Gpr182 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gpr182
Entrez Gene ID	11536
Full Name	G protein-coupled receptor 182
Synonyms	AM-R,Admr,G10-D,Gpcr17,Gpcr22,MB10,NOW
General protein information	Preferred Names G protein-coupled receptor 182 Names G-protein coupled receptor 182 G10D adrenomedullin receptor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10 D3\|10 75.07 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007412.2	NP_031438.2	G-protein coupled receptor 182

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Gpr182	NP_445754.2
Danio rerio (zebrafish)	gpr182	NP_001018314.1
Homo sapiens (human)	GPR182	NP_009195.1
Canis lupus familiaris (dog)	GPR182	XP_538241.1
Bos taurus (cattle)	GPR182	NP_001193346.1
Pan troglodytes (chimpanzee)	GPR182	XP_003952198.1
Gallus gallus (chicken)	GPR182	XP_004950283.1
	GPR182	XP_001115515.1
Mus musculus (house mouse)	Gpr182	NP_031438.2
Xenopus tropicalis (tropical clawed frog)	LOC100498373	XP_002939752.1

Gene Ontology
Bibliography

Related articles in PubMed

Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation.
Kechele DO, Blue RE, Zwarycz B, Espenschied ST, Mah AT, Siegel MB, Perou CM, Ding S, Magness ST, Lund PK, Caron KM
The Journal of clinical investigation127(2)593-607(2017 Feb)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression.
West DB, Engelhard EK, Adkisson M, Nava AJ, Kirov JV, Cipollone A, Willis B, Rapp J, de Jong PJ, Lloyd KC
PLoS genetics12(2)e1005691(2016 Feb)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Genome-wide identification of endothelial cell-enriched genes in the mouse embryo.
Takase H, Matsumoto K, Yamadera R, Kubota Y, Otsu A, Suzuki R, Ishitobi H, Mochizuki H, Kojima T, Takano S, Uchida K, Takahashi S, Ema M
Blood120(4)914-23(2012 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Gpr182 reduction led to increased activation of ERK1/2 in basal and challenge models, demonstrating a potential role for this orphan GPCR in regulating the proliferative capacity of the intestine.
Title: Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation.

ADMR mediates the stimulatory effects of adrenomedullin on cancer cells and on endothelial and stellate cells within the tumor microenvironment
Title: The ADMR receptor mediates the effects of adrenomedullin on pancreatic cancer cells and on cells of the tumor microenvironment.

The following Gpr182 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpr182 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00126	NM_007412.2 Latest version!	Mus musculus G protein-coupled receptor 182 (Gpr182), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gpr182 ( NM_007412.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031438.2 Mus musculus G protein-coupled receptor 182 (Gpr182), mRNA.

Price & Availability↑

CloneID	OMu00126
Clone ID Related Accession (Same CDS sequence)	NM_007412.2
Accession Version	NM_007412.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	G-protein coupled receptor 182
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY121440.1, BC125279.1, BY590401.1 and BB806742.1. On Nov 8, 2006 this sequence version replaced NM_007412.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK031480.1, BC125279.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164143 [ECO:0000348] ##Evidence-Data-END##

ATGTCAGTCA TACCCAGCCC CAGGCCCGTC TCCACCTTGG AACCGGACAA TGATTTTAGA 
GACATCCACA ACTGGACAGA GCTGCTCCAC CTCTTCAACC AGACCTTTAC CGATTGCCAC 
ATAGAATTCA ACGAGAACAC CAAACACGTG GTCCTCTTCG TCTTCTACCT GGCCATCTTC 
GTGGTAGGCT TAGTAGAGAA CGTCCTGGTG ATATGTGTCA ACTGCCGCCG TTCAGGCCGG 
GTGGGGATGC TGAACCTGTA CATCCTCAAC ATGGCCATCG CAGACCTGGG CATCATCCTG 
TCTCTGCCTG TTTGGATGCT GGAGGTCATG CTGGAGTACA CTTGGCTCTG GGGCAGCTTC 
TCCTGTCGCT TCATTCATTA TTTCTACCTT GTCAACATGT ACAGCAGCAT CTTCTTCCTG 
ACGTGCCTCA GCATTGACCG CTACGTCACC CTCACCAACA CCTCTCCCTC CTGGCAGCGC 
CACCAGCACC GAATACGGAG GGCCGTGTGC GCAGGCGTCT GGGTCCTCTC CGCCATTATC 
CCACTGCCGG AGGTGGTGCA CATCCAGCTG TTGGATGGCT CCGAGCCCAT GTGCCTCTTC 
CTAGCACCTT TTGAAACGTA CAGCGCCTGG GCCCTGGCAG TGGCCCTGTC GGCCACCATC 
CTGGGCTTCC TACTGCCTTT TCTTCTCATC GCAGTGTTCA ATATCCTGAC AGCCTGCCGG 
CTTCGGAGGC AAAGGCAGAC GGAGAGCAGG CGCCACTGCC TGTTGATGTG GGCTTACATA 
GTTGTCTTTG CCATCTGCTG GCTGCCCTAC CAAGTGACTA TGCTGCTGCT CACTCTGCAC 
GGGACCCACA TCTTCCTCCA CTGTCACCTG GTTAACCTTC TCTACTTCTT CTACGAAATC 
ATCGACTGCT TTTCCATGCT GCACTGTGTG GCCAACCCCA TCCTCTACAA CTTTCTCAGC 
CCGAGCTTCC GGGGCCGACT GCTGAGCCTT GTGGTCCGTT ACCTTCCCAA GGAGCAGGCC 
AGGGCAGCAG GTGGTCGAGC CTCCTCTTCT TCTTCCACCC AGCACTCCAT CATCATTACC 
AAAGAGGGCA GCCTGCCCGC TGCAGCGGAT CTCCACACCC ACCCCATCCG AAACGTTCAG 
GCGTCCTCTC CGCCTCCAAA CACCTCACCT ACACTCTGCA ATTCTGTAGC CAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031438.2
CDS	216..1412
Translation	MSVIPSPRPVSTLEPDNDFRDIHNWTELLHLFNQTFTDCHIEFNENTKHVVLFVFYLAIFVVGLVENVLVICVNCRRSGRVGMLNLYILNMAIADLGIILSLPVWMLEVMLEYTWLWGSFSCRFIHYFYLVNMYSSIFFLTCLSIDRYVTLTNTSPSWQRHQHRIRRAVCAGVWVLSAIIPLPEVVHIQLLDGSEPMCLFLAPFETYSAWALAVALSATILGFLLPFLLIAVFNILTACRLRRQRQTESRRHCLLMWAYIVVFAICWLPYQVTMLLLTLHGTHIFLHCHLVNLLYFFYEIIDCFSMLHCVANPILYNFLSPSFRGRLLSLVVRYLPKEQARAAGGRASSSSSTQHSIIITKEGSLPAAADLHTHPIRNVQASSPPPNTSPTLCNSVAS

