Adsl cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adsl
Entrez Gene ID	11564
Full Name	adenylosuccinate lyase
Synonyms	Adl,Asl
General protein information	Preferred Names adenylosuccinate lyase Names adenylosuccinate lyase ASase adenylosuccinase adenylosuccinate lyase 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15 E1\|15 37.95 cM
Summary	This gene encodes a protein that is involved in adenosine monophosphate (AMP) biosynthesis and maintaining AMP levels in the muscle. The encoded enzyme catalyzes the release of fumarate during AMP biosynthesis by cleaving the substrates succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide (AICA) ribotide, and adenylosuccinate to give adenylate. In humans, this gene is associated with adenylosuccinate deficiency, a rare autosomal disorder resulting in a spectrum of neurological symptoms. A pseudogene associated with this gene is located on the X chromosome. [provided by RefSeq, Jan 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_009634.6	NP_033764.2	adenylosuccinate lyase

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ADSL	XP_531727.4
Kluyveromyces lactis	KLLA0B13189g	XP_452119.1
Schizosaccharomyces pombe (fission yeast)	ade8	NP_596735.1
Neurospora crassa	NCU06187	XP_962999.2
Mus musculus (house mouse)	Adsl	NP_033764.2
Danio rerio (zebrafish)	adsl	NP_956193.2
Drosophila melanogaster (fruit fly)	CG3590	NP_650586.2
Saccharomyces cerevisiae (baker's yeast)	ADE13	NP_013463.1
Eremothecium gossypii	AGOS_ABL006C	NP_982941.2
Xenopus tropicalis (tropical clawed frog)	adsl	NP_001005457.1
Magnaporthe oryzae (rice blast fungus)	MGG_03645	XP_003716244.1
Homo sapiens (human)	ADSL	NP_000017.1
Pan troglodytes (chimpanzee)	ADSL	XP_003317301.1
Bos taurus (cattle)	ADSL	NP_001095847.1
Gallus gallus (chicken)	ADSL	NP_990860.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002378	XP_312577.3
Rattus norvegicus (Norway rat)	Adsl	NP_001123975.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Magnetic resonance imaging of the brain in adenylosuccinate lyase deficiency: a report of seven cases and a review of the literature.
Jurecka A, Jurkiewicz E, Tylki-Szymanska A
European journal of pediatrics171(1)131-8(2012 Jan)

Human homology and candidate genes for the Dominant megacolon locus, a mouse model of Hirschsprung disease.
Pingault V, Puliti A, Pr?hu MO, Samadi A, Bondurand N, Goossens M
Genomics39(1)86-9(1997 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Adsl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adsl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04545	NM_009634.6 Latest version!	Mus musculus adenylosuccinate lyase (Adsl), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adsl ( NM_009634.6 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033764.2 Mus musculus adenylosuccinate lyase (Adsl), mRNA.

Price & Availability↑

CloneID	OMu04545
Clone ID Related Accession (Same CDS sequence)	NM_009634.6
Accession Version	NM_009634.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1455bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-09
Organism	Mus musculus(house mouse)
Product	adenylosuccinate lyase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY032654.1, AC125540.4, AK049372.1 and AC141880.3. On Jan 24, 2013 this sequence version replaced NM_009634.5. ##Evidence-Data-START## Transcript exon combination :: AK049372.1, AK168906.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCAT CCGGCGACCC TGGCAGTGCT GAAAGTTACC GTTCTCCGCT GGCGGCCCGC 
TACGCCAGCC GCGAGATGTG TTTCTTGTTC AGCGACAGGT ACAAGTTCCA GACGTGGCGG 
CAGCTGTGGC TGTGGCTGGC GGAGGCCGAA CAGACGCTGG GTTTGCCTAT CACAGATGAA 
CAAATCCAGG AGATGAAGTC GAACCTGAAC AACATTGACT TCCAGATGGC AGCTGAGGAA 
GAGAAGCGCC TGCGGCACGA CGTGATGGCT CACGTGCACA CGTTTGGCCA CTGCTGTCCG 
AAAGCTGCGG GCATTATTCA TCTGGGCGCC ACCTCCTGCT ATGTCGGAGA CAATACGGAC 
CTGATTATTC TGAGAAATGC ATTTGACCTA CTTTTGCCAA AGCTTGCTAG AGTGATCTCG 
AGGCTTGCCG ACTTTGCTAA GGATCGTGCT GATCTGCCCA CGTTAGGTTT CACACACTTT 
CAGCCTGCTC AGCTGACCAC GGTTGGGAAA CGATGCTGCC TTTGGATTCA AGATCTCTGC 
ATGGATCTCC AGAACTTGAA GCGTGTCCGG GATGAGCTGC GCTTCCGAGG AGTAAAGGGC 
ACCACTGGCA CGCAGGCCAG CTTCCTGCAG CTCTTCGAGG GGGATCACCA GAAGGTGGAG 
CAGCTGGACA AGATGGTGAC AGAAAAGGCA GGGTTTAAAA GAGCCTTCAT CATCACAGGA 
CAGACGTACA CACGGAAAGT GGACATCGAA GTGCTGTCTG TGCTGGCCAG CTTAGGAGCA 
TCGGTGCACA AGATTTGCAC TGACATACGC CTGCTGGCAA ACCTGAAGGA GATGGAGGAG 
CCCTTTGAGA AACAGCAGAT TGGCTCCAGT GCGATGCCGT ACAAGCGGAA CCCCATGCGC 
TCCGAACGTT GCTGCAGCCT GGCCCGTCAC CTGATGGCCC TTACCATGGA CCCACTACAG 
ACAGCGTCTG TGCAGTGGTT TGAACGTACT CTGGATGACA GTGCCAACCG ACGGATCTGT 
TTGGCTGAAG CGTTTCTCAC TGCAGATACT ATATTAAACA CCCTACAGAA CATTTCTGAA 
GGATTGGTGG TGTACCCCAA AGTAATTGAA CGGCGCATTC GGCAAGAGCT GCCTTTCATG 
GCCACAGAGA ACATCATCAT GGCAATGGTG AAAGCCGGGG GCAGCCGACA GGACTGCCAT 
GAGAAAATTA GAGTGCTTTC CCAGCAGGCA GCTGCTGTGG TCAAGCAGGA AGGAGGTGAC 
AATGACCTTA TAGAGCGCAT CCGGGCAGAT GCCTACTTCA GCCCCATCCA CTCACAGCTG 
GAGCACTTGC TGGACCCCTC TTCTTTCACT GGCCGAGCAC CCCAGCAGGT CCACAGATTC 
CTGGAAGAGG AAGTGCGCCC CCTGCTAAAG CCCTATGGGA ATGAGATGGC GGTGAAAGCA 
GAGCTGTGTC TGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033764.2
CDS	59..1513
Translation	MAASGDPGSAESYRSPLAARYASREMCFLFSDRYKFQTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLNNIDFQMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNAFDLLLPKLARVISRLADFAKDRADLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDELRFRGVKGTTGTQASFLQLFEGDHQKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMALTMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAAAVVKQEGGDNDLIERIRADAYFSPIHSQLEHLLDPSSFTGRAPQQVHRFLEEEVRPLLKPYGNEMAVKAELCL

