRKEFQEGLNMYFPGVSRLGKEAVLFYYVDWLGEQSPEVYRDALDDVIGDYNIICPALEFTKKFAELENNAFFYFFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLGRRVNYTRAEEIFSRSIMKTWANFAKYGHPNGTQGNSTMWPVFTSTEQKYLTLNTEKSKIYSKLRAPQCQFWRLFFPKVLEMTGDIDETEQEWKAGFHRWSNYMMDWQNQFNDYTSKKESCTAL

Target ORF information:

RefSeq Version	NM_009738.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus butyrylcholinesterase (Bche), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009738.3

ORF Insert Sequence:

ATGCAGACTC AGCATACCAA GGTAACACAG ACCCACTTCC TCCTATGGAT TCTTCTGCTC 
TGCATGCCTT TTGGGAAGTC ACACACTGAA GAAGACTTCA TAATTACAAC CAAGACCGGA 
AGGGTCCGAG GGCTGAGCAT GCCAGTTCTT GGTGGCACGG TGACTGCCTT TCTCGGTATC 
CCCTATGCAC AACCTCCTCT GGGTAGCCTA AGATTCAAAA AGCCGCAACC CTTAAACAAA 
TGGCCTGACA TCCATAATGC CACTCAATAT GCAAATTCTT GTTATCAGAA CATAGACCAA 
GCCTTCCCAG GCTTCCAGGG GTCAGAAATG TGGAATCCAA ACACAAACCT CAGTGAAGAC 
TGCTTGTATC TGAATGTTTG GATTCCAGTA CCGAAGCCTA AAAATGCCAC TGTCATGGTA 
TGGATCTATG GTGGTGGCTT TCAAACTGGG ACCTCTTCTC TACCTGTTTA CGATGGGAAG 
TTTCTAGCTC GTGTTGAAAG AGTTATTGTA GTTTCGATGA ACTATAGGGT AGGTGCTCTA 
GGATTCCTAG CTTTTCCCGG AAATCCCGAT GCTCCAGGAA ACATGGGTTT ATTTGATCAA 
CAGTTGGCAC TTCAATGGGT CCAAAGAAAT ATAGCTGCTT TTGGAGGGAA TCCTAAAAGT 
ATAACGATTT TTGGAGAAAG TGCAGGGGCA GCTTCAGTTA GCTTACATTT GCTCTGCCCC 
CAAAGTTATC CTTTGTTTAC CAGAGCCATT CTTGAAAGTG GCTCCTCTAA TGCCCCCTGG 
GCAGTAAAGC ATCCTGAGGA AGCCAGAAAC AGAACCTTGA CCTTAGCTAA ATTTACTGGT 
TGCTCAAAGG AAAATGAGAT GGAGATGATT AAATGCCTTC GAAGTAAAGA TCCTCAGGAA 
ATTCTTCGCA ATGAAAGGTT CGTTCTCCCC TCTGATTCCA TCTTATCCAT AAATTTTGGT 
CCAACAGTGG ATGGCGATTT TCTCACCGAT ATGCCCCACA CACTACTCCA ACTAGGAAAA 
GTGAAAAAAG CTCAGATCTT AGTGGGAGTT AACAAAGATG AAGGGACAGC TTTCCTAGTG 
TACGGTGCTC CGGGTTTCAG CAAAGACAAT GATAGCCTTA TCACAAGGAA GGAATTTCAA 
GAAGGTTTAA ATATGTATTT CCCTGGAGTG AGCAGATTGG GCAAGGAAGC AGTTCTTTTC 
TACTACGTGG ACTGGTTAGG TGAGCAGTCA CCAGAAGTCT ACCGTGACGC TTTGGATGAT 
GTTATTGGAG ATTACAACAT CATCTGCCCT GCACTGGAGT TTACCAAGAA ATTTGCAGAG 
