HAND2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HAND2
Entrez Gene ID	9464
Full Name	heart and neural crest derivatives expressed 2
Synonyms	DHAND2,Hed,Thing2,bHLHa26,dHand
General protein information	Preferred Names heart and neural crest derivatives expressed 2 Names heart- and neural crest derivatives-expressed protein 2 basic helix-loop-helix transcription factor HAND2 class A basic helix-loop-helix protein 26 deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q34.1
Summary	The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq, Jul 2008].
Disorder MIM:	602407

mRNA and Protein(s)

mRNA	Protein	Name
NM_021973.3	NP_068808.1	heart- and neural crest derivatives-expressed protein 2
NM_021973.2	NP_068808.1	heart- and neural crest derivatives-expressed protein 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HAND2	XP_003310653.1
Homo sapiens (human)	HAND2	NP_068808.1
	HAND2	XP_001085842.1
Canis lupus familiaris (dog)	HAND2	XP_005635942.1
Xenopus tropicalis (tropical clawed frog)	hand2	NP_001093695.1
Bos taurus (cattle)	HAND2	XP_003586406.1
Rattus norvegicus (Norway rat)	Hand2	NP_073187.1
Mus musculus (house mouse)	Hand2	NP_034532.3
Danio rerio (zebrafish)	hand2	NP_571701.2

Gene Ontology
Bibliography

Related articles in PubMed

Korean atrial fibrillation network genome-wide association study for early-onset atrial fibrillation identifies novel susceptibility loci.
Lee JY, Kim TH, Yang PS, Lim HE, Choi EK, Shim J, Shin E, Uhm JS, Kim JS, Joung B, Oh S, Lee MH, Kim YH, Pak HN
European heart journal38(34)2586-2594(2017 Sep)

A HAND to TBX5 Explains the Link Between Thalidomide and Cardiac Diseases.
Khalil A, Tanos R, El-Hachem N, Kurban M, Bouvagnet P, Bitar F, Nemer G
Scientific reports7(1)1416(2017 May)

Single cell qPCR reveals that additional HAND2 and microRNA-1 facilitate the early reprogramming progress of seven-factor-induced human myocytes.
Bektik E, Dennis A, Prasanna P, Madabhushi A, Fu JD
PloS one12(8)e0183000(2017)

A HAND2 Loss-of-Function Mutation Causes Familial Ventricular Septal Defect and Pulmonary Stenosis.
Sun YM, Wang J, Qiu XB, Yuan F, Li RG, Xu YJ, Qu XK, Shi HY, Hou XM, Huang RT, Xue S, Yang YQ
G3 (Bethesda, Md.)6(4)987-92(2016 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HAND2 and microRNA-1 facilitated the early progress of human induced cardiomyocyte-like cells reprogramming.
Title: Single cell qPCR reveals that additional HAND2 and microRNA-1 facilitate the early reprogramming progress of seven-factor-induced human myocytes.

These findings indicate that HAND2 loss-of-function mutation contributes to human CHD, perhaps via its interaction with GATA4 and NKX2.5.
Title: A HAND2 Loss-of-Function Mutation Causes Familial Ventricular Septal Defect and Pulmonary Stenosis.

this study is the first to report the association of a HAND2 loss-of-function mutation with an increased vulnerability to tetralogy of Fallot in humans, which provides novel insight into the molecular mechanism underpinning congenital heart disease
Title: A novel HAND2 loss-of-function mutation responsible for tetralogy of Fallot.

HAND2-mediated proteolysis negatively regulates the function of estrogen receptor alpha.
Title: HAND2-mediated proteolysis negatively regulates the function of estrogen receptor ?.

suggest that HAND2 plays a key role in the regulation of progestin-induced decidualization of human endometrial stromal cells.
Title: Requirement of heart and neural crest derivatives-expressed transcript 2 during decidualization of human endometrial stromal cells in vitro.

The following HAND2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HAND2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04891	NM_021973.3 Latest version!	Homo sapiens heart and neural crest derivatives expressed 2 (HAND2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
View Old Accession Versions >>
OHu04891	NM_021973.2	Homo sapiens heart and neural crest derivatives expressed 2 (HAND2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HAND2 ( NM_021973.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_068808.1 Homo sapiens heart and neural crest derivatives expressed 2 (HAND2), mRNA.