Target ORF information:

RefSeq Version	NM_009634.6
Organism	Mus musculus(house mouse)
Definition	Mus musculus adenylosuccinate lyase (Adsl), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009634.6

ORF Insert Sequence:

ATGGCTGCAT CCGGCGACCC TGGCAGTGCT GAAAGTTACC GTTCTCCGCT GGCGGCCCGC 
TACGCCAGCC GCGAGATGTG TTTCTTGTTC AGCGACAGGT ACAAGTTCCA GACGTGGCGG 
CAGCTGTGGC TGTGGCTGGC GGAGGCCGAA CAGACGCTGG GTTTGCCTAT CACAGATGAA 
CAAATCCAGG AGATGAAGTC GAACCTGAAC AACATTGACT TCCAGATGGC AGCTGAGGAA 
GAGAAGCGCC TGCGGCACGA CGTGATGGCT CACGTGCACA CGTTTGGCCA CTGCTGTCCG 
AAAGCTGCGG GCATTATTCA TCTGGGCGCC ACCTCCTGCT ATGTCGGAGA CAATACGGAC 
CTGATTATTC TGAGAAATGC ATTTGACCTA CTTTTGCCAA AGCTTGCTAG AGTGATCTCG 
AGGCTTGCCG ACTTTGCTAA GGATCGTGCT GATCTGCCCA CGTTAGGTTT CACACACTTT 
CAGCCTGCTC AGCTGACCAC GGTTGGGAAA CGATGCTGCC TTTGGATTCA AGATCTCTGC 
ATGGATCTCC AGAACTTGAA GCGTGTCCGG GATGAGCTGC GCTTCCGAGG AGTAAAGGGC 
ACCACTGGCA CGCAGGCCAG CTTCCTGCAG CTCTTCGAGG GGGATCACCA GAAGGTGGAG 
CAGCTGGACA AGATGGTGAC AGAAAAGGCA GGGTTTAAAA GAGCCTTCAT CATCACAGGA 
CAGACGTACA CACGGAAAGT GGACATCGAA GTGCTGTCTG TGCTGGCCAG CTTAGGAGCA 
TCGGTGCACA AGATTTGCAC TGACATACGC CTGCTGGCAA ACCTGAAGGA GATGGAGGAG 
CCCTTTGAGA AACAGCAGAT TGGCTCCAGT GCGATGCCGT ACAAGCGGAA CCCCATGCGC 
TCCGAACGTT GCTGCAGCCT GGCCCGTCAC CTGATGGCCC TTACCATGGA CCCACTACAG 
ACAGCGTCTG TGCAGTGGTT TGAACGTACT CTGGATGACA GTGCCAACCG ACGGATCTGT 
TTGGCTGAAG CGTTTCTCAC TGCAGATACT ATATTAAACA CCCTACAGAA CATTTCTGAA 
GGATTGGTGG TGTACCCCAA AGTAATTGAA CGGCGCATTC GGCAAGAGCT GCCTTTCATG 
GCCACAGAGA ACATCATCAT GGCAATGGTG AAAGCCGGGG GCAGCCGACA GGACTGCCAT 
GAGAAAATTA GAGTGCTTTC CCAGCAGGCA GCTGCTGTGG TCAAGCAGGA AGGAGGTGAC 
AATGACCTTA TAGAGCGCAT CCGGGCAGAT GCCTACTTCA GCCCCATCCA CTCACAGCTG 
GAGCACTTGC TGGACCCCTC TTCTTTCACT GGCCGAGCAC CCCAGCAGGT CCACAGATTC 
CTGGAAGAGG AAGTGCGCCC CCTGCTAAAG CCCTATGGGA ATGAGATGGC GGTGAAAGCA 
GAGCTGTGTC TGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Magnetic resonance imaging of the brain in adenylosuccinate lyase deficiency: a report of seven cases and a review of the literature.
European journal of pediatrics171(1)131-8(2012 Jan)
Jurecka A,Jurkiewicz E,Tylki-Szymanska A

Human homology and candidate genes for the Dominant megacolon locus, a mouse model of Hirschsprung disease.
Genomics39(1)86-9(1997 Jan)
Pingault V,Puliti A,Pr?hu MO,Samadi A,Bondurand N,Goossens M

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Adsl cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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