PIGM cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PIGM
Entrez Gene ID	93183
Full Name	phosphatidylinositol glycan anchor biosynthesis class M
Synonyms	GPI-MT-I
General protein information	Preferred Names phosphatidylinositol glycan anchor biosynthesis class M Names GPI mannosyltransferase 1 DPM:GlcN-(acyl-)PI mannosyltransferase GPI mannosyltransferase I PIG-M mannosyltransferase dol-P-Man dependent GPI mannosyltransferase phosphatidylinositol-glycan biosynthesis class M protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q23.2
Summary	This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]. COMPLETENESS: complete on the 3' end.
Disorder MIM:	610273
Disorder Html:	Glycosylphosphatidylinositol deficiency, 610293 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_145167.3	NP_660150.1	GPI mannosyltransferase 1
NM_145167.2	NP_660150.1	GPI mannosyltransferase 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PIGM	XP_005640959.1
Gallus gallus (chicken)	PIGM	NP_001026693.2
Danio rerio (zebrafish)	pigm	NP_956684.1
Schizosaccharomyces pombe (fission yeast)	gpi14	NP_596260.1
Bos taurus (cattle)	PIGM	NP_001015563.1
Rattus norvegicus (Norway rat)	Pigm	NP_077058.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010434	XP_311512.4
Caenorhabditis elegans (roundworm)	B0491.1	NP_496426.1
Saccharomyces cerevisiae (baker's yeast)	GPI14	NP_012547.2
Eremothecium gossypii	AGOS_ACR034W	NP_983437.1
	LOC719582	XP_001117359.1
Mus musculus (house mouse)	Pigm	NP_080510.1
Kluyveromyces lactis	KLLA0D09647g	XP_453492.1
Magnaporthe oryzae (rice blast fungus)	MGG_09243	XP_003709869.1
Neurospora crassa	NCU06057	XP_959820.1
Oryza sativa (rice)	Os03g0670200	NP_001050869.1
Homo sapiens (human)	PIGM	NP_660150.1
Pan troglodytes (chimpanzee)	PIGM	NP_001233402.1
Drosophila melanogaster (fruit fly)	CG9865	NP_611600.1
Arabidopsis thaliana (thale cress)	PNT1	NP_001190361.1
Xenopus tropicalis (tropical clawed frog)	pigm	NP_001008120.1

Gene Ontology
Bibliography

Related articles in PubMed

Cell-type-specific transcriptional regulation of PIGM underpins the divergent hematologic phenotype in inherited GPl deficiency.
Costa JR, Caputo VS, Makarona K, Layton DM, Roberts IA, Almeida AM, Karadimitris A
Blood124(20)3151-4(2014 Nov)

Understanding human glycosylation disorders: biochemistry leads the charge.
Freeze HH
The Journal of biological chemistry288(10)6936-45(2013 Mar)

Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency.
Almeida AM, Murakami Y, Layton DM, Hillmen P, Sellick GS, Maeda Y, Richards S, Patterson S, Kotsianidis I, Mollica L, Crawford DH, Baker A, Ferguson M, Roberts I, Houlston R, Kinoshita T, Karadimitris A
Nature medicine12(7)846-51(2006 Jul)

PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER.
Maeda Y, Watanabe R, Harris CL, Hong Y, Ohishi K, Kinoshita K, Kinoshita T
The EMBO journal20(1-2)250-61(2001 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

B cells but not red cells are glycosylphosphatidylinositol deficient in PIGM-associated inherited glycosylphosphatidylinositol deficiency, caused by a core promoter mutation that abrogates Sp1 binding.
Title: Cell-type-specific transcriptional regulation of PIGM underpins the divergent hematologic phenotype in inherited GPl deficiency.

Studies indicate that mutations in PGM1 by exome sequencing cause hypoglycemia and liver abnormalities.
Title: Understanding human glycosylation disorders: biochemistry leads the charge.

Mutation substantially reduces transcription of PIGM and blocks mannosylation of glycosylphosphatidylinositol(GPI), leading to partial but severe deficiency of GPI.
Title: Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency.

