EIF4A3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EIF4A3
Entrez Gene ID	9775
Full Name	eukaryotic translation initiation factor 4A3
Synonyms	DDX48,Fal1,MUK34,NMP265,NUK34,RCPS,eIF4AIII
General protein information	Preferred Names eukaryotic translation initiation factor 4A3 Names eukaryotic initiation factor 4A-III ATP-dependent RNA helicase DDX48 ATP-dependent RNA helicase eIF4A-3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 48 DEAD box protein 48 NMP 265 eIF-4A-III eIF4A-III eukaryotic initiation factor 4A-like NUK-34 eukaryotic translation initiation factor 4A hNMP 265 nuclear matrix protein 265
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q25.3
Summary	This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [provided by RefSeq, Jul 2008].
Disorder MIM:	608546
Disorder Html:	Robin sequence with cleft mandible and limb anomalies, 268305 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011525522.1	XP_011523824.1	eukaryotic initiation factor 4A-III isoform X1
NM_014740.4	NP_055555.1	eukaryotic initiation factor 4A-III
XM_011525522.2	XP_011523824.1	eukaryotic initiation factor 4A-III isoform X1
NM_014740.3	NP_055555.1	eukaryotic initiation factor 4A-III

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	EIF4A3	XP_533130.2
Bos taurus (cattle)	EIF4A3	NP_001039653.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003089	XP_312776.3
Caenorhabditis elegans (roundworm)	F33D11.10	NP_491703.1
Saccharomyces cerevisiae (baker's yeast)	FAL1	NP_010304.3
Neurospora crassa	NCU01234	XP_961600.1
Arabidopsis thaliana (thale cress)	EIF4A-III	NP_188610.1
Gallus gallus (chicken)	EIF4A3	NP_001025820.1
Danio rerio (zebrafish)	eif4a3	NP_957372.1
Drosophila melanogaster (fruit fly)	eIF4AIII	NP_649788.2
Caenorhabditis elegans (roundworm)	Y65B4A.6	NP_490761.2
Oryza sativa (rice)	Os01g0639100	NP_001043673.1
Homo sapiens (human)	EIF4A3	NP_055555.1
	EIF4A3	XP_001110130.1
Mus musculus (house mouse)	Eif4a3	NP_619610.1
Rattus norvegicus (Norway rat)	Eif4a3	NP_001093628.1
Schizosaccharomyces pombe (fission yeast)	SPAC1F5.10	NP_592863.1
Oryza sativa (rice)	Os03g0566800	NP_001050506.1
Xenopus tropicalis (tropical clawed frog)	eif4a3	NP_001107349.1
Pan troglodytes (chimpanzee)	EIF4A3	XP_511724.3
Kluyveromyces lactis	KLLA0A10659g	XP_451466.1
Eremothecium gossypii	AGOS_AER408W	NP_985263.2
Magnaporthe oryzae (rice blast fungus)	MGG_04885	XP_003712368.1

Gene Ontology
Bibliography

Related articles in PubMed

Structure of a human catalytic step I spliceosome.
Zhan X, Yan C, Zhang X, Lei J, Shi Y
Science (New York, N.Y.)(2018 Jan)

Richieri-Costa-Pereira syndrome: expanding its phenotypic and genotypic spectrum.
Bertola DR, Hsia G, Alvizi L, Gardham A, Wakeling E, Yamamoto GL, Honjo RS, Oliveira LAN, Di Francesco RC, Perez BA, Kim CA, Passos-Bueno MR
Clinical genetics(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MYC, DUX4, and EIF4A3 might contribute to facioscapulohumeral dystrophy pathophysiology
Title: DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy.

High EIF4A expression is associated with malignant peripheral nerve sheath tumors and vestibular schwannomas.
Title: Components of the eIF4F complex are potential therapeutic targets for malignant peripheral nerve sheath tumors and vestibular schwannomas.

we firstly report that the lncRNA H19 recruits eIF4A3 and promotes the colorectal cancer cell proliferation
Title: Long noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3.

