COX5A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COX5A
Entrez Gene ID	9377
Full Name	cytochrome c oxidase subunit 5A
Synonyms	COX,COX-VA,VA
General protein information	Preferred Names cytochrome c oxidase subunit 5A Names cytochrome c oxidase subunit 5A, mitochondrial cytochrome c oxidase polypeptide Va cytochrome c oxidase polypeptide, mitochondrial cytochrome c oxidase subunit Va mitochondrial cytochrome c oxidase subunit Va
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q24.2
Summary	Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22. [provided by RefSeq, Jul 2008].
Disorder MIM:	603773

mRNA and Protein(s)

mRNA	Protein	Name
NM_004255.3	NP_004246.2	cytochrome c oxidase subunit 5A, mitochondrial precursor
NM_004255.4	NP_004246.2	cytochrome c oxidase subunit 5A, mitochondrial precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	COX5A	XP_003641852.1
Danio rerio (zebrafish)	LOC100537689	XP_003201496.1
Homo sapiens (human)	COX5A	NP_004246.2
	COX5A	NP_001035369.1
Bos taurus (cattle)	COX5A	NP_001002891.1
Mus musculus (house mouse)	Cox5a	NP_031773.2
Xenopus tropicalis (tropical clawed frog)	cox5a	NP_001017049.1
Pan troglodytes (chimpanzee)	COX5A	NP_001112385.1
Caenorhabditis elegans (roundworm)	cco-2	NP_499681.1
Canis lupus familiaris (dog)	COX5A	XP_535544.1
Danio rerio (zebrafish)	cox5aa	NP_001019574.1
Drosophila melanogaster (fruit fly)	CoVa	NP_001262488.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011159	XP_309490.3
Rattus norvegicus (Norway rat)	Cox5a	NP_665726.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutation in mitochondrial complex IV subunit COX5A causes pulmonary arterial hypertension, lactic acidemia, and failure to thrive.
Baertling F, Al-Murshedi F, S?nchez-Caballero L, Al-Senaidi K, Joshi NP, Venselaar H, van den Brand MA, Nijtmans LG, Rodenburg RJ
Human mutation38(6)692-703(2017 Jun)

The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits.
Cesnekova J, Rodinova M, Hansikova H, Houstek J, Zeman J, Stiburek L
The Biochemical journal473(6)797-804(2016 Mar)

The role of cytochrome c oxidase subunit Va in non-small cell lung carcinoma cells: association with migration, invasion and prediction of distant metastasis.
Chen WL, Kuo KT, Chou TY, Chen CL, Wang CH, Wei YH, Wang LS
BMC cancer12273(2012 Jun)

Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
Cornelis MC, Monda KL, Yu K, Paynter N, Azzato EM, Bennett SN, Berndt SI, Boerwinkle E, Chanock S, Chatterjee N, Couper D, Curhan G, Heiss G, Hu FB, Hunter DJ, Jacobs K, Jensen MK, Kraft P, Landi MT, Nettleton JA, Purdue MP, Rajaraman P, Rimm EB, Rose LM, Rothman N, Silverman D, Stolzenberg-Solomon R, Subar A, Yeager M, Chasman DI, van Dam RM, Caporaso NE
PLoS genetics7(4)e1002033(2011 Apr)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our current study showed that COX Va may play a role in migration and invasion of NSCLC cells and can be used as a biomarker to predict aggressiveness of NSCLC.
Title: The role of cytochrome c oxidase subunit Va in non-small cell lung carcinoma cells: association with migration, invasion and prediction of distant metastasis.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 5a
Title: Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b.

Data show that Bcl-2 expression positively influences the targeting of nuclear-encoded COX Va and Vb to the mitochondria of cancer cells.
Title: Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2.

study points to a role for surfeit 1(SURF1) in promoting the association of cytochrome c oxidase II with the cytochrome c oxidase I.cytochrome c oxidase subunit 4.cytochrome c oxidase subunit 5A subassembly
Title: Cytochrome c oxidase subassemblies in fibroblast cultures from patients carrying mutations in COX10, SCO1, or SURF1.

