Slc25a5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc25a5
Entrez Gene ID	11740
Full Name	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5
Synonyms	Ant2
General protein information	Preferred Names solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 Names ADP/ATP translocase 2 ADP, ATP carrier protein 2 adenine nucleotide translocase adenine nucleotide translocator 2, fibroblast
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X A3.3\|X 21.2 cM
Summary	This gene encodes a transmembrane domain-containing protein that localizes to the mitochondrial inner membrane. The encoded protein facilitates the exchange of ADP from the cytoplasm with ATP from the mitochondria. Pseudogenes for this gene are found on multiple chromosomes. [provided by RefSeq, May 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_007451.4	NP_031477.1	ADP/ATP translocase 2

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	MGC75700	NP_988913.1
Bos taurus (cattle)	SLC25A5	NP_777084.1
Homo sapiens (human)	SLC25A5	NP_001143.2
Canis lupus familiaris (dog)	SLC25A5	XP_851701.1
	SLC25A5	XP_002806416.1
Mus musculus (house mouse)	Slc25a5	NP_031477.1
Rattus norvegicus (Norway rat)	Slc25a5	NP_476443.1
Gallus gallus (chicken)	SLC25A5	XP_004940900.1
Danio rerio (zebrafish)	slc25a5	NP_775354.1

Gene Ontology
Bibliography

Related articles in PubMed

Novel insights into SLC25A46-related pathologies in a genetic mouse model.
Terzenidou ME, Segklia A, Kano T, Papastefanaki F, Karakostas A, Charalambous M, Ioakeimidis F, Papadaki M, Kloukina I, Chrysanthou-Piterou M, Samiotaki M, Panayotou G, Matsas R, Douni E
PLoS genetics13(4)e1006656(2017 Apr)

Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance.
Cho J, Zhang Y, Park SY, Joseph AM, Han C, Park HJ, Kalavalapalli S, Chun SK, Morgan D, Kim JS, Someya S, Mathews CE, Lee YJ, Wohlgemuth SE, Sunny NE, Lee HY, Choi CS, Shiratsuchi T, Oh SP, Terada N
Nature communications814477(2017 Feb)

Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction.
Kokoszka JE, Waymire KG, Flierl A, Sweeney KM, Angelin A, MacGregor GR, Wallace DC
Biochimica et biophysica acta1857(8)1203-1212(2016 Aug)

IFN? induces oxidative stress, DNA damage and tumor cell senescence via TGF?/SMAD signaling-dependent induction of Nox4 and suppression of ANT2.
Hubackova S, Kucerova A, Michlits G, Kyjacova L, Reinis M, Korolov O, Bartek J, Hodny Z
Oncogene35(10)1236-49(2016 Mar)

Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
Cho J, Seo J, Lim CH, Yang L, Shiratsuchi T, Lee MH, Chowdhury RR, Kasahara H, Kim JS, Oh SP, Lee YJ, Terada N
Cell death and differentiation22(9)1437-50(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Deficiency in the mouse mitochondrial ANT2 gene is associated with cardiac noncompaction.
Title: Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction.

IFNgamma induces oxidative stress, DNA damage and tumor cell senescence via TGFbeta/SMAD signaling-dependent induction of Nox4 and suppression of ANT2
Title: IFN? induces oxidative stress, DNA damage and tumor cell senescence via TGF?/SMAD signaling-dependent induction of Nox4 and suppression of ANT2.

Erythroid and B-cell development may be particularly vulnerable to Ant2 depletion-mediated mitochondrial dysfunction and oxidative stress.
Title: Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.

Sirt4 regulates ATP levels via ANT2 and a feedback loop involving AMPK.
Title: SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK.

The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly.
Title: The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly.

The following Slc25a5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc25a5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14760	NM_007451.4 Latest version!	Mus musculus solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 (Slc25a5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc25a5 ( NM_007451.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031477.1 Mus musculus solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 (Slc25a5), mRNA.