Price & Availability↑

CloneID	OHu04891
Clone ID Related Accession (Same CDS sequence)	NM_021973.3 , NM_021973.2
Accession Version	NM_021973.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	heart- and neural crest derivatives-expressed protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC093849.2. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_021973.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FJ226608.1, BX404434.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000359562.4/ ENSP00000352565.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTCTGG TAGGTGGTTT TCCCCACCAC CCGGTGGTGC ACCACGAGGG CTACCCGTTT 
GCCGCCGCCG CCGCCGCAGC TGCCGCCGCC GCCGCCAGCC GCTGCAGCCA TGAGGAGAAC 
CCCTACTTCC ATGGCTGGCT CATCGGCCAC CCCGAGATGT CGCCCCCCGA CTACAGCATG 
GCCCTGTCCT ACAGCCCCGA GTATGCCAGC GGCGCCGCCG GCCTGGACCA CTCCCATTAC 
GGGGGGGTGC CGCCGGGCGC CGGGCCCCCG GGCCTGGGGG GGCCGCGCCC GGTGAAGCGC 
CGAGGCACCG CCAACCGCAA GGAGCGGCGC AGGACTCAGA GCATCAACAG CGCCTTCGCC 
GAACTGCGCG AGTGCATCCC CAACGTACCC GCCGACACCA AACTCTCCAA AATCAAGACC 
CTGCGCCTGG CCACCAGCTA CATCGCCTAC CTCATGGACC TGCTGGCCAA GGACGACCAG 
AATGGCGAGG CGGAGGCCTT CAAGGCAGAG ATCAAGAAGA CCGACGTGAA AGAGGAGAAG 
AGGAAGAAGG AGCTGAACGA AATCTTGAAA AGCACAGTGA GCAGCAACGA CAAGAAAACC 
AAAGGCCGGA CGGGCTGGCC GCAGCACGTC TGGGCCCTGG AGCTCAAGCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068808.1
CDS	941..1594
Translation	MSLVGGFPHHPVVHHEGYPFAAAAAAAAAAAASRCSHEENPYFHGWLIGHPEMSPPDYSMALSYSPEYASGAAGLDHSHYGGVPPGAGPPGLGGPRPVKRRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQNGEAEAFKAEIKKTDVKEEKRKKELNEILKSTVSSNDKKTKGRTGWPQHVWALELKQ

Target ORF information:

RefSeq Version	NM_021973.3
Organism	Homo sapiens(human)
Definition	Homo sapiens heart and neural crest derivatives expressed 2 (HAND2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021973.3

ORF Insert Sequence:

ATGAGTCTGG TAGGTGGTTT TCCCCACCAC CCGGTGGTGC ACCACGAGGG CTACCCGTTT 
GCCGCCGCCG CCGCCGCAGC TGCCGCCGCC GCCGCCAGCC GCTGCAGCCA TGAGGAGAAC 
CCCTACTTCC ATGGCTGGCT CATCGGCCAC CCCGAGATGT CGCCCCCCGA CTACAGCATG 
GCCCTGTCCT ACAGCCCCGA GTATGCCAGC GGCGCCGCCG GCCTGGACCA CTCCCATTAC 
GGGGGGGTGC CGCCGGGCGC CGGGCCCCCG GGCCTGGGGG GGCCGCGCCC GGTGAAGCGC 
CGAGGCACCG CCAACCGCAA GGAGCGGCGC AGGACTCAGA GCATCAACAG CGCCTTCGCC 
GAACTGCGCG AGTGCATCCC CAACGTACCC GCCGACACCA AACTCTCCAA AATCAAGACC 
CTGCGCCTGG CCACCAGCTA CATCGCCTAC CTCATGGACC TGCTGGCCAA GGACGACCAG 
AATGGCGAGG CGGAGGCCTT CAAGGCAGAG ATCAAGAAGA CCGACGTGAA AGAGGAGAAG 
AGGAAGAAGG AGCTGAACGA AATCTTGAAA AGCACAGTGA GCAGCAACGA CAAGAAAACC 
AAAGGCCGGA CGGGCTGGCC GCAGCACGTC TGGGCCCTGG AGCTCAAGCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HAND2 ( NM_021973.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_068808.1 Homo sapiens heart and neural crest derivatives expressed 2 (HAND2), mRNA.