The following PIGM gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PIGM cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19090	NM_145167.3 Latest version!	Homo sapiens phosphatidylinositol glycan anchor biosynthesis class M (PIGM), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu19090	NM_145167.2	Homo sapiens phosphatidylinositol glycan anchor biosynthesis class M (PIGM), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PIGM ( NM_145167.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_660150.1 Homo sapiens phosphatidylinositol glycan anchor biosynthesis class M (PIGM), mRNA.

Price & Availability↑

CloneID	OHu19090
Clone ID Related Accession (Same CDS sequence)	NM_145167.3 , NM_145167.2
Accession Version	NM_145167.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	GPI mannosyltransferase 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX643162.1, BC019865.1 and AL513302.15. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_145167.2. ##Evidence-Data-START## Transcript is intronless :: SRR1803617.251961.1, SRR1803616.260342.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368090.5/ ENSP00000357069.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGCTCCA CCAAGCACTG GGGCGAATGG CTCCTGAACT TGAAGGTGGC TCCAGCCGGC 
GTCTTTGGTG TGGCCTTTCT AGCCAGAGTC GCCCTGGTTT TCTATGGCGT CTTCCAGGAC 
CGGACCCTGC ACGTGAGGTA TACGGACATC GACTACCAGG TCTTCACCGA CGCCGCGCGC 
TTCGTCACGG AGGGGCGCTC GCCTTACCTG AGAGCCACGT ACCGTTACAC CCCGCTGCTG 
GGTTGGCTCC TCACTCCCAA CATCTACCTC AGCGAGCTCT TTGGAAAGTT TCTCTTCATC 
AGCTGCGACC TCCTCACCGC TTTCCTCTTA TACCGCCTGC TGCTGCTGAA GGGGCTGGGG 
CGCCGCCAGG CTTGTGGCTA CTGTGTCTTT TGGCTTCTTA ACCCCCTGCC TATGGCAGTA 
TCCAGCCGCG GTAATGCGGA CTCTATTGTC GCCTCCCTGG TCCTGATGGT CCTCTACTTG 
ATAAAGAAAA GACTCGTCGC GTGTGCAGCT GTATTCTATG GTTTCGCGGT GCATATGAAG 
ATATATCCAG TGACTTACAT CCTTCCCATA ACCCTCCACC TGCTTCCAGA TCGCGACAAT 
GACAAAAGCC TCCGTCAATT CCGGTACACT TTCCAGGCTT GTTTGTACGA GCTCCTGAAA 
AGGCTGTGTA ATCGGGCTGT GCTGCTGTTT GTAGCAGTTG CTGGACTCAC GTTTTTTGCC 
CTGAGCTTTG GTTTTTACTA TGAGTACGGC TGGGAATTTT TGGAACACAC CTACTTTTAT 
CACCTGACTA GGCGGGATAT CCGTCACAAC TTTTCTCCGT ACTTCTACAT GCTGTATTTG 
ACTGCAGAGA GCAAGTGGAG TTTTTCCCTG GGAATTGCTG CATTCCTGCC ACAGCTCATC 
TTGCTTTCAG CTGTGTCTTT CGCCTATTAC AGAGACCTCG TTTTTTGTTG TTTTCTTCAT 
ACGTCCATTT TTGTGACTTT TAACAAAGTC TGCACCTCCC AGTACTTTCT TTGGTACCTC 
TGCTTACTGC CTCTTGTGAT GCCACTAGTC AGAATGCCTT GGAAAAGAGC TGTAGTTCTC 
CTAATGTTAT GGTTTATAGG GCAGGCCATG TGGCTGGCTC CTGCCTATGT TCTAGAGTTT 
CAAGGAAAGA ACACCTTTCT GTTTATTTGG TTAGCTGGTT TGTTCTTTCT TCTTATCAAT 
TGTTCCATCC TGATTCAAAT TATTTCCCAT TACAAAGAAG AACCCCTGAC AGAGAGAATC 
AAATATGACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_660150.1
CDS	252..1523
Translation	MGSTKHWGEWLLNLKVAPAGVFGVAFLARVALVFYGVFQDRTLHVRYTDIDYQVFTDAARFVTEGRSPYLRATYRYTPLLGWLLTPNIYLSELFGKFLFISCDLLTAFLLYRLLLLKGLGRRQACGYCVFWLLNPLPMAVSSRGNADSIVASLVLMVLYLIKKRLVACAAVFYGFAVHMKIYPVTYILPITLHLLPDRDNDKSLRQFRYTFQACLYELLKRLCNRAVLLFVAVAGLTFFALSFGFYYEYGWEFLEHTYFYHLTRRDIRHNFSPYFYMLYLTAESKWSFSLGIAAFLPQLILLSAVSFAYYRDLVFCCFLHTSIFVTFNKVCTSQYFLWYLCLLPLVMPLVRMPWKRAVVLLMLWFIGQAMWLAPAYVLEFQGKNTFLFIWLAGLFFLLINCSILIQIISHYKEEPLTERIKYD

