FXR2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FXR2
Entrez Gene ID	9513
Full Name	FMR1 autosomal homolog 2
Synonyms	FMR1L2,FXR2P
General protein information	Preferred Names FMR1 autosomal homolog 2 Names fragile X mental retardation syndrome-related protein 2 fragile X mental retardation, autosomal homolog 2 fragile X-mental retardation 1-like 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.1
Summary	The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X cognitive disability syndrome. [provided by RefSeq, Jul 2008].
Disorder MIM:	605339

mRNA and Protein(s)

mRNA	Protein	Name
NM_004860.3	NP_004851.2	fragile X mental retardation syndrome-related protein 2
NM_004860.4	NP_004851.2	fragile X mental retardation syndrome-related protein 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FXR2	XP_001171317.2
	FXR2	XP_001118084.2
Bos taurus (cattle)	FXR2	NP_001193218.1
Danio rerio (zebrafish)	fxr2	NP_956505.2
Canis lupus familiaris (dog)	FXR2	XP_546596.3
Mus musculus (house mouse)	Fxr2	NP_035944.2
Rattus norvegicus (Norway rat)	Fxr2	NP_001094117.1
Homo sapiens (human)	FXR2	NP_004851.2

Gene Ontology
Bibliography

Related articles in PubMed

FXR1 regulates transcription and is required for growth of human cancer cells with
Fan Y, Yue J, Xiao M, Han-Zhang H, Wang YV, Ma C, Deng Z, Li Y, Yu Y, Wang X, Niu S, Hua Y, Weng Z, Atadja P, Li E, Xiang B
eLife6(2017 Aug)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes.
Stepniak B, K?stner A, Poggi G, Mitjans M, Begemann M, Hartmann A, Van der Auwera S, Sananbenesi F, Krueger-Burg D, Matuszko G, Brosi C, Homuth G, V?lzke H, Benseler F, Bagni C, Fischer U, Dityatev A, Grabe HJ, Rujescu D, Fischer A, Ehrenreich H
EMBO molecular medicine7(12)1565-79(2015 Dec)

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Trigg SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M, Iakoucheva LM
Nature communications53650(2014 Apr)

Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step.
Gumireddy K, Li A, Yan J, Setoyama T, Johannes GJ, Orom UA, Tchou J, Liu Q, Zhang L, Speicher DW, Calin GA, Huang Q
The EMBO journal32(20)2672-84(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

An accumulation of 8 SNPs in the fragile gene family (FMR1, FXR1 and FXR2)were found associated with autistic traits in a sample of male patients.
Title: Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes.

Data show that the nuclear localization signals of the FXR1 and FXR2 comprise tandem Tudor domain architectures.
Title: Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.

These results indicate that FMR1 gene function is evolutionarily conserved in neural mechanisms and cannot be compensated by either FXR1 or FXR2, but that all three proteins can substitute for each other in non-neuronal requirements.
Title: Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P.

FXR1P and FXR2P KH2 domains bind G-quadruplex and kissing complex RNA with the same affinity as the FMRP KH2 domain.
Title: Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs.

The following FXR2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FXR2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18140	NM_004860.4 Latest version!	Homo sapiens FMR1 autosomal homolog 2 (FXR2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu18140	NM_004860.3	Homo sapiens FMR1 autosomal homolog 2 (FXR2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FXR2 ( NM_004860.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004851.2 Homo sapiens FMR1 autosomal homolog 2 (FXR2), mRNA.

