Ric8a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ric8a
Entrez Gene ID	101489
Full Name	RIC8 guanine nucleotide exchange factor A
Synonyms	AI114950,RIC-8,Ric8
General protein information	Preferred Names RIC8 guanine nucleotide exchange factor A Names synembryn-A resistance to inhibitors of cholinesterase 8 homolog synembryn
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 F4

mRNA and Protein(s)

mRNA	Protein	Name
NM_053194.4	NP_444424.1	synembryn-A

Pathways from BioSystems

Homologies

Homo sapiens (human)	RIC8A	NP_001273063.1
Rattus norvegicus (Norway rat)	Ric8a	NP_001093990.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010793	XP_318515.3
Canis lupus familiaris (dog)	RIC8A	XP_005631129.1
Mus musculus (house mouse)	Ric8	NP_444424.1
	RIC8A	XP_001083119.2
Bos taurus (cattle)	RIC8A	NP_001015627.1
Danio rerio (zebrafish)	ric8a	NP_001005588.1
Pan troglodytes (chimpanzee)	RIC8A	XP_521700.2
Drosophila melanogaster (fruit fly)	ric8a	NP_572550.2
Xenopus tropicalis (tropical clawed frog)	ric8a	NP_989159.1
Gallus gallus (chicken)	RIC8A	NP_001026345.1

Gene Ontology
Bibliography

Related articles in PubMed

RIC8A is essential for the organisation of actin cytoskeleton and cell-matrix interaction.
Ruisu K, Meier R, Kask K, T?nissoo T, Velling T, Pooga M
Experimental cell research357(2)181-191(2017 08)

A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis.
Ma S, Santhosh D, Kumar T P, Huang Z
Developmental cell41(4)366-381.e4(2017 05)

Ric-8A gene deletion or phorbol ester suppresses tumorigenesis in a mouse model of GNAQ(Q209L)-driven melanoma.
Patel BR, Tall GG
Oncogenesis5(6)e236(2016 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

found that RIC8A plays an important role in the organisation and remodelling of actin cytoskeleton and cell-extracellular matrix association
Title: RIC8A is essential for the organisation of actin cytoskeleton and cell-matrix interaction.

Data show that disrupting resistance to inhibitors of cholinesterase 8A (Ric-8A) expression in hematopoietic cells results in a loss of GTP-binding protein alpha subunits Galphai2, Galphai3, and Galphaq.
Title: B Lymphocyte-Specific Loss of Ric-8A Results in a G? Protein Deficit and Severe Humoral Immunodeficiency.

Results suggest that RIC8A has an essential role in the development of mammalian nervous system by maintaining the integrity of pial basement membrane and modulating cell division
Title: Deletion of RIC8A in neural precursor cells leads to altered neurogenesis and neonatal lethality of mouse.

Data show that the localization of maternally expressed RIC8 protein is highly dynamic and is dependent on the stage of folliculogenesis, oogenesis and cleavage, and imply that it may have a regulatory function in mammalian gametogenesis.
Title: Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis.

The activity of RIC8A in neurons is essential for survival and its deficiency causes a severe neuromuscular phenotype.
Title: Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal death.

The following Ric8a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ric8a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09337	NM_053194.4 Latest version!	Mus musculus RIC8 guanine nucleotide exchange factor A (Ric8a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$314.30 $449.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ric8a ( NM_053194.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_444424.1 Mus musculus RIC8 guanine nucleotide exchange factor A (Ric8a), mRNA.

