Cops8 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cops8
Entrez Gene ID	108679
Full Name	COP9 signalosome subunit 8
Synonyms	9430009J09Rik,AA408242,Csn8,Sgn8
General protein information	Preferred Names COP9 signalosome subunit 8 Names COP9 signalosome complex subunit 8 COP9 (constitutive photomorphogenic) homolog, subunit 8 COP9 homolog JAB1-containing signalosome subunit 8 signalosome subunit 8
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 D

mRNA and Protein(s)

mRNA	Protein	Name
XM_006529064.2	XP_006529127.1	COP9 signalosome complex subunit 8 isoform X1
XM_006529064.3	XP_006529127.1	COP9 signalosome complex subunit 8 isoform X1
NM_133805.3	NP_598566.3	COP9 signalosome complex subunit 8

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	cops8	NP_956523.1
Homo sapiens (human)	COPS8	NP_006701.1
Bos taurus (cattle)	COPS8	NP_001076966.1
Drosophila melanogaster (fruit fly)	CSN8	NP_723378.2
Pan troglodytes (chimpanzee)	COPS8	XP_003950051.1
Oryza sativa (rice)	Os04g0428900	NP_001052805.1
Canis lupus familiaris (dog)	COPS8	XP_534612.2
Mus musculus (house mouse)	Cops8	NP_598566.3
Gallus gallus (chicken)	COPS8	NP_001041472.1
Rattus norvegicus (Norway rat)	Cops8	NP_001013245.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008857	XP_319600.4
Arabidopsis thaliana (thale cress)	COP9	NP_193147.1
Xenopus tropicalis (tropical clawed frog)	cops8	NP_989106.1

Gene Ontology
Bibliography

Related articles in PubMed

COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity.
Su H, Li J, Zhang H, Ma W, Wei N, Liu J, Wang X
Circulation research117(11)956-66(2015 Nov)

The COP9 signalosome is required for autophagy, proteasome-mediated proteolysis, and cardiomyocyte survival in adult mice.
Su H, Li J, Osinska H, Li F, Robbins J, Liu J, Wei N, Wang X
Circulation. Heart failure6(5)1049-57(2013 Sep)

COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase.
Liu C, Guo LQ, Menon S, Jin D, Pick E, Wang X, Deng XW, Wei N
The Journal of biological chemistry288(28)20443-52(2013 Jul)

Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers.
Lei D, Li F, Su H, Liu J, Wei N, Wang X
PloS one8(7)e67793(2013)

COP9 signalosome regulates autophagosome maturation.
Su H, Li F, Ranek MJ, Wei N, Wang X
Circulation124(19)2117-28(2011 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CSN8/CSN promotes the ubiquitination and degradation of misfolded proteins and protects against cardiac proteotoxicity, and cullin-RING ligases participate in degradation of cytosolic misfolded proteins.
Title: COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity.

CSN8/COP9 signalosome regulates both proteasome-mediated proteolysis and the autophagic-lysosomal pathway, critical to the removal of oxidized proteins in the heart.
Title: The COP9 signalosome is required for autophagy, proteasome-mediated proteolysis, and cardiomyocyte survival in adult mice.

Data indicate that a decreased level of Csn8 accelerated cell growth and shortened G1 duration.
Title: COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase.

Csn8 exerts profound impacts on hepatic ubiquitin-proteasome system function and is critical to the stability of the pro-apoptotic protein Bim.
Title: Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers.

Likely through regulating the expression of Rab7, Csn8/CSN plays a critical role in autophagosome maturation in myocardium.
Title: COP9 signalosome regulates autophagosome maturation.

The following Cops8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cops8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu10237	NM_133805.3 Latest version!	Mus musculus COP9 signalosome subunit 8 (Cops8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu27856	XM_006529064.3 Latest version!	Mus musculus COP9 signalosome subunit 8 (Cops8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu27856	XM_006529064.2	Mus musculus COP9 signalosome subunit 8 (Cops8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cops8 ( NM_133805.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598566.3 Mus musculus COP9 signalosome subunit 8 (Cops8), mRNA.