Price & Availability↑

CloneID	OHu18140
Clone ID Related Accession (Same CDS sequence)	NM_004860.3 , NM_004860.4
Accession Version	NM_004860.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2022bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	fragile X mental retardation syndrome-related protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA114906.1, BC020090.1 and AA593676.1. This sequence is a reference standard in the RefSeqGene project. On Sep 22, 2009 this sequence version replaced NM_004860.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC067272.1, SRR1163658.5964.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCGGCC TGGCCTCTGG GGGGGATGTG GAGCCGGGAC TGCCCGTCGA GGTGCGCGGC 
TCCAACGGGG CCTTCTACAA GGGCTTTGTG AAGGATGTCC ATGAAGACTC TGTCACCATC 
TTCTTTGAAA ACAACTGGCA GAGTGAGAGA CAAATTCCTT TTGGGGATGT CCGGCTACCA 
CCTCCAGCTG ACTATAATAA GGAGATCACA GAAGGGGATG AAGTGGAGGT TTATTCTCGA 
GCCAATGAAC AGGAACCTTG TGGCTGGTGG CTGGCCCGGG TGCGGATGAT GAAGGGAGAT 
TTCTATGTCA TTGAATATGC TGCCTGTGAT GCCACCTACA ATGAAATTGT TACCCTGGAG 
CGACTTCGGC CAGTTAATCC CAATCCCCTT GCAACCAAAG GCAGCTTCTT CAAGGTTACC 
ATGGCTGTGC CCGAGGATCT GAGAGAAGCC TGCTCCAATG AAAACGTCCA TAAAGAGTTC 
AAGAAAGCCC TGGGAGCCAA CTGCATCTTT CTCAACATCA CAAACAGTGA GCTCTTCATT 
CTGTCAACCA CAGAAGCCCC TGTGAAGCGA GCATCTCTGC TGGGTGATAT GCATTTCCGA 
AGCCTGCGCA CCAAACTGCT ACTTATGTCC CGCAATGAAG AAGCTACCAA GCACCTAGAG 
ACAAGCAAGC AGTTGGCAGC AGCCTTCCAA GAGGAGTTCA CAGTGCGAGA GGACCTGATG 
GGACTGGCAA TTGGGACTCA CGGTGCCAAC ATCCAGCAGG CCCGAAAAGT ACCTGGGGTG 
ACCGCCATTG AGTTGGGTGA AGAGACCTGC ACTTTCCGCA TCTATGGGGA GACTCCCGAG 
GCTTGCCGAC AGGCCCGAAG CTACCTTGAG TTTTCTGAGG ACTCAGTGCA AGTGCCCAGG 
AACCTGGTTG GCAAAGTGAT TGGAAAGAAC GGGAAAGTGA TCCAGGAGAT TGTGGATAAA 
