Gene Symbol | VEGFA |
Entrez Gene ID | 574209 |
Full Name | vascular endothelial growth factor A |
Synonyms | VEGF |
Gene Type | protein-coding |
Organism | Macaca mulatta(Rhesus monkey) |
ORF » Species Summary » Macaca mulatta » VEGFA cDNA ORF clone
Gene Symbol | VEGFA |
Entrez Gene ID | 574209 |
Full Name | vascular endothelial growth factor A |
Synonyms | VEGF |
Gene Type | protein-coding |
Organism | Macaca mulatta(Rhesus monkey) |
mRNA | Protein | Name |
---|---|---|
NM_001278385.1 | NP_001265314.1 | vascular endothelial growth factor A isoform 2 precursor |
NM_001278437.1 | NP_001265366.1 | vascular endothelial growth factor A isoform 4 |
NM_001278384.1 | NP_001265313.1 | vascular endothelial growth factor A isoform 1 precursor |
NM_001278410.1 | NP_001265339.1 | vascular endothelial growth factor A isoform 3 precursor |
MiR-126 overexpression inhibits high glucose-induced migration and tube formation of rhesus macaque choroid-retinal endothelial cells by obstructing VEGFA and PIK3R2.
Yang WZ, Yang J, Xue LP, Xiao LB, Li Y
Journal of diabetes and its complications31(4)653-663(2017 Apr)
A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S, Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Mar?ais G, Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA, Norgren RB Jr
Biology direct9(1)20(2014 Oct)
Vascular endothelial growth factor regulates primate choroid-retinal endothelial cell proliferation and tube formation through PI3K/Akt and MEK/ERK dependent signaling.
Jin J, Yuan F, Shen MQ, Feng YF, He QL
Molecular and cellular biochemistry381(1-2)267-72(2013 Sep)
Overexpression of fibulin-5 in retinal pigment epithelial cells inhibits cell proliferation and migration and downregulates VEGF, CXCR4, and TGFB1 expression in cocultured choroidal endothelial cells.
Li F, Xu H, Zeng Y, Yin ZQ
Current eye research37(6)540-8(2012 Jun)
Effects of apelin and vascular endothelial growth factor on central retinal vein occlusion in monkey eyes intravitreally injected with bevacizumab: a preliminary study.
Zhao T, Lu Q, Tao Y, Liang XY, Wang K, Jiang YR
Molecular vision171044-55(2011 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
VEGF plays an important role in choroid-retinal endothelial cell proliferation and tube formation.
Title: Vascular endothelial growth factor regulates primate choroid-retinal endothelial cell proliferation and tube formation through PI3K/Akt and MEK/ERK dependent signaling.
These findings suggest that FBLN5 may interfere with choroidal neovascularization by downregulating VEGF, CXCR4, and TGFB1 expression and inhibiting choroidl endothelial cell proliferation.
Title: Overexpression of fibulin-5 in retinal pigment epithelial cells inhibits cell proliferation and migration and downregulates VEGF, CXCR4, and TGFB1 expression in cocultured choroidal endothelial cells.
Dll4 play an important role in choroidal neovascularization (CNV) angiogenesis, which appears to be regulated by HIF-1alpha and VEGF during the progression of CNV under hypoxic conditions.
Title: Influence of Dll4 via HIF-1?-VEGF signaling on the angiogenesis of choroidal neovascularization under hypoxic conditions.
A functional network involving VEGF, IGF2, and MMP9 in early placental trophoblast cells and maternal endometrium appears to be important for normal placentation.
Title: IGF2, IGF binding protein 1, and matrix metalloproteinases 2 and 9 in implantation-stage endometrium following immunoneutralization of vascular endothelial growth factor in the rhesus monkey.
Apelin may play a role in the development of central retinal vein occlusion (CRVO). Apelin has a unique upstream signaling pathway, independent of the VEGF pathway.
Title: Effects of apelin and vascular endothelial growth factor on central retinal vein occlusion in monkey eyes intravitreally injected with bevacizumab: a preliminary study.