CTTGAAAACA ATGCTTTTTT CTACTTTTTC GAACATCGAT CTTCCAAACT ACCTTGGCCG 
GAATGGATGG GAGTGATGCA TGGCTATGAA ATTGAATTTG TGTTTGGCTT ACCTCTGGGA 
AGAAGAGTTA ATTATACGAG AGCTGAGGAA ATCTTTAGTC GATCCATAAT GAAAACTTGG 
GCAAATTTTG CAAAATATGG ACATCCCAAT GGGACCCAGG GCAATAGCAC AATGTGGCCT 
GTCTTCACAA GTACTGAACA AAAATACCTA ACATTGAACA CAGAGAAGTC AAAAATATAC 
TCTAAACTTC GTGCTCCCCA ATGTCAGTTC TGGAGACTAT TTTTTCCAAA AGTCTTGGAA 
ATGACAGGAG ATATTGATGA AACGGAGCAA GAGTGGAAGG CAGGATTTCA TCGCTGGAGC 
AATTACATGA TGGACTGGCA AAATCAATTT AACGATTACA CTAGCAAGAA AGAGAGCTGT 
ACAGCTCTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bche ( XM_011240000.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011238302.1 Mus musculus butyrylcholinesterase (Bche), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu67197
Clone ID Related Accession (Same CDS sequence)	XM_011240000.2
Accession Version	XM_011240000.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1848bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	cholinesterase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011240000.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGCCCAT CCAAGCAGCC TGTTCAAGAA ATCAACATGC AGACTCAGCA TACCAAGGTA 
ACACAGACCC ACTTCCTCCT ATGGATTCTT CTGCTCTGCA TGCCTTTTGG GAAGTCACAC 
ACTGAAGAAG ACTTCATAAT TACAACCAAG ACCGGAAGGG TCCGAGGGCT GAGCATGCCA 
GTTCTTGGTG GCACGGTGAC TGCCTTTCTC GGTATCCCCT ATGCACAACC TCCTCTGGGT 
AGCCTAAGAT TCAAAAAGCC GCAACCCTTA AACAAATGGC CTGACATCCA TAATGCCACT 
CAATATGCAA ATTCTTGTTA TCAGAACATA GACCAAGCCT TCCCAGGCTT CCAGGGGTCA 
GAAATGTGGA ATCCAAACAC AAACCTCAGT GAAGACTGCT TGTATCTGAA TGTTTGGATT 
CCAGTACCGA AGCCTAAAAA TGCCACTGTC ATGGTATGGA TCTATGGTGG TGGCTTTCAA 
ACTGGGACCT CTTCTCTACC TGTTTACGAT GGGAAGTTTC TAGCTCGTGT TGAAAGAGTT 
ATTGTAGTTT CGATGAACTA TAGGGTAGGT GCTCTAGGAT TCCTAGCTTT TCCCGGAAAT 
CCCGATGCTC CAGGAAACAT GGGTTTATTT GATCAACAGT TGGCACTTCA ATGGGTCCAA 
AGAAATATAG CTGCTTTTGG AGGGAATCCT AAAAGTATAA CGATTTTTGG AGAAAGTGCA 
GGGGCAGCTT CAGTTAGCTT ACATTTGCTC TGCCCCCAAA GTTATCCTTT GTTTACCAGA 