TCTGGTGTGG TGAGGGTTCG AGTGGAAGGT GATAATGACA AGAAGAACCC CAGGGAGGAG 
GGAATGGTTC CCTTCATTTT TGTTGGCACC CGAGAGAACA TCAGCAATGC CCAGGCTTTG 
CTGGAGTATC ACCTCTCCTA CCTGCAGGAG GTAGAGCAGC TTCGCTTGGA GAGGCTACAA 
ATTGATGAGC AGCTTCGGCA GATTGGGCTG GGCTTTCGCC CTCCTGGGAG TGGGCGGGGC 
AGCGGTGGCA GCGACAAGGC TGGATATAGC ACTGATGAGA GCTCCTCCTC CTCCCTCCAT 
GCGACTCGAA CCTATGGGGG CAGCTATGGG GGCCGTGGCC GTGGCCGGAG GACAGGCGGT 
CCTGCCTATG GCCCCAGCTC AGATGTGTCT ACAGCTTCAG AGACTGAGTC AGAGAAGAGA 
GAGGAGCCCA ACCGAGCTGG GCCTGGCGAC AGGGATCCCC CAACCCGAGG GGAAGAAAGC 
CGGAGGCGGC CGACTGGGGG CCGGGGTAGG GGACCCCCAC CTGCCCCCCG GCCCACTTCG 
AGATACAATT CTTCATCTAT TAGCTCAGTG CTGAAGGATC CAGACAGTAA TCCCTACAGC 
CTATTGGACA CGTCTGAACC AGAGCCCCCG GTTGATTCAG AACCTGGGGA ACCCCCCCCA 
GCAAGTGCCA GGCGCCGCCG CTCCCGCCGC CGCCGCACTG ATGAAGACAG GACCGTCATG 
GATGGAGGCC TGGAATCAGA TGGGCCCAAC ATGACAGAGA ATGGCCTGGA AGATGAATCA 
AGACCTCAAC GTCGTAATCG CAGCCGCCGC CGCCGTAACC GTGGTAATCG GACTGATGGC 
TCTATCAGTG GAGACCGCCA GCCAGTGACT GTGGCTGACT ATATCTCACG AGCAGAGTCT 
CAGAGCCGCC AGAGGCCACC CCTGGAACGC ACTAAACCCT CAGAAGACTC TCTTTCAGGA 
CAGAAGGGTG ACTCTGTCAG CAAGCTTCCT AAGGGCCCCT CGGAGAATGG GGAGCTCTCC 
GCCCCCTTGG AGTTGGGTAG TATGGTGAAT GGGGTTTCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004851.2
CDS	366..2387
Translation	MGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDKKNPREEGMVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGFRPPGSGRGSGGSDKAGYSTDESSSSSLHATRTYGGSYGGRGRGRRTGGPAYGPSSDVSTASETESEKREEPNRAGPGDRDPPTRGEESRRRPTGGRGRGPPPAPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGLESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSRQRPPLERTKPSEDSLSGQKGDSVSKLPKGPSENGELSAPLELGSMVNGVS