Price & Availability↑

CloneID	OMu10237
Clone ID Related Accession (Same CDS sequence)	NM_133805.3
Accession Version	NM_133805.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	COP9 signalosome complex subunit 8
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC110895.14, AK079111.1 and DV645014.1. On Sep 8, 2006 this sequence version replaced NM_133805.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC021488.1, AK088323.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCAGTGG CGGTGATGGC GGACAACGCC TTCAGTTTCA GAAAGCTGTT GGATCAGTGC 
GAGAACCAGG AACTCGAGGC TCCTGGAGGA ATTGCCACAC CGCCAGTGTA CGGTCAGCTT 
CTAGCTTTGT ACTTGCTCCA GAACGACATG AATAATGCAA GATATCTGTG GAAGAGGATA 
CCACCTGCTA TAAAGTCTGC AAATTCTGAA CTTGGGGGAA TTTGGTCAGT TGGACAGCGA 
ATCTGGCAAA GAGATTTCCC TGGGATCTAT ACAACCATCA ACGCCCACCA GTGGTCAGAG 
ACTGTGCAGC CAATCATGGA AGCCCTTAGA GATGCAACAA GGAGACGCGC CTTTGCCCTG 
GTCTCTCAAG CTTATACCTC CATCATCGCA GATGATTTTG CAGCGTTTGT TGGACTTCCT 
GTGGAAGAGG CTGTGAAAGG CGTGTTGGAA CAAGGATGGC AGGCCGACTC CACCACAAGA 
ATGGTTCTTC CCAGGAAGCC AGCCTCAGGA ACCCTGGATG TCTCCTTGAA CAGGTTTATC 
CCCTTATCAG AGCCTGCCCC AGTTCCGCCA ATCCCCAATG AGCAGCAGCT CGCCCGGCTC 
ACCGATTATG TGGCTTTCCT GGAAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598566.3
CDS	126..755
Translation	MPVAVMADNAFSFRKLLDQCENQELEAPGGIATPPVYGQLLALYLLQNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGVLEQGWQADSTTRMVLPRKPASGTLDVSLNRFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN

Target ORF information:

RefSeq Version	NM_133805.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus COP9 signalosome subunit 8 (Cops8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133805.3

ORF Insert Sequence:

ATGCCAGTGG CGGTGATGGC GGACAACGCC TTCAGTTTCA GAAAGCTGTT GGATCAGTGC 
GAGAACCAGG AACTCGAGGC TCCTGGAGGA ATTGCCACAC CGCCAGTGTA CGGTCAGCTT 
CTAGCTTTGT ACTTGCTCCA GAACGACATG AATAATGCAA GATATCTGTG GAAGAGGATA 
CCACCTGCTA TAAAGTCTGC AAATTCTGAA CTTGGGGGAA TTTGGTCAGT TGGACAGCGA 
ATCTGGCAAA GAGATTTCCC TGGGATCTAT ACAACCATCA ACGCCCACCA GTGGTCAGAG 
ACTGTGCAGC CAATCATGGA AGCCCTTAGA GATGCAACAA GGAGACGCGC CTTTGCCCTG 
GTCTCTCAAG CTTATACCTC CATCATCGCA GATGATTTTG CAGCGTTTGT TGGACTTCCT 
GTGGAAGAGG CTGTGAAAGG CGTGTTGGAA CAAGGATGGC AGGCCGACTC CACCACAAGA 
ATGGTTCTTC CCAGGAAGCC AGCCTCAGGA ACCCTGGATG TCTCCTTGAA CAGGTTTATC 
CCCTTATCAG AGCCTGCCCC AGTTCCGCCA ATCCCCAATG AGCAGCAGCT CGCCCGGCTC 
ACCGATTATG TGGCTTTCCT GGAAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cops8 ( XM_006529064.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006529127.1 Mus musculus COP9 signalosome subunit 8 (Cops8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu27856
Clone ID Related Accession (Same CDS sequence)	XM_006529064.2 , XM_006529064.3
Accession Version	XM_006529064.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	COP9 signalosome complex subunit 8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006529064.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCAGTGT ACGGTCAGCT TCTAGCTTTG TACTTGCTCC AGAACGACAT GAATAATGCA 
AGATATCTGT GGAAGAGGAT ACCACCTGCT ATAAAGTCTG CAAATTCTGA ACTTGGGGGA 
ATTTGGTCAG TTGGACAGCG AATCTGGCAA AGAGATTTCC CTGGGATCTA TACAACCATC 
AACGCCCACC AGTGGTCAGA GACTGTGCAG CCAATCATGG AAGCCCTTAG AGATGCAACA 
AGGAGACGCG CCTTTGCCCT GGTCTCTCAA GCTTATACCT CCATCATCGC AGATGATTTT 
GCAGCGTTTG TTGGACTTCC TGTGGAAGAG GCTGTGAAAG GCGTGTTGGA ACAAGGATGG 
CAGGCCGACT CCACCACAAG AATGGTTCTT CCCAGGAAGC CAGCCTCAGG AACCCTGGAT 
GTCTCCTTGA ACAGGTTTAT CCCCTTATCA GAGCCTGCCC CAGTTCCGCC AATCCCCAAT 
GAGCAGCAGC TCGCCCGGCT CACCGATTAT GTGGCTTTCC TGGAAAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006529127.1
CDS	97..627
Translation	MPVYGQLLALYLLQNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGVLEQGWQADSTTRMVLPRKPASGTLDVSLNRFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN

Target ORF information:

RefSeq Version	XM_006529064.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus COP9 signalosome subunit 8 (Cops8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006529064.2

ORF Insert Sequence:

ATGCCAGTGT ACGGTCAGCT TCTAGCTTTG TACTTGCTCC AGAACGACAT GAATAATGCA 
AGATATCTGT GGAAGAGGAT ACCACCTGCT ATAAAGTCTG CAAATTCTGA ACTTGGGGGA 
ATTTGGTCAG TTGGACAGCG AATCTGGCAA AGAGATTTCC CTGGGATCTA TACAACCATC 
AACGCCCACC AGTGGTCAGA GACTGTGCAG CCAATCATGG AAGCCCTTAG AGATGCAACA 
AGGAGACGCG CCTTTGCCCT GGTCTCTCAA GCTTATACCT CCATCATCGC AGATGATTTT 
GCAGCGTTTG TTGGACTTCC TGTGGAAGAG GCTGTGAAAG GCGTGTTGGA ACAAGGATGG 
CAGGCCGACT CCACCACAAG AATGGTTCTT CCCAGGAAGC CAGCCTCAGG AACCCTGGAT 
GTCTCCTTGA ACAGGTTTAT CCCCTTATCA GAGCCTGCCC CAGTTCCGCC AATCCCCAAT 
GAGCAGCAGC TCGCCCGGCT CACCGATTAT GTGGCTTTCC TGGAAAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cops8 ( XM_006529064.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006529127.1 Mus musculus COP9 signalosome subunit 8 (Cops8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu27856
Clone ID Related Accession (Same CDS sequence)	XM_006529064.2 , XM_006529064.3
Accession Version	XM_006529064.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	COP9 signalosome complex subunit 8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006529064.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCAGTGT ACGGTCAGCT TCTAGCTTTG TACTTGCTCC AGAACGACAT GAATAATGCA 
AGATATCTGT GGAAGAGGAT ACCACCTGCT ATAAAGTCTG CAAATTCTGA ACTTGGGGGA 
ATTTGGTCAG TTGGACAGCG AATCTGGCAA AGAGATTTCC CTGGGATCTA TACAACCATC 
AACGCCCACC AGTGGTCAGA GACTGTGCAG CCAATCATGG AAGCCCTTAG AGATGCAACA 
AGGAGACGCG CCTTTGCCCT GGTCTCTCAA GCTTATACCT CCATCATCGC AGATGATTTT 
GCAGCGTTTG TTGGACTTCC TGTGGAAGAG GCTGTGAAAG GCGTGTTGGA ACAAGGATGG 
CAGGCCGACT CCACCACAAG AATGGTTCTT CCCAGGAAGC CAGCCTCAGG AACCCTGGAT 
GTCTCCTTGA ACAGGTTTAT CCCCTTATCA GAGCCTGCCC CAGTTCCGCC AATCCCCAAT 
GAGCAGCAGC TCGCCCGGCT CACCGATTAT GTGGCTTTCC TGGAAAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006529127.1
CDS	591..1121
Translation	MPVYGQLLALYLLQNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGVLEQGWQADSTTRMVLPRKPASGTLDVSLNRFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN

Target ORF information:

RefSeq Version	XM_006529064.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus COP9 signalosome subunit 8 (Cops8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006529064.3

ORF Insert Sequence:

ATGCCAGTGT ACGGTCAGCT TCTAGCTTTG TACTTGCTCC AGAACGACAT GAATAATGCA 
AGATATCTGT GGAAGAGGAT ACCACCTGCT ATAAAGTCTG CAAATTCTGA ACTTGGGGGA 
ATTTGGTCAG TTGGACAGCG AATCTGGCAA AGAGATTTCC CTGGGATCTA TACAACCATC 
AACGCCCACC AGTGGTCAGA GACTGTGCAG CCAATCATGG AAGCCCTTAG AGATGCAACA 
AGGAGACGCG CCTTTGCCCT GGTCTCTCAA GCTTATACCT CCATCATCGC AGATGATTTT 
GCAGCGTTTG TTGGACTTCC TGTGGAAGAG GCTGTGAAAG GCGTGTTGGA ACAAGGATGG 
CAGGCCGACT CCACCACAAG AATGGTTCTT CCCAGGAAGC CAGCCTCAGG AACCCTGGAT 
GTCTCCTTGA ACAGGTTTAT CCCCTTATCA GAGCCTGCCC CAGTTCCGCC AATCCCCAAT 
GAGCAGCAGC TCGCCCGGCT CACCGATTAT GTGGCTTTCC TGGAAAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity.
Circulation research117(11)956-66(2015 Nov)
Su H,Li J,Zhang H,Ma W,Wei N,Liu J,Wang X

The COP9 signalosome is required for autophagy, proteasome-mediated proteolysis, and cardiomyocyte survival in adult mice.
Circulation. Heart failure6(5)1049-57(2013 Sep)
Su H,Li J,Osinska H,Li F,Robbins J,Liu J,Wei N,Wang X

COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase.
The Journal of biological chemistry288(28)20443-52(2013 Jul)
Liu C,Guo LQ,Menon S,Jin D,Pick E,Wang X,Deng XW,Wei N

Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers.
PloS one8(7)e67793(2013)
Lei D,Li F,Su H,Liu J,Wei N,Wang X

COP9 signalosome regulates autophagosome maturation.
Circulation124(19)2117-28(2011 Nov)
Su H,Li F,Ranek MJ,Wei N,Wang X

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Cops8 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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