Apoa2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Apoa2
Entrez Gene ID	11807
Full Name	apolipoprotein A-II
Synonyms	Alp-2,Apo-AII,ApoA-II,ApoAII,Apoa-2,Hdl-1
General protein information	Preferred Names apolipoprotein A-II Names apolipoprotein A-II apolipoprotein A2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 H3\|1 79.22 cM
Summary	This gene encodes a component of high density lipoproteins (HDL). Mice lacking the encoded protein have low HDL-cholesterol levels, smaller HDL particles, increased clearance of triglyceride-rich lipoproteins and insulin hypersensitivity. Transgenic mice overexpressing the encoded protein have elevated levels of HDL-cholesterol and show increased susceptibility to atherosclerosis. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001305585.1	NP_001292514.1	apolipoprotein A-II preproprotein
NM_001305550.1	NP_001292479.1	apolipoprotein A-II preproprotein
NM_001305549.1	NP_001292478.1	apolipoprotein A-II preproprotein
NM_013474.2	NP_038502.2	apolipoprotein A-II preproprotein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Apoa2	NP_038502.2
Homo sapiens (human)	APOA2	NP_001634.1
Pan troglodytes (chimpanzee)	APOA2	NP_001008976.1
	APOA2	XP_001117975.1
Canis lupus familiaris (dog)	APOA2	XP_536139.3
Bos taurus (cattle)	APOA2	NP_001039381.1
Rattus norvegicus (Norway rat)	Apoa2	NP_037244.1

Gene Ontology
Bibliography

Related articles in PubMed

C57BL/6J mouse apolipoprotein A2 gene is deterministic for apnea.
Gillombardo CB, Darrah R, Dick TE, Moore M, Kong N, Decker MJ, Han F, Yamauchi M, Dutschmann M, Azzam S, Strohl KP
Respiratory physiology & neurobiology23588-94(2017 01)

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.
Janssen L, Dupont L, Bekhouche M, Noel A, Leduc C, Voz M, Peers B, Cataldo D, Apte SS, Dubail J, Colige A
Angiogenesis19(1)53-65(2016 Jan)

Spatiotemporal regulation of GLI target genes in the mammalian limb bud.
Lewandowski JP, Du F, Zhang S, Powell MB, Falkenstein KN, Ji H, Vokes SA
Developmental biology406(1)92-103(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study reports a deterministic role for the B6 apoa2 gene polymorphism in respiratory rhythmogenesis. The in vivo inheritance pattern discloses a recessive effect of the B6 allele on the apnea phenotype, as the presence of both B6 alleles in the brain is required for transcript and trait expression; in contrast, apoa2 mRNA expression in the liver requires only one allele.
Title: C57BL/6J mouse apolipoprotein A2 gene is deterministic for apnea.

Data show that reticulum (ER) stress responses differed among tissues with extracellular AApoAII amyloid fibril deposition.
Title: Extracellular deposition of mouse senile AApoAII amyloid fibrils induced different unfolded protein responses in the liver, kidney, and heart.

The C-terminal APOA2F peptide might inhibit further extension of amyloid fibrils by blocking the active ends of nuclei.
Title: C-terminal sequence of amyloid-resistant type F apolipoprotein A-II inhibits amyloid fibril formation of apolipoprotein A-II in mice.

In vivo, neither C57 nor FVB apoA-II protein levels are affected by the absence of apoE, while an apoE/apoA-I double deficiency results in a 50% decrease of plasma FVB apoA-II but results in undetectable levels of C57 apoA-II in the plasma.
Title: Polymorphisms of mouse apolipoprotein A-II alter its physical and functional nature.

ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosis.
Title: ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosis.

The following Apoa2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Apoa2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu15170	NM_013474.2 Latest version!	Mus musculus apolipoprotein A-II (Apoa2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu15170	NM_001305585.1 Latest version!	Mus musculus apolipoprotein A-II (Apoa2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu15170	NM_001305550.1 Latest version!	Mus musculus apolipoprotein A-II (Apoa2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu15170	NM_001305549.1 Latest version!	Mus musculus apolipoprotein A-II (Apoa2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Apoa2 ( NM_001305585.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001292514.1 Mus musculus apolipoprotein A-II (Apoa2), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OMu15170
Clone ID Related Accession (Same CDS sequence)	NM_001305585.1 , NM_001305550.1 , NM_001305549.1 , NM_013474.2
Accession Version	NM_001305585.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Mus musculus(house mouse)
Product	apolipoprotein A-II preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC084821.26 and BU609941.1. Transcript Variant: This variant (4) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU609941.1, BQ175011.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTGC TCGCAATGGT CGCACTGCTG GTCACCATCT GTAGCCTGGA AGGAGCTTTG 
GTTAAGAGAC AGGCAGACGG ACCGGATATG CAGAGCCTGT TCACTCAATA CTTTCAGAGC 
ATGACTGATT ATGGCAAAGA TTTGATGGAG AAGGCCAAGA CCTCAGAGAT TCAGAGCCAG 
GCCAAGGCAT ACTTTGAGAA GACACACGAG CAGCTGACAC CCCTTGTCAG GTCAGCAGGA 
ACTAGTCTGG TGAACTTCTT CAGCAGTTTA ATGAACCTTG AGGAGAAACC GGCTCCTGCG 
GCTAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001292514.1
CDS	444..752
Translation	MKLLAMVALLVTICSLEGALVKRQADGPDMQSLFTQYFQSMTDYGKDLMEKAKTSEIQSQAKAYFEKTHEQLTPLVRSAGTSLVNFFSSLMNLEEKPAPAAK