Target ORF information:

RefSeq Version	NM_004860.3
Organism	Homo sapiens(human)
Definition	Homo sapiens FMR1 autosomal homolog 2 (FXR2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004860.3

ORF Insert Sequence:

ATGGGCGGCC TGGCCTCTGG GGGGGATGTG GAGCCGGGAC TGCCCGTCGA GGTGCGCGGC 
TCCAACGGGG CCTTCTACAA GGGCTTTGTG AAGGATGTCC ATGAAGACTC TGTCACCATC 
TTCTTTGAAA ACAACTGGCA GAGTGAGAGA CAAATTCCTT TTGGGGATGT CCGGCTACCA 
CCTCCAGCTG ACTATAATAA GGAGATCACA GAAGGGGATG AAGTGGAGGT TTATTCTCGA 
GCCAATGAAC AGGAACCTTG TGGCTGGTGG CTGGCCCGGG TGCGGATGAT GAAGGGAGAT 
TTCTATGTCA TTGAATATGC TGCCTGTGAT GCCACCTACA ATGAAATTGT TACCCTGGAG 
CGACTTCGGC CAGTTAATCC CAATCCCCTT GCAACCAAAG GCAGCTTCTT CAAGGTTACC 
ATGGCTGTGC CCGAGGATCT GAGAGAAGCC TGCTCCAATG AAAACGTCCA TAAAGAGTTC 
AAGAAAGCCC TGGGAGCCAA CTGCATCTTT CTCAACATCA CAAACAGTGA GCTCTTCATT 
CTGTCAACCA CAGAAGCCCC TGTGAAGCGA GCATCTCTGC TGGGTGATAT GCATTTCCGA 
AGCCTGCGCA CCAAACTGCT ACTTATGTCC CGCAATGAAG AAGCTACCAA GCACCTAGAG 
ACAAGCAAGC AGTTGGCAGC AGCCTTCCAA GAGGAGTTCA CAGTGCGAGA GGACCTGATG 
GGACTGGCAA TTGGGACTCA CGGTGCCAAC ATCCAGCAGG CCCGAAAAGT ACCTGGGGTG 
ACCGCCATTG AGTTGGGTGA AGAGACCTGC ACTTTCCGCA TCTATGGGGA GACTCCCGAG 
GCTTGCCGAC AGGCCCGAAG CTACCTTGAG TTTTCTGAGG ACTCAGTGCA AGTGCCCAGG 
AACCTGGTTG GCAAAGTGAT TGGAAAGAAC GGGAAAGTGA TCCAGGAGAT TGTGGATAAA 
TCTGGTGTGG TGAGGGTTCG AGTGGAAGGT GATAATGACA AGAAGAACCC CAGGGAGGAG 
GGAATGGTTC CCTTCATTTT TGTTGGCACC CGAGAGAACA TCAGCAATGC CCAGGCTTTG 
CTGGAGTATC ACCTCTCCTA CCTGCAGGAG GTAGAGCAGC TTCGCTTGGA GAGGCTACAA 
ATTGATGAGC AGCTTCGGCA GATTGGGCTG GGCTTTCGCC CTCCTGGGAG TGGGCGGGGC 
AGCGGTGGCA GCGACAAGGC TGGATATAGC ACTGATGAGA GCTCCTCCTC CTCCCTCCAT 
GCGACTCGAA CCTATGGGGG CAGCTATGGG GGCCGTGGCC GTGGCCGGAG GACAGGCGGT 
CCTGCCTATG GCCCCAGCTC AGATGTGTCT ACAGCTTCAG AGACTGAGTC AGAGAAGAGA 
GAGGAGCCCA ACCGAGCTGG GCCTGGCGAC AGGGATCCCC CAACCCGAGG GGAAGAAAGC 
CGGAGGCGGC CGACTGGGGG CCGGGGTAGG GGACCCCCAC CTGCCCCCCG GCCCACTTCG 
AGATACAATT CTTCATCTAT TAGCTCAGTG CTGAAGGATC CAGACAGTAA TCCCTACAGC 
CTATTGGACA CGTCTGAACC AGAGCCCCCG GTTGATTCAG AACCTGGGGA ACCCCCCCCA 
GCAAGTGCCA GGCGCCGCCG CTCCCGCCGC CGCCGCACTG ATGAAGACAG GACCGTCATG 
GATGGAGGCC TGGAATCAGA TGGGCCCAAC ATGACAGAGA ATGGCCTGGA AGATGAATCA 
AGACCTCAAC GTCGTAATCG CAGCCGCCGC CGCCGTAACC GTGGTAATCG GACTGATGGC 
TCTATCAGTG GAGACCGCCA GCCAGTGACT GTGGCTGACT ATATCTCACG AGCAGAGTCT 
CAGAGCCGCC AGAGGCCACC CCTGGAACGC ACTAAACCCT CAGAAGACTC TCTTTCAGGA 
CAGAAGGGTG ACTCTGTCAG CAAGCTTCCT AAGGGCCCCT CGGAGAATGG GGAGCTCTCC 
GCCCCCTTGG AGTTGGGTAG TATGGTGAAT GGGGTTTCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FXR2 ( NM_004860.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004851.2 Homo sapiens FMR1 autosomal homolog 2 (FXR2), mRNA.