Target ORF information:

RefSeq Version	NM_145167.3
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphatidylinositol glycan anchor biosynthesis class M (PIGM), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145167.3

ORF Insert Sequence:

ATGGGCTCCA CCAAGCACTG GGGCGAATGG CTCCTGAACT TGAAGGTGGC TCCAGCCGGC 
GTCTTTGGTG TGGCCTTTCT AGCCAGAGTC GCCCTGGTTT TCTATGGCGT CTTCCAGGAC 
CGGACCCTGC ACGTGAGGTA TACGGACATC GACTACCAGG TCTTCACCGA CGCCGCGCGC 
TTCGTCACGG AGGGGCGCTC GCCTTACCTG AGAGCCACGT ACCGTTACAC CCCGCTGCTG 
GGTTGGCTCC TCACTCCCAA CATCTACCTC AGCGAGCTCT TTGGAAAGTT TCTCTTCATC 
AGCTGCGACC TCCTCACCGC TTTCCTCTTA TACCGCCTGC TGCTGCTGAA GGGGCTGGGG 
CGCCGCCAGG CTTGTGGCTA CTGTGTCTTT TGGCTTCTTA ACCCCCTGCC TATGGCAGTA 
TCCAGCCGCG GTAATGCGGA CTCTATTGTC GCCTCCCTGG TCCTGATGGT CCTCTACTTG 
ATAAAGAAAA GACTCGTCGC GTGTGCAGCT GTATTCTATG GTTTCGCGGT GCATATGAAG 
ATATATCCAG TGACTTACAT CCTTCCCATA ACCCTCCACC TGCTTCCAGA TCGCGACAAT 
GACAAAAGCC TCCGTCAATT CCGGTACACT TTCCAGGCTT GTTTGTACGA GCTCCTGAAA 
AGGCTGTGTA ATCGGGCTGT GCTGCTGTTT GTAGCAGTTG CTGGACTCAC GTTTTTTGCC 
CTGAGCTTTG GTTTTTACTA TGAGTACGGC TGGGAATTTT TGGAACACAC CTACTTTTAT 
CACCTGACTA GGCGGGATAT CCGTCACAAC TTTTCTCCGT ACTTCTACAT GCTGTATTTG 
ACTGCAGAGA GCAAGTGGAG TTTTTCCCTG GGAATTGCTG CATTCCTGCC ACAGCTCATC 
TTGCTTTCAG CTGTGTCTTT CGCCTATTAC AGAGACCTCG TTTTTTGTTG TTTTCTTCAT 
ACGTCCATTT TTGTGACTTT TAACAAAGTC TGCACCTCCC AGTACTTTCT TTGGTACCTC 
TGCTTACTGC CTCTTGTGAT GCCACTAGTC AGAATGCCTT GGAAAAGAGC TGTAGTTCTC 
CTAATGTTAT GGTTTATAGG GCAGGCCATG TGGCTGGCTC CTGCCTATGT TCTAGAGTTT 
CAAGGAAAGA ACACCTTTCT GTTTATTTGG TTAGCTGGTT TGTTCTTTCT TCTTATCAAT 
TGTTCCATCC TGATTCAAAT TATTTCCCAT TACAAAGAAG AACCCCTGAC AGAGAGAATC 
AAATATGACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PIGM ( NM_145167.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_660150.1 Homo sapiens phosphatidylinositol glycan anchor biosynthesis class M (PIGM), mRNA.

Price & Availability↑

CloneID	OHu19090
Clone ID Related Accession (Same CDS sequence)	NM_145167.3 , NM_145167.2
Accession Version	NM_145167.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	GPI mannosyltransferase 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX643162.1, BC019865.1 and AL513302.15. This sequence is a reference standard in the RefSeqGene project. On Jul 6, 2006 this sequence version replaced NM_145167.1. COMPLETENESS: complete on the 3' end.

