CLEC2B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLEC2B
Entrez Gene ID	9976
Full Name	C-type lectin domain family 2 member B
Synonyms	AICL,CLECSF2,HP10085,IFNRG1
General protein information	Preferred Names C-type lectin domain family 2 member B Names C-type lectin domain family 2 member B C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 2 (activation-induced) C-type lectin superfamily member 2 IFN-alpha-2b-inducing-related protein 1 IFN-alpha2b-inducing related protein 1 activation-induced C-type lectin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.31
Summary	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008].
Disorder MIM:	603242

mRNA and Protein(s)

mRNA	Protein	Name
NM_005127.2	NP_005118.2	C-type lectin domain family 2 member B

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CLEC2B	XP_854186.2
Homo sapiens (human)	CLEC2B	NP_005118.2
Pan troglodytes (chimpanzee)	CLEC2B	XP_528730.2
	CLEC2B	XP_001114778.2
Bos taurus (cattle)	CLEC2B	XP_002687879.2

Gene Ontology
Bibliography

Related articles in PubMed

Physiologic and pathophysiologic roles of interaction between C-type lectin-like receptor 2 and podoplanin: partners from in utero to adulthood.
Suzuki-Inoue K, Osada M, Ozaki Y
Journal of thrombosis and haemostasis : JTH15(2)219-229(2017 Feb)

C-type lectin like receptor 2 (CLEC-2) signals independently of lipid raft microdomains in platelets.
Manne BK, Badolia R, Dangelmaier CA, Kunapuli SP
Biochemical pharmacology93(2)163-70(2015 Jan)

Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis.
Inoue O, Hokamura K, Shirai T, Osada M, Tsukiji N, Hatakeyama K, Umemura K, Asada Y, Suzuki-Inoue K, Ozaki Y
PloS one10(9)e0139357(2015)

Genetically coupled receptor-ligand pair NKp80-AICL enables autonomous control of human NK cell responses.
Klimosch SN, Bartel Y, Wiemann S, Steinle A
Blood122(14)2380-9(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Lipid rafts do not directly contribute to CLEC-2 receptor activation in platelets.
Title: C-type lectin like receptor 2 (CLEC-2) signals independently of lipid raft microdomains in platelets.

Data suggest that vascular smooth muscle cells (VSMCs) stimulate platelets through platelet receptor CLEC-2, possibly leading to thrombus formation after plaque erosion.
Title: Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis.

our data report a previously unrecognized regulatory circuit enabling autonomous control of human NK cell responses via the NKp80-AICL axis.
Title: Genetically coupled receptor-ligand pair NKp80-AICL enables autonomous control of human NK cell responses.

expressed in primary liver cancers
Title: Tumor cells of non-hematopoietic and hematopoietic origins express activation-induced C-type lectin, the ligand for killer cell lectin-like receptor F1.

Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.

The following CLEC2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLEC2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu11881	NM_005127.2 Latest version!	Homo sapiens C-type lectin domain family 2 member B (CLEC2B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLEC2B ( NM_005127.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005118.2 Homo sapiens C-type lectin domain family 2 member B (CLEC2B), mRNA.

Price & Availability↑

CloneID	OHu11881
Clone ID Related Accession (Same CDS sequence)	NM_005127.2
Accession Version	NM_005127.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 450bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	C-type lectin domain family 2 member B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG779377.1, AC091814.10, AK313916.1, AC007068.17 and BM973072.1. On Oct 8, 2003 this sequence version replaced NM_005127.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.267603.1, SRR1803615.357743.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATGACCA AACATAAAAA GTGTTTTATA ATTGTTGGTG TTTTAATAAC AACTAATATT 
ATTACTCTGA TAGTTAAACT AACTCGAGAT TCTCAGAGTT TATGCCCCTA TGATTGGATT 
GGTTTCCAAA ACAAATGCTA TTATTTCTCT AAAGAAGAAG GAGATTGGAA TTCAAGTAAA 
TACAACTGTT CCACTCAACA TGCCGACCTA ACTATAATTG ACAACATAGA AGAAATGAAT 
TTTCTTAGGC GGTATAAATG CAGTTCTGAT CACTGGATTG GACTGAAGAT GGCAAAAAAT 
CGAACAGGAC AATGGGTAGA TGGAGCTACA TTTACCAAAT CGTTTGGCAT GAGAGGGAGT 
GAAGGATGTG CCTACCTCAG CGATGATGGT GCAGCAACAG CTAGATGTTA CACCGAAAGA 
AAATGGATTT GCAGGAAAAG AATACACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005118.2
CDS	658..1107
Translation	MMTKHKKCFIIVGVLITTNIITLIVKLTRDSQSLCPYDWIGFQNKCYYFSKEEGDWNSSKYNCSTQHADLTIIDNIEEMNFLRRYKCSSDHWIGLKMAKNRTGQWVDGATFTKSFGMRGSEGCAYLSDDGAATARCYTERKWICRKRIH

Target ORF information:

RefSeq Version	NM_005127.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-type lectin domain family 2 member B (CLEC2B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005127.2

ORF Insert Sequence:

ATGATGACCA AACATAAAAA GTGTTTTATA ATTGTTGGTG TTTTAATAAC AACTAATATT 
ATTACTCTGA TAGTTAAACT AACTCGAGAT TCTCAGAGTT TATGCCCCTA TGATTGGATT 
GGTTTCCAAA ACAAATGCTA TTATTTCTCT AAAGAAGAAG GAGATTGGAA TTCAAGTAAA 
TACAACTGTT CCACTCAACA TGCCGACCTA ACTATAATTG ACAACATAGA AGAAATGAAT 
TTTCTTAGGC GGTATAAATG CAGTTCTGAT CACTGGATTG GACTGAAGAT GGCAAAAAAT 
CGAACAGGAC AATGGGTAGA TGGAGCTACA TTTACCAAAT CGTTTGGCAT GAGAGGGAGT 
GAAGGATGTG CCTACCTCAG CGATGATGGT GCAGCAACAG CTAGATGTTA CACCGAAAGA 
AAATGGATTT GCAGGAAAAG AATACACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Physiologic and pathophysiologic roles of interaction between C-type lectin-like receptor 2 and podoplanin: partners from in utero to adulthood.
Journal of thrombosis and haemostasis : JTH15(2)219-229(2017 Feb)
Suzuki-Inoue K,Osada M,Ozaki Y

C-type lectin like receptor 2 (CLEC-2) signals independently of lipid raft microdomains in platelets.
Biochemical pharmacology93(2)163-70(2015 Jan)
Manne BK,Badolia R,Dangelmaier CA,Kunapuli SP

Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis.
PloS one10(9)e0139357(2015)
Inoue O,Hokamura K,Shirai T,Osada M,Tsukiji N,Hatakeyama K,Umemura K,Asada Y,Suzuki-Inoue K,Ozaki Y

Genetically coupled receptor-ligand pair NKp80-AICL enables autonomous control of human NK cell responses.
Blood122(14)2380-9(2013 Oct)
Klimosch SN,Bartel Y,Wiemann S,Steinle A

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CLEC2B cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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