Host eIF4AIII RNA helicase is required for efficient human cytomegalovirus replication.
Title: The eIF4AIII RNA helicase is a critical determinant of human cytomegalovirus replication.

EIF4A3 is a gene involved in RNA metabolism, plays a role in mandible, laryngeal, and limb morphogenesis. Richieri-Costa-Pereira syndrome is caused by mutations in EIF4A3.
Title: A noncoding expansion in EIF4A3 causes Richieri-Costa-Pereira syndrome, a craniofacial disorder associated with limb defects.

The following EIF4A3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EIF4A3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09937	NM_014740.4 Latest version!	Homo sapiens eukaryotic translation initiation factor 4A3 (EIF4A3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu63289	XM_011525522.2 Latest version!	Homo sapiens eukaryotic translation initiation factor 4A3 (EIF4A3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu63289	XM_011525522.1	Homo sapiens eukaryotic translation initiation factor 4A3 (EIF4A3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu09937	NM_014740.3	Homo sapiens eukaryotic translation initiation factor 4A3 (EIF4A3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EIF4A3 ( NM_014740.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055555.1 Homo sapiens eukaryotic translation initiation factor 4A3 (EIF4A3), mRNA.

Price & Availability↑

CloneID	OHu09937
Clone ID Related Accession (Same CDS sequence)	NM_014740.4 , NM_014740.3
Accession Version	NM_014740.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	eukaryotic initiation factor 4A-III
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA667983.1, BC004386.1 and AC087741.18. This sequence is a reference standard in the RefSeqGene project. On Sep 24, 2018 this sequence version replaced NM_014740.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.2930.1, SRR1803616.253898.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000649764.2/ ENSP00000497641.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGACCA CGGCCACGAT GGCGACCTCG GGCTCGGCGC GAAAGCGGCT GCTCAAAGAG 
GAAGACATGA CTAAAGTGGA ATTCGAGACC AGCGAGGAGG TGGATGTGAC CCCCACGTTC 
GACACCATGG GCCTGCGGGA GGACCTGCTG CGGGGCATCT ACGCTTACGG TTTTGAAAAA 
CCATCAGCAA TCCAGCAACG AGCAATCAAG CAGATCATCA AAGGGAGAGA TGTCATCGCA 
CAGTCTCAGT CCGGCACAGG AAAAACAGCC ACCTTCAGTA TCTCAGTCCT CCAGTGTTTG 
GATATTCAGG TTCGTGAAAC TCAAGCTTTG ATCTTGGCTC CCACAAGAGA GTTGGCTGTG 
CAGATCCAGA AGGGGCTGCT TGCTCTCGGT GACTACATGA ATGTCCAGTG CCATGCCTGC 
ATTGGAGGCA CCAATGTTGG CGAGGACATC AGGAAGCTGG ATTACGGACA GCATGTTGTC 
GCGGGCACTC CAGGGCGTGT TTTTGATATG ATTCGTCGCA GAAGCCTAAG GACACGTGCT 
ATCAAAATGT TGGTTTTGGA TGAAGCTGAT GAAATGTTGA ATAAAGGTTT CAAAGAGCAG 
ATTTACGATG TATACAGGTA CCTGCCTCCA GCCACACAGG TGGTTCTCAT CAGTGCCACG 
CTGCCACACG AGATTCTGGA GATGACCAAC AAGTTCATGA CCGACCCAAT CCGCATCTTG 
GTGAAACGTG ATGAATTGAC TCTGGAAGGC ATCAAGCAAT TTTTCGTGGC AGTGGAGAGG 
GAAGAGTGGA AATTTGACAC TCTGTGTGAC CTCTACGACA CACTGACCAT CACTCAGGCG 
GTCATCTTCT GCAACACCAA AAGAAAGGTG GACTGGCTGA CGGAGAAAAT GAGGGAAGCC 
AACTTCACTG TATCCTCAAT GCATGGAGAC ATGCCCCAGA AAGAGCGGGA GTCCATCATG 
AAGGAGTTCC GGTCGGGCGC CAGCCGAGTG CTTATTTCTA CAGATGTCTG GGCCAGGGGG 
TTGGATGTCC CTCAGGTGTC CCTCATCATT AACTATGATC TCCCTAATAA CAGAGAATTG 
TACATACACA GAATTGGGAG ATCAGGTCGA TACGGCCGGA AGGGTGTGGC CATTAACTTT 
GTAAAGAATG ACGACATCCG CATCCTCAGA GATATCGAGC AGTACTATTC CACTCAGATT 
GATGAGATGC CGATGAACGT TGCTGATCTT ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055555.1
CDS	168..1403
Translation	MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAVQIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI

Target ORF information:

RefSeq Version	NM_014740.4
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 4A3 (EIF4A3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014740.4

ORF Insert Sequence:

ATGGCGACCA CGGCCACGAT GGCGACCTCG GGCTCGGCGC GAAAGCGGCT GCTCAAAGAG 
GAAGACATGA CTAAAGTGGA ATTCGAGACC AGCGAGGAGG TGGATGTGAC CCCCACGTTC 
GACACCATGG GCCTGCGGGA GGACCTGCTG CGGGGCATCT ACGCTTACGG TTTTGAAAAA 
CCATCAGCAA TCCAGCAACG AGCAATCAAG CAGATCATCA AAGGGAGAGA TGTCATCGCA 
CAGTCTCAGT CCGGCACAGG AAAAACAGCC ACCTTCAGTA TCTCAGTCCT CCAGTGTTTG 
GATATTCAGG TTCGTGAAAC TCAAGCTTTG ATCTTGGCTC CCACAAGAGA GTTGGCTGTG 
CAGATCCAGA AGGGGCTGCT TGCTCTCGGT GACTACATGA ATGTCCAGTG CCATGCCTGC 
ATTGGAGGCA CCAATGTTGG CGAGGACATC AGGAAGCTGG ATTACGGACA GCATGTTGTC 
GCGGGCACTC CAGGGCGTGT TTTTGATATG ATTCGTCGCA GAAGCCTAAG GACACGTGCT 
ATCAAAATGT TGGTTTTGGA TGAAGCTGAT GAAATGTTGA ATAAAGGTTT CAAAGAGCAG 
ATTTACGATG TATACAGGTA CCTGCCTCCA GCCACACAGG TGGTTCTCAT CAGTGCCACG 
CTGCCACACG AGATTCTGGA GATGACCAAC AAGTTCATGA CCGACCCAAT CCGCATCTTG 
GTGAAACGTG ATGAATTGAC TCTGGAAGGC ATCAAGCAAT TTTTCGTGGC AGTGGAGAGG 
GAAGAGTGGA AATTTGACAC TCTGTGTGAC CTCTACGACA CACTGACCAT CACTCAGGCG 
GTCATCTTCT GCAACACCAA AAGAAAGGTG GACTGGCTGA CGGAGAAAAT GAGGGAAGCC 
AACTTCACTG TATCCTCAAT GCATGGAGAC ATGCCCCAGA AAGAGCGGGA GTCCATCATG 
AAGGAGTTCC GGTCGGGCGC CAGCCGAGTG CTTATTTCTA CAGATGTCTG GGCCAGGGGG 
TTGGATGTCC CTCAGGTGTC CCTCATCATT AACTATGATC TCCCTAATAA CAGAGAATTG 
TACATACACA GAATTGGGAG ATCAGGTCGA TACGGCCGGA AGGGTGTGGC CATTAACTTT 
GTAAAGAATG ACGACATCCG CATCCTCAGA GATATCGAGC AGTACTATTC CACTCAGATT 
GATGAGATGC CGATGAACGT TGCTGATCTT ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF4A3 ( NM_014740.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055555.1 Homo sapiens eukaryotic translation initiation factor 4A3 (EIF4A3), mRNA.

Price & Availability↑

CloneID	OHu09937
Clone ID Related Accession (Same CDS sequence)	NM_014740.4 , NM_014740.3
Accession Version	NM_014740.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	eukaryotic initiation factor 4A-III
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA667983.1, BC004386.1 and AC087741.18. This sequence is a reference standard in the RefSeqGene project. On Feb 17, 2010 this sequence version replaced NM_014740.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.70903.1, SRR1163658.2833.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGACCA CGGCCACGAT GGCGACCTCG GGCTCGGCGC GAAAGCGGCT GCTCAAAGAG 
GAAGACATGA CTAAAGTGGA ATTCGAGACC AGCGAGGAGG TGGATGTGAC CCCCACGTTC 
GACACCATGG GCCTGCGGGA GGACCTGCTG CGGGGCATCT ACGCTTACGG TTTTGAAAAA 
CCATCAGCAA TCCAGCAACG AGCAATCAAG CAGATCATCA AAGGGAGAGA TGTCATCGCA 
CAGTCTCAGT CCGGCACAGG AAAAACAGCC ACCTTCAGTA TCTCAGTCCT CCAGTGTTTG 
GATATTCAGG TTCGTGAAAC TCAAGCTTTG ATCTTGGCTC CCACAAGAGA GTTGGCTGTG 
CAGATCCAGA AGGGGCTGCT TGCTCTCGGT GACTACATGA ATGTCCAGTG CCATGCCTGC 
ATTGGAGGCA CCAATGTTGG CGAGGACATC AGGAAGCTGG ATTACGGACA GCATGTTGTC 
GCGGGCACTC CAGGGCGTGT TTTTGATATG ATTCGTCGCA GAAGCCTAAG GACACGTGCT 
ATCAAAATGT TGGTTTTGGA TGAAGCTGAT GAAATGTTGA ATAAAGGTTT CAAAGAGCAG 
ATTTACGATG TATACAGGTA CCTGCCTCCA GCCACACAGG TGGTTCTCAT CAGTGCCACG 
CTGCCACACG AGATTCTGGA GATGACCAAC AAGTTCATGA CCGACCCAAT CCGCATCTTG 
GTGAAACGTG ATGAATTGAC TCTGGAAGGC ATCAAGCAAT TTTTCGTGGC AGTGGAGAGG 
GAAGAGTGGA AATTTGACAC TCTGTGTGAC CTCTACGACA CACTGACCAT CACTCAGGCG 
GTCATCTTCT GCAACACCAA AAGAAAGGTG GACTGGCTGA CGGAGAAAAT GAGGGAAGCC 
AACTTCACTG TATCCTCAAT GCATGGAGAC ATGCCCCAGA AAGAGCGGGA GTCCATCATG 
AAGGAGTTCC GGTCGGGCGC CAGCCGAGTG CTTATTTCTA CAGATGTCTG GGCCAGGGGG 
TTGGATGTCC CTCAGGTGTC CCTCATCATT AACTATGATC TCCCTAATAA CAGAGAATTG 
TACATACACA GAATTGGGAG ATCAGGTCGA TACGGCCGGA AGGGTGTGGC CATTAACTTT 
GTAAAGAATG ACGACATCCG CATCCTCAGA GATATCGAGC AGTACTATTC CACTCAGATT 
GATGAGATGC CGATGAACGT TGCTGATCTT ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055555.1
CDS	223..1458
Translation	MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAVQIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI

Target ORF information:

RefSeq Version	NM_014740.3
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 4A3 (EIF4A3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014740.3

ORF Insert Sequence:

ATGGCGACCA CGGCCACGAT GGCGACCTCG GGCTCGGCGC GAAAGCGGCT GCTCAAAGAG 
GAAGACATGA CTAAAGTGGA ATTCGAGACC AGCGAGGAGG TGGATGTGAC CCCCACGTTC 
GACACCATGG GCCTGCGGGA GGACCTGCTG CGGGGCATCT ACGCTTACGG TTTTGAAAAA 
CCATCAGCAA TCCAGCAACG AGCAATCAAG CAGATCATCA AAGGGAGAGA TGTCATCGCA 
CAGTCTCAGT CCGGCACAGG AAAAACAGCC ACCTTCAGTA TCTCAGTCCT CCAGTGTTTG 
GATATTCAGG TTCGTGAAAC TCAAGCTTTG ATCTTGGCTC CCACAAGAGA GTTGGCTGTG 
CAGATCCAGA AGGGGCTGCT TGCTCTCGGT GACTACATGA ATGTCCAGTG CCATGCCTGC 
ATTGGAGGCA CCAATGTTGG CGAGGACATC AGGAAGCTGG ATTACGGACA GCATGTTGTC 
GCGGGCACTC CAGGGCGTGT TTTTGATATG ATTCGTCGCA GAAGCCTAAG GACACGTGCT 
ATCAAAATGT TGGTTTTGGA TGAAGCTGAT GAAATGTTGA ATAAAGGTTT CAAAGAGCAG 
ATTTACGATG TATACAGGTA CCTGCCTCCA GCCACACAGG TGGTTCTCAT CAGTGCCACG 
CTGCCACACG AGATTCTGGA GATGACCAAC AAGTTCATGA CCGACCCAAT CCGCATCTTG 
GTGAAACGTG ATGAATTGAC TCTGGAAGGC ATCAAGCAAT TTTTCGTGGC AGTGGAGAGG 
GAAGAGTGGA AATTTGACAC TCTGTGTGAC CTCTACGACA CACTGACCAT CACTCAGGCG 
GTCATCTTCT GCAACACCAA AAGAAAGGTG GACTGGCTGA CGGAGAAAAT GAGGGAAGCC 
AACTTCACTG TATCCTCAAT GCATGGAGAC ATGCCCCAGA AAGAGCGGGA GTCCATCATG 
AAGGAGTTCC GGTCGGGCGC CAGCCGAGTG CTTATTTCTA CAGATGTCTG GGCCAGGGGG 
TTGGATGTCC CTCAGGTGTC CCTCATCATT AACTATGATC TCCCTAATAA CAGAGAATTG 
TACATACACA GAATTGGGAG ATCAGGTCGA TACGGCCGGA AGGGTGTGGC CATTAACTTT 
GTAAAGAATG ACGACATCCG CATCCTCAGA GATATCGAGC AGTACTATTC CACTCAGATT 
GATGAGATGC CGATGAACGT TGCTGATCTT ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF4A3 ( XM_011525522.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011523824.1 Homo sapiens eukaryotic translation initiation factor 4A3 (EIF4A3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu63289
Clone ID Related Accession (Same CDS sequence)	XM_011525522.1 , XM_011525522.2
Accession Version	XM_011525522.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1173bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	eukaryotic initiation factor 4A-III isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGACCA CGGCCACGAT GGCGACCTCG GGCTCGGCGC GAAAGCGGCT GCTCAAAGAG 
GAAGACATGA CTAAAGTGGA ATTCGAGACC AGCGAGGAGG TGGATGTGAC CCCCACGTTC 
GACACCATGG GCCTGCGGGA GGACCTGCTG CGGGGCATCT ACGCTTACGG TTTTGAAAAA 
CCATCAGCAA TCCAGCAACG AGCAATCAAG CAGATCATCA AAGGGAGAGA TGTCATCGCA 
CAGTCTCAGT CCGGCACAGG AAAAACAGCC ACCTTCAGTA TCTCAGTCCT CCAGTGTTTG 
GATATTCAGG GGCTGCTTGC TCTCGGTGAC TACATGAATG TCCAGTGCCA TGCCTGCATT 
GGAGGCACCA ATGTTGGCGA GGACATCAGG AAGCTGGATT ACGGACAGCA TGTTGTCGCG 
GGCACTCCAG GGCGTGTTTT TGATATGATT CGTCGCAGAA GCCTAAGGAC ACGTGCTATC 
AAAATGTTGG TTTTGGATGA AGCTGATGAA ATGTTGAATA AAGGTTTCAA AGAGCAGATT 
TACGATGTAT ACAGGTACCT GCCTCCAGCC ACACAGGTGG TTCTCATCAG TGCCACGCTG 
CCACACGAGA TTCTGGAGAT GACCAACAAG TTCATGACCG ACCCAATCCG CATCTTGGTG 
AAACGTGATG AATTGACTCT GGAAGGCATC AAGCAATTTT TCGTGGCAGT GGAGAGGGAA 
GAGTGGAAAT TTGACACTCT GTGTGACCTC TACGACACAC TGACCATCAC TCAGGCGGTC 
ATCTTCTGCA ACACCAAAAG AAAGGTGGAC TGGCTGACGG AGAAAATGAG GGAAGCCAAC 
TTCACTGTAT CCTCAATGCA TGGAGACATG CCCCAGAAAG AGCGGGAGTC CATCATGAAG 
GAGTTCCGGT CGGGCGCCAG CCGAGTGCTT ATTTCTACAG ATGTCTGGGC CAGGGGGTTG 
GATGTCCCTC AGGTGTCCCT CATCATTAAC TATGATCTCC CTAATAACAG AGAATTGTAC 
ATACACAGAA TTGGGAGATC AGGTCGATAC GGCCGGAAGG GTGTGGCCAT TAACTTTGTA 
AAGAATGACG ACATCCGCAT CCTCAGAGAT ATCGAGCAGT ACTATTCCAC TCAGATTGAT 
GAGATGCCGA TGAACGTTGC TGATCTTATC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011523824.1
CDS	179..1351
Translation	MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI

Target ORF information:

RefSeq Version	XM_011525522.1
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 4A3 (EIF4A3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011525522.1

ORF Insert Sequence:

ATGGCGACCA CGGCCACGAT GGCGACCTCG GGCTCGGCGC GAAAGCGGCT GCTCAAAGAG 
GAAGACATGA CTAAAGTGGA ATTCGAGACC AGCGAGGAGG TGGATGTGAC CCCCACGTTC 
GACACCATGG GCCTGCGGGA GGACCTGCTG CGGGGCATCT ACGCTTACGG TTTTGAAAAA 
CCATCAGCAA TCCAGCAACG AGCAATCAAG CAGATCATCA AAGGGAGAGA TGTCATCGCA 
CAGTCTCAGT CCGGCACAGG AAAAACAGCC ACCTTCAGTA TCTCAGTCCT CCAGTGTTTG 
GATATTCAGG GGCTGCTTGC TCTCGGTGAC TACATGAATG TCCAGTGCCA TGCCTGCATT 
GGAGGCACCA ATGTTGGCGA GGACATCAGG AAGCTGGATT ACGGACAGCA TGTTGTCGCG 
GGCACTCCAG GGCGTGTTTT TGATATGATT CGTCGCAGAA GCCTAAGGAC ACGTGCTATC 
AAAATGTTGG TTTTGGATGA AGCTGATGAA ATGTTGAATA AAGGTTTCAA AGAGCAGATT 
TACGATGTAT ACAGGTACCT GCCTCCAGCC ACACAGGTGG TTCTCATCAG TGCCACGCTG 
CCACACGAGA TTCTGGAGAT GACCAACAAG TTCATGACCG ACCCAATCCG CATCTTGGTG 
AAACGTGATG AATTGACTCT GGAAGGCATC AAGCAATTTT TCGTGGCAGT GGAGAGGGAA 
GAGTGGAAAT TTGACACTCT GTGTGACCTC TACGACACAC TGACCATCAC TCAGGCGGTC 
ATCTTCTGCA ACACCAAAAG AAAGGTGGAC TGGCTGACGG AGAAAATGAG GGAAGCCAAC 
TTCACTGTAT CCTCAATGCA TGGAGACATG CCCCAGAAAG AGCGGGAGTC CATCATGAAG 
GAGTTCCGGT CGGGCGCCAG CCGAGTGCTT ATTTCTACAG ATGTCTGGGC CAGGGGGTTG 
GATGTCCCTC AGGTGTCCCT CATCATTAAC TATGATCTCC CTAATAACAG AGAATTGTAC 
ATACACAGAA TTGGGAGATC AGGTCGATAC GGCCGGAAGG GTGTGGCCAT TAACTTTGTA 
AAGAATGACG ACATCCGCAT CCTCAGAGAT ATCGAGCAGT ACTATTCCAC TCAGATTGAT 
GAGATGCCGA TGAACGTTGC TGATCTTATC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF4A3 ( XM_011525522.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011523824.1 Homo sapiens eukaryotic translation initiation factor 4A3 (EIF4A3), transcript variant X1, mRNA.

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CloneID	OHu63289
Clone ID Related Accession (Same CDS sequence)	XM_011525522.1 , XM_011525522.2
Accession Version	XM_011525522.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1173bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	eukaryotic initiation factor 4A-III isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011525522.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGACCA CGGCCACGAT GGCGACCTCG GGCTCGGCGC GAAAGCGGCT GCTCAAAGAG 
GAAGACATGA CTAAAGTGGA ATTCGAGACC AGCGAGGAGG TGGATGTGAC CCCCACGTTC 
GACACCATGG GCCTGCGGGA GGACCTGCTG CGGGGCATCT ACGCTTACGG TTTTGAAAAA 
CCATCAGCAA TCCAGCAACG AGCAATCAAG CAGATCATCA AAGGGAGAGA TGTCATCGCA 
CAGTCTCAGT CCGGCACAGG AAAAACAGCC ACCTTCAGTA TCTCAGTCCT CCAGTGTTTG 
GATATTCAGG GGCTGCTTGC TCTCGGTGAC TACATGAATG TCCAGTGCCA TGCCTGCATT 
GGAGGCACCA ATGTTGGCGA GGACATCAGG AAGCTGGATT ACGGACAGCA TGTTGTCGCG 
GGCACTCCAG GGCGTGTTTT TGATATGATT CGTCGCAGAA GCCTAAGGAC ACGTGCTATC 
AAAATGTTGG TTTTGGATGA AGCTGATGAA ATGTTGAATA AAGGTTTCAA AGAGCAGATT 
TACGATGTAT ACAGGTACCT GCCTCCAGCC ACACAGGTGG TTCTCATCAG TGCCACGCTG 
CCACACGAGA TTCTGGAGAT GACCAACAAG TTCATGACCG ACCCAATCCG CATCTTGGTG 
AAACGTGATG AATTGACTCT GGAAGGCATC AAGCAATTTT TCGTGGCAGT GGAGAGGGAA 
GAGTGGAAAT TTGACACTCT GTGTGACCTC TACGACACAC TGACCATCAC TCAGGCGGTC 
ATCTTCTGCA ACACCAAAAG AAAGGTGGAC TGGCTGACGG AGAAAATGAG GGAAGCCAAC 
TTCACTGTAT CCTCAATGCA TGGAGACATG CCCCAGAAAG AGCGGGAGTC CATCATGAAG 
GAGTTCCGGT CGGGCGCCAG CCGAGTGCTT ATTTCTACAG ATGTCTGGGC CAGGGGGTTG 
GATGTCCCTC AGGTGTCCCT CATCATTAAC TATGATCTCC CTAATAACAG AGAATTGTAC 
ATACACAGAA TTGGGAGATC AGGTCGATAC GGCCGGAAGG GTGTGGCCAT TAACTTTGTA 
AAGAATGACG ACATCCGCAT CCTCAGAGAT ATCGAGCAGT ACTATTCCAC TCAGATTGAT 
GAGATGCCGA TGAACGTTGC TGATCTTATC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011523824.1
CDS	168..1340
Translation	MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI

Target ORF information:

RefSeq Version	XM_011525522.2
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 4A3 (EIF4A3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011525522.2

ORF Insert Sequence:

ATGGCGACCA CGGCCACGAT GGCGACCTCG GGCTCGGCGC GAAAGCGGCT GCTCAAAGAG 
GAAGACATGA CTAAAGTGGA ATTCGAGACC AGCGAGGAGG TGGATGTGAC CCCCACGTTC 
GACACCATGG GCCTGCGGGA GGACCTGCTG CGGGGCATCT ACGCTTACGG TTTTGAAAAA 
CCATCAGCAA TCCAGCAACG AGCAATCAAG CAGATCATCA AAGGGAGAGA TGTCATCGCA 
CAGTCTCAGT CCGGCACAGG AAAAACAGCC ACCTTCAGTA TCTCAGTCCT CCAGTGTTTG 
GATATTCAGG GGCTGCTTGC TCTCGGTGAC TACATGAATG TCCAGTGCCA TGCCTGCATT 
GGAGGCACCA ATGTTGGCGA GGACATCAGG AAGCTGGATT ACGGACAGCA TGTTGTCGCG 
GGCACTCCAG GGCGTGTTTT TGATATGATT CGTCGCAGAA GCCTAAGGAC ACGTGCTATC 
AAAATGTTGG TTTTGGATGA AGCTGATGAA ATGTTGAATA AAGGTTTCAA AGAGCAGATT 
TACGATGTAT ACAGGTACCT GCCTCCAGCC ACACAGGTGG TTCTCATCAG TGCCACGCTG 
CCACACGAGA TTCTGGAGAT GACCAACAAG TTCATGACCG ACCCAATCCG CATCTTGGTG 
AAACGTGATG AATTGACTCT GGAAGGCATC AAGCAATTTT TCGTGGCAGT GGAGAGGGAA 
GAGTGGAAAT TTGACACTCT GTGTGACCTC TACGACACAC TGACCATCAC TCAGGCGGTC 
ATCTTCTGCA ACACCAAAAG AAAGGTGGAC TGGCTGACGG AGAAAATGAG GGAAGCCAAC 
TTCACTGTAT CCTCAATGCA TGGAGACATG CCCCAGAAAG AGCGGGAGTC CATCATGAAG 
GAGTTCCGGT CGGGCGCCAG CCGAGTGCTT ATTTCTACAG ATGTCTGGGC CAGGGGGTTG 
GATGTCCCTC AGGTGTCCCT CATCATTAAC TATGATCTCC CTAATAACAG AGAATTGTAC 
ATACACAGAA TTGGGAGATC AGGTCGATAC GGCCGGAAGG GTGTGGCCAT TAACTTTGTA 
AAGAATGACG ACATCCGCAT CCTCAGAGAT ATCGAGCAGT ACTATTCCAC TCAGATTGAT 
GAGATGCCGA TGAACGTTGC TGATCTTATC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structure of a human catalytic step I spliceosome.
Science (New York, N.Y.)(2018 Jan)
Zhan X,Yan C,Zhang X,Lei J,Shi Y

Richieri-Costa-Pereira syndrome: expanding its phenotypic and genotypic spectrum.
Clinical genetics(2017 Nov)
Bertola DR,Hsia G,Alvizi L,Gardham A,Wakeling E,Yamamoto GL,Honjo RS,Oliveira LAN,Di Francesco RC,Perez BA,Kim CA,Passos-Bueno MR

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EIF4A3 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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