Topors cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Topors
Entrez Gene ID	106021
Full Name	topoisomerase I binding, arginine/serine-rich
Synonyms	AW105885,LUN,TP53BPL,p53BP3/LUN
General protein information	Preferred Names topoisomerase I binding, arginine/serine-rich Names E3 ubiquitin-protein ligase Topors RING-type E3 ubiquitin transferase Topors SUMO1-protein E3 ligase Topors p53-binding protein 3 p53BP3 topoisomerase 1-binding RING finger topoisomerase I-binding RING finger protein topoisomerase I-binding arginine/serine-rich protein tumor suppressor p53-binding protein 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 A5

mRNA and Protein(s)

mRNA	Protein	Name
NM_134097.3	NP_598858.2	E3 ubiquitin-protein ligase Topors

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TOPORS	XP_003639434.1
Bos taurus (cattle)	TOPORS	NP_001179507.2
Mus musculus (house mouse)	Topors	NP_598858.2
Homo sapiens (human)	TOPORS	NP_005793.2
Pan troglodytes (chimpanzee)	TOPORS	XP_003951457.1
	TOPORS	XP_001092273.2
Gallus gallus (chicken)	TOPORS	XP_424920.4
Rattus norvegicus (Norway rat)	Topors	NP_001102128.1
Xenopus tropicalis (tropical clawed frog)	topors	XP_002940310.1

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, Topors.
Braun KR, DeWispelaere AM, Bressler SL, Fukai N, Kenagy RD, Chen L, Clowes AW, Kinsella MG
PloS one7(8)e43701(2012)

TOPORS, implicated in retinal degeneration, is a cilia-centrosomal protein.
Chakarova CF, Khanna H, Shah AZ, Patil SB, Sedmak T, Murga-Zamalloa CA, Papaioannou MG, Nagel-Wolfrum K, Lopez I, Munro P, Cheetham M, Koenekoop RK, Rios RM, Matter K, Wolfrum U, Swaroop A, Bhattacharya SS
Human molecular genetics20(5)975-87(2011 Mar)

Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice.
Marshall H, Bhaumik M, Aviv H, Moore D, Yao M, Dutta J, Rahim H, Gounder M, Ganesan S, Saleem A, Rubin E
BMC molecular biology1131(2010 Apr)

Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1.
Guan B, Pungaliya P, Li X, Uquillas C, Mutton LN, Rubin EH, Bieberich CJ
The Journal of biological chemistry283(8)4834-40(2008 Feb)

topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage.
Lin L, Ozaki T, Takada Y, Kageyama H, Nakamura Y, Hata A, Zhang JH, Simonds WF, Nakagawara A, Koseki H
Oncogene24(21)3385-96(2005 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest a mechanism for the inhibitory effects of Sdc-1 on cell growth that involves the interaction between the cytoplasmic domain of Sdc-1 and the SUMO-1 E3 ligase, Topors.
Title: Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, Topors.

These results indicate a unique role for Topors in the maintenance of genomic stability and pericentric heterochromatin, as well as in cellular sensitivity to histone deacetylase inhibitors.
Title: Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice.

NKX3.1 can be ubiquitinated by TOPORS in vitro and in vivo, and overexpression of TOPORS leads to NKX3.1 proteasomal degradation in prostate cancer cells
Title: Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1.

The following Topors gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Topors cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10537	NM_134097.3 Latest version!	Mus musculus topoisomerase I binding, arginine/serine-rich (Topors), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$608.30 $869.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Topors ( NM_134097.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598858.2 Mus musculus topoisomerase I binding, arginine/serine-rich (Topors), mRNA.

Price & Availability↑

CloneID	OMu10537
Clone ID Related Accession (Same CDS sequence)	NM_134097.3
Accession Version	NM_134097.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3102bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase Topors
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL831793.4. On May 24, 2006 this sequence version replaced NM_134097.2. ##Evidence-Data-START## Transcript exon combination :: AB104865.1, BC040797.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGTCGC AGCCGCCGCC ACCGGGGTCT CCGCTGTCTC GCGAGGAGGG TGAAGCGCCC 
CCTCTGGTGC CTGCCGAGGA GGGGAGGCGC CGAAGCCGCC GGGTACGCCT TCGCGGATCC 
TGCCGCCACC GGCCGAGCTT ACTGAGCCGG CGGGAGCTGG CTTCCAACGG CCCAGCGGTT 
CCTGCCACCG CGTCCTCGGA GATAATGGCC TCAGCTGCTA AGGAATTTAA AATGGACAAC 
TTTTCACCTA AAGCTGGCAC TAGCAAATTG CAGCAGACAG TACCAGCTGA TGCGTCTCCT 
GATTCTAAGT GTCCTATATG CTTGGATAGA TTTGATAATG TGTCTTACTT AGATCGTTGC 
CTACATAAGT TCTGTTTTCG CTGTGTACAA GAGTGGTCCA AAAACAAAGC CGAATGCCCA 
CTGTGTAAAC AGCCCTTTGA TTCTATTTTC CATTCAGTGA GGGCTGAAGA TGACTTCAAG 
GAGTATGTCC TGAGGCCTTC CTATAATGGT TCCTTTACTA ACCCTGAGGT TCGAAGGTTT 
CGCTACCGGA CAACTATGAC GAGAGAACGG AGCGCCTCTC TTTATTCACC CAGTAGTACT 
GTAAGTAGGA GAACAACCAC GCCACCAGAT AGTGGAGTGC TGTTTGAAGG GTTAGGCATT 
TCGACAAGAC CTAGAGATGT TGACATTCCT CAATTTATGA GACAAATGGC ATTAAGGGGG 
CCAACTACTA CAGATGAGAG ATCTTTGCGG AAAATTCAAG AACAAGATAT TATTAATTTC 
AGGCGAACTC TTTATCGTGC TGGTGTTCGA GTTAGAAGTA TTGAAGATGG TGGCCGCTAC 
AGGGATATTT CAGCTGAGTT CTTCCGTAGA AATCCAGCTT GCCTTCACAG ATTAGTTCCT 
TGGTTAAAGC GTGAACTTAC TGTGCTTTTT GGAGCCCATG GTTCGCTAGT CAATATCGTC 
CAGCACATCA TCATGAGTAA TGTTACTCGC TATGATTTGG AGAGTCAGGC ATTTGTGTCT 
GACTTAAGAC CATTTTTGCT TAATCGAACT GAGCATTTTA TACATGAATT TATCAGTTTT 
GCTAGATCTC CCTTCAATAT GGCAGCTTTT GACCAGCATG CTAATTATGA TTGCCCTCCT 
TCATCTGAAG AAGGCAGCCG TTCAGATTCT TCAGTCATTA CAATATCACC AGATGAGGCT 
GAAACTCAAG AGCTAGATAT GAATGCATCT ACTGTTAGGC AGGCACCGTG GGATGATGAA 
ACTCCTGGAC CATCTTATTC AAGTTCAGAG CAAGTGCATG TTGGCGTGTC TTCCCTTTTA 
AATTCTTCAG ACAGTTCAGA TGAAGAGCTT GTCTCTGGAG GAACCACATC TCAGATACAA 
GGAGTACAGA CCAATGACGA TGTCAATAAT GACAGTGATT CATCGTCAGA TAATTGTGTC 
ATTGTTGGGT TTGTTAAGCC ATTGGCTGAA AGGACCCCGG AACTTGTTGA ACTGTCTTCT 
GATTCTGAGG AGTTGGGCCC TTATGAGAAA GTGGAGACAG TGAAGACTCA GGAGCAAGAG 
CAGTCGTACA GTTCAGGTGA CAGTGATGTT AGCCGGGCGT CATCTCCACG CTCTGTCCTT 
GGAAAAGATG AACAAATGAG TAAAAGCCAT TGTGATTCTG ACACAAGAAT AAGCTCAAAG 
AAAGAAGAGA AACGATCTAC ATCATTGCCA GCTCCCAGGG ACAGCTCATC TACAAGAGGT 
GACAGGGTAT GCTCCCCATA TAACCATCGA CACAGGAAGG GAGGAAGGTC GAGGAGTTCA 
GATTCCCGGT CCCAGAGTAG AAGTGGCCAT GACCCGAGGA ATCACAGGAA GCACGGGAAG 
AAAAGACTGA GGAACAAGAG GTCCAGAAGC AGGGAGAGTA GTAGCAGGCC GAGAGCAAGA 
AAGGACAAAA AGAGATCCAG AACTAGAGAT AGCAGCTGGT CCCGGAGGAG CCAGACACTT 
TCTCTAAGTA GTGGAAGCAC CAGTAGATCG AGGTCTCGTA GCAGTGATCA TGGCAAAAGA 
AGATCACGAA GCAGAAATCG AGATCGCTAT TATTTAAGAA ATAATTATGG AAGCAAATAT 
AAGTGGGAAT ACACTTACTA CAGCAGAAAC AAGGACAGAG ATGGCTATGA ATCATCATAC 
AGGAGGAGGA CTCTTTCAAG AGCCCATTAC TCTAGACAGT CTTCAAGTCC AGAATTTAGA 
ATTCAGTCTT TTTCTGAAAG AACAAATGCG AGGAAGAAGA ATCACAGTGA AAGGAAATAC 
TACTACTATG AAAGGCGCCG GTCCAGGAGC GTGTCCAGTA ACAGGTCGAG GACTACATCC 
GCCGGGCCCG ACCGGGTGAG AAATGAGAAG CCCGGAGGGA AACGCAAGTA CAAAACCCGG 
CATTTGGAAG GTACCAGTGA AGAGGCTCAG CCGGCTCGGG AGTTCACTTC CAAAGGGAAG 
GACAGTCATT ACCAAAAATC AAAATTGGAT GGCAGTTATA AAAATGAGAG TGACAGCTTT 
TCAGATAGCA GATCATCAGA CAGAGAGACA AAACACAAGA GGAGGAGGAG GAGGACCCGG 
AGCCTAAGTG TAGAGATAGT TTATGAAGGA AAGGCTACGG ACACAAGCAA ACACCATAAG 
AAGAAAAAGA AGAAACATAA GAAGAAGCAT AAGAAACACC ATGGAGATAA TACTTCACGG 
TCGCCGGTGG TTATAACCAT CGACAGTGAC AGCGATGGAG AGTCTGAAGT AAAGGCGGGT 
ATTGAATGTA GCAATGGCAG TCTTCCACAG CCTATACAAG ATGGAGCATT TGAAACTAAA 
GATGTTGTCA CAATCGAAGA TGAGCTTGGT GTCCTGGACA AGGACTGTGA CGTTACAGCA 
CTTGCTGATG ACTTGAGCAC CAGCCAAACT GTGGAGAATT GTGACTCGCC GGCAGTCCCA 
GTTGAACAAA CTCTTGATGT AAGAGAAGAA AGCACCTTTG CCTCTGATTT GGAGAGCCAG 
TCGAGTAATG TGTCTATTCA GGCTGAACCA TCGAGACCAG TGCCATCTCC ACGGACCTCA 
CTGTCATCAG TGTCTCCTGG TAGAGACTGT GATGTGTCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598858.2
CDS	166..3267
Translation	MGSQPPPPGSPLSREEGEAPPLVPAEEGRRRSRRVRLRGSCRHRPSLLSRRELASNGPAVPATASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFTNPEVRRFRYRTTMTRERSASLYSPSSTVSRRTTTPPDSGVLFEGLGISTRPRDVDIPQFMRQMALRGPTTTDERSLRKIQEQDIINFRRTLYRAGVRVRSIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPPSSEEGSRSDSSVITISPDEAETQELDMNASTVRQAPWDDETPGPSYSSSEQVHVGVSSLLNSSDSSDEELVSGGTTSQIQGVQTNDDVNNDSDSSSDNCVIVGFVKPLAERTPELVELSSDSEELGPYEKVETVKTQEQEQSYSSGDSDVSRASSPRSVLGKDEQMSKSHCDSDTRISSKKEEKRSTSLPAPRDSSSTRGDRVCSPYNHRHRKGGRSRSSDSRSQSRSGHDPRNHRKHGKKRLRNKRSRSRESSSRPRARKDKKRSRTRDSSWSRRSQTLSLSSGSTSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSKYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEFRIQSFSERTNARKKNHSERKYYYYERRRSRSVSSNRSRTTSAGPDRVRNEKPGGKRKYKTRHLEGTSEEAQPAREFTSKGKDSHYQKSKLDGSYKNESDSFSDSRSSDRETKHKRRRRRTRSLSVEIVYEGKATDTSKHHKKKKKKHKKKHKKHHGDNTSRSPVVITIDSDSDGESEVKAGIECSNGSLPQPIQDGAFETKDVVTIEDELGVLDKDCDVTALADDLSTSQTVENCDSPAVPVEQTLDVREESTFASDLESQSSNVSIQAEPSRPVPSPRTSLSSVSPGRDCDVS

Target ORF information:

RefSeq Version	NM_134097.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus topoisomerase I binding, arginine/serine-rich (Topors), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134097.3

ORF Insert Sequence:

ATGGGGTCGC AGCCGCCGCC ACCGGGGTCT CCGCTGTCTC GCGAGGAGGG TGAAGCGCCC 
CCTCTGGTGC CTGCCGAGGA GGGGAGGCGC CGAAGCCGCC GGGTACGCCT TCGCGGATCC 
TGCCGCCACC GGCCGAGCTT ACTGAGCCGG CGGGAGCTGG CTTCCAACGG CCCAGCGGTT 
CCTGCCACCG CGTCCTCGGA GATAATGGCC TCAGCTGCTA AGGAATTTAA AATGGACAAC 
TTTTCACCTA AAGCTGGCAC TAGCAAATTG CAGCAGACAG TACCAGCTGA TGCGTCTCCT 
GATTCTAAGT GTCCTATATG CTTGGATAGA TTTGATAATG TGTCTTACTT AGATCGTTGC 
CTACATAAGT TCTGTTTTCG CTGTGTACAA GAGTGGTCCA AAAACAAAGC CGAATGCCCA 
CTGTGTAAAC AGCCCTTTGA TTCTATTTTC CATTCAGTGA GGGCTGAAGA TGACTTCAAG 
GAGTATGTCC TGAGGCCTTC CTATAATGGT TCCTTTACTA ACCCTGAGGT TCGAAGGTTT 
CGCTACCGGA CAACTATGAC GAGAGAACGG AGCGCCTCTC TTTATTCACC CAGTAGTACT 
GTAAGTAGGA GAACAACCAC GCCACCAGAT AGTGGAGTGC TGTTTGAAGG GTTAGGCATT 
TCGACAAGAC CTAGAGATGT TGACATTCCT CAATTTATGA GACAAATGGC ATTAAGGGGG 
CCAACTACTA CAGATGAGAG ATCTTTGCGG AAAATTCAAG AACAAGATAT TATTAATTTC 
AGGCGAACTC TTTATCGTGC TGGTGTTCGA GTTAGAAGTA TTGAAGATGG TGGCCGCTAC 
AGGGATATTT CAGCTGAGTT CTTCCGTAGA AATCCAGCTT GCCTTCACAG ATTAGTTCCT 
TGGTTAAAGC GTGAACTTAC TGTGCTTTTT GGAGCCCATG GTTCGCTAGT CAATATCGTC 
CAGCACATCA TCATGAGTAA TGTTACTCGC TATGATTTGG AGAGTCAGGC ATTTGTGTCT 
GACTTAAGAC CATTTTTGCT TAATCGAACT GAGCATTTTA TACATGAATT TATCAGTTTT 
GCTAGATCTC CCTTCAATAT GGCAGCTTTT GACCAGCATG CTAATTATGA TTGCCCTCCT 
TCATCTGAAG AAGGCAGCCG TTCAGATTCT TCAGTCATTA CAATATCACC AGATGAGGCT 
GAAACTCAAG AGCTAGATAT GAATGCATCT ACTGTTAGGC AGGCACCGTG GGATGATGAA 
ACTCCTGGAC CATCTTATTC AAGTTCAGAG CAAGTGCATG TTGGCGTGTC TTCCCTTTTA 
AATTCTTCAG ACAGTTCAGA TGAAGAGCTT GTCTCTGGAG GAACCACATC TCAGATACAA 
GGAGTACAGA CCAATGACGA TGTCAATAAT GACAGTGATT CATCGTCAGA TAATTGTGTC 
ATTGTTGGGT TTGTTAAGCC ATTGGCTGAA AGGACCCCGG AACTTGTTGA ACTGTCTTCT 
GATTCTGAGG AGTTGGGCCC TTATGAGAAA GTGGAGACAG TGAAGACTCA GGAGCAAGAG 
CAGTCGTACA GTTCAGGTGA CAGTGATGTT AGCCGGGCGT CATCTCCACG CTCTGTCCTT 
GGAAAAGATG AACAAATGAG TAAAAGCCAT TGTGATTCTG ACACAAGAAT AAGCTCAAAG 
AAAGAAGAGA AACGATCTAC ATCATTGCCA GCTCCCAGGG ACAGCTCATC TACAAGAGGT 
GACAGGGTAT GCTCCCCATA TAACCATCGA CACAGGAAGG GAGGAAGGTC GAGGAGTTCA 
GATTCCCGGT CCCAGAGTAG AAGTGGCCAT GACCCGAGGA ATCACAGGAA GCACGGGAAG 
AAAAGACTGA GGAACAAGAG GTCCAGAAGC AGGGAGAGTA GTAGCAGGCC GAGAGCAAGA 
AAGGACAAAA AGAGATCCAG AACTAGAGAT AGCAGCTGGT CCCGGAGGAG CCAGACACTT 
TCTCTAAGTA GTGGAAGCAC CAGTAGATCG AGGTCTCGTA GCAGTGATCA TGGCAAAAGA 
AGATCACGAA GCAGAAATCG AGATCGCTAT TATTTAAGAA ATAATTATGG AAGCAAATAT 
AAGTGGGAAT ACACTTACTA CAGCAGAAAC AAGGACAGAG ATGGCTATGA ATCATCATAC 
AGGAGGAGGA CTCTTTCAAG AGCCCATTAC TCTAGACAGT CTTCAAGTCC AGAATTTAGA 
ATTCAGTCTT TTTCTGAAAG AACAAATGCG AGGAAGAAGA ATCACAGTGA AAGGAAATAC 
TACTACTATG AAAGGCGCCG GTCCAGGAGC GTGTCCAGTA ACAGGTCGAG GACTACATCC 
GCCGGGCCCG ACCGGGTGAG AAATGAGAAG CCCGGAGGGA AACGCAAGTA CAAAACCCGG 
CATTTGGAAG GTACCAGTGA AGAGGCTCAG CCGGCTCGGG AGTTCACTTC CAAAGGGAAG 
GACAGTCATT ACCAAAAATC AAAATTGGAT GGCAGTTATA AAAATGAGAG TGACAGCTTT 
TCAGATAGCA GATCATCAGA CAGAGAGACA AAACACAAGA GGAGGAGGAG GAGGACCCGG 
AGCCTAAGTG TAGAGATAGT TTATGAAGGA AAGGCTACGG ACACAAGCAA ACACCATAAG 
AAGAAAAAGA AGAAACATAA GAAGAAGCAT AAGAAACACC ATGGAGATAA TACTTCACGG 
TCGCCGGTGG TTATAACCAT CGACAGTGAC AGCGATGGAG AGTCTGAAGT AAAGGCGGGT 
ATTGAATGTA GCAATGGCAG TCTTCCACAG CCTATACAAG ATGGAGCATT TGAAACTAAA 
GATGTTGTCA CAATCGAAGA TGAGCTTGGT GTCCTGGACA AGGACTGTGA CGTTACAGCA 
CTTGCTGATG ACTTGAGCAC CAGCCAAACT GTGGAGAATT GTGACTCGCC GGCAGTCCCA 
GTTGAACAAA CTCTTGATGT AAGAGAAGAA AGCACCTTTG CCTCTGATTT GGAGAGCCAG 
TCGAGTAATG TGTCTATTCA GGCTGAACCA TCGAGACCAG TGCCATCTCC ACGGACCTCA 
CTGTCATCAG TGTCTCCTGG TAGAGACTGT GATGTGTCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, Topors.
PloS one7(8)e43701(2012)
Braun KR,DeWispelaere AM,Bressler SL,Fukai N,Kenagy RD,Chen L,Clowes AW,Kinsella MG

TOPORS, implicated in retinal degeneration, is a cilia-centrosomal protein.
Human molecular genetics20(5)975-87(2011 Mar)
Chakarova CF,Khanna H,Shah AZ,Patil SB,Sedmak T,Murga-Zamalloa CA,Papaioannou MG,Nagel-Wolfrum K,Lopez I,Munro P,Cheetham M,Koenekoop RK,Rios RM,Matter K,Wolfrum U,Swaroop A,Bhattacharya SS

Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice.
BMC molecular biology1131(2010 Apr)
Marshall H,Bhaumik M,Aviv H,Moore D,Yao M,Dutta J,Rahim H,Gounder M,Ganesan S,Saleem A,Rubin E

Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1.
The Journal of biological chemistry283(8)4834-40(2008 Feb)
Guan B,Pungaliya P,Li X,Uquillas C,Mutton LN,Rubin EH,Bieberich CJ

topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage.
Oncogene24(21)3385-96(2005 May)
Lin L,Ozaki T,Takada Y,Kageyama H,Nakamura Y,Hata A,Zhang JH,Simonds WF,Nakagawara A,Koseki H

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Topors cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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