Gene Symbol | CCR5 |
Entrez Gene ID | 735311 |
Full Name | C-C motif chemokine receptor 5 |
Gene Type | protein-coding |
Organism | Macaca mulatta(Rhesus monkey) |
ORF » Species Summary » Macaca mulatta » CCR5 cDNA ORF clone
Gene Symbol | CCR5 |
Entrez Gene ID | 735311 |
Full Name | C-C motif chemokine receptor 5 |
Gene Type | protein-coding |
Organism | Macaca mulatta(Rhesus monkey) |
mRNA | Protein | Name |
---|---|---|
XM_015131082.1 | XP_014986568.1 | C-C chemokine receptor type 5 isoform X1 |
XM_015131082.2 | XP_014986568.1 | C-C chemokine receptor type 5 isoform X1 |
NM_001042773.3 | NP_001036238.2 | C-C chemokine receptor type 5 |
NM_001309402.1 | NP_001296331.1 | C-C chemokine receptor type 5 |
CCR5 | NP_001036238.2 | |
Canis lupus familiaris (dog) | CCR5 | NP_001012342.2 |
Bos taurus (cattle) | CCR5 | NP_001011672.2 |
Pan troglodytes (chimpanzee) | CCR5 | NP_001009046.1 |
Mus musculus (house mouse) | Ccr5 | NP_034047.2 |
Rattus norvegicus (Norway rat) | Ccr5 | NP_446412.2 |
Danio rerio (zebrafish) | LOC100004988 | XP_001344151.1 |
Homo sapiens (human) | CCR5 | NP_001093638.1 |
Danio rerio (zebrafish) | LOC100005081 | XP_001344220.4 |
Danio rerio (zebrafish) | LOC100004625 | XP_001343879.1 |
Xenopus tropicalis (tropical clawed frog) | LOC101731980 | XP_004915406.1 |
A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S, Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Mar?ais G, Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA, Norgren RB Jr
Biology direct9(1)20(2014 Oct)
CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV.
Kelly KM, Tocchetti CG, Lyashkov A, Tarwater PM, Bedja D, Graham DR, Beck SE, Metcalf Pate KA, Queen SE, Adams RJ, Paolocci N, Mankowski JL
Journal of the American Heart Association3(2)e000874(2014 Apr)
A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251.
Van Rompay KK, Hunter Z, Jayashankar K, Peabody J, Montefiori D, LaBranche CC, Keele BF, Jensen K, Abel K, Chackerian B
Journal of virology88(4)2011-24(2014 Feb)
Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques.
Yan G, Zhang G, Fang X, Zhang Y, Li C, Ling F, Cooper DN, Li Q, Li Y, van Gool AJ, Du H, Chen J, Chen R, Zhang P, Huang Z, Thompson JR, Meng Y, Bai Y, Wang J, Zhuo M, Wang T, Huang Y, Wei L, Li J, Wang Z, Hu H, Yang P, Le L, Stenson PD, Li B, Liu X, Ball EV, An N, Huang Q, Zhang Y, Fan W, Zhang X, Li Y, Wang W, Katze MG, Su B, Nielsen R, Yang H, Wang J, Wang X, Wang J
Nature biotechnology29(11)1019-23(2011 Oct)
TCR triggering transcriptionally downregulates CCR5 expression on rhesus macaque CD4(+) T-cells with no measurable effect on susceptibility to SIV infection.
Minang JT, Trivett MT, Barsov EV, Del Prete GQ, Trubey CM, Thomas JA, Gorelick RJ, Piatak M Jr, Ott DE, Ohlen C
Virology409(1)132-40(2011 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
CCR5 inhibition may provide a cardioprotective benefit in SIV infection by preventing cardiomyocyte CCR5 signaling.
Title: CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV.
A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251.
Title: A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251.
CCR5 downregulation on CD4(+) T cells by TCR activation has no measurable effect on susceptibility to SAIDS.