The following COX5A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX5A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09156	NM_004255.4 Latest version!	Homo sapiens cytochrome c oxidase subunit 5A (COX5A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu09156	NM_004255.3	Homo sapiens cytochrome c oxidase subunit 5A (COX5A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COX5A ( NM_004255.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004246.2 Homo sapiens cytochrome c oxidase subunit 5A (COX5A), mRNA.

Price & Availability↑

CloneID	OHu09156
Clone ID Related Accession (Same CDS sequence)	NM_004255.3 , NM_004255.4
Accession Version	NM_004255.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 5A, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI815421.1 and AK026623.1. On Jun 20, 2008 this sequence version replaced NM_004255.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.85208.1, BC024240.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGGGCG CCGCTCTCCG CCGCTGCGCT GTGGCCGCAA CCACCCGGGC CGACCCTCGA 
GGCCTCCTGC ACTCCGCCCG GACCCCCGGC CCCGCCGTGG CTATCCAGTC AGTTCGCTGC 
TATTCCCATG GGTCACAGGA GACAGATGAG GAGTTTGATG CTCGCTGGGT AACATACTTC 
AACAAGCCAG ATATAGATGC CTGGGAATTG CGTAAAGGGA TAAACACACT TGTTACCTAT 
GATATGGTTC CAGAGCCCAA AATCATTGAT GCTGCTTTGC GGGCATGCAG ACGGTTAAAT 
GATTTTGCTA GTACAGTTCG TATCCTAGAG GTTGTTAAGG ACAAAGCAGG ACCTCATAAG 
GAAATCTACC CCTATGTCAT CCAGGAACTT AGACCAACTT TAAATGAACT GGGAATCTCC 
ACTCCGGAGG AACTGGGCCT TGACAAAGTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004246.2
CDS	141..593
Translation	MLGAALRRCAVAATTRADPRGLLHSARTPGPAVAIQSVRCYSHGSQETDEEFDARWVTYFNKPDIDAWELRKGINTLVTYDMVPEPKIIDAALRACRRLNDFASTVRILEVVKDKAGPHKEIYPYVIQELRPTLNELGISTPEELGLDKV

Target ORF information:

RefSeq Version	NM_004255.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 5A (COX5A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004255.3

ORF Insert Sequence:

ATGCTGGGCG CCGCTCTCCG CCGCTGCGCT GTGGCCGCAA CCACCCGGGC CGACCCTCGA 
GGCCTCCTGC ACTCCGCCCG GACCCCCGGC CCCGCCGTGG CTATCCAGTC AGTTCGCTGC 
TATTCCCATG GGTCACAGGA GACAGATGAG GAGTTTGATG CTCGCTGGGT AACATACTTC 
AACAAGCCAG ATATAGATGC CTGGGAATTG CGTAAAGGGA TAAACACACT TGTTACCTAT 
GATATGGTTC CAGAGCCCAA AATCATTGAT GCTGCTTTGC GGGCATGCAG ACGGTTAAAT 
GATTTTGCTA GTACAGTTCG TATCCTAGAG GTTGTTAAGG ACAAAGCAGG ACCTCATAAG 
GAAATCTACC CCTATGTCAT CCAGGAACTT AGACCAACTT TAAATGAACT GGGAATCTCC 
ACTCCGGAGG AACTGGGCCT TGACAAAGTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX5A ( NM_004255.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004246.2 Homo sapiens cytochrome c oxidase subunit 5A (COX5A), mRNA.