Price & Availability↑

CloneID	OHu18140
Clone ID Related Accession (Same CDS sequence)	NM_004860.3 , NM_004860.4
Accession Version	NM_004860.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2022bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	fragile X mental retardation syndrome-related protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA114906.1, BC020090.1 and AA593676.1. On May 17, 2019 this sequence version replaced NM_004860.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC067272.1, U31501.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000250113.12/ ENSP00000250113.7 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGCGGCC TGGCCTCTGG GGGGGATGTG GAGCCGGGAC TGCCCGTCGA GGTGCGCGGC 
TCCAACGGGG CCTTCTACAA GGGCTTTGTG AAGGATGTCC ATGAAGACTC TGTCACCATC 
TTCTTTGAAA ACAACTGGCA GAGTGAGAGA CAAATTCCTT TTGGGGATGT CCGGCTACCA 
CCTCCAGCTG ACTATAATAA GGAGATCACA GAAGGGGATG AAGTGGAGGT TTATTCTCGA 
GCCAATGAAC AGGAACCTTG TGGCTGGTGG CTGGCCCGGG TGCGGATGAT GAAGGGAGAT 
TTCTATGTCA TTGAATATGC TGCCTGTGAT GCCACCTACA ATGAAATTGT TACCCTGGAG 
CGACTTCGGC CAGTTAATCC CAATCCCCTT GCAACCAAAG GCAGCTTCTT CAAGGTTACC 
ATGGCTGTGC CCGAGGATCT GAGAGAAGCC TGCTCCAATG AAAACGTCCA TAAAGAGTTC 
AAGAAAGCCC TGGGAGCCAA CTGCATCTTT CTCAACATCA CAAACAGTGA GCTCTTCATT 
CTGTCAACCA CAGAAGCCCC TGTGAAGCGA GCATCTCTGC TGGGTGATAT GCATTTCCGA 
AGCCTGCGCA CCAAACTGCT ACTTATGTCC CGCAATGAAG AAGCTACCAA GCACCTAGAG 
ACAAGCAAGC AGTTGGCAGC AGCCTTCCAA GAGGAGTTCA CAGTGCGAGA GGACCTGATG 
GGACTGGCAA TTGGGACTCA CGGTGCCAAC ATCCAGCAGG CCCGAAAAGT ACCTGGGGTG 
ACCGCCATTG AGTTGGGTGA AGAGACCTGC ACTTTCCGCA TCTATGGGGA GACTCCCGAG 
GCTTGCCGAC AGGCCCGAAG CTACCTTGAG TTTTCTGAGG ACTCAGTGCA AGTGCCCAGG 
AACCTGGTTG GCAAAGTGAT TGGAAAGAAC GGGAAAGTGA TCCAGGAGAT TGTGGATAAA 
TCTGGTGTGG TGAGGGTTCG AGTGGAAGGT GATAATGACA AGAAGAACCC CAGGGAGGAG 
GGAATGGTTC CCTTCATTTT TGTTGGCACC CGAGAGAACA TCAGCAATGC CCAGGCTTTG 
CTGGAGTATC ACCTCTCCTA CCTGCAGGAG GTAGAGCAGC TTCGCTTGGA GAGGCTACAA 
ATTGATGAGC AGCTTCGGCA GATTGGGCTG GGCTTTCGCC CTCCTGGGAG TGGGCGGGGC 
AGCGGTGGCA GCGACAAGGC TGGATATAGC ACTGATGAGA GCTCCTCCTC CTCCCTCCAT 
GCGACTCGAA CCTATGGGGG CAGCTATGGG GGCCGTGGCC GTGGCCGGAG GACAGGCGGT 
CCTGCCTATG GCCCCAGCTC AGATGTGTCT ACAGCTTCAG AGACTGAGTC AGAGAAGAGA 
GAGGAGCCCA ACCGAGCTGG GCCTGGCGAC AGGGATCCCC CAACCCGAGG GGAAGAAAGC 
CGGAGGCGGC CGACTGGGGG CCGGGGTAGG GGACCCCCAC CTGCCCCCCG GCCCACTTCG 
AGATACAATT CTTCATCTAT TAGCTCAGTG CTGAAGGATC CAGACAGTAA TCCCTACAGC 
CTATTGGACA CGTCTGAACC AGAGCCCCCG GTTGATTCAG AACCTGGGGA ACCCCCCCCA 
GCAAGTGCCA GGCGCCGCCG CTCCCGCCGC CGCCGCACTG ATGAAGACAG GACCGTCATG 
GATGGAGGCC TGGAATCAGA TGGGCCCAAC ATGACAGAGA ATGGCCTGGA AGATGAATCA 
AGACCTCAAC GTCGTAATCG CAGCCGCCGC CGCCGTAACC GTGGTAATCG GACTGATGGC 
TCTATCAGTG GAGACCGCCA GCCAGTGACT GTGGCTGACT ATATCTCACG AGCAGAGTCT 
CAGAGCCGCC AGAGGCCACC CCTGGAACGC ACTAAACCCT CAGAAGACTC TCTTTCAGGA 
CAGAAGGGTG ACTCTGTCAG CAAGCTTCCT AAGGGCCCCT CGGAGAATGG GGAGCTCTCC 
GCCCCCTTGG AGTTGGGTAG TATGGTGAAT GGGGTTTCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004851.2
CDS	366..2387
Translation	MGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDKKNPREEGMVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGFRPPGSGRGSGGSDKAGYSTDESSSSSLHATRTYGGSYGGRGRGRRTGGPAYGPSSDVSTASETESEKREEPNRAGPGDRDPPTRGEESRRRPTGGRGRGPPPAPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGLESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSRQRPPLERTKPSEDSLSGQKGDSVSKLPKGPSENGELSAPLELGSMVNGVS

