KCNE2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNE2
Entrez Gene ID	9992
Full Name	potassium voltage-gated channel subfamily E regulatory subunit 2
Synonyms	ATFB4,LQT5,LQT6,MIRP1
General protein information	Preferred Names potassium voltage-gated channel subfamily E regulatory subunit 2 Names potassium voltage-gated channel subfamily E member 2 cardiac voltage-gated potassium channel accessory subunit 2 minK-related peptide-1 minimum potassium ion channel-related peptide 1 potassium channel subunit beta MiRP1 potassium channel subunit, MiRP1 potassium channel, voltage gated subfamily E regulatory beta subunit 2 potassium voltage-gated channel, Isk-related family, member 2 voltage-gated K+ channel subunit MIRP1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q22.11
Summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008].
Disorder MIM:	603796
Disorder Html:	Long QT syndrome 6, 613693 (3); Atrial fibrillation, familial, 4, 611493 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_172201.1	NP_751951.1	potassium voltage-gated channel subfamily E member 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	KCNE2	XP_001167267.1
Bos taurus (cattle)	KCNE2	NP_001070552.1
Gallus gallus (chicken)	KCNE2	XP_004934590.1
	KCNE2	XP_001089749.1
Homo sapiens (human)	KCNE2	NP_751951.1
Mus musculus (house mouse)	Kcne2	NP_598871.1
Xenopus tropicalis (tropical clawed frog)	LOC100490092	XP_002937553.1
Rattus norvegicus (Norway rat)	Kcne2	NP_598287.1
Canis lupus familiaris (dog)	KCNE2	NP_001181892.1

Gene Ontology
Bibliography

Related articles in PubMed

Loss-of-Function
Roberts JD, Krahn AD, Ackerman MJ, Rohatgi RK, Moss AJ, Nazer B, Tadros R, Gerull B, Sanatani S, Wijeyeratne YD, Baruteau AE, Muir AR, Pang B, Cadrin-Tourigny J, Talajic M, Rivard L, Tester DJ, Liu T, Whitman IR, Wojciak J, Conacher S, Gula LJ, Leong-Sit P, Manlucu J, Green MS, Hamilton R, Healey JS, Lopes CM, Behr ER, Wilde AA, Gollob MH, Scheinman MM
Circulation. Arrhythmia and electrophysiology10(8)(2017 Aug)

Lee SM, Baik J, Nguyen D, Nguyen V, Liu S, Hu Z, Abbott GW
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(6)2674-2685(2017 06)

Filamin C: a novel component of the KCNE2 interactome during hypoxia.
Neethling A, Mouton J, Loos B, Corfield V, de Villiers C, Kinnear C
Cardiovascular journal of Africa27(1)4-11(2016 Jan-Feb)

The KCNE2 K? channel regulatory subunit: Ubiquitous influence, complex pathobiology.
Abbott GW
Gene569(2)162-72(2015 Sep)

Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese women.
Parkington HC, Stevenson J, Tonta MA, Paul J, Butler T, Maiti K, Chan EC, Sheehan PM, Brennecke SP, Coleman HA, Smith R
Nature communications54108(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

On the basis of clinical phenotype, the high allelic frequencies of LQT6 mutations in the Exome Aggregation Consortium database, and absence of previous documentation of genotype-phenotype segregation, our findings suggest that many KCNE2 variants, and perhaps all, have been erroneously designated as LQTS-causative mutations. Instead, KCNE2 variants may confer proarrhythmic susceptibility when provoked by additional envir
Title: Loss-of-Function

These results demonstrate that KCNE2 is required for normal beta-cell electrical activity and insulin secretion, and that Kcne2 deletion causes T2DM.

The identification of Filamin C as a novel KCNE2 ligand not only enhances current understanding of ion channel function and regulation, but also provides valuable information about possible pathways likely to be involved in long-QT syndrome pathogenesis
Title: Filamin C: a novel component of the KCNE2 interactome during hypoxia.

KCNE2 has been widely studied since its role in the heart was discovered; it is association with inherited and acquired human Long QT syndrome; physiological analyses together with genetics studies have uncovered a startling array of functions for KCNE2, in the heart, stomach, thyroid and choroid plexus. [Review]
Title: The KCNE2 K? channel regulatory subunit: Ubiquitous influence, complex pathobiology.