GCCATTCTTG AAAGTGGCTC CTCTAATGCC CCCTGGGCAG TAAAGCATCC TGAGGAAGCC 
AGAAACAGAA CCTTGACCTT AGCTAAATTT ACTGGTTGCT CAAAGGAAAA TGAGATGGAG 
ATGATTAAAT GCCTTCGAAG TAAAGATCCT CAGGAAATTC TTCGCAATGA AAGGTTCGTT 
CTCCCCTCTG ATTCCATCTT ATCCATAAAT TTTGGTCCAA CAGTGGATGG CGATTTTCTC 
ACCGATATGC CCCACACACT ACTCCAACTA GGAAAAGTGA AAAAAGCTCA GATCTTAGTG 
GGAGTTAACA AAGATGAAGG GACAGCTTTC CTAGTGTACG GTGCTCCGGG TTTCAGCAAA 
GACAATGATA GCCTTATCAC AAGGAAGGAA TTTCAAGAAG GTTTAAATAT GTATTTCCCT 
GGAGTGAGCA GATTGGGCAA GGAAGCAGTT CTTTTCTACT ACGTGGACTG GTTAGGTGAG 
CAGTCACCAG AAGTCTACCG TGACGCTTTG GATGATGTTA TTGGAGATTA CAACATCATC 
TGCCCTGCAC TGGAGTTTAC CAAGAAATTT GCAGAGCTTG AAAACAATGC TTTTTTCTAC 
TTTTTCGAAC ATCGATCTTC CAAACTACCT TGGCCGGAAT GGATGGGAGT GATGCATGGC 
TATGAAATTG AATTTGTGTT TGGCTTACCT CTGGGAAGAA GAGTTAATTA TACGAGAGCT 
GAGGAAATCT TTAGTCGATC CATAATGAAA ACTTGGGCAA ATTTTGCAAA ATATGGACAT 
CCCAATGGGA CCCAGGGCAA TAGCACAATG TGGCCTGTCT TCACAAGTAC TGAACAAAAA 
TACCTAACAT TGAACACAGA GAAGTCAAAA ATATACTCTA AACTTCGTGC TCCCCAATGT 
CAGTTCTGGA GACTATTTTT TCCAAAAGTC TTGGAAATGA CAGGAGATAT TGATGAAACG 
GAGCAAGAGT GGAAGGCAGG ATTTCATCGC TGGAGCAATT ACATGATGGA CTGGCAAAAT 
CAATTTAACG ATTACACTAG CAAGAAAGAG AGCTGTACAG CTCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011238302.1
CDS	331..2178
Translation	MCPSKQPVQEINMQTQHTKVTQTHFLLWILLLCMPFGKSHTEEDFIITTKTGRVRGLSMPVLGGTVTAFLGIPYAQPPLGSLRFKKPQPLNKWPDIHNATQYANSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYLNVWIPVPKPKNATVMVWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLAFPGNPDAPGNMGLFDQQLALQWVQRNIAAFGGNPKSITIFGESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNRTLTLAKFTGCSKENEMEMIKCLRSKDPQEILRNERFVLPSDSILSINFGPTVDGDFLTDMPHTLLQLGKVKKAQILVGVNKDEGTAFLVYGAPGFSKDNDSLITRKEFQEGLNMYFPGVSRLGKEAVLFYYVDWLGEQSPEVYRDALDDVIGDYNIICPALEFTKKFAELENNAFFYFFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLGRRVNYTRAEEIFSRSIMKTWANFAKYGHPNGTQGNSTMWPVFTSTEQKYLTLNTEKSKIYSKLRAPQCQFWRLFFPKVLEMTGDIDETEQEWKAGFHRWSNYMMDWQNQFNDYTSKKESCTAL