Price & Availability↑

CloneID	OHu09156
Clone ID Related Accession (Same CDS sequence)	NM_004255.3 , NM_004255.4
Accession Version	NM_004255.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 5A, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI815421.1, AK026623.1 and AC125435.8. On Nov 22, 2018 this sequence version replaced NM_004255.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.40972.1, SRR1163655.347096.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000322347.11/ ENSP00000317780.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGGGCG CCGCTCTCCG CCGCTGCGCT GTGGCCGCAA CCACCCGGGC CGACCCTCGA 
GGCCTCCTGC ACTCCGCCCG GACCCCCGGC CCCGCCGTGG CTATCCAGTC AGTTCGCTGC 
TATTCCCATG GGTCACAGGA GACAGATGAG GAGTTTGATG CTCGCTGGGT AACATACTTC 
AACAAGCCAG ATATAGATGC CTGGGAATTG CGTAAAGGGA TAAACACACT TGTTACCTAT 
GATATGGTTC CAGAGCCCAA AATCATTGAT GCTGCTTTGC GGGCATGCAG ACGGTTAAAT 
GATTTTGCTA GTACAGTTCG TATCCTAGAG GTTGTTAAGG ACAAAGCAGG ACCTCATAAG 
GAAATCTACC CCTATGTCAT CCAGGAACTT AGACCAACTT TAAATGAACT GGGAATCTCC 
ACTCCGGAGG AACTGGGCCT TGACAAAGTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004246.2
CDS	60..512
Translation	MLGAALRRCAVAATTRADPRGLLHSARTPGPAVAIQSVRCYSHGSQETDEEFDARWVTYFNKPDIDAWELRKGINTLVTYDMVPEPKIIDAALRACRRLNDFASTVRILEVVKDKAGPHKEIYPYVIQELRPTLNELGISTPEELGLDKV

Target ORF information:

RefSeq Version	NM_004255.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 5A (COX5A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004255.4

ORF Insert Sequence:

ATGCTGGGCG CCGCTCTCCG CCGCTGCGCT GTGGCCGCAA CCACCCGGGC CGACCCTCGA 
GGCCTCCTGC ACTCCGCCCG GACCCCCGGC CCCGCCGTGG CTATCCAGTC AGTTCGCTGC 
TATTCCCATG GGTCACAGGA GACAGATGAG GAGTTTGATG CTCGCTGGGT AACATACTTC 
AACAAGCCAG ATATAGATGC CTGGGAATTG CGTAAAGGGA TAAACACACT TGTTACCTAT 
GATATGGTTC CAGAGCCCAA AATCATTGAT GCTGCTTTGC GGGCATGCAG ACGGTTAAAT 
GATTTTGCTA GTACAGTTCG TATCCTAGAG GTTGTTAAGG ACAAAGCAGG ACCTCATAAG 
GAAATCTACC CCTATGTCAT CCAGGAACTT AGACCAACTT TAAATGAACT GGGAATCTCC 
ACTCCGGAGG AACTGGGCCT TGACAAAGTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutation in mitochondrial complex IV subunit COX5A causes pulmonary arterial hypertension, lactic acidemia, and failure to thrive.
Human mutation38(6)692-703(2017 Jun)
Baertling F,Al-Murshedi F,S?nchez-Caballero L,Al-Senaidi K,Joshi NP,Venselaar H,van den Brand MA,Nijtmans LG,Rodenburg RJ

The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits.
The Biochemical journal473(6)797-804(2016 Mar)
Cesnekova J,Rodinova M,Hansikova H,Houstek J,Zeman J,Stiburek L

The role of cytochrome c oxidase subunit Va in non-small cell lung carcinoma cells: association with migration, invasion and prediction of distant metastasis.
BMC cancer12273(2012 Jun)
Chen WL,Kuo KT,Chou TY,Chen CL,Wang CH,Wei YH,Wang LS

Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
PLoS genetics7(4)e1002033(2011 Apr)
Cornelis MC,Monda KL,Yu K,Paynter N,Azzato EM,Bennett SN,Berndt SI,Boerwinkle E,Chanock S,Chatterjee N,Couper D,Curhan G,Heiss G,Hu FB,Hunter DJ,Jacobs K,Jensen MK,Kraft P,Landi MT,Nettleton JA,Purdue MP,Rajaraman P,Rimm EB,Rose LM,Rothman N,Silverman D,Stolzenberg-Solomon R,Subar A,Yeager M,Chasman DI,van Dam RM,Caporaso NE

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

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COX5A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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