Aqp8 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Aqp8
Entrez Gene ID	11833
Full Name	aquaporin 8
Synonyms	AI255744,AQP-8
General protein information	Preferred Names aquaporin 8 Names aquaporin-8
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 67.42 cM\|7 F3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001109045.1	NP_001102515.1	aquaporin-8 isoform 2
NM_007474.2	NP_031500.1	aquaporin-8 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	AQP8	NP_001160.2
Danio rerio (zebrafish)	aqp8a.1	NP_001004661.1
Caenorhabditis elegans (roundworm)	aqp-4	NP_505512.3
Pan troglodytes (chimpanzee)	AQP8	XP_523487.2
	AQP8	XP_001099227.1
Bos taurus (cattle)	AQP8	NP_001193536.1
Mus musculus (house mouse)	Aqp8	NP_031500.1
Caenorhabditis elegans (roundworm)	aqp-5	NP_505691.2
Gallus gallus (chicken)	AQP8	XP_414866.2
Xenopus tropicalis (tropical clawed frog)	aqp8	NP_001107728.1
Canis lupus familiaris (dog)	AQP8	XP_850126.1
Caenorhabditis elegans (roundworm)	aqp-6	NP_001256246.1
Rattus norvegicus (Norway rat)	Aqp8	NP_062031.1

Gene Ontology
Bibliography

Related articles in PubMed

Growth deficits in cystic fibrosis mice begin in utero prior to IGF-1 reduction.
Darrah R, Bederman I, Vitko M, Valerio DM, Drumm ML, Hodges CA
PloS one12(4)e0175467(2017)

Epithelial Markers aSMA, Krt14, and Krt19 Unveil Elements of Murine Lacrimal Gland Morphogenesis and Maturation.
Kuony A, Michon F
Frontiers in physiology8739(2017)

AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells.
Bertolotti M, Farinelli G, Galli M, Aiuti A, Sitia R
Journal of leukocyte biology100(5)1071-1079(2016 11)

Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance.
Tanahashi H, Tian QB, Hara Y, Sakagami H, Endo S, Suzuki T
Scientific reports620241(2016 Feb)

Involvement of aquaporins in a mouse model of rotavirus diarrhea.
Cao M, Yang M, Ou Z, Li D, Geng L, Chen P, Chen H, Gong S
Virologica Sinica29(4)211-7(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

AQP8 silencing impairs H2O2 entry into I.29micro+ B lymphoma cells. AQP8 can act as an efficient H2O2 channel also in cells of the B lineage.
Title: AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells.

Rotavirus diarrhea is associated with the downregulation of AQP1, -4, and -8 expression.
Title: Involvement of aquaporins in a mouse model of rotavirus diarrhea.

AQP8 has a role in the formation of follicles and provided new insight into the molecular mechanisms of folliculogenesis.
Title: Occurrence of multi-oocyte follicles in aquaporin 8-deficient mice.

Data indicate selective expression of aquaporins 3 and 8 in primitive erythroblasts and aquaporins 1 and 9 in adult definitive erythroblasts.
Title: Ontogeny of erythroid gene expression.

we conclude that AQP8 deficiency increases the number of mature follicles by reducing the apoptosis of granulosa cells, thus increasing the fertility of female mice[aquaporin 8]
Title: Increased female fertility in aquaporin 8-deficient mice.

The following Aqp8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aqp8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17399	NM_007474.2 Latest version!	Mus musculus aquaporin 8 (Aqp8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu13008	NM_001109045.1 Latest version!	Mus musculus aquaporin 8 (Aqp8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Aqp8 ( NM_007474.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031500.1 Mus musculus aquaporin 8 (Aqp8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu17399
Clone ID Related Accession (Same CDS sequence)	NM_007474.2
Accession Version	NM_007474.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	aquaporin-8 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY713653.1, AF018952.1, AK146660.1 and AV374360.1. On Oct 3, 2007 this sequence version replaced NM_007474.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849378 [ECO:0000348] ##Evidence-Data-END##