Target ORF information:

RefSeq Version	XM_011240000.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus butyrylcholinesterase (Bche), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011240000.2

ORF Insert Sequence:

ATGTGCCCAT CCAAGCAGCC TGTTCAAGAA ATCAACATGC AGACTCAGCA TACCAAGGTA 
ACACAGACCC ACTTCCTCCT ATGGATTCTT CTGCTCTGCA TGCCTTTTGG GAAGTCACAC 
ACTGAAGAAG ACTTCATAAT TACAACCAAG ACCGGAAGGG TCCGAGGGCT GAGCATGCCA 
GTTCTTGGTG GCACGGTGAC TGCCTTTCTC GGTATCCCCT ATGCACAACC TCCTCTGGGT 
AGCCTAAGAT TCAAAAAGCC GCAACCCTTA AACAAATGGC CTGACATCCA TAATGCCACT 
CAATATGCAA ATTCTTGTTA TCAGAACATA GACCAAGCCT TCCCAGGCTT CCAGGGGTCA 
GAAATGTGGA ATCCAAACAC AAACCTCAGT GAAGACTGCT TGTATCTGAA TGTTTGGATT 
CCAGTACCGA AGCCTAAAAA TGCCACTGTC ATGGTATGGA TCTATGGTGG TGGCTTTCAA 
ACTGGGACCT CTTCTCTACC TGTTTACGAT GGGAAGTTTC TAGCTCGTGT TGAAAGAGTT 
ATTGTAGTTT CGATGAACTA TAGGGTAGGT GCTCTAGGAT TCCTAGCTTT TCCCGGAAAT 
CCCGATGCTC CAGGAAACAT GGGTTTATTT GATCAACAGT TGGCACTTCA ATGGGTCCAA 
AGAAATATAG CTGCTTTTGG AGGGAATCCT AAAAGTATAA CGATTTTTGG AGAAAGTGCA 
GGGGCAGCTT CAGTTAGCTT ACATTTGCTC TGCCCCCAAA GTTATCCTTT GTTTACCAGA 
GCCATTCTTG AAAGTGGCTC CTCTAATGCC CCCTGGGCAG TAAAGCATCC TGAGGAAGCC 
AGAAACAGAA CCTTGACCTT AGCTAAATTT ACTGGTTGCT CAAAGGAAAA TGAGATGGAG 
ATGATTAAAT GCCTTCGAAG TAAAGATCCT CAGGAAATTC TTCGCAATGA AAGGTTCGTT 
CTCCCCTCTG ATTCCATCTT ATCCATAAAT TTTGGTCCAA CAGTGGATGG CGATTTTCTC 
ACCGATATGC CCCACACACT ACTCCAACTA GGAAAAGTGA AAAAAGCTCA GATCTTAGTG 
GGAGTTAACA AAGATGAAGG GACAGCTTTC CTAGTGTACG GTGCTCCGGG TTTCAGCAAA 
GACAATGATA GCCTTATCAC AAGGAAGGAA TTTCAAGAAG GTTTAAATAT GTATTTCCCT 
GGAGTGAGCA GATTGGGCAA GGAAGCAGTT CTTTTCTACT ACGTGGACTG GTTAGGTGAG 
CAGTCACCAG AAGTCTACCG TGACGCTTTG GATGATGTTA TTGGAGATTA CAACATCATC 
TGCCCTGCAC TGGAGTTTAC CAAGAAATTT GCAGAGCTTG AAAACAATGC TTTTTTCTAC 
TTTTTCGAAC ATCGATCTTC CAAACTACCT TGGCCGGAAT GGATGGGAGT GATGCATGGC 
TATGAAATTG AATTTGTGTT TGGCTTACCT CTGGGAAGAA GAGTTAATTA TACGAGAGCT 
GAGGAAATCT TTAGTCGATC CATAATGAAA ACTTGGGCAA ATTTTGCAAA ATATGGACAT 
CCCAATGGGA CCCAGGGCAA TAGCACAATG TGGCCTGTCT TCACAAGTAC TGAACAAAAA 
TACCTAACAT TGAACACAGA GAAGTCAAAA ATATACTCTA AACTTCGTGC TCCCCAATGT 
CAGTTCTGGA GACTATTTTT TCCAAAAGTC TTGGAAATGA CAGGAGATAT TGATGAAACG 
GAGCAAGAGT GGAAGGCAGG ATTTCATCGC TGGAGCAATT ACATGATGGA CTGGCAAAAT 
CAATTTAACG ATTACACTAG CAAGAAAGAG AGCTGTACAG CTCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Endochondral Ossification Is Accelerated in Cholinesterase-Deficient Mice and in Avian Mesenchymal Micromass Cultures.
PloS one12(1)e0170252(2017)
Spieker J,Mudersbach T,Vogel-H?pker A,Layer PG

Reduced fibrillar ?-amyloid in subcortical structures in a butyrylcholinesterase-knockout Alzheimer disease mouse model.
Chemico-biological interactions259(Pt B)307-312(2016 Nov)
Darvesh S,Reid GA

Butyrylcholinesterase Deficiency Promotes Adipose Tissue Growth and Hepatic Lipid Accumulation in Male Mice on High-Fat Diet.
Endocrinology157(8)3086-95(2016 Aug)
Chen VP,Gao Y,Geng L,Stout MB,Jensen MD,Brimijoin S

Learning performances and vulnerability to amyloid toxicity in the butyrylcholinesterase knockout mouse.
Behavioural brain research296351-360(2016 Jan)
Maurice T,Strehaiano M,Sim?on N,Bertrand C,Chatonnet A

Bone status of adult female butyrylcholinesterase gene-deficient mice.
International immunopharmacology29(1)208-14(2015 Nov)
Haupt M,Kauschke V,Sender J,Kampschulte M,Kovtun A,D?rselen L,Heiss C,Lips KS

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Bche cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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