Target ORF information:

RefSeq Version	NM_004860.4
Organism	Homo sapiens(human)
Definition	Homo sapiens FMR1 autosomal homolog 2 (FXR2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004860.4

ORF Insert Sequence:

ATGGGCGGCC TGGCCTCTGG GGGGGATGTG GAGCCGGGAC TGCCCGTCGA GGTGCGCGGC 
TCCAACGGGG CCTTCTACAA GGGCTTTGTG AAGGATGTCC ATGAAGACTC TGTCACCATC 
TTCTTTGAAA ACAACTGGCA GAGTGAGAGA CAAATTCCTT TTGGGGATGT CCGGCTACCA 
CCTCCAGCTG ACTATAATAA GGAGATCACA GAAGGGGATG AAGTGGAGGT TTATTCTCGA 
GCCAATGAAC AGGAACCTTG TGGCTGGTGG CTGGCCCGGG TGCGGATGAT GAAGGGAGAT 
TTCTATGTCA TTGAATATGC TGCCTGTGAT GCCACCTACA ATGAAATTGT TACCCTGGAG 
CGACTTCGGC CAGTTAATCC CAATCCCCTT GCAACCAAAG GCAGCTTCTT CAAGGTTACC 
ATGGCTGTGC CCGAGGATCT GAGAGAAGCC TGCTCCAATG AAAACGTCCA TAAAGAGTTC 
AAGAAAGCCC TGGGAGCCAA CTGCATCTTT CTCAACATCA CAAACAGTGA GCTCTTCATT 
CTGTCAACCA CAGAAGCCCC TGTGAAGCGA GCATCTCTGC TGGGTGATAT GCATTTCCGA 
AGCCTGCGCA CCAAACTGCT ACTTATGTCC CGCAATGAAG AAGCTACCAA GCACCTAGAG 
ACAAGCAAGC AGTTGGCAGC AGCCTTCCAA GAGGAGTTCA CAGTGCGAGA GGACCTGATG 
GGACTGGCAA TTGGGACTCA CGGTGCCAAC ATCCAGCAGG CCCGAAAAGT ACCTGGGGTG 
ACCGCCATTG AGTTGGGTGA AGAGACCTGC ACTTTCCGCA TCTATGGGGA GACTCCCGAG 
GCTTGCCGAC AGGCCCGAAG CTACCTTGAG TTTTCTGAGG ACTCAGTGCA AGTGCCCAGG 
AACCTGGTTG GCAAAGTGAT TGGAAAGAAC GGGAAAGTGA TCCAGGAGAT TGTGGATAAA 
TCTGGTGTGG TGAGGGTTCG AGTGGAAGGT GATAATGACA AGAAGAACCC CAGGGAGGAG 
GGAATGGTTC CCTTCATTTT TGTTGGCACC CGAGAGAACA TCAGCAATGC CCAGGCTTTG 
CTGGAGTATC ACCTCTCCTA CCTGCAGGAG GTAGAGCAGC TTCGCTTGGA GAGGCTACAA 
ATTGATGAGC AGCTTCGGCA GATTGGGCTG GGCTTTCGCC CTCCTGGGAG TGGGCGGGGC 
AGCGGTGGCA GCGACAAGGC TGGATATAGC ACTGATGAGA GCTCCTCCTC CTCCCTCCAT 
GCGACTCGAA CCTATGGGGG CAGCTATGGG GGCCGTGGCC GTGGCCGGAG GACAGGCGGT 
CCTGCCTATG GCCCCAGCTC AGATGTGTCT ACAGCTTCAG AGACTGAGTC AGAGAAGAGA 
GAGGAGCCCA ACCGAGCTGG GCCTGGCGAC AGGGATCCCC CAACCCGAGG GGAAGAAAGC 
CGGAGGCGGC CGACTGGGGG CCGGGGTAGG GGACCCCCAC CTGCCCCCCG GCCCACTTCG 
