ATP6V1G1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATP6V1G1
Entrez Gene ID	9550
Full Name	ATPase H+ transporting V1 subunit G1
Synonyms	ATP6G,ATP6G1,ATP6GL,ATP6J,Vma10
General protein information	Preferred Names ATPase H+ transporting V1 subunit G1 Names V-type proton ATPase subunit G 1 ATPase, H+ transporting, lysosomal (vacuolar proton pump), member J ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 V-ATPase 13 kDa subunit 1 V-ATPase subunit G 1 vacuolar ATP synthase subunit M16 vacuolar H(+)-ATPase subunit G 1 vacuolar proton pump subunit G 1 vacuolar proton pump subunit M16
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q32
Summary	This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized. [provided by RefSeq, Jul 2008].
Disorder MIM:	607296

mRNA and Protein(s)

mRNA	Protein	Name
NM_004888.3	NP_004879.1	V-type proton ATPase subunit G 1
NM_004888.4	NP_004879.1	V-type proton ATPase subunit G 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ATP6V1G1	XP_005627060.1
Mus musculus (house mouse)	Atp6v1g1	NP_077135.1
Danio rerio (zebrafish)	atp6v1g1	NP_956228.1
Homo sapiens (human)	ATP6V1G1	NP_004879.1
	ATP6V1G1	XP_002800049.1
	LOC699522	XP_001084453.1
Bos taurus (cattle)	ATP6V1G1	NP_776670.1
Pan troglodytes (chimpanzee)	ATP6V1G1	XP_003312298.1
Rattus norvegicus (Norway rat)	Atp6v1g1	NP_001100130.1
Gallus gallus (chicken)	ATP6V1G1	NP_001264606.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004867	XP_314319.3
Caenorhabditis elegans (roundworm)	vha-10	NP_491641.1
Xenopus tropicalis (tropical clawed frog)	atp6v1g1	NP_001005022.1

Gene Ontology
Bibliography

Related articles in PubMed

The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1? prolyl hydroxylation by regulating cellular iron levels.
Miles AL, Burr SP, Grice GL, Nathan JA
eLife6(2017 03)

Methylation and expression analyses of Pallister-Killian syndrome reveal partial dosage compensation of tetrasomy 12p and hypomethylation of gene-poor regions on 12p.
Davidsson J, Johansson B
Epigenetics11(3)194-204(2016 03)

Bivariate Genome-Wide Association Study Implicates ATP6V1G1 as a Novel Pleiotropic Locus Underlying Osteoporosis and Age at Menarche.
Tan LJ, Wang ZE, Wu KH, Chen XD, Zhu H, Lu S, Tian Q, Liu XG, Papasian CJ, Deng HW
The Journal of clinical endocrinology and metabolism100(11)E1457-66(2015 Nov)

RILP regulates vacuolar ATPase through interaction with the V1G1 subunit.
De Luca M, Cogli L, Progida C, Nisi V, Pascolutti R, Sigismund S, Di Fiore PP, Bucci C
Journal of cell science128(14)2565(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Three genes-ATP6V1G1 in 9q32, GMPS in 3q25.31, and TBX5 in 12q24.21-exhibited concomitant hypermethylation and decreased expression. The i(12p)-positive cells displayed global hypomethylation of gene-poor regions on 12p, a footprint previously associated with constitutional and acquired gains of whole chromosomes as well as with X-chromosome inactivation in females
Title: Methylation and expression analyses of Pallister-Killian syndrome reveal partial dosage compensation of tetrasomy 12p and hypomethylation of gene-poor regions on 12p.

genome-wide association study in population in China: Data suggest 4 SNPs upstream of ATP6V1G1 (rs10817638, rs7851259, rs10982287, rs4979427) are associated (in bivariate manner) with age at menarche and bone density. [includes META-ANALYSIS]
Title: Bivariate Genome-Wide Association Study Implicates ATP6V1G1 as a Novel Pleiotropic Locus Underlying Osteoporosis and Age at Menarche.

RILP regulates vacuolar ATPase through interaction with the V1G1 subunit
Title: RILP regulates vacuolar ATPase through interaction with the V1G1 subunit.

RILP regulates the activity of the V-ATPase through its interaction with V1G1.
Title: RILP regulates vacuolar ATPase through interaction with the V1G1 subunit.

The following ATP6V1G1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP6V1G1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12880	NM_004888.4 Latest version!	Homo sapiens ATPase H+ transporting V1 subunit G1 (ATP6V1G1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu12880	NM_004888.3	Homo sapiens ATPase H+ transporting V1 subunit G1 (ATP6V1G1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATP6V1G1 ( NM_004888.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004879.1 Homo sapiens ATPase H+ transporting V1 subunit G1 (ATP6V1G1), mRNA.

Price & Availability↑

CloneID	OHu12880
Clone ID Related Accession (Same CDS sequence)	NM_004888.3 , NM_004888.4
Accession Version	NM_004888.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	V-type proton ATPase subunit G 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF692207.1, BC008452.1, AL160275.14 and AI092246.1. On Feb 10, 2006 this sequence version replaced NM_004888.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.441819.1, SRR1660807.67861.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTAGTC AGTCTCAGGG GATTCAGCAG CTGCTGCAGG CCGAGAAGCG GGCAGCCGAG 
AAGGTGTCCG AGGCCCGCAA AAGAAAGAAC CGGAGGCTGA AGCAGGCCAA AGAAGAAGCT 
CAGGCTGAAA TTGAACAGTA CCGCCTGCAG AGGGAGAAAG AATTCAAGGC CAAGGAAGCT 
GCGGCATTGG GATCCCGTGG CAGTTGCAGC ACTGAAGTGG AGAAGGAGAC CCAGGAGAAG 
ATGACCATCC TCCAGACATA CTTCCGGCAG AACAGGGATG AAGTCTTGGA CAACCTCTTG 
GCTTTTGTCT GTGACATTCG GCCAGAAATC CATGAAAACT ACCGCATAAA TGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004879.1
CDS	126..482
Translation	MASQSQGIQQLLQAEKRAAEKVSEARKRKNRRLKQAKEEAQAEIEQYRLQREKEFKAKEAAALGSRGSCSTEVEKETQEKMTILQTYFRQNRDEVLDNLLAFVCDIRPEIHENYRING

Target ORF information:

RefSeq Version	NM_004888.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase H+ transporting V1 subunit G1 (ATP6V1G1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004888.3

ORF Insert Sequence:

ATGGCTAGTC AGTCTCAGGG GATTCAGCAG CTGCTGCAGG CCGAGAAGCG GGCAGCCGAG 
AAGGTGTCCG AGGCCCGCAA AAGAAAGAAC CGGAGGCTGA AGCAGGCCAA AGAAGAAGCT 
CAGGCTGAAA TTGAACAGTA CCGCCTGCAG AGGGAGAAAG AATTCAAGGC CAAGGAAGCT 
GCGGCATTGG GATCCCGTGG CAGTTGCAGC ACTGAAGTGG AGAAGGAGAC CCAGGAGAAG 
ATGACCATCC TCCAGACATA CTTCCGGCAG AACAGGGATG AAGTCTTGGA CAACCTCTTG 
GCTTTTGTCT GTGACATTCG GCCAGAAATC CATGAAAACT ACCGCATAAA TGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP6V1G1 ( NM_004888.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004879.1 Homo sapiens ATPase H+ transporting V1 subunit G1 (ATP6V1G1), mRNA.

Price & Availability↑

CloneID	OHu12880
Clone ID Related Accession (Same CDS sequence)	NM_004888.3 , NM_004888.4
Accession Version	NM_004888.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	V-type proton ATPase subunit G 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF692207.1, BC008452.1, AL160275.14 and AI092246.1. On Nov 23, 2018 this sequence version replaced NM_004888.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.67861.1, SRR3476690.91132.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000374050.4/ ENSP00000363162.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTAGTC AGTCTCAGGG GATTCAGCAG CTGCTGCAGG CCGAGAAGCG GGCAGCCGAG 
AAGGTGTCCG AGGCCCGCAA AAGAAAGAAC CGGAGGCTGA AGCAGGCCAA AGAAGAAGCT 
CAGGCTGAAA TTGAACAGTA CCGCCTGCAG AGGGAGAAAG AATTCAAGGC CAAGGAAGCT 
GCGGCATTGG GATCCCGTGG CAGTTGCAGC ACTGAAGTGG AGAAGGAGAC CCAGGAGAAG 
ATGACCATCC TCCAGACATA CTTCCGGCAG AACAGGGATG AAGTCTTGGA CAACCTCTTG 
GCTTTTGTCT GTGACATTCG GCCAGAAATC CATGAAAACT ACCGCATAAA TGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004879.1
CDS	71..427
Translation	MASQSQGIQQLLQAEKRAAEKVSEARKRKNRRLKQAKEEAQAEIEQYRLQREKEFKAKEAAALGSRGSCSTEVEKETQEKMTILQTYFRQNRDEVLDNLLAFVCDIRPEIHENYRING

Target ORF information:

RefSeq Version	NM_004888.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase H+ transporting V1 subunit G1 (ATP6V1G1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004888.4

ORF Insert Sequence:

ATGGCTAGTC AGTCTCAGGG GATTCAGCAG CTGCTGCAGG CCGAGAAGCG GGCAGCCGAG 
AAGGTGTCCG AGGCCCGCAA AAGAAAGAAC CGGAGGCTGA AGCAGGCCAA AGAAGAAGCT 
CAGGCTGAAA TTGAACAGTA CCGCCTGCAG AGGGAGAAAG AATTCAAGGC CAAGGAAGCT 
GCGGCATTGG GATCCCGTGG CAGTTGCAGC ACTGAAGTGG AGAAGGAGAC CCAGGAGAAG 
ATGACCATCC TCCAGACATA CTTCCGGCAG AACAGGGATG AAGTCTTGGA CAACCTCTTG 
GCTTTTGTCT GTGACATTCG GCCAGAAATC CATGAAAACT ACCGCATAAA TGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1? prolyl hydroxylation by regulating cellular iron levels.
eLife6(2017 03)
Miles AL,Burr SP,Grice GL,Nathan JA

Methylation and expression analyses of Pallister-Killian syndrome reveal partial dosage compensation of tetrasomy 12p and hypomethylation of gene-poor regions on 12p.
Epigenetics11(3)194-204(2016 03)
Davidsson J,Johansson B

Bivariate Genome-Wide Association Study Implicates ATP6V1G1 as a Novel Pleiotropic Locus Underlying Osteoporosis and Age at Menarche.
The Journal of clinical endocrinology and metabolism100(11)E1457-66(2015 Nov)
Tan LJ,Wang ZE,Wu KH,Chen XD,Zhu H,Lu S,Tian Q,Liu XG,Papasian CJ,Deng HW

RILP regulates vacuolar ATPase through interaction with the V1G1 subunit.
Journal of cell science128(14)2565(2015 Jul)
De Luca M,Cogli L,Progida C,Nisi V,Pascolutti R,Sigismund S,Di Fiore PP,Bucci C

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ATP6V1G1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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