EPM2AIP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EPM2AIP1
Entrez Gene ID	9852
Full Name	EPM2A interacting protein 1
General protein information	Preferred Names EPM2A interacting protein 1 Names EPM2A-interacting protein 1 EPM2A (laforin) interacting protein 1 laforin-interacting protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p22.2
Summary	The EPM2A gene, which encodes laforin, is mutated in an autosomal recessive form of adolescent progressive myoclonus epilepsy. The protein encoded by this gene binds to laforin, but its function is not known. This gene is intronless. [provided by RefSeq, Oct 2008]. COMPLETENESS: complete on the 3' end.
Disorder MIM:	607911

mRNA and Protein(s)

mRNA	Protein	Name
NM_014805.3	NP_055620.1	EPM2A-interacting protein 1
NM_014805.4	NP_055620.1	EPM2A-interacting protein 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	EPM2AIP1	XP_526480.1
Bos taurus (cattle)	EPM2AIP1	XP_005222648.1
Canis lupus familiaris (dog)	EPM2AIP1	XP_005634284.1
	EPM2AIP1	XP_001090676.1
Rattus norvegicus (Norway rat)	Epm2aip1	NP_001258313.1
Homo sapiens (human)	EPM2AIP1	NP_055620.1
Mus musculus (house mouse)	Epm2aip1	NP_780475.1

Gene Ontology
Bibliography

Related articles in PubMed

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Functional effects of the MLH1-93G>A polymorphism on MLH1/EPM2AIP1 promoter activity.
Perera S, Mrkonjic M, Rawson JB, Bapat B
Oncology reports25(3)809-15(2011 Mar)

Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.
Walker LC, Waddell N, Ten Haaf A, , Grimmond S, Spurdle AB
Breast cancer research and treatment112(2)229-36(2008 Nov)

Mutations in NHLRC1 cause progressive myoclonus epilepsy.
Chan EM, Young EJ, Ianzano L, Munteanu I, Zhao X, Christopoulos CC, Avanzini G, Elia M, Ackerley CA, Jovic NJ, Bohlega S, Andermann E, Rouleau GA, Delgado-Escueta AV, Minassian BA, Scherer SW
Nature genetics35(2)125-7(2003 Oct)

Identification of a novel protein interacting with laforin, the EPM2a progressive myoclonus epilepsy gene product.
Ianzano L, Zhao XC, Minassian BA, Scherer SW
Genomics81(6)579-87(2003 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The -93G>A polymorphism modifies the efficiency of MLH1/EPM2AIP1 transcription.
Title: Functional effects of the MLH1-93G>A polymorphism on MLH1/EPM2AIP1 promoter activity.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.

The EPM2AIP1 gene was identified and characterized in a screen for laforin-interacting proteins with a human brain cDNA library; the specificity of the interaction was confirmed; subcellular colocalization of laforin and EPM2AIP1 protein was demonstrated
Title: Identification of a novel protein interacting with laforin, the EPM2a progressive myoclonus epilepsy gene product.

The following EPM2AIP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EPM2AIP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18781	NM_014805.4 Latest version!	Homo sapiens EPM2A interacting protein 1 (EPM2AIP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
View Old Accession Versions >>
OHu18781	NM_014805.3	Homo sapiens EPM2A interacting protein 1 (EPM2AIP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EPM2AIP1 ( NM_014805.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055620.1 Homo sapiens EPM2A interacting protein 1 (EPM2AIP1), mRNA.

Price & Availability↑

CloneID	OHu18781
Clone ID Related Accession (Same CDS sequence)	NM_014805.3 , NM_014805.4
Accession Version	NM_014805.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1824bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	EPM2A-interacting protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY178832.1 and AC011816.17. This sequence is a reference standard in the RefSeqGene project. On Aug 21, 2008 this sequence version replaced NM_014805.2. COMPLETENESS: complete on the 3' end.