Price & Availability↑

CloneID	OMu14760
Clone ID Related Accession (Same CDS sequence)	NM_007451.4
Accession Version	NM_007451.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	ADP/ATP translocase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY280917.1, AK003467.1 and BY472909.1. On May 7, 2015 this sequence version replaced NM_007451.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK012751.1, BC004570.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACAGATG CCGCTGTGTC CTTCGCCAAG GACTTCTTGG CCGGTGGAGT GGCCGCAGCC 
ATCTCCAAGA CAGCGGTAGC ACCCATCGAG AGGGTCAAGC TGCTGCTGCA GGTGCAGCAT 
GCCAGCAAGC AAATCACGGC AGATAAGCAA TACAAGGGCA TCATAGACTG CGTGGTTCGT 
ATCCCCAAGG AACAGGGAGT CCTGTCCTTC TGGCGTGGGA ACCTGGCCAA TGTCATCAGA 
TACTTCCCCA CCCAGGCTCT CAACTTTGCC TTCAAAGATA AATACAAGCA GATCTTTCTG 
GGTGGTGTGG ACAAGAGGAC CCAGTTCTGG CGCTACTTTG CAGGGAACCT GGCATCAGGT 
GGTGCCGCTG GGGCTACATC CTTGTGCTTT GTGTACCCTC TTGATTTTGC CCGTACCCGT 
CTAGCAGCTG ATGTGGGCAA AGCTGGAGCT GAAAGGGAAT TCAAAGGCCT TGGTGACTGC 
CTGGTTAAGA TCTACAAATC TGATGGGATT AAGGGCCTGT ACCAAGGCTT TAATGTGTCA 
GTACAGGGCA TTATCATCTA CCGAGCTGCC TACTTTGGTA TCTATGACAC TGCAAAGGGA 
ATGCTCCCAG ATCCCAAGAA TACTCACATC TTCATCAGCT GGATGATTGC ACAGTCTGTC 
ACTGCTGTCG CTGGCCTGAC TTCCTATCCT TTTGACACGG TTCGCCGTCG TATGATGATG 
CAGTCTGGAC GCAAAGGAAC TGATATCATG TACACAGGCA CGCTTGACTG CTGGCGGAAG 
ATCGCGCGCG ATGAAGGGAG CAAGGCTTTT TTCAAGGGCG CATGGTCCAA CGTTCTCAGA 
GGCATGGGTG GCGCCTTTGT GCTTGTCTTG TATGATGAGA TCAAGAAATA CACATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031477.1
CDS	135..1031
Translation	MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKAGAEREFKGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAKGMLPDPKNTHIFISWMIAQSVTAVAGLTSYPFDTVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGSKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYT

Target ORF information:

RefSeq Version	NM_007451.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 (Slc25a5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007451.4

ORF Insert Sequence:

ATGACAGATG CCGCTGTGTC CTTCGCCAAG GACTTCTTGG CCGGTGGAGT GGCCGCAGCC 
ATCTCCAAGA CAGCGGTAGC ACCCATCGAG AGGGTCAAGC TGCTGCTGCA GGTGCAGCAT 
GCCAGCAAGC AAATCACGGC AGATAAGCAA TACAAGGGCA TCATAGACTG CGTGGTTCGT 
ATCCCCAAGG AACAGGGAGT CCTGTCCTTC TGGCGTGGGA ACCTGGCCAA TGTCATCAGA 
TACTTCCCCA CCCAGGCTCT CAACTTTGCC TTCAAAGATA AATACAAGCA GATCTTTCTG 
GGTGGTGTGG ACAAGAGGAC CCAGTTCTGG CGCTACTTTG CAGGGAACCT GGCATCAGGT 
GGTGCCGCTG GGGCTACATC CTTGTGCTTT GTGTACCCTC TTGATTTTGC CCGTACCCGT 
CTAGCAGCTG ATGTGGGCAA AGCTGGAGCT GAAAGGGAAT TCAAAGGCCT TGGTGACTGC 
CTGGTTAAGA TCTACAAATC TGATGGGATT AAGGGCCTGT ACCAAGGCTT TAATGTGTCA 
GTACAGGGCA TTATCATCTA CCGAGCTGCC TACTTTGGTA TCTATGACAC TGCAAAGGGA 
ATGCTCCCAG ATCCCAAGAA TACTCACATC TTCATCAGCT GGATGATTGC ACAGTCTGTC 
ACTGCTGTCG CTGGCCTGAC TTCCTATCCT TTTGACACGG TTCGCCGTCG TATGATGATG 
CAGTCTGGAC GCAAAGGAAC TGATATCATG TACACAGGCA CGCTTGACTG CTGGCGGAAG 
ATCGCGCGCG ATGAAGGGAG CAAGGCTTTT TTCAAGGGCG CATGGTCCAA CGTTCTCAGA 
GGCATGGGTG GCGCCTTTGT GCTTGTCTTG TATGATGAGA TCAAGAAATA CACATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel insights into SLC25A46-related pathologies in a genetic mouse model.
PLoS genetics13(4)e1006656(2017 Apr)
Terzenidou ME,Segklia A,Kano T,Papastefanaki F,Karakostas A,Charalambous M,Ioakeimidis F,Papadaki M,Kloukina I,Chrysanthou-Piterou M,Samiotaki M,Panayotou G,Matsas R,Douni E

Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance.
Nature communications814477(2017 Feb)
Cho J,Zhang Y,Park SY,Joseph AM,Han C,Park HJ,Kalavalapalli S,Chun SK,Morgan D,Kim JS,Someya S,Mathews CE,Lee YJ,Wohlgemuth SE,Sunny NE,Lee HY,Choi CS,Shiratsuchi T,Oh SP,Terada N

Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction.
Biochimica et biophysica acta1857(8)1203-1212(2016 Aug)
Kokoszka JE,Waymire KG,Flierl A,Sweeney KM,Angelin A,MacGregor GR,Wallace DC

IFN? induces oxidative stress, DNA damage and tumor cell senescence via TGF?/SMAD signaling-dependent induction of Nox4 and suppression of ANT2.
Oncogene35(10)1236-49(2016 Mar)
Hubackova S,Kucerova A,Michlits G,Kyjacova L,Reinis M,Korolov O,Bartek J,Hodny Z

Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
Cell death and differentiation22(9)1437-50(2015 Sep)
Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N

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Slc25a5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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