ATGTCTGGGG AGCAGACACC AATGTGTAGT ATGGACCTAC CTGAGGTCAA GGTGAAGACC 
AGCATGGCTG GCAGATGCCG TGTGTTCTGG TATGAGCAAT ACGTACAACC ATGTATAGTG 
GAACTTGTGG GCTCCGCTCT CTTCATCTTC ATCGGATGTC TATCGGTCAT TGAGAATAGT 
CCGAATACTG GGCTCCTGCA GCCTGCCTTG GCTCATGGGC TGGCCTTGGG GCTCATCATT 
GCTACCTTGG GGAACATCAG CGGTGGACAC TTCAACCCTG CTGTGTCGCT GGCAGTCACA 
GTGATCGGAG GCCTCAAGAC CATGCTGCTA ATTCCCTATT GGATCTCCCA GCTATTTGGA 
GGGCTGATTG GGGCTGCCTT GGCTAAAGTG GTGAGTCCAG AGGAAAGATT CTGGAATGCA 
TCTGGGGCAG CCTTTGCCAT CGTCCAGGAG CAGGAGCAGG TGGCAGAAGC CCTGGGGATA 
GAGATCATTC TGACAATGCT GTTGGTATTG GCTGTGTGTA TGGGTGCTGT CAATGAGAAG 
ACAATGGGCC CTTTAGCCCC ATTCTCCATT GGCTTCTCTG TCATTGTGGA CATCCTGGCA 
GGTGGTAGCA TCTCTGGAGC CTGCATGAAC CCTGCTCGTG CCTTTGGACC TGCTGTGATG 
GCTGGCTACT GGGACTTCCA TTGGATCTAC TGGCTGGGCC CCCTCCTGGC TGGCCTCTTT 
GTAGGACTGC TCATTAGGCT CCTCATCGGA GATGAGAAAA CCCGCCTAAT TCTAAAGTCG 
AGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031500.1
CDS	154..939
Translation	MSGEQTPMCSMDLPEVKVKTSMAGRCRVFWYEQYVQPCIVELVGSALFIFIGCLSVIENSPNTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTVIGGLKTMLLIPYWISQLFGGLIGAALAKVVSPEERFWNASGAAFAIVQEQEQVAEALGIEIILTMLLVLAVCMGAVNEKTMGPLAPFSIGFSVIVDILAGGSISGACMNPARAFGPAVMAGYWDFHWIYWLGPLLAGLFVGLLIRLLIGDEKTRLILKSR

Target ORF information:

RefSeq Version	NM_007474.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus aquaporin 8 (Aqp8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007474.2

ORF Insert Sequence:

ATGTCTGGGG AGCAGACACC AATGTGTAGT ATGGACCTAC CTGAGGTCAA GGTGAAGACC 
AGCATGGCTG GCAGATGCCG TGTGTTCTGG TATGAGCAAT ACGTACAACC ATGTATAGTG 
GAACTTGTGG GCTCCGCTCT CTTCATCTTC ATCGGATGTC TATCGGTCAT TGAGAATAGT 
CCGAATACTG GGCTCCTGCA GCCTGCCTTG GCTCATGGGC TGGCCTTGGG GCTCATCATT 
GCTACCTTGG GGAACATCAG CGGTGGACAC TTCAACCCTG CTGTGTCGCT GGCAGTCACA 
GTGATCGGAG GCCTCAAGAC CATGCTGCTA ATTCCCTATT GGATCTCCCA GCTATTTGGA 
GGGCTGATTG GGGCTGCCTT GGCTAAAGTG GTGAGTCCAG AGGAAAGATT CTGGAATGCA 
TCTGGGGCAG CCTTTGCCAT CGTCCAGGAG CAGGAGCAGG TGGCAGAAGC CCTGGGGATA 
GAGATCATTC TGACAATGCT GTTGGTATTG GCTGTGTGTA TGGGTGCTGT CAATGAGAAG 
ACAATGGGCC CTTTAGCCCC ATTCTCCATT GGCTTCTCTG TCATTGTGGA CATCCTGGCA 
GGTGGTAGCA TCTCTGGAGC CTGCATGAAC CCTGCTCGTG CCTTTGGACC TGCTGTGATG 
GCTGGCTACT GGGACTTCCA TTGGATCTAC TGGCTGGGCC CCCTCCTGGC TGGCCTCTTT 
GTAGGACTGC TCATTAGGCT CCTCATCGGA GATGAGAAAA CCCGCCTAAT TCTAAAGTCG 
AGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Aqp8 ( NM_001109045.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001102515.1 Mus musculus aquaporin 8 (Aqp8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu13008
Clone ID Related Accession (Same CDS sequence)	NM_001109045.1
Accession Version	NM_001109045.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	aquaporin-8 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY713653.1, CF617211.1, AK146660.1 and AV374360.1. Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ948906.1, BQ932329.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGTCTGGGG AGACACCAAT GTGTAGTATG GACCTACCTG AGGTCAAGGT GAAGACCAGC 
ATGGCTGGCA GATGCCGTGT GTTCTGGTAT GAGCAATACG TACAACCATG TATAGTGGAA 
CTTGTGGGCT CCGCTCTCTT CATCTTCATC GGATGTCTAT CGGTCATTGA GAATAGTCCG 
AATACTGGGC TCCTGCAGCC TGCCTTGGCT CATGGGCTGG CCTTGGGGCT CATCATTGCT 
ACCTTGGGGA ACATCAGCGG TGGACACTTC AACCCTGCTG TGTCGCTGGC AGTCACAGTG 
ATCGGAGGCC TCAAGACCAT GCTGCTAATT CCCTATTGGA TCTCCCAGCT ATTTGGAGGG 
CTGATTGGGG CTGCCTTGGC TAAAGTGGTG AGTCCAGAGG AAAGATTCTG GAATGCATCT 
GGGGCAGCCT TTGCCATCGT CCAGGAGCAG GAGCAGGTGG CAGAAGCCCT GGGGATAGAG 
ATCATTCTGA CAATGCTGTT GGTATTGGCT GTGTGTATGG GTGCTGTCAA TGAGAAGACA 
ATGGGCCCTT TAGCCCCATT CTCCATTGGC TTCTCTGTCA TTGTGGACAT CCTGGCAGGT 
GGTAGCATCT CTGGAGCCTG CATGAACCCT GCTCGTGCCT TTGGACCTGC TGTGATGGCT 
GGCTACTGGG ACTTCCATTG GATCTACTGG CTGGGCCCCC TCCTGGCTGG CCTCTTTGTA 
GGACTGCTCA TTAGGCTCCT CATCGGAGAT GAGAAAACCC GCCTAATTCT AAAGTCGAGG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102515.1
CDS	154..936
Translation	MSGETPMCSMDLPEVKVKTSMAGRCRVFWYEQYVQPCIVELVGSALFIFIGCLSVIENSPNTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTVIGGLKTMLLIPYWISQLFGGLIGAALAKVVSPEERFWNASGAAFAIVQEQEQVAEALGIEIILTMLLVLAVCMGAVNEKTMGPLAPFSIGFSVIVDILAGGSISGACMNPARAFGPAVMAGYWDFHWIYWLGPLLAGLFVGLLIRLLIGDEKTRLILKSR