Target ORF information:

RefSeq Version	NM_001305585.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus apolipoprotein A-II (Apoa2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001305585.1

ORF Insert Sequence:

ATGAAGCTGC TCGCAATGGT CGCACTGCTG GTCACCATCT GTAGCCTGGA AGGAGCTTTG 
GTTAAGAGAC AGGCAGACGG ACCGGATATG CAGAGCCTGT TCACTCAATA CTTTCAGAGC 
ATGACTGATT ATGGCAAAGA TTTGATGGAG AAGGCCAAGA CCTCAGAGAT TCAGAGCCAG 
GCCAAGGCAT ACTTTGAGAA GACACACGAG CAGCTGACAC CCCTTGTCAG GTCAGCAGGA 
ACTAGTCTGG TGAACTTCTT CAGCAGTTTA ATGAACCTTG AGGAGAAACC GGCTCCTGCG 
GCTAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Apoa2 ( NM_001305550.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001292479.1 Mus musculus apolipoprotein A-II (Apoa2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu15170
Clone ID Related Accession (Same CDS sequence)	NM_001305585.1 , NM_001305550.1 , NM_001305549.1 , NM_013474.2
Accession Version	NM_001305550.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-26
Organism	Mus musculus(house mouse)
Product	apolipoprotein A-II preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY780589.1, X62772.1 and AC084821.26. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB593952.1, CB947999.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTGC TCGCAATGGT CGCACTGCTG GTCACCATCT GTAGCCTGGA AGGAGCTTTG 
GTTAAGAGAC AGGCAGACGG ACCGGATATG CAGAGCCTGT TCACTCAATA CTTTCAGAGC 
ATGACTGATT ATGGCAAAGA TTTGATGGAG AAGGCCAAGA CCTCAGAGAT TCAGAGCCAG 
GCCAAGGCAT ACTTTGAGAA GACACACGAG CAGCTGACAC CCCTTGTCAG GTCAGCAGGA 
ACTAGTCTGG TGAACTTCTT CAGCAGTTTA ATGAACCTTG AGGAGAAACC GGCTCCTGCG 
GCTAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001292479.1
CDS	85..393
Translation	MKLLAMVALLVTICSLEGALVKRQADGPDMQSLFTQYFQSMTDYGKDLMEKAKTSEIQSQAKAYFEKTHEQLTPLVRSAGTSLVNFFSSLMNLEEKPAPAAK

Target ORF information:

RefSeq Version	NM_001305550.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus apolipoprotein A-II (Apoa2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001305550.1

ORF Insert Sequence:

ATGAAGCTGC TCGCAATGGT CGCACTGCTG GTCACCATCT GTAGCCTGGA AGGAGCTTTG 
GTTAAGAGAC AGGCAGACGG ACCGGATATG CAGAGCCTGT TCACTCAATA CTTTCAGAGC 
ATGACTGATT ATGGCAAAGA TTTGATGGAG AAGGCCAAGA CCTCAGAGAT TCAGAGCCAG 
GCCAAGGCAT ACTTTGAGAA GACACACGAG CAGCTGACAC CCCTTGTCAG GTCAGCAGGA 
ACTAGTCTGG TGAACTTCTT CAGCAGTTTA ATGAACCTTG AGGAGAAACC GGCTCCTGCG 
GCTAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Apoa2 ( NM_001305549.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001292478.1 Mus musculus apolipoprotein A-II (Apoa2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu15170
Clone ID Related Accession (Same CDS sequence)	NM_001305585.1 , NM_001305550.1 , NM_001305549.1 , NM_013474.2
Accession Version	NM_001305549.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Mus musculus(house mouse)
Product	apolipoprotein A-II preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY780589.1, X62772.1 and AC084821.26. On Mar 20, 2015 this sequence version replaced XM_006496625.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB947382.1, CA456623.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTGC TCGCAATGGT CGCACTGCTG GTCACCATCT GTAGCCTGGA AGGAGCTTTG 
GTTAAGAGAC AGGCAGACGG ACCGGATATG CAGAGCCTGT TCACTCAATA CTTTCAGAGC 
ATGACTGATT ATGGCAAAGA TTTGATGGAG AAGGCCAAGA CCTCAGAGAT TCAGAGCCAG 
GCCAAGGCAT ACTTTGAGAA GACACACGAG CAGCTGACAC CCCTTGTCAG GTCAGCAGGA 
ACTAGTCTGG TGAACTTCTT CAGCAGTTTA ATGAACCTTG AGGAGAAACC GGCTCCTGCG 
GCTAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001292478.1
CDS	97..405
Translation	MKLLAMVALLVTICSLEGALVKRQADGPDMQSLFTQYFQSMTDYGKDLMEKAKTSEIQSQAKAYFEKTHEQLTPLVRSAGTSLVNFFSSLMNLEEKPAPAAK

