Lrrtm2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lrrtm2
Entrez Gene ID	107065
Full Name	leucine rich repeat transmembrane neuronal 2
Synonyms	AI851755,BB129880,C630011A14Rik,mKIAA0416
General protein information	Preferred Names leucine rich repeat transmembrane neuronal 2 Names leucine-rich repeat transmembrane neuronal protein 2 leucine-rich repeat transmembrane neuronal 2 protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18\|18 B1

mRNA and Protein(s)

mRNA	Protein	Name
NM_178005.4	NP_821072.1	leucine-rich repeat transmembrane neuronal protein 2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LRRTM2	XP_001172386.1
Danio rerio (zebrafish)	LOC100538061	XP_003201382.1
Mus musculus (house mouse)	Lrrtm2	NP_821072.1
	LRRTM2	XP_001114014.1
Canis lupus familiaris (dog)	LRRTM2	XP_538650.2
Rattus norvegicus (Norway rat)	Lrrtm2	NP_001102939.1
Homo sapiens (human)	LRRTM2	NP_056379.1
Bos taurus (cattle)	LRRTM2	NP_001092847.1
Gallus gallus (chicken)	LRRTM2	XP_004944826.1
Danio rerio (zebrafish)	LOC101884631	XP_005157392.1

Gene Ontology
Bibliography

Related articles in PubMed

Mapping the dynamics and nanoscale organization of synaptic adhesion proteins using monomeric streptavidin.
Chamma I, Letellier M, Butler C, Tessier B, Lim KH, Gauthereau I, Choquet D, Sibarita JB, Park S, Sainlos M, Thoumine O
Nature communications710773(2016 Mar)

Crystal Structure of an Engineered LRRTM2 Synaptic Adhesion Molecule and a Model for Neurexin Binding.
Paatero A, Rosti K, Shkumatov AV, Sele C, Brunello C, Kysenius K, Singha P, Jokinen V, Huttunen H, Kajander T
Biochemistry55(6)914-26(2016 Feb)

Nuclear calcium signaling induces expression of the synaptic organizers Lrrtm1 and Lrrtm2.
Hayer SN, Bading H
The Journal of biological chemistry290(9)5523-32(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The crystal structure of a thermostabilized LRRTM2 protein was determined.
Title: Crystal Structure of an Engineered LRRTM2 Synaptic Adhesion Molecule and a Model for Neurexin Binding.

Data indicate that neural Cell Adhesion Molecules Lrrtm1 and Lrrtm2 mRNA expression is controlled by synaptic activity and nuclear calcium signaling.
Title: Nuclear calcium signaling induces expression of the synaptic organizers Lrrtm1 and Lrrtm2.

This study demonistrated that LRRTM2 is essential for maintenance of long-term potentiation in mice hippocampus.
Title: Leucine-rich repeat transmembrane proteins are essential for maintenance of long-term potentiation.

The LRRTM2 acts redundantly to maintain excitatory synapses and that synapse elimination caused by the absence of LRRTM2 is promoted by synaptic activity and mediated by a postsynaptic Ca(2+)/CaM-dependent signaling pathway.
Title: Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons.

The following Lrrtm2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lrrtm2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu07099	NM_178005.4 Latest version!	Mus musculus leucine rich repeat transmembrane neuronal 2 (Lrrtm2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$300.30 $429.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lrrtm2 ( NM_178005.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_821072.1 Mus musculus leucine rich repeat transmembrane neuronal 2 (Lrrtm2), mRNA.