ATGGGCTCCA CCAAGCACTG GGGCGAATGG CTCCTGAACT TGAAGGTGGC TCCAGCCGGC 
GTCTTTGGTG TGGCCTTTCT AGCCAGAGTC GCCCTGGTTT TCTATGGCGT CTTCCAGGAC 
CGGACCCTGC ACGTGAGGTA TACGGACATC GACTACCAGG TCTTCACCGA CGCCGCGCGC 
TTCGTCACGG AGGGGCGCTC GCCTTACCTG AGAGCCACGT ACCGTTACAC CCCGCTGCTG 
GGTTGGCTCC TCACTCCCAA CATCTACCTC AGCGAGCTCT TTGGAAAGTT TCTCTTCATC 
AGCTGCGACC TCCTCACCGC TTTCCTCTTA TACCGCCTGC TGCTGCTGAA GGGGCTGGGG 
CGCCGCCAGG CTTGTGGCTA CTGTGTCTTT TGGCTTCTTA ACCCCCTGCC TATGGCAGTA 
TCCAGCCGCG GTAATGCGGA CTCTATTGTC GCCTCCCTGG TCCTGATGGT CCTCTACTTG 
ATAAAGAAAA GACTCGTCGC GTGTGCAGCT GTATTCTATG GTTTCGCGGT GCATATGAAG 
ATATATCCAG TGACTTACAT CCTTCCCATA ACCCTCCACC TGCTTCCAGA TCGCGACAAT 
GACAAAAGCC TCCGTCAATT CCGGTACACT TTCCAGGCTT GTTTGTACGA GCTCCTGAAA 
AGGCTGTGTA ATCGGGCTGT GCTGCTGTTT GTAGCAGTTG CTGGACTCAC GTTTTTTGCC 
CTGAGCTTTG GTTTTTACTA TGAGTACGGC TGGGAATTTT TGGAACACAC CTACTTTTAT 
CACCTGACTA GGCGGGATAT CCGTCACAAC TTTTCTCCGT ACTTCTACAT GCTGTATTTG 
ACTGCAGAGA GCAAGTGGAG TTTTTCCCTG GGAATTGCTG CATTCCTGCC ACAGCTCATC 
TTGCTTTCAG CTGTGTCTTT CGCCTATTAC AGAGACCTCG TTTTTTGTTG TTTTCTTCAT 
ACGTCCATTT TTGTGACTTT TAACAAAGTC TGCACCTCCC AGTACTTTCT TTGGTACCTC 
TGCTTACTGC CTCTTGTGAT GCCACTAGTC AGAATGCCTT GGAAAAGAGC TGTAGTTCTC 
CTAATGTTAT GGTTTATAGG GCAGGCCATG TGGCTGGCTC CTGCCTATGT TCTAGAGTTT 
CAAGGAAAGA ACACCTTTCT GTTTATTTGG TTAGCTGGTT TGTTCTTTCT TCTTATCAAT 
TGTTCCATCC TGATTCAAAT TATTTCCCAT TACAAAGAAG AACCCCTGAC AGAGAGAATC 
AAATATGACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_660150.1
CDS	255..1526
Translation	MGSTKHWGEWLLNLKVAPAGVFGVAFLARVALVFYGVFQDRTLHVRYTDIDYQVFTDAARFVTEGRSPYLRATYRYTPLLGWLLTPNIYLSELFGKFLFISCDLLTAFLLYRLLLLKGLGRRQACGYCVFWLLNPLPMAVSSRGNADSIVASLVLMVLYLIKKRLVACAAVFYGFAVHMKIYPVTYILPITLHLLPDRDNDKSLRQFRYTFQACLYELLKRLCNRAVLLFVAVAGLTFFALSFGFYYEYGWEFLEHTYFYHLTRRDIRHNFSPYFYMLYLTAESKWSFSLGIAAFLPQLILLSAVSFAYYRDLVFCCFLHTSIFVTFNKVCTSQYFLWYLCLLPLVMPLVRMPWKRAVVLLMLWFIGQAMWLAPAYVLEFQGKNTFLFIWLAGLFFLLINCSILIQIISHYKEEPLTERIKYD