ATGTGGATGA CGCCCAAAAG AAGCAAGATG GAAGTCGACG AGGCTCTAGT TTTCCGGCCC 
GAGTGGACCC AGCGTTATTT GGTGGTGGAG CCTCCGGAGG GCGATGGGGC CCTGTGCCTG 
GTCTGTCGCC GCCTCATCGT AGCTACCCGC GAACGCGACG TCAGGCGCCA CTACGAGGCT 
GAGCACGAAT ACTACGAGCG GTATGTGGCG GACGGCGAGC GCGCGGCCCT GGTGGAGCGT 
CTGCGTCAGG GCGACTTGCC CGTGGCCTCC TTCACTCCTG AAGAGAGAGC TGCTCGTGCA 
GGCCTCGGGC TCTGCCGCCT CTTGGCCTTG AAGGGTCGCG GCTGGGGTGA GGGGGACTTT 
GTATACCAGT GCATGGAGGT GTTGCTGAGA GAGGTACTGC CCGAGCATGT AAGCGTCCTG 
CAAGGCGTTG ACTTATCTCC AGATATCACA AGGCAGAGGA TCCTGAGCAT TGACAGGAAT 
CTACGCAACC AGCTTTTTAA CCGAGCCAGG GACTTTAAAG CCTATTCTCT TGCCTTGGAC 
GACCAGGCTT TTGTGGCCTA TGAGAACTAC CTCCTGGTCT TTATCCGCGG TGTAGGCCCT 
GAGTTGGAGG TGCAAGAAGA TCTTCTGACC ATAATCAACC TGACTCATCA TTTCAGTGTT 
GGTGCGCTCA TGTCGGCAAT CCTAGAGTCC CTGCAGACAG CAGGGCTTAG CTTGCAGAGA 
ATGGTTGGAC TGACCACGAC CCATACTTTG AGGATGATTG GTGAGAACTC AGGACTCGTC 
TCATACATGA GAGAAAAGGC CGTAAGCCCC AACTGTTGGA ATGTCATTCA TTATTCAGGA 
TTTCTTCACT TGGAACTGTT GAGCTCCTAT GATGTAGATG TTAATCAGAT CATAAATACC 
ATATCCGAAT GGATAGTTTT GATTAAGACC AGAGGCGTTA GGCGACCTGA ATTTCAGACT 
TTACTAACGG AATCTGAATC AGAGCATGGT GAAAGGGTTA ATGGACGATG TCTGAACAAT 
TGGCTTAGGA GAGGGAAAAC TTTAAAACTA ATATTCTCTC TAAGAAAAGA AATGGAAGCG 
TTCTTGGTTT CAGTAGGGGC AACAACAGTC CACTTCTCAG ACAAACAATG GCTTTGTGAC 
TTTGGCTTCT TGGTGGACAT TATGGAACAC CTTCGAGAAC TCAGTGAAGA ATTACGAGTT 
AGTAAAGTCT TTGCTGCTGC TGCCTTTGAC CATATTTGTA CTTTCGAAGT TAAGCTGAAT 
TTATTTCAAA GACATATTGA GGAAAAAAAT CTAACAGACT TTCCTGCCCT CAGAGAAGTT 
GTTGATGAGC TAAAACAGCA AAATAAGGAA GATGAAAAAA TATTTGATCC TGATAGGTAT 
CAAATGGTGA TCTGTCGTCT CCAAAAAGAA TTTGAGAGAC ATTTTAAGGA CCTCAGGTTC 
ATTAAAAAGG ACTTAGAACT TTTTTCAAAT CCATTTAACT TTAAACCTGA ATATGCACCT 
ATTTCAGTGA GGGTGGAGCT AACAAAACTT CAGGCAAACA CTAATCTTTG GAATGAATAC 
AGAATCAAAG ACTTGGGGCA GTTTTATGCT GGATTGTCTG CTGAATCCTA CCCAATTATC 
AAAGGGGTTG CCTGTAAGGT GGCATCCTTG TTTGATAGTA ACCAAATCTG TGAAAAGGCT 
TTTTCATATT TGACTCGAAA CCAACACACT TTGAGTCAGC CATTAACAGA TGAGCATCTC 
CAAGCCCTGT TTCGGGTTGC CACAACTGAA ATGGAGCCCG GTTGGGATGA CCTTGTGAGA 
GAAAGAAATG AATCTAATCC ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055620.1
CDS	228..2051
Translation	MWMTPKRSKMEVDEALVFRPEWTQRYLVVEPPEGDGALCLVCRRLIVATRERDVRRHYEAEHEYYERYVADGERAALVERLRQGDLPVASFTPEERAARAGLGLCRLLALKGRGWGEGDFVYQCMEVLLREVLPEHVSVLQGVDLSPDITRQRILSIDRNLRNQLFNRARDFKAYSLALDDQAFVAYENYLLVFIRGVGPELEVQEDLLTIINLTHHFSVGALMSAILESLQTAGLSLQRMVGLTTTHTLRMIGENSGLVSYMREKAVSPNCWNVIHYSGFLHLELLSSYDVDVNQIINTISEWIVLIKTRGVRRPEFQTLLTESESEHGERVNGRCLNNWLRRGKTLKLIFSLRKEMEAFLVSVGATTVHFSDKQWLCDFGFLVDIMEHLRELSEELRVSKVFAAAAFDHICTFEVKLNLFQRHIEEKNLTDFPALREVVDELKQQNKEDEKIFDPDRYQMVICRLQKEFERHFKDLRFIKKDLELFSNPFNFKPEYAPISVRVELTKLQANTNLWNEYRIKDLGQFYAGLSAESYPIIKGVACKVASLFDSNQICEKAFSYLTRNQHTLSQPLTDEHLQALFRVATTEMEPGWDDLVRERNESNP

