Acadl cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Acadl
Entrez Gene ID	11363
Full Name	acyl-Coenzyme A dehydrogenase, long-chain
Synonyms	AA960361,AU018452,C79855,LCAD
General protein information	Preferred Names acyl-Coenzyme A dehydrogenase, long-chain Names long-chain specific acyl-CoA dehydrogenase, mitochondrial acetyl-Coenzyme A dehydrogenase, long-chain
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 C3\|1 33.64 cM
Summary	This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C12- and C16-acylCoA. In mice, deficiency of this gene can cause sudden death, cardiomyopathy as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012].

mRNA and Protein(s)

mRNA	Protein	Name
NM_007381.4	NP_031407.2	long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Acadl	NP_031407.2
Homo sapiens (human)	ACADL	NP_001599.1
	LOC711485	XP_001109931.2
Canis lupus familiaris (dog)	ACADL	XP_536053.3
Rattus norvegicus (Norway rat)	Acadl	NP_036951.1
Bos taurus (cattle)	ACADL	NP_001070404.1
Pan troglodytes (chimpanzee)	ACADL	XP_516063.3
Xenopus tropicalis (tropical clawed frog)	acadl	NP_001039250.1
Gallus gallus (chicken)	ACADL	NP_001006511.1
Danio rerio (zebrafish)	acadl	NP_957475.1

Gene Ontology
Bibliography

Related articles in PubMed

Lipoprotein secretion and triglyceride stores in the heart.
Bjorkegren J, V?niant M, Kim SK, Withycombe SK, Wood PA, Hellerstein MK, Neese RA, Young SG
The Journal of biological chemistry276(42)38511-7(2001 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SIRT3 may play an essential role in attenuating lipid accumulation in the heart through the deacetylation of LCAD
Title: Mouse SIRT3 attenuates hypertrophy-related lipid accumulation in the heart through the deacetylation of LCAD.

the fatty acid oxidation pathway and LCAD are factors contributing to the pathophysiology of pulmonary disease
Title: Long-chain acyl-CoA dehydrogenase deficiency as a cause of pulmonary surfactant dysfunction.

LCAD KO mice are ineffective in maintaining metabolic homeostasis during fasting, which is reflected by an impaired myocardial energy status in fasted LCAD KO mice.
Title: Myocardial energy shortage and unmet anaplerotic needs in the fasted long-chain acyl-CoA dehydrogenase knockout mouse.

Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.
Title: Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.

Carnitine supplementation lowered myocardial triglycerides, normalizing myocardial triglycerides levels in LCAD Knock-out mice.
Title: Carnitine supplementation attenuates myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice.

The following Acadl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Acadl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu23146	NM_007381.4 Latest version!	Mus musculus acyl-Coenzyme A dehydrogenase, long-chain (Acadl), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Acadl ( NM_007381.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031407.2 Mus musculus acyl-Coenzyme A dehydrogenase, long-chain (Acadl), mRNA.

Price & Availability↑

CloneID	OMu23146
Clone ID Related Accession (Same CDS sequence)	NM_007381.4
Accession Version	NM_007381.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1293bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC124389.4, AK005140.1 and AK151845.1. On Nov 29, 2012 this sequence version replaced NM_007381.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. The transit peptide annotated at aa 1-30 is inferred by similarity to the cleavage site in the orthologous rat protein as described in PMID: 2777793. The software program TargetP1.1 predicts that the transit peptide in mouse is aa 1-27. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK151845.1, AK167537.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164143 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCGC GCCTGCTCCT CCGCTCCCTG CGCGTCCTGA GCGCCCGCTC GGCGCCACGC 
CCGCTGCCCT CCGCCCGATG TTCTCATTCT GGAGCAGAAG CGCGTCTAGA AACTCCTTCT 
GCTAAAAAAT TAACTGACAT TGGAATCAGG AGAATCTTTT CCTCGGAGCA TGACATTTTC 
CGGGAGAGTG TAAGGAAGTT TTTCCAAGAA GAAGTGATTC CTCACCACAC AGAATGGGAG 
AAAGCTGGAG AAGTGAGTAG AGAGGTCTGG GAAAAAGCTG GCAAGCAGGG CTTGCTTGGC 
ATCAACATCG CAGAGAAACA TGGCGGCATT GGTGGGGACT TGCTCTCAAC AGCAGTTACT 
TGGGAAGAGC AAGCGTACTC CAATTGCACA GGCCCTGGCT TCAGCCTCCA CTCAGATATT 
GTCATGCCCT ATATTGCGAA TTACGGCACA AAAGAACAGA TCGAGAAGTT CATCCCCCAG 
ATGACGGCGG GCAAGTGTAT CGGTGCCATA GCCATGACAG AGCCTGGGGC TGGAAGTGAC 
TTACAAGGAG TAAGAACGAA CGCCAAAAGA TCTGGGAGTG ATTGGATTCT CAATGGAAGC 
AAGGTGTTCA TCACTAATGG CTGGTTAAGT GATCTCGTGA TCGTCGTGGC CGTCACCAAC 
CGTGAAGCTC GATCGCCTGC CCATGGCATT AGCCTCTTTT TGGTGGAAAA CGGAATGAAA 
GGATTTATCA AGGGCCGGAA GCTGCATAAG ATGGGAATGA AAGCTCAGGA CACAGCAGAA 
CTATTCTTTG AAGATGTCCG ATTGCCAGCT AATGCCTTAC TTGGAGAAGA GAATAAAGGC 
TTCTACTACC TCATGCAAGA GCTTCCACAG GAAAGGCTCT TAATTGCTGA GTTGGCGATT 
TCTGCCTGTG AGTTCATGTT TGAAGAAACC AGGAACTACG TGAAGCAAAG AAAAGCTTTT 
GGGAAAACAG TTGCACACAT ACAGACGGTG CAGCATAAAC TAGCAGAATT AAAGACACAC 
ATATGTGTCA CCAGAGCTTT TGTGGACAGC TGTCTGCAGT TGCATGAAAC CAAACGTCTG 
GACTCCGGTT CTGCTTCCAT GGCAAAATAC TGGGCATCTG AATTACAAAA CAGTGTAGCT 
TATGAATGTG TGCAACTCCA CGGAGGCTGG GGGTACATGT GGGAGTACCC GATTGCAAAA 
GCTTACGTGG ATGCTCGGGT GCAGCCGATC TACGGTGGTA CCAACGAAAT AATGAAAGAG 
CTGATCGCAA GACAGATCGT CAGTGACAGC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031407.2
CDS	61..1353
Translation	MAARLLLRSLRVLSARSAPRPLPSARCSHSGAEARLETPSAKKLTDIGIRRIFSSEHDIFRESVRKFFQEEVIPHHTEWEKAGEVSREVWEKAGKQGLLGINIAEKHGGIGGDLLSTAVTWEEQAYSNCTGPGFSLHSDIVMPYIANYGTKEQIEKFIPQMTAGKCIGAIAMTEPGAGSDLQGVRTNAKRSGSDWILNGSKVFITNGWLSDLVIVVAVTNREARSPAHGISLFLVENGMKGFIKGRKLHKMGMKAQDTAELFFEDVRLPANALLGEENKGFYYLMQELPQERLLIAELAISACEFMFEETRNYVKQRKAFGKTVAHIQTVQHKLAELKTHICVTRAFVDSCLQLHETKRLDSGSASMAKYWASELQNSVAYECVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIARQIVSDS

Target ORF information:

RefSeq Version	NM_007381.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus acyl-Coenzyme A dehydrogenase, long-chain (Acadl), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007381.4

ORF Insert Sequence:

ATGGCTGCGC GCCTGCTCCT CCGCTCCCTG CGCGTCCTGA GCGCCCGCTC GGCGCCACGC 
CCGCTGCCCT CCGCCCGATG TTCTCATTCT GGAGCAGAAG CGCGTCTAGA AACTCCTTCT 
GCTAAAAAAT TAACTGACAT TGGAATCAGG AGAATCTTTT CCTCGGAGCA TGACATTTTC 
CGGGAGAGTG TAAGGAAGTT TTTCCAAGAA GAAGTGATTC CTCACCACAC AGAATGGGAG 
AAAGCTGGAG AAGTGAGTAG AGAGGTCTGG GAAAAAGCTG GCAAGCAGGG CTTGCTTGGC 
ATCAACATCG CAGAGAAACA TGGCGGCATT GGTGGGGACT TGCTCTCAAC AGCAGTTACT 
TGGGAAGAGC AAGCGTACTC CAATTGCACA GGCCCTGGCT TCAGCCTCCA CTCAGATATT 
GTCATGCCCT ATATTGCGAA TTACGGCACA AAAGAACAGA TCGAGAAGTT CATCCCCCAG 
ATGACGGCGG GCAAGTGTAT CGGTGCCATA GCCATGACAG AGCCTGGGGC TGGAAGTGAC 
TTACAAGGAG TAAGAACGAA CGCCAAAAGA TCTGGGAGTG ATTGGATTCT CAATGGAAGC 
AAGGTGTTCA TCACTAATGG CTGGTTAAGT GATCTCGTGA TCGTCGTGGC CGTCACCAAC 
CGTGAAGCTC GATCGCCTGC CCATGGCATT AGCCTCTTTT TGGTGGAAAA CGGAATGAAA 
GGATTTATCA AGGGCCGGAA GCTGCATAAG ATGGGAATGA AAGCTCAGGA CACAGCAGAA 
CTATTCTTTG AAGATGTCCG ATTGCCAGCT AATGCCTTAC TTGGAGAAGA GAATAAAGGC 
TTCTACTACC TCATGCAAGA GCTTCCACAG GAAAGGCTCT TAATTGCTGA GTTGGCGATT 
TCTGCCTGTG AGTTCATGTT TGAAGAAACC AGGAACTACG TGAAGCAAAG AAAAGCTTTT 
GGGAAAACAG TTGCACACAT ACAGACGGTG CAGCATAAAC TAGCAGAATT AAAGACACAC 
ATATGTGTCA CCAGAGCTTT TGTGGACAGC TGTCTGCAGT TGCATGAAAC CAAACGTCTG 
GACTCCGGTT CTGCTTCCAT GGCAAAATAC TGGGCATCTG AATTACAAAA CAGTGTAGCT 
TATGAATGTG TGCAACTCCA CGGAGGCTGG GGGTACATGT GGGAGTACCC GATTGCAAAA 
GCTTACGTGG ATGCTCGGGT GCAGCCGATC TACGGTGGTA CCAACGAAAT AATGAAAGAG 
CTGATCGCAA GACAGATCGT CAGTGACAGC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lipoprotein secretion and triglyceride stores in the heart.
The Journal of biological chemistry276(42)38511-7(2001 Oct)
Bjorkegren J,V?niant M,Kim SK,Withycombe SK,Wood PA,Hellerstein MK,Neese RA,Young SG

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Acadl cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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