Target ORF information:

RefSeq Version	NM_145167.2
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphatidylinositol glycan anchor biosynthesis class M (PIGM), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145167.2

ORF Insert Sequence:

ATGGGCTCCA CCAAGCACTG GGGCGAATGG CTCCTGAACT TGAAGGTGGC TCCAGCCGGC 
GTCTTTGGTG TGGCCTTTCT AGCCAGAGTC GCCCTGGTTT TCTATGGCGT CTTCCAGGAC 
CGGACCCTGC ACGTGAGGTA TACGGACATC GACTACCAGG TCTTCACCGA CGCCGCGCGC 
TTCGTCACGG AGGGGCGCTC GCCTTACCTG AGAGCCACGT ACCGTTACAC CCCGCTGCTG 
GGTTGGCTCC TCACTCCCAA CATCTACCTC AGCGAGCTCT TTGGAAAGTT TCTCTTCATC 
AGCTGCGACC TCCTCACCGC TTTCCTCTTA TACCGCCTGC TGCTGCTGAA GGGGCTGGGG 
CGCCGCCAGG CTTGTGGCTA CTGTGTCTTT TGGCTTCTTA ACCCCCTGCC TATGGCAGTA 
TCCAGCCGCG GTAATGCGGA CTCTATTGTC GCCTCCCTGG TCCTGATGGT CCTCTACTTG 
ATAAAGAAAA GACTCGTCGC GTGTGCAGCT GTATTCTATG GTTTCGCGGT GCATATGAAG 
ATATATCCAG TGACTTACAT CCTTCCCATA ACCCTCCACC TGCTTCCAGA TCGCGACAAT 
GACAAAAGCC TCCGTCAATT CCGGTACACT TTCCAGGCTT GTTTGTACGA GCTCCTGAAA 
AGGCTGTGTA ATCGGGCTGT GCTGCTGTTT GTAGCAGTTG CTGGACTCAC GTTTTTTGCC 
CTGAGCTTTG GTTTTTACTA TGAGTACGGC TGGGAATTTT TGGAACACAC CTACTTTTAT 
CACCTGACTA GGCGGGATAT CCGTCACAAC TTTTCTCCGT ACTTCTACAT GCTGTATTTG 
ACTGCAGAGA GCAAGTGGAG TTTTTCCCTG GGAATTGCTG CATTCCTGCC ACAGCTCATC 
TTGCTTTCAG CTGTGTCTTT CGCCTATTAC AGAGACCTCG TTTTTTGTTG TTTTCTTCAT 
ACGTCCATTT TTGTGACTTT TAACAAAGTC TGCACCTCCC AGTACTTTCT TTGGTACCTC 
TGCTTACTGC CTCTTGTGAT GCCACTAGTC AGAATGCCTT GGAAAAGAGC TGTAGTTCTC 
CTAATGTTAT GGTTTATAGG GCAGGCCATG TGGCTGGCTC CTGCCTATGT TCTAGAGTTT 
CAAGGAAAGA ACACCTTTCT GTTTATTTGG TTAGCTGGTT TGTTCTTTCT TCTTATCAAT 
TGTTCCATCC TGATTCAAAT TATTTCCCAT TACAAAGAAG AACCCCTGAC AGAGAGAATC 
AAATATGACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cell-type-specific transcriptional regulation of PIGM underpins the divergent hematologic phenotype in inherited GPl deficiency.
Blood124(20)3151-4(2014 Nov)
Costa JR,Caputo VS,Makarona K,Layton DM,Roberts IA,Almeida AM,Karadimitris A

Understanding human glycosylation disorders: biochemistry leads the charge.
The Journal of biological chemistry288(10)6936-45(2013 Mar)
Freeze HH

Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency.
Nature medicine12(7)846-51(2006 Jul)
Almeida AM,Murakami Y,Layton DM,Hillmen P,Sellick GS,Maeda Y,Richards S,Patterson S,Kotsianidis I,Mollica L,Crawford DH,Baker A,Ferguson M,Roberts I,Houlston R,Kinoshita T,Karadimitris A

PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER.
The EMBO journal20(1-2)250-61(2001 Jan)
Maeda Y,Watanabe R,Harris CL,Hong Y,Ohishi K,Kinoshita K,Kinoshita T

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PIGM cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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