Price & Availability↑

CloneID	OMu07099
Clone ID Related Accession (Same CDS sequence)	NM_178005.4
Accession Version	NM_178005.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1548bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	leucine-rich repeat transmembrane neuronal protein 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK046774.1 and AC121874.2. On Aug 22, 2007 this sequence version replaced NM_178005.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK122278.1, AK049920.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849379, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCTTAC ATTTCAAGTG GCCATTAGGG GCCCCTATGC TGGCAGCAAT ATATGCAATG 
AGTGTGGTAT TAAAAATGCT GCCTGCCCTG GGTATGGCGT GTCCACCTAA ATGCCGCTGT 
GAGAAGCTGC TATTCTACTG CGACTCTCAG GGCTTCCACT CAGTGCCAAA CGCCACAGAC 
AAGGGTTCTT TGGGTCTGTC CCTGAGGCAC AATCACATCA CAGCGCTTGA AAGAGATCAA 
TTTGCCAGCT TCAGTCAACT CACCTGGCTC CACTTAGATC ACAATCAAAT TTCCACAGTA 
AAAGAAGACG CTTTCCAAGG ACTGTATAAA CTAAAGGAGT TAATCTTAAG TTCCAACAAA 
ATATTCTACT TGCCAAACAC AACTTTTACC CAACTGATTA ATCTGCAAAA TTTGGACCTG 
TCTTTTAATC AGCTGTCATC TCTGCATCCT GAGCTCTTCT ATGGCCTTCG GAAGCTGCAG 
ACCTTGCATT TACGTTCCAA CTCCCTGCGG ACTATCCCAG TACGCCTGTT CTGGGACTGT 
CGTAGTCTAG AGTTTCTGGA TCTGAGCACA AACCGTTTGC GAAGTTTGGC TCGAAATGGA 
TTTGCAGGAT TAATCAAACT GAGAGAGCTT CATCTAGAGC ACAATCAGCT GACGAAGATT 
AATTTTGCTC ACTTCCTCCG GCTAAGCAGT CTGCACACAC TCTTCTTACA ATGGAACAAA 
ATCAGCAACT TGACGTGTGG GATGGACTGG ACCTGGAGCA CTTTAGAAAA GCTAGACCTA 
ACTGGAAATG AAATCAAAGC CATCGACTTG ACAGTGTTCG AGACCATGCC TAATCTTAAA 
ATACTTCTCA TGGATAACAA CAAGTTAAAC AGTCTTGATT CCAAAATCTT AAACTCCCTG 
AAATCCCTCA CGACCGTTGG CCTCTCTGGC AATCTGTGGG AATGCAGCCC CAGAGTGTGT 
GCTCTTGCCT CCTGGCTGGG CAGTTTCCAA GGTCGGTGGG AGCACTCCAT CCTATGCCAC 
AGCCCTGACC ACACCCAAGG AGAGGATATT CTAGATGCAG TCCACGGGTT TCAGCTCTGC 
TGGAATTTAT CAACCACTGT CACTGCCATG GCTACAACTT ATAGAGATCC AACCACTGAA 
TATACAAAAA TAAGCTCGTC GAGTTACCAT GTAGGAGACA AAGAAATTCC AACTACTGCA 
GGCATAGCAG TCACTACAGA GGAACACTTT CCTGAACCTG ACAATGCCAT CTTTACTCAG 
AGAGTAATTA CAGGAACAAT GGCTTTATTG TTTTCTTTCT TTTTTATTAT TTTTATAGTG 
TTCATTTCCA GGAAGTGCTG CCCTCCCACT TTGAGAAGAA TTAGGCAGTG CTCAATGATT 
CAGAACCACA GGCAGCTCCG ATCCCAAACA CGACTCCATA TGTCAAACAT GTCAGACCAA 
GGACCGTATA ATGAGTATGA ACCCACCCAT GAAGGACCTT TCATCATCAT TAATGGTTAT 
GGACAGTGCA AGTGTCAGCA GCTGCCATAC AAAGAATGTG AAGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_821072.1
CDS	429..1976
Translation	MGLHFKWPLGAPMLAAIYAMSVVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITALERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMDWTWSTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLKSLTTVGLSGNLWECSPRVCALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLCWNLSTTVTAMATTYRDPTTEYTKISSSSYHVGDKEIPTTAGIAVTTEEHFPEPDNAIFTQRVITGTMALLFSFFFIIFIVFISRKCCPPTLRRIRQCSMIQNHRQLRSQTRLHMSNMSDQGPYNEYEPTHEGPFIIINGYGQCKCQQLPYKECEV

Target ORF information:

RefSeq Version	NM_178005.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus leucine rich repeat transmembrane neuronal 2 (Lrrtm2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178005.4

ORF Insert Sequence:

ATGGGCTTAC ATTTCAAGTG GCCATTAGGG GCCCCTATGC TGGCAGCAAT ATATGCAATG 
AGTGTGGTAT TAAAAATGCT GCCTGCCCTG GGTATGGCGT GTCCACCTAA ATGCCGCTGT 
GAGAAGCTGC TATTCTACTG CGACTCTCAG GGCTTCCACT CAGTGCCAAA CGCCACAGAC 
AAGGGTTCTT TGGGTCTGTC CCTGAGGCAC AATCACATCA CAGCGCTTGA AAGAGATCAA 
TTTGCCAGCT TCAGTCAACT CACCTGGCTC CACTTAGATC ACAATCAAAT TTCCACAGTA 
AAAGAAGACG CTTTCCAAGG ACTGTATAAA CTAAAGGAGT TAATCTTAAG TTCCAACAAA 
ATATTCTACT TGCCAAACAC AACTTTTACC CAACTGATTA ATCTGCAAAA TTTGGACCTG 
TCTTTTAATC AGCTGTCATC TCTGCATCCT GAGCTCTTCT ATGGCCTTCG GAAGCTGCAG 
ACCTTGCATT TACGTTCCAA CTCCCTGCGG ACTATCCCAG TACGCCTGTT CTGGGACTGT 
CGTAGTCTAG AGTTTCTGGA TCTGAGCACA AACCGTTTGC GAAGTTTGGC TCGAAATGGA 
TTTGCAGGAT TAATCAAACT GAGAGAGCTT CATCTAGAGC ACAATCAGCT GACGAAGATT 
AATTTTGCTC ACTTCCTCCG GCTAAGCAGT CTGCACACAC TCTTCTTACA ATGGAACAAA 
ATCAGCAACT TGACGTGTGG GATGGACTGG ACCTGGAGCA CTTTAGAAAA GCTAGACCTA 
ACTGGAAATG AAATCAAAGC CATCGACTTG ACAGTGTTCG AGACCATGCC TAATCTTAAA 
ATACTTCTCA TGGATAACAA CAAGTTAAAC AGTCTTGATT CCAAAATCTT AAACTCCCTG 
AAATCCCTCA CGACCGTTGG CCTCTCTGGC AATCTGTGGG AATGCAGCCC CAGAGTGTGT 
GCTCTTGCCT CCTGGCTGGG CAGTTTCCAA GGTCGGTGGG AGCACTCCAT CCTATGCCAC 
AGCCCTGACC ACACCCAAGG AGAGGATATT CTAGATGCAG TCCACGGGTT TCAGCTCTGC 
TGGAATTTAT CAACCACTGT CACTGCCATG GCTACAACTT ATAGAGATCC AACCACTGAA 
TATACAAAAA TAAGCTCGTC GAGTTACCAT GTAGGAGACA AAGAAATTCC AACTACTGCA 
GGCATAGCAG TCACTACAGA GGAACACTTT CCTGAACCTG ACAATGCCAT CTTTACTCAG 
AGAGTAATTA CAGGAACAAT GGCTTTATTG TTTTCTTTCT TTTTTATTAT TTTTATAGTG 
TTCATTTCCA GGAAGTGCTG CCCTCCCACT TTGAGAAGAA TTAGGCAGTG CTCAATGATT 
CAGAACCACA GGCAGCTCCG ATCCCAAACA CGACTCCATA TGTCAAACAT GTCAGACCAA 
GGACCGTATA ATGAGTATGA ACCCACCCAT GAAGGACCTT TCATCATCAT TAATGGTTAT 
GGACAGTGCA AGTGTCAGCA GCTGCCATAC AAAGAATGTG AAGTATAA