The following VEGFA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VEGFA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMb04540 | |
Clone ID Related Accession (Same CDS sequence) | NM_001278384.1 | |
Accession Version | NM_001278384.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-13 | |
Organism | Macaca mulatta(Rhesus monkey) | |
Product | vascular endothelial growth factor A isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JV667190.1, JV627796.1, JV722608.1 and JU348048.1. Transcript Variant: This variant (1) represents the longest transcript. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (1) represented in this RefSeq is derived from the AUG start codon. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA4688457 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAACTTTC TGCTCTCTTG GGTGCATTGG AGCCTTGCCT TGCTGCTGTA CCTCCACCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001265313.1 |
CDS | 858..1505 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001278384.1 |
1 | ATGAACTTTC TGCTCTCTTG GGTGCATTGG AGCCTTGCCT TGCTGCTGTA CCTCCACCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMb04541 | |
Clone ID Related Accession (Same CDS sequence) | NM_001278385.1 | |
Accession Version | NM_001278385.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-13 | |
Organism | Macaca mulatta(Rhesus monkey) | |
Product | vascular endothelial growth factor A isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JV667190.1, JV627796.1, JV722609.1 and JU348048.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (2) represented in this RefSeq is derived from the AUG start codon, and is shorter than isoform 1. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA4688457 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAACTTTC TGCTCTCTTG GGTGCATTGG AGCCTTGCCT TGCTGCTGTA CCTCCACCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001265314.1 |
CDS | 858..1433 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001278385.1 |
1 | ATGAACTTTC TGCTCTCTTG GGTGCATTGG AGCCTTGCCT TGCTGCTGTA CCTCCACCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMb04563 | |
Clone ID Related Accession (Same CDS sequence) | NM_001278410.1 | |
Accession Version | NM_001278410.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 444bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-13 | |
Organism | Macaca mulatta(Rhesus monkey) | |
Product | vascular endothelial growth factor A isoform 3 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JV667190.1, JV627796.1, JV048891.1, JV722608.1 and JU348048.1. Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (3) represented in this RefSeq is derived from the AUG start codon, and is shorter than isoform 1. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA4688457 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAACTTTC TGCTCTCTTG GGTGCATTGG AGCCTTGCCT TGCTGCTGTA CCTCCACCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001265339.1 |
CDS | 858..1301 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001278410.1 |
1 | ATGAACTTTC TGCTCTCTTG GGTGCATTGG AGCCTTGCCT TGCTGCTGTA CCTCCACCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMb04567 | |
Clone ID Related Accession (Same CDS sequence) | NM_001278437.1 | |
Accession Version | NM_001278437.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1116bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-13 | |
Organism | Macaca mulatta(Rhesus monkey) | |
Product | vascular endothelial growth factor A isoform 4 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JV667190.1, JV722608.1 and JU348048.1. On Jun 7, 2013 this sequence version replaced XM_001089925.2. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (4) represented in this RefSeq is derived from the 5'-most CUG start codon, and is longer than isoform 1. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA4688457 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | CTGACGGACA GACAGACAGA CACCGCCCCC AGCCCCAGCG CCCACCTCCT CCCCGGCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001265366.1 |
CDS | 318..1433 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001278437.1 |
1 | CTGACGGACA GACAGACAGA CACCGCCCCC AGCCCCAGCG CCCACCTCCT CCCCGGCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
MiR-126 overexpression inhibits high glucose-induced migration and tube formation of rhesus macaque choroid-retinal endothelial cells by obstructing VEGFA and PIK3R2. |
A new rhesus macaque assembly and annotation for next-generation sequencing analyses. |
Vascular endothelial growth factor regulates primate choroid-retinal endothelial cell proliferation and tube formation through PI3K/Akt and MEK/ERK dependent signaling. |
Overexpression of fibulin-5 in retinal pigment epithelial cells inhibits cell proliferation and migration and downregulates VEGF, CXCR4, and TGFB1 expression in cocultured choroidal endothelial cells. |
Effects of apelin and vascular endothelial growth factor on central retinal vein occlusion in monkey eyes intravitreally injected with bevacizumab: a preliminary study. |