Target ORF information:

RefSeq Version	NM_001305549.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus apolipoprotein A-II (Apoa2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001305549.1

ORF Insert Sequence:

ATGAAGCTGC TCGCAATGGT CGCACTGCTG GTCACCATCT GTAGCCTGGA AGGAGCTTTG 
GTTAAGAGAC AGGCAGACGG ACCGGATATG CAGAGCCTGT TCACTCAATA CTTTCAGAGC 
ATGACTGATT ATGGCAAAGA TTTGATGGAG AAGGCCAAGA CCTCAGAGAT TCAGAGCCAG 
GCCAAGGCAT ACTTTGAGAA GACACACGAG CAGCTGACAC CCCTTGTCAG GTCAGCAGGA 
ACTAGTCTGG TGAACTTCTT CAGCAGTTTA ATGAACCTTG AGGAGAAACC GGCTCCTGCG 
GCTAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Apoa2 ( NM_013474.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038502.2 Mus musculus apolipoprotein A-II (Apoa2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu15170
Clone ID Related Accession (Same CDS sequence)	NM_001305585.1 , NM_001305550.1 , NM_001305549.1 , NM_013474.2
Accession Version	NM_013474.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-26
Organism	Mus musculus(house mouse)
Product	apolipoprotein A-II preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY780589.1, AK145823.1 and CB947382.1. On Oct 6, 2007 this sequence version replaced NM_013474.1. Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 2, 3 and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA456480.1, CB948484.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTGC TCGCAATGGT CGCACTGCTG GTCACCATCT GTAGCCTGGA AGGAGCTTTG 
GTTAAGAGAC AGGCAGACGG ACCGGATATG CAGAGCCTGT TCACTCAATA CTTTCAGAGC 
ATGACTGATT ATGGCAAAGA TTTGATGGAG AAGGCCAAGA CCTCAGAGAT TCAGAGCCAG 
GCCAAGGCAT ACTTTGAGAA GACACACGAG CAGCTGACAC CCCTTGTCAG GTCAGCAGGA 
ACTAGTCTGG TGAACTTCTT CAGCAGTTTA ATGAACCTTG AGGAGAAACC GGCTCCTGCG 
GCTAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038502.2
CDS	100..408
Translation	MKLLAMVALLVTICSLEGALVKRQADGPDMQSLFTQYFQSMTDYGKDLMEKAKTSEIQSQAKAYFEKTHEQLTPLVRSAGTSLVNFFSSLMNLEEKPAPAAK

Target ORF information:

RefSeq Version	NM_013474.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus apolipoprotein A-II (Apoa2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013474.2

ORF Insert Sequence:

ATGAAGCTGC TCGCAATGGT CGCACTGCTG GTCACCATCT GTAGCCTGGA AGGAGCTTTG 
GTTAAGAGAC AGGCAGACGG ACCGGATATG CAGAGCCTGT TCACTCAATA CTTTCAGAGC 
ATGACTGATT ATGGCAAAGA TTTGATGGAG AAGGCCAAGA CCTCAGAGAT TCAGAGCCAG 
GCCAAGGCAT ACTTTGAGAA GACACACGAG CAGCTGACAC CCCTTGTCAG GTCAGCAGGA 
ACTAGTCTGG TGAACTTCTT CAGCAGTTTA ATGAACCTTG AGGAGAAACC GGCTCCTGCG 
GCTAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

C57BL/6J mouse apolipoprotein A2 gene is deterministic for apnea.
Respiratory physiology & neurobiology23588-94(2017 01)
Gillombardo CB,Darrah R,Dick TE,Moore M,Kong N,Decker MJ,Han F,Yamauchi M,Dutschmann M,Azzam S,Strohl KP

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.
Angiogenesis19(1)53-65(2016 Jan)
Janssen L,Dupont L,Bekhouche M,Noel A,Leduc C,Voz M,Peers B,Cataldo D,Apte SS,Dubail J,Colige A

Spatiotemporal regulation of GLI target genes in the mammalian limb bud.
Developmental biology406(1)92-103(2015 Oct)
Lewandowski JP,Du F,Zhang S,Powell MB,Falkenstein KN,Ji H,Vokes SA

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Apoa2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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