Target ORF information:

RefSeq Version	NM_014805.3
Organism	Homo sapiens(human)
Definition	Homo sapiens EPM2A interacting protein 1 (EPM2AIP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014805.3

ORF Insert Sequence:

ATGTGGATGA CGCCCAAAAG AAGCAAGATG GAAGTCGACG AGGCTCTAGT TTTCCGGCCC 
GAGTGGACCC AGCGTTATTT GGTGGTGGAG CCTCCGGAGG GCGATGGGGC CCTGTGCCTG 
GTCTGTCGCC GCCTCATCGT AGCTACCCGC GAACGCGACG TCAGGCGCCA CTACGAGGCT 
GAGCACGAAT ACTACGAGCG GTATGTGGCG GACGGCGAGC GCGCGGCCCT GGTGGAGCGT 
CTGCGTCAGG GCGACTTGCC CGTGGCCTCC TTCACTCCTG AAGAGAGAGC TGCTCGTGCA 
GGCCTCGGGC TCTGCCGCCT CTTGGCCTTG AAGGGTCGCG GCTGGGGTGA GGGGGACTTT 
GTATACCAGT GCATGGAGGT GTTGCTGAGA GAGGTACTGC CCGAGCATGT AAGCGTCCTG 
CAAGGCGTTG ACTTATCTCC AGATATCACA AGGCAGAGGA TCCTGAGCAT TGACAGGAAT 
CTACGCAACC AGCTTTTTAA CCGAGCCAGG GACTTTAAAG CCTATTCTCT TGCCTTGGAC 
GACCAGGCTT TTGTGGCCTA TGAGAACTAC CTCCTGGTCT TTATCCGCGG TGTAGGCCCT 
GAGTTGGAGG TGCAAGAAGA TCTTCTGACC ATAATCAACC TGACTCATCA TTTCAGTGTT 
GGTGCGCTCA TGTCGGCAAT CCTAGAGTCC CTGCAGACAG CAGGGCTTAG CTTGCAGAGA 
ATGGTTGGAC TGACCACGAC CCATACTTTG AGGATGATTG GTGAGAACTC AGGACTCGTC 
TCATACATGA GAGAAAAGGC CGTAAGCCCC AACTGTTGGA ATGTCATTCA TTATTCAGGA 
TTTCTTCACT TGGAACTGTT GAGCTCCTAT GATGTAGATG TTAATCAGAT CATAAATACC 
ATATCCGAAT GGATAGTTTT GATTAAGACC AGAGGCGTTA GGCGACCTGA ATTTCAGACT 
TTACTAACGG AATCTGAATC AGAGCATGGT GAAAGGGTTA ATGGACGATG TCTGAACAAT 
TGGCTTAGGA GAGGGAAAAC TTTAAAACTA ATATTCTCTC TAAGAAAAGA AATGGAAGCG 
TTCTTGGTTT CAGTAGGGGC AACAACAGTC CACTTCTCAG ACAAACAATG GCTTTGTGAC 
TTTGGCTTCT TGGTGGACAT TATGGAACAC CTTCGAGAAC TCAGTGAAGA ATTACGAGTT 
AGTAAAGTCT TTGCTGCTGC TGCCTTTGAC CATATTTGTA CTTTCGAAGT TAAGCTGAAT 
TTATTTCAAA GACATATTGA GGAAAAAAAT CTAACAGACT TTCCTGCCCT CAGAGAAGTT 
GTTGATGAGC TAAAACAGCA AAATAAGGAA GATGAAAAAA TATTTGATCC TGATAGGTAT 
CAAATGGTGA TCTGTCGTCT CCAAAAAGAA TTTGAGAGAC ATTTTAAGGA CCTCAGGTTC 
ATTAAAAAGG ACTTAGAACT TTTTTCAAAT CCATTTAACT TTAAACCTGA ATATGCACCT 
ATTTCAGTGA GGGTGGAGCT AACAAAACTT CAGGCAAACA CTAATCTTTG GAATGAATAC 
AGAATCAAAG ACTTGGGGCA GTTTTATGCT GGATTGTCTG CTGAATCCTA CCCAATTATC 
AAAGGGGTTG CCTGTAAGGT GGCATCCTTG TTTGATAGTA ACCAAATCTG TGAAAAGGCT 
TTTTCATATT TGACTCGAAA CCAACACACT TTGAGTCAGC CATTAACAGA TGAGCATCTC 
CAAGCCCTGT TTCGGGTTGC CACAACTGAA ATGGAGCCCG GTTGGGATGA CCTTGTGAGA 
GAAAGAAATG AATCTAATCC ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EPM2AIP1 ( NM_014805.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055620.1 Homo sapiens EPM2A interacting protein 1 (EPM2AIP1), mRNA.