Price & Availability↑

CloneID	OHu04891
Clone ID Related Accession (Same CDS sequence)	NM_021973.3 , NM_021973.2
Accession Version	NM_021973.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	heart- and neural crest derivatives-expressed protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC093849.2. This sequence is a reference standard in the RefSeqGene project. On Feb 28, 2006 this sequence version replaced NM_021973.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FJ226608.1, BX404434.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTCTGG TAGGTGGTTT TCCCCACCAC CCGGTGGTGC ACCACGAGGG CTACCCGTTT 
GCCGCCGCCG CCGCCGCAGC TGCCGCCGCC GCCGCCAGCC GCTGCAGCCA TGAGGAGAAC 
CCCTACTTCC ATGGCTGGCT CATCGGCCAC CCCGAGATGT CGCCCCCCGA CTACAGCATG 
GCCCTGTCCT ACAGCCCCGA GTATGCCAGC GGCGCCGCCG GCCTGGACCA CTCCCATTAC 
GGGGGGGTGC CGCCGGGCGC CGGGCCCCCG GGCCTGGGGG GGCCGCGCCC GGTGAAGCGC 
CGAGGCACCG CCAACCGCAA GGAGCGGCGC AGGACTCAGA GCATCAACAG CGCCTTCGCC 
GAACTGCGCG AGTGCATCCC CAACGTACCC GCCGACACCA AACTCTCCAA AATCAAGACC 
CTGCGCCTGG CCACCAGCTA CATCGCCTAC CTCATGGACC TGCTGGCCAA GGACGACCAG 
AATGGCGAGG CGGAGGCCTT CAAGGCAGAG ATCAAGAAGA CCGACGTGAA AGAGGAGAAG 
AGGAAGAAGG AGCTGAACGA AATCTTGAAA AGCACAGTGA GCAGCAACGA CAAGAAAACC 
AAAGGCCGGA CGGGCTGGCC GCAGCACGTC TGGGCCCTGG AGCTCAAGCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068808.1
CDS	939..1592
Translation	MSLVGGFPHHPVVHHEGYPFAAAAAAAAAAAASRCSHEENPYFHGWLIGHPEMSPPDYSMALSYSPEYASGAAGLDHSHYGGVPPGAGPPGLGGPRPVKRRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQNGEAEAFKAEIKKTDVKEEKRKKELNEILKSTVSSNDKKTKGRTGWPQHVWALELKQ

Target ORF information:

RefSeq Version	NM_021973.2
Organism	Homo sapiens(human)
Definition	Homo sapiens heart and neural crest derivatives expressed 2 (HAND2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021973.2

ORF Insert Sequence:

ATGAGTCTGG TAGGTGGTTT TCCCCACCAC CCGGTGGTGC ACCACGAGGG CTACCCGTTT 
GCCGCCGCCG CCGCCGCAGC TGCCGCCGCC GCCGCCAGCC GCTGCAGCCA TGAGGAGAAC 
CCCTACTTCC ATGGCTGGCT CATCGGCCAC CCCGAGATGT CGCCCCCCGA CTACAGCATG 
GCCCTGTCCT ACAGCCCCGA GTATGCCAGC GGCGCCGCCG GCCTGGACCA CTCCCATTAC 
GGGGGGGTGC CGCCGGGCGC CGGGCCCCCG GGCCTGGGGG GGCCGCGCCC GGTGAAGCGC 
CGAGGCACCG CCAACCGCAA GGAGCGGCGC AGGACTCAGA GCATCAACAG CGCCTTCGCC 
GAACTGCGCG AGTGCATCCC CAACGTACCC GCCGACACCA AACTCTCCAA AATCAAGACC 
CTGCGCCTGG CCACCAGCTA CATCGCCTAC CTCATGGACC TGCTGGCCAA GGACGACCAG 
AATGGCGAGG CGGAGGCCTT CAAGGCAGAG ATCAAGAAGA CCGACGTGAA AGAGGAGAAG 
AGGAAGAAGG AGCTGAACGA AATCTTGAAA AGCACAGTGA GCAGCAACGA CAAGAAAACC 
AAAGGCCGGA CGGGCTGGCC GCAGCACGTC TGGGCCCTGG AGCTCAAGCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Korean atrial fibrillation network genome-wide association study for early-onset atrial fibrillation identifies novel susceptibility loci.
European heart journal38(34)2586-2594(2017 Sep)
Lee JY,Kim TH,Yang PS,Lim HE,Choi EK,Shim J,Shin E,Uhm JS,Kim JS,Joung B,Oh S,Lee MH,Kim YH,Pak HN

A HAND to TBX5 Explains the Link Between Thalidomide and Cardiac Diseases.
Scientific reports7(1)1416(2017 May)
Khalil A,Tanos R,El-Hachem N,Kurban M,Bouvagnet P,Bitar F,Nemer G

Single cell qPCR reveals that additional HAND2 and microRNA-1 facilitate the early reprogramming progress of seven-factor-induced human myocytes.
PloS one12(8)e0183000(2017)
Bektik E,Dennis A,Prasanna P,Madabhushi A,Fu JD

A HAND2 Loss-of-Function Mutation Causes Familial Ventricular Septal Defect and Pulmonary Stenosis.
G3 (Bethesda, Md.)6(4)987-92(2016 04)
Sun YM,Wang J,Qiu XB,Yuan F,Li RG,Xu YJ,Qu XK,Shi HY,Hou XM,Huang RT,Xue S,Yang YQ

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HAND2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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