Target ORF information:

RefSeq Version	NM_001109045.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus aquaporin 8 (Aqp8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001109045.1

ORF Insert Sequence:

ATGTCTGGGG AGACACCAAT GTGTAGTATG GACCTACCTG AGGTCAAGGT GAAGACCAGC 
ATGGCTGGCA GATGCCGTGT GTTCTGGTAT GAGCAATACG TACAACCATG TATAGTGGAA 
CTTGTGGGCT CCGCTCTCTT CATCTTCATC GGATGTCTAT CGGTCATTGA GAATAGTCCG 
AATACTGGGC TCCTGCAGCC TGCCTTGGCT CATGGGCTGG CCTTGGGGCT CATCATTGCT 
ACCTTGGGGA ACATCAGCGG TGGACACTTC AACCCTGCTG TGTCGCTGGC AGTCACAGTG 
ATCGGAGGCC TCAAGACCAT GCTGCTAATT CCCTATTGGA TCTCCCAGCT ATTTGGAGGG 
CTGATTGGGG CTGCCTTGGC TAAAGTGGTG AGTCCAGAGG AAAGATTCTG GAATGCATCT 
GGGGCAGCCT TTGCCATCGT CCAGGAGCAG GAGCAGGTGG CAGAAGCCCT GGGGATAGAG 
ATCATTCTGA CAATGCTGTT GGTATTGGCT GTGTGTATGG GTGCTGTCAA TGAGAAGACA 
ATGGGCCCTT TAGCCCCATT CTCCATTGGC TTCTCTGTCA TTGTGGACAT CCTGGCAGGT 
GGTAGCATCT CTGGAGCCTG CATGAACCCT GCTCGTGCCT TTGGACCTGC TGTGATGGCT 
GGCTACTGGG ACTTCCATTG GATCTACTGG CTGGGCCCCC TCCTGGCTGG CCTCTTTGTA 
GGACTGCTCA TTAGGCTCCT CATCGGAGAT GAGAAAACCC GCCTAATTCT AAAGTCGAGG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Growth deficits in cystic fibrosis mice begin in utero prior to IGF-1 reduction.
PloS one12(4)e0175467(2017)
Darrah R,Bederman I,Vitko M,Valerio DM,Drumm ML,Hodges CA

Epithelial Markers aSMA, Krt14, and Krt19 Unveil Elements of Murine Lacrimal Gland Morphogenesis and Maturation.
Frontiers in physiology8739(2017)
Kuony A,Michon F

AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells.
Journal of leukocyte biology100(5)1071-1079(2016 11)
Bertolotti M,Farinelli G,Galli M,Aiuti A,Sitia R

Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance.
Scientific reports620241(2016 Feb)
Tanahashi H,Tian QB,Hara Y,Sakagami H,Endo S,Suzuki T

Involvement of aquaporins in a mouse model of rotavirus diarrhea.
Virologica Sinica29(4)211-7(2014 Aug)
Cao M,Yang M,Ou Z,Li D,Geng L,Chen P,Chen H,Gong S

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Aqp8 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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