Women with elevated BMI have enhanced hERG activity as a result of low beta-inhibitory protein expression, which likely contributes to weak contractions and poor labour outcomes.
Title: Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese women.

The following KCNE2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNE2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu25916	NM_172201.1 Latest version!	Homo sapiens potassium voltage-gated channel subfamily E regulatory subunit 2 (KCNE2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNE2 ( NM_172201.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_751951.1 Homo sapiens potassium voltage-gated channel subfamily E regulatory subunit 2 (KCNE2), mRNA.

Price & Availability↑

CloneID	OHu25916
Clone ID Related Accession (Same CDS sequence)	NM_172201.1
Accession Version	NM_172201.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily E member 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF302095.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF302095.1, BC112087.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTACTT TATCCAATTT CACACAGACG CTGGAAGACG TCTTCCGAAG GATTTTTATT 
ACTTATATGG ACAATTGGCG CCAGAACACA ACAGCTGAGC AAGAGGCCCT CCAAGCCAAA 
GTTGATGCTG AGAACTTCTA CTATGTCATC CTGTACCTCA TGGTGATGAT TGGAATGTTC 
TCTTTCATCA TCGTGGCCAT CCTGGTGAGC ACTGTGAAAT CCAAGAGACG GGAACACTCC 
AATGACCCCT ACCACCAGTA CATTGTAGAG GACTGGCAGG AAAAGTACAA GAGCCAAATC 
TTGAATCTAG AAGAATCGAA GGCCACCATC CATGAGAACA TTGGTGCGGC TGGGTTCAAA 
ATGTCCCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_751951.1
CDS	141..512
Translation	MSTLSNFTQTLEDVFRRIFITYMDNWRQNTTAEQEALQAKVDAENFYYVILYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVEDWQEKYKSQILNLEESKATIHENIGAAGFKMSP

Target ORF information:

RefSeq Version	NM_172201.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily E regulatory subunit 2 (KCNE2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172201.1

ORF Insert Sequence:

ATGTCTACTT TATCCAATTT CACACAGACG CTGGAAGACG TCTTCCGAAG GATTTTTATT 
ACTTATATGG ACAATTGGCG CCAGAACACA ACAGCTGAGC AAGAGGCCCT CCAAGCCAAA 
GTTGATGCTG AGAACTTCTA CTATGTCATC CTGTACCTCA TGGTGATGAT TGGAATGTTC 
TCTTTCATCA TCGTGGCCAT CCTGGTGAGC ACTGTGAAAT CCAAGAGACG GGAACACTCC 
AATGACCCCT ACCACCAGTA CATTGTAGAG GACTGGCAGG AAAAGTACAA GAGCCAAATC 
TTGAATCTAG AAGAATCGAA GGCCACCATC CATGAGAACA TTGGTGCGGC TGGGTTCAAA 
ATGTCCCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss-of-Function
Circulation. Arrhythmia and electrophysiology10(8)(2017 Aug)
Roberts JD,Krahn AD,Ackerman MJ,Rohatgi RK,Moss AJ,Nazer B,Tadros R,Gerull B,Sanatani S,Wijeyeratne YD,Baruteau AE,Muir AR,Pang B,Cadrin-Tourigny J,Talajic M,Rivard L,Tester DJ,Liu T,Whitman IR,Wojciak J,Conacher S,Gula LJ,Leong-Sit P,Manlucu J,Green MS,Hamilton R,Healey JS,Lopes CM,Behr ER,Wilde AA,Gollob MH,Scheinman MM

FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(6)2674-2685(2017 06)
Lee SM,Baik J,Nguyen D,Nguyen V,Liu S,Hu Z,Abbott GW

Filamin C: a novel component of the KCNE2 interactome during hypoxia.
Cardiovascular journal of Africa27(1)4-11(2016 Jan-Feb)
Neethling A,Mouton J,Loos B,Corfield V,de Villiers C,Kinnear C

The KCNE2 K? channel regulatory subunit: Ubiquitous influence, complex pathobiology.
Gene569(2)162-72(2015 Sep)
Abbott GW

Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese women.
Nature communications54108(2014 Jun)
Parkington HC,Stevenson J,Tonta MA,Paul J,Butler T,Maiti K,Chan EC,Sheehan PM,Brennecke SP,Coleman HA,Smith R

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KCNE2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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