Price & Availability↑

CloneID	OHu18781
Clone ID Related Accession (Same CDS sequence)	NM_014805.3 , NM_014805.4
Accession Version	NM_014805.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1824bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	EPM2A-interacting protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY178832.1 and AC011816.17. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_014805.3. ##Evidence-Data-START## Transcript is intronless :: SRR1803615.57690.1, SRR7346977.1761328.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000322716.8/ ENSP00000406027.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGATGA CGCCCAAAAG AAGCAAGATG GAAGTCGACG AGGCTCTAGT TTTCCGGCCC 
GAGTGGACCC AGCGTTATTT GGTGGTGGAG CCTCCGGAGG GCGATGGGGC CCTGTGCCTG 
GTCTGTCGCC GCCTCATCGT AGCTACCCGC GAACGCGACG TCAGGCGCCA CTACGAGGCT 
GAGCACGAAT ACTACGAGCG GTATGTGGCG GACGGCGAGC GCGCGGCCCT GGTGGAGCGT 
CTGCGTCAGG GCGACTTGCC CGTGGCCTCC TTCACTCCTG AAGAGAGAGC TGCTCGTGCA 
GGCCTCGGGC TCTGCCGCCT CTTGGCCTTG AAGGGTCGCG GCTGGGGTGA GGGGGACTTT 
GTATACCAGT GCATGGAGGT GTTGCTGAGA GAGGTACTGC CCGAGCATGT AAGCGTCCTG 
CAAGGCGTTG ACTTATCTCC AGATATCACA AGGCAGAGGA TCCTGAGCAT TGACAGGAAT 
CTACGCAACC AGCTTTTTAA CCGAGCCAGG GACTTTAAAG CCTATTCTCT TGCCTTGGAC 
GACCAGGCTT TTGTGGCCTA TGAGAACTAC CTCCTGGTCT TTATCCGCGG TGTAGGCCCT 
GAGTTGGAGG TGCAAGAAGA TCTTCTGACC ATAATCAACC TGACTCATCA TTTCAGTGTT 
GGTGCGCTCA TGTCGGCAAT CCTAGAGTCC CTGCAGACAG CAGGGCTTAG CTTGCAGAGA 
ATGGTTGGAC TGACCACGAC CCATACTTTG AGGATGATTG GTGAGAACTC AGGACTCGTC 
TCATACATGA GAGAAAAGGC CGTAAGCCCC AACTGTTGGA ATGTCATTCA TTATTCAGGA 
TTTCTTCACT TGGAACTGTT GAGCTCCTAT GATGTAGATG TTAATCAGAT CATAAATACC 
ATATCCGAAT GGATAGTTTT GATTAAGACC AGAGGCGTTA GGCGACCTGA ATTTCAGACT 
TTACTAACGG AATCTGAATC AGAGCATGGT GAAAGGGTTA ATGGACGATG TCTGAACAAT 