Target ORF information:

RefSeq Version	NM_007412.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus G protein-coupled receptor 182 (Gpr182), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007412.2

ORF Insert Sequence:

ATGTCAGTCA TACCCAGCCC CAGGCCCGTC TCCACCTTGG AACCGGACAA TGATTTTAGA 
GACATCCACA ACTGGACAGA GCTGCTCCAC CTCTTCAACC AGACCTTTAC CGATTGCCAC 
ATAGAATTCA ACGAGAACAC CAAACACGTG GTCCTCTTCG TCTTCTACCT GGCCATCTTC 
GTGGTAGGCT TAGTAGAGAA CGTCCTGGTG ATATGTGTCA ACTGCCGCCG TTCAGGCCGG 
GTGGGGATGC TGAACCTGTA CATCCTCAAC ATGGCCATCG CAGACCTGGG CATCATCCTG 
TCTCTGCCTG TTTGGATGCT GGAGGTCATG CTGGAGTACA CTTGGCTCTG GGGCAGCTTC 
TCCTGTCGCT TCATTCATTA TTTCTACCTT GTCAACATGT ACAGCAGCAT CTTCTTCCTG 
ACGTGCCTCA GCATTGACCG CTACGTCACC CTCACCAACA CCTCTCCCTC CTGGCAGCGC 
CACCAGCACC GAATACGGAG GGCCGTGTGC GCAGGCGTCT GGGTCCTCTC CGCCATTATC 
CCACTGCCGG AGGTGGTGCA CATCCAGCTG TTGGATGGCT CCGAGCCCAT GTGCCTCTTC 
CTAGCACCTT TTGAAACGTA CAGCGCCTGG GCCCTGGCAG TGGCCCTGTC GGCCACCATC 
CTGGGCTTCC TACTGCCTTT TCTTCTCATC GCAGTGTTCA ATATCCTGAC AGCCTGCCGG 
CTTCGGAGGC AAAGGCAGAC GGAGAGCAGG CGCCACTGCC TGTTGATGTG GGCTTACATA 
GTTGTCTTTG CCATCTGCTG GCTGCCCTAC CAAGTGACTA TGCTGCTGCT CACTCTGCAC 
GGGACCCACA TCTTCCTCCA CTGTCACCTG GTTAACCTTC TCTACTTCTT CTACGAAATC 
ATCGACTGCT TTTCCATGCT GCACTGTGTG GCCAACCCCA TCCTCTACAA CTTTCTCAGC 
CCGAGCTTCC GGGGCCGACT GCTGAGCCTT GTGGTCCGTT ACCTTCCCAA GGAGCAGGCC 
AGGGCAGCAG GTGGTCGAGC CTCCTCTTCT TCTTCCACCC AGCACTCCAT CATCATTACC 
AAAGAGGGCA GCCTGCCCGC TGCAGCGGAT CTCCACACCC ACCCCATCCG AAACGTTCAG 
GCGTCCTCTC CGCCTCCAAA CACCTCACCT ACACTCTGCA ATTCTGTAGC CAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation.
The Journal of clinical investigation127(2)593-607(2017 Feb)
Kechele DO,Blue RE,Zwarycz B,Espenschied ST,Mah AT,Siegel MB,Perou CM,Ding S,Magness ST,Lund PK,Caron KM

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression.
PLoS genetics12(2)e1005691(2016 Feb)
West DB,Engelhard EK,Adkisson M,Nava AJ,Kirov JV,Cipollone A,Willis B,Rapp J,de Jong PJ,Lloyd KC

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Genome-wide identification of endothelial cell-enriched genes in the mouse embryo.
Blood120(4)914-23(2012 Jul)
Takase H,Matsumoto K,Yamadera R,Kubota Y,Otsu A,Suzuki R,Ishitobi H,Mochizuki H,Kojima T,Takano S,Uchida K,Takahashi S,Ema M

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Gpr182 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報