Title: TCR triggering transcriptionally downregulates CCR5 expression on rhesus macaque CD4(+) T-cells with no measurable effect on susceptibility to SIV infection.
CD4 and CD8 T cells are more vulnerable to SIV infection, indicating the the ability to express CCR5 may activate and hassten T cell death by SIV infection in vitro.
Title: Peripheral blood CD4 and CD8 double-positive T cells of rhesus macaques become vulnerable to Simian Immunodeficiency Virus by in vitro stimulation due to the induction of CCR5.
Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively
Title: Different mutational pathways to CXCR4 coreceptor switch of CCR5-using simian-human immunodeficiency virus.
The following CCR5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCR5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMb24180 | |
Clone ID Related Accession (Same CDS sequence) | NM_001042773.3 , NM_001309402.1 | |
Accession Version | NM_001042773.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-04 | |
Organism | Macaca mulatta(Rhesus monkey) | |
Product | C-C chemokine receptor type 5 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DQ902537.1 and DQ499963.1. On May 29, 2015 this sequence version replaced NM_001042773.2. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. |
1 | ATGGACTATC AAGTGTCAAG TCCAACCTAT GACATCGATT ATTATACATC GGAACCCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001036238.2 |
CDS | 233..1291 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001042773.3 |
1 | ATGGACTATC AAGTGTCAAG TCCAACCTAT GACATCGATT ATTATACATC GGAACCCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMb24180 | |
Clone ID Related Accession (Same CDS sequence) | NM_001042773.3 , NM_001309402.1 | |
Accession Version | NM_001309402.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-04 | |
Organism | Macaca mulatta(Rhesus monkey) | |
Product | C-C chemokine receptor type 5 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JU480013.1 and DQ499963.1. Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: JU480013.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4688317, SAMEA4688318 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGACTATC AAGTGTCAAG TCCAACCTAT GACATCGATT ATTATACATC GGAACCCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001296331.1 |
CDS | 38..1096 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001309402.1 |
1 | ATGGACTATC AAGTGTCAAG TCCAACCTAT GACATCGATT ATTATACATC GGAACCCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMb28605 | |
Clone ID Related Accession (Same CDS sequence) | XM_015131082.1 , XM_015131082.2 | |
Accession Version | XM_015131082.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1140bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-12-20 | |
Organism | Macaca mulatta(Rhesus monkey) | |
Product | C-C chemokine receptor type 5 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_014804632.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Macaca mulatta Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATTGATT TGCACAACTC ATCTGCCAGA AGAGCTGAGA CATCCGTTCC CCTACAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_014986568.1 |
CDS | 207..1346 |
Translation |
Target ORF information:
Target ORF information:
|
XM_015131082.1 |
1 | ATGATTGATT TGCACAACTC ATCTGCCAGA AGAGCTGAGA CATCCGTTCC CCTACAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMb28605 | |
Clone ID Related Accession (Same CDS sequence) | XM_015131082.1 , XM_015131082.2 | |
Accession Version | XM_015131082.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1140bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-25 | |
Organism | Macaca mulatta(Rhesus monkey) | |
Product | C-C chemokine receptor type 5 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_041755.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 23, 2019 this sequence version replaced XM_015131082.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Macaca mulatta Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATTGATT TGCACAACTC ATCTGCCAGA AGAGCTGAGA CATCCGTTCC CCTACAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_014986568.1 |
CDS | 176..1315 |
Translation |
Target ORF information:
Target ORF information:
|
XM_015131082.2 |
1 | ATGATTGATT TGCACAACTC ATCTGCCAGA AGAGCTGAGA CATCCGTTCC CCTACAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
A new rhesus macaque assembly and annotation for next-generation sequencing analyses. |
CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV. |
A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251. |
Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. |
TCR triggering transcriptionally downregulates CCR5 expression on rhesus macaque CD4(+) T-cells with no measurable effect on susceptibility to SIV infection. |