TGGCTTAGGA GAGGGAAAAC TTTAAAACTA ATATTCTCTC TAAGAAAAGA AATGGAAGCG 
TTCTTGGTTT CAGTAGGGGC AACAACAGTC CACTTCTCAG ACAAACAATG GCTTTGTGAC 
TTTGGCTTCT TGGTGGACAT TATGGAACAC CTTCGAGAAC TCAGTGAAGA ATTACGAGTT 
AGTAAAGTCT TTGCTGCTGC TGCCTTTGAC CATATTTGTA CTTTCGAAGT TAAGCTGAAT 
TTATTTCAAA GACATATTGA GGAAAAAAAT CTAACAGACT TTCCTGCCCT CAGAGAAGTT 
GTTGATGAGC TAAAACAGCA AAATAAGGAA GATGAAAAAA TATTTGATCC TGATAGGTAT 
CAAATGGTGA TCTGTCGTCT CCAAAAAGAA TTTGAGAGAC ATTTTAAGGA CCTCAGGTTC 
ATTAAAAAGG ACTTAGAACT TTTTTCAAAT CCATTTAACT TTAAACCTGA ATATGCACCT 
ATTTCAGTGA GGGTGGAGCT AACAAAACTT CAGGCAAACA CTAATCTTTG GAATGAATAC 
AGAATCAAAG ACTTGGGGCA GTTTTATGCT GGATTGTCTG CTGAATCCTA CCCAATTATC 
AAAGGGGTTG CCTGTAAGGT GGCATCCTTG TTTGATAGTA ACCAAATCTG TGAAAAGGCT 
TTTTCATATT TGACTCGAAA CCAACACACT TTGAGTCAGC CATTAACAGA TGAGCATCTC 
CAAGCCCTGT TTCGGGTTGC CACAACTGAA ATGGAGCCCG GTTGGGATGA CCTTGTGAGA 
GAAAGAAATG AATCTAATCC ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055620.1
CDS	55..1878
Translation	MWMTPKRSKMEVDEALVFRPEWTQRYLVVEPPEGDGALCLVCRRLIVATRERDVRRHYEAEHEYYERYVADGERAALVERLRQGDLPVASFTPEERAARAGLGLCRLLALKGRGWGEGDFVYQCMEVLLREVLPEHVSVLQGVDLSPDITRQRILSIDRNLRNQLFNRARDFKAYSLALDDQAFVAYENYLLVFIRGVGPELEVQEDLLTIINLTHHFSVGALMSAILESLQTAGLSLQRMVGLTTTHTLRMIGENSGLVSYMREKAVSPNCWNVIHYSGFLHLELLSSYDVDVNQIINTISEWIVLIKTRGVRRPEFQTLLTESESEHGERVNGRCLNNWLRRGKTLKLIFSLRKEMEAFLVSVGATTVHFSDKQWLCDFGFLVDIMEHLRELSEELRVSKVFAAAAFDHICTFEVKLNLFQRHIEEKNLTDFPALREVVDELKQQNKEDEKIFDPDRYQMVICRLQKEFERHFKDLRFIKKDLELFSNPFNFKPEYAPISVRVELTKLQANTNLWNEYRIKDLGQFYAGLSAESYPIIKGVACKVASLFDSNQICEKAFSYLTRNQHTLSQPLTDEHLQALFRVATTEMEPGWDDLVRERNESNP

Target ORF information:

RefSeq Version	NM_014805.4
Organism	Homo sapiens(human)
Definition	Homo sapiens EPM2A interacting protein 1 (EPM2AIP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014805.4

ORF Insert Sequence:

ATGTGGATGA CGCCCAAAAG AAGCAAGATG GAAGTCGACG AGGCTCTAGT TTTCCGGCCC 
GAGTGGACCC AGCGTTATTT GGTGGTGGAG CCTCCGGAGG GCGATGGGGC CCTGTGCCTG 
GTCTGTCGCC GCCTCATCGT AGCTACCCGC GAACGCGACG TCAGGCGCCA CTACGAGGCT 
GAGCACGAAT ACTACGAGCG GTATGTGGCG GACGGCGAGC GCGCGGCCCT GGTGGAGCGT 
CTGCGTCAGG GCGACTTGCC CGTGGCCTCC TTCACTCCTG AAGAGAGAGC TGCTCGTGCA 
GGCCTCGGGC TCTGCCGCCT CTTGGCCTTG AAGGGTCGCG GCTGGGGTGA GGGGGACTTT 
GTATACCAGT GCATGGAGGT GTTGCTGAGA GAGGTACTGC CCGAGCATGT AAGCGTCCTG 
CAAGGCGTTG ACTTATCTCC AGATATCACA AGGCAGAGGA TCCTGAGCAT TGACAGGAAT 
CTACGCAACC AGCTTTTTAA CCGAGCCAGG GACTTTAAAG CCTATTCTCT TGCCTTGGAC 
GACCAGGCTT TTGTGGCCTA TGAGAACTAC CTCCTGGTCT TTATCCGCGG TGTAGGCCCT 
GAGTTGGAGG TGCAAGAAGA TCTTCTGACC ATAATCAACC TGACTCATCA TTTCAGTGTT 
GGTGCGCTCA TGTCGGCAAT CCTAGAGTCC CTGCAGACAG CAGGGCTTAG CTTGCAGAGA 
ATGGTTGGAC TGACCACGAC CCATACTTTG AGGATGATTG GTGAGAACTC AGGACTCGTC 
TCATACATGA GAGAAAAGGC CGTAAGCCCC AACTGTTGGA ATGTCATTCA TTATTCAGGA 
TTTCTTCACT TGGAACTGTT GAGCTCCTAT GATGTAGATG TTAATCAGAT CATAAATACC 
ATATCCGAAT GGATAGTTTT GATTAAGACC AGAGGCGTTA GGCGACCTGA ATTTCAGACT 
TTACTAACGG AATCTGAATC AGAGCATGGT GAAAGGGTTA ATGGACGATG TCTGAACAAT 
TGGCTTAGGA GAGGGAAAAC TTTAAAACTA ATATTCTCTC TAAGAAAAGA AATGGAAGCG 
TTCTTGGTTT CAGTAGGGGC AACAACAGTC CACTTCTCAG ACAAACAATG GCTTTGTGAC 
TTTGGCTTCT TGGTGGACAT TATGGAACAC CTTCGAGAAC TCAGTGAAGA ATTACGAGTT 
AGTAAAGTCT TTGCTGCTGC TGCCTTTGAC CATATTTGTA CTTTCGAAGT TAAGCTGAAT 
TTATTTCAAA GACATATTGA GGAAAAAAAT CTAACAGACT TTCCTGCCCT CAGAGAAGTT 
GTTGATGAGC TAAAACAGCA AAATAAGGAA GATGAAAAAA TATTTGATCC TGATAGGTAT 
CAAATGGTGA TCTGTCGTCT CCAAAAAGAA TTTGAGAGAC ATTTTAAGGA CCTCAGGTTC 
ATTAAAAAGG ACTTAGAACT TTTTTCAAAT CCATTTAACT TTAAACCTGA ATATGCACCT 
ATTTCAGTGA GGGTGGAGCT AACAAAACTT CAGGCAAACA CTAATCTTTG GAATGAATAC 
AGAATCAAAG ACTTGGGGCA GTTTTATGCT GGATTGTCTG CTGAATCCTA CCCAATTATC 
AAAGGGGTTG CCTGTAAGGT GGCATCCTTG TTTGATAGTA ACCAAATCTG TGAAAAGGCT 
TTTTCATATT TGACTCGAAA CCAACACACT TTGAGTCAGC CATTAACAGA TGAGCATCTC 
CAAGCCCTGT TTCGGGTTGC CACAACTGAA ATGGAGCCCG GTTGGGATGA CCTTGTGAGA 
GAAAGAAATG AATCTAATCC ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

Functional effects of the MLH1-93G>A polymorphism on MLH1/EPM2AIP1 promoter activity.
Oncology reports25(3)809-15(2011 Mar)
Perera S,Mrkonjic M,Rawson JB,Bapat B

Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.
Breast cancer research and treatment112(2)229-36(2008 Nov)
Walker LC,Waddell N,Ten Haaf A,,Grimmond S,Spurdle AB

Mutations in NHLRC1 cause progressive myoclonus epilepsy.
Nature genetics35(2)125-7(2003 Oct)
Chan EM,Young EJ,Ianzano L,Munteanu I,Zhao X,Christopoulos CC,Avanzini G,Elia M,Ackerley CA,Jovic NJ,Bohlega S,Andermann E,Rouleau GA,Delgado-Escueta AV,Minassian BA,Scherer SW

Identification of a novel protein interacting with laforin, the EPM2a progressive myoclonus epilepsy gene product.
Genomics81(6)579-87(2003 Jun)
Ianzano L,Zhao XC,Minassian BA,Scherer SW

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EPM2AIP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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