AGATACAATT CTTCATCTAT TAGCTCAGTG CTGAAGGATC CAGACAGTAA TCCCTACAGC 
CTATTGGACA CGTCTGAACC AGAGCCCCCG GTTGATTCAG AACCTGGGGA ACCCCCCCCA 
GCAAGTGCCA GGCGCCGCCG CTCCCGCCGC CGCCGCACTG ATGAAGACAG GACCGTCATG 
GATGGAGGCC TGGAATCAGA TGGGCCCAAC ATGACAGAGA ATGGCCTGGA AGATGAATCA 
AGACCTCAAC GTCGTAATCG CAGCCGCCGC CGCCGTAACC GTGGTAATCG GACTGATGGC 
TCTATCAGTG GAGACCGCCA GCCAGTGACT GTGGCTGACT ATATCTCACG AGCAGAGTCT 
CAGAGCCGCC AGAGGCCACC CCTGGAACGC ACTAAACCCT CAGAAGACTC TCTTTCAGGA 
CAGAAGGGTG ACTCTGTCAG CAAGCTTCCT AAGGGCCCCT CGGAGAATGG GGAGCTCTCC 
GCCCCCTTGG AGTTGGGTAG TATGGTGAAT GGGGTTTCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FXR1 regulates transcription and is required for growth of human cancer cells with
eLife6(2017 Aug)
Fan Y,Yue J,Xiao M,Han-Zhang H,Wang YV,Ma C,Deng Z,Li Y,Yu Y,Wang X,Niu S,Hua Y,Weng Z,Atadja P,Li E,Xiang B

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes.
EMBO molecular medicine7(12)1565-79(2015 Dec)
Stepniak B,K?stner A,Poggi G,Mitjans M,Begemann M,Hartmann A,Van der Auwera S,Sananbenesi F,Krueger-Burg D,Matuszko G,Brosi C,Homuth G,V?lzke H,Benseler F,Bagni C,Fischer U,Dityatev A,Grabe HJ,Rujescu D,Fischer A,Ehrenreich H

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Nature communications53650(2014 Apr)
Corominas R,Yang X,Lin GN,Kang S,Shen Y,Ghamsari L,Broly M,Rodriguez M,Tam S,Trigg SA,Fan C,Yi S,Tasan M,Lemmens I,Kuang X,Zhao N,Malhotra D,Michaelson JJ,Vacic V,Calderwood MA,Roth FP,Tavernier J,Horvath S,Salehi-Ashtiani K,Korkin D,Sebat J,Hill DE,Hao T,Vidal M,Iakoucheva LM

Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step.
The EMBO journal32(20)2672-84(2013 Oct)
Gumireddy K,Li A,Yan J,Setoyama T,Johannes GJ,Orom UA,Tchou J,Liu Q,Zhang L,Speicher DW,Calin GA,Huang Q

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FXR2 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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