Price & Availability↑

CloneID	OMu09337
Clone ID Related Accession (Same CDS sequence)	NM_053194.4
Accession Version	NM_053194.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1593bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	synembryn-A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC107815.11. On Nov 17, 2006 this sequence version replaced NM_053194.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK031466.1, AK167746.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCCC GGGCAGTTGC GGATGCCTTG GAGACCGGAG AGGAAGATGC GGTGACAGAA 
GCTCTGCGGT CGTTCAACCG GGAGCATTCT CAGAGCTTCA CCTTCGATGA TGCCCAGCAG 
GAGGACAGGA AGAGACTCGC AAAGCTACTG GTCTCCGTCC TGGAGCAGGG CTTGTCACCA 
AAGCACCGTG TCACCTGGCT GCAGACTATC CGAATCCTAT CCCGAGACCG CAGCTGCCTG 
GACTCATTTG CCAGCCGCCA GAGCTTACAT GCACTAGCCT GCTATGCTGA CATTACCGTC 
TCAGAGGAAC CCATCCCACA GTCCCCAGAC ATGGATGTCC TCCTCGAGTC TCTCAAATGC 
CTGTGTAATC TTGTGCTCAG CAGTCCAACA GCACAGATGC TAGCAGCAGA GGCTCGCCTG 
GTGGTGAGGC TAGCGGAGCG TGTGGGACTG TACCGCAAGA GGAGCTATCC CCACGAAGTC 
CAGTTCTTTG ACTTGAGGCT CCTTTTCCTG CTAACAGCCC TTCGCACGGA TGTGCGCCAG 
CAACTGTTTC AGGAGCTGCA CGGTGTACGC CTGCTGACTG ATGCGCTGGA ACTAACACTG 
GGCGTGGCCC CCAAAGAAAA CCCTCCGGTG ATGCTTCCAG CCCAAGAGAC GGAGAGGGCC 
ATGGAGATCC TCAAAGTGCT CTTTAATATC ACCTTTGACT CTGTCAAGAG GGAAGTTGAT 
GAGGAAGATG CTGCCCTTTA CCGGTACCTG GGGACTCTTC TGCGGCACTG CGTGATGGTT 
GAAGCTGCTG GGGACCGCAC AGAGGAGTTC CACGGCCACA CGGTGAATCT CCTGGGGAAC 
TTGCCCCTCA AGTGTTTGGA TGTGCTTCTG GCCCTGGAGC TCCACGAAGG ATCCTTAGAG 
TTCATGGGAG TTAACATGGA TGTGATCAGT GCCCTCCTCG CCTTCCTAGA GAAACGTCTG 
CACCAGACCC ACAGGCTGAA GGAATGTGTG GCACCTGTGC TGAACGTGTT GACAGAATGT 
GCCCGCATGC ACCGTCCTGC CAGGAAGTTC CTGAAGGCCC AGGTCCTGCC CCCTCTGAGG 
GATGTGAGGA CTCGGCCTGA GGTGGGGGAC CTGCTTCGAA ACAAGCTTGT CCGCCTCATG 
ACACACCTGG ATACAGATGT GAAGAGAGTA GCTGCCGAGT TCCTCTTTGT CTTATGTTCT 
GAAAGTGTGC CCCGATTCAT CAAGTACACA GGCTACGGGA ATGCTGCCGG CCTCCTGGCT 
GCCAGGGGCC TCATGGCTGG GGGCCGACCC GAGGGCCAGT ACTCAGAGGA CGAGGACACG 
GACACAGAGG AGTACAGGGA AGCCAAGGCC AGCATCAACC CTGTGACTGG AAGGGTGGAG 
GAGAAGCCGC CTAATCCTAT GGAAGGCATG ACAGAGGAGC AGAAGGAACA TGAGGCCATG 
AAGCTAGTGA ACATGTTTGA CAAGCTCTCC AGGCACAGAG TCATCCAACC CATGGGGATG 
AGTCCCAGGG GTCACCTCAC TTCTCTGCAA GATGCGATGT GTGAGACAAT GGAGGGACAG 
CTCTCCTCAG ACCCTGACTC AGATCCTGAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444424.1
CDS	75..1667
Translation	MEPRAVADALETGEEDAVTEALRSFNREHSQSFTFDDAQQEDRKRLAKLLVSVLEQGLSPKHRVTWLQTIRILSRDRSCLDSFASRQSLHALACYADITVSEEPIPQSPDMDVLLESLKCLCNLVLSSPTAQMLAAEARLVVRLAERVGLYRKRSYPHEVQFFDLRLLFLLTALRTDVRQQLFQELHGVRLLTDALELTLGVAPKENPPVMLPAQETERAMEILKVLFNITFDSVKREVDEEDAALYRYLGTLLRHCVMVEAAGDRTEEFHGHTVNLLGNLPLKCLDVLLALELHEGSLEFMGVNMDVISALLAFLEKRLHQTHRLKECVAPVLNVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGDLLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTEEYREAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVNMFDKLSRHRVIQPMGMSPRGHLTSLQDAMCETMEGQLSSDPDSDPD

Target ORF information:

RefSeq Version	NM_053194.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus RIC8 guanine nucleotide exchange factor A (Ric8a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053194.4

ORF Insert Sequence:

ATGGAGCCCC GGGCAGTTGC GGATGCCTTG GAGACCGGAG AGGAAGATGC GGTGACAGAA 
GCTCTGCGGT CGTTCAACCG GGAGCATTCT CAGAGCTTCA CCTTCGATGA TGCCCAGCAG 
GAGGACAGGA AGAGACTCGC AAAGCTACTG GTCTCCGTCC TGGAGCAGGG CTTGTCACCA 
AAGCACCGTG TCACCTGGCT GCAGACTATC CGAATCCTAT CCCGAGACCG CAGCTGCCTG 
GACTCATTTG CCAGCCGCCA GAGCTTACAT GCACTAGCCT GCTATGCTGA CATTACCGTC 
TCAGAGGAAC CCATCCCACA GTCCCCAGAC ATGGATGTCC TCCTCGAGTC TCTCAAATGC 
CTGTGTAATC TTGTGCTCAG CAGTCCAACA GCACAGATGC TAGCAGCAGA GGCTCGCCTG 
GTGGTGAGGC TAGCGGAGCG TGTGGGACTG TACCGCAAGA GGAGCTATCC CCACGAAGTC 
CAGTTCTTTG ACTTGAGGCT CCTTTTCCTG CTAACAGCCC TTCGCACGGA TGTGCGCCAG 
CAACTGTTTC AGGAGCTGCA CGGTGTACGC CTGCTGACTG ATGCGCTGGA ACTAACACTG 
GGCGTGGCCC CCAAAGAAAA CCCTCCGGTG ATGCTTCCAG CCCAAGAGAC GGAGAGGGCC 
ATGGAGATCC TCAAAGTGCT CTTTAATATC ACCTTTGACT CTGTCAAGAG GGAAGTTGAT 
GAGGAAGATG CTGCCCTTTA CCGGTACCTG GGGACTCTTC TGCGGCACTG CGTGATGGTT 
GAAGCTGCTG GGGACCGCAC AGAGGAGTTC CACGGCCACA CGGTGAATCT CCTGGGGAAC 
TTGCCCCTCA AGTGTTTGGA TGTGCTTCTG GCCCTGGAGC TCCACGAAGG ATCCTTAGAG 
TTCATGGGAG TTAACATGGA TGTGATCAGT GCCCTCCTCG CCTTCCTAGA GAAACGTCTG 
CACCAGACCC ACAGGCTGAA GGAATGTGTG GCACCTGTGC TGAACGTGTT GACAGAATGT 
GCCCGCATGC ACCGTCCTGC CAGGAAGTTC CTGAAGGCCC AGGTCCTGCC CCCTCTGAGG 
GATGTGAGGA CTCGGCCTGA GGTGGGGGAC CTGCTTCGAA ACAAGCTTGT CCGCCTCATG 
ACACACCTGG ATACAGATGT GAAGAGAGTA GCTGCCGAGT TCCTCTTTGT CTTATGTTCT 
GAAAGTGTGC CCCGATTCAT CAAGTACACA GGCTACGGGA ATGCTGCCGG CCTCCTGGCT 
GCCAGGGGCC TCATGGCTGG GGGCCGACCC GAGGGCCAGT ACTCAGAGGA CGAGGACACG 
GACACAGAGG AGTACAGGGA AGCCAAGGCC AGCATCAACC CTGTGACTGG AAGGGTGGAG 
GAGAAGCCGC CTAATCCTAT GGAAGGCATG ACAGAGGAGC AGAAGGAACA TGAGGCCATG 
AAGCTAGTGA ACATGTTTGA CAAGCTCTCC AGGCACAGAG TCATCCAACC CATGGGGATG 
AGTCCCAGGG GTCACCTCAC TTCTCTGCAA GATGCGATGT GTGAGACAAT GGAGGGACAG 
CTCTCCTCAG ACCCTGACTC AGATCCTGAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RIC8A is essential for the organisation of actin cytoskeleton and cell-matrix interaction.
Experimental cell research357(2)181-191(2017 08)
Ruisu K,Meier R,Kask K,T?nissoo T,Velling T,Pooga M

A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis.
Developmental cell41(4)366-381.e4(2017 05)
Ma S,Santhosh D,Kumar T P,Huang Z

Ric-8A gene deletion or phorbol ester suppresses tumorigenesis in a mouse model of GNAQ(Q209L)-driven melanoma.
Oncogenesis5(6)e236(2016 Jun)
Patel BR,